Article
Biochemistry & Molecular Biology
Mona A. Eldosoky, Reham Hammad, Asmaa A. Elmadbouly, Reda Badr Aglan, Sherihan G. Abdel-Hamid, Mohamed Alboraie, Donia Ahmed Hassan, Mohamed A. Shaheen, Areej Rushdi, Reem M. Ahmed, Alzahra Abdelbadea, Neamat A. Abdelmageed, Ahmed Elshafei, Elham Ali, Omaima I. Abo-Elkheir, Samy Zaky, Nadia M. Hamdy, Claude Lambert
Summary: Early HCC diagnosis is challenging, especially for AFP-negative cases. miRNA profiles may serve as potential molecular markers for HCC. This study aimed to evaluate the expression levels of four miRNAs (hsa-miR-21-5p, hsa-miR-155-5p, hsa-miR-192-5p, and hsa-miR-199a-5p) as biomarkers for HCC in CHCV patients with liver cirrhosis, particularly AFP-negative HCC cases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Pedro M. Rodrigues, Marta B. Afonso, Andre L. Simao, Tawhidul Islam, Maria M. Gaspar, Colm J. O'Rourke, Monika Lewinska, Jesper B. Andersen, Enara Arretxe, Cristina Alonso, Alvaro Santos-Laso, Laura Izquierdo-Sanchez, Raul Jimenez-Aguero, Emma Eizaguirre, Luis Bujanda, Maria J. Pareja, Carina Prip-Buus, Jesus M. Banales, Cecilia M. P. Rodrigues, Rui E. Castro
Summary: This study evaluated the role of hsa-miRNA-21-5p in the development of hepatocellular carcinoma (HCC) in non-alcoholic fatty liver disease (NAFLD) patients. The expression of hsa-miRNA-21-5p was found to increase with NAFLD severity and was associated with hepatic lipotoxicity. Inhibition of hsa-miRNA-21-5p was shown to prevent the progression of NAFLD to NASH and HCC.
LIVER INTERNATIONAL
(2023)
Article
Biotechnology & Applied Microbiology
Lu Xie, Zhihong Pan
Summary: The study demonstrates that circ_0000467 promotes CRC development by modulating the miR-382-5p/EN2 axis, and inhibition of circ_0000467 can reduce the malignant behaviors of CRC cells. Therefore, circ_0000467 may serve as a potential target for CRC therapy.
Article
Pharmacology & Pharmacy
Dan Sun, Ying-Chun Li, Xiao-Yu Zhang
Summary: Lidocaine has been shown to enhance ferroptosis and suppress cell proliferation, apoptosis, invasion, and migration in ovarian and breast cancer cells. By downregulating SLC7A11 expression through the miR-382-5p/SLC7A11 axis, lidocaine promotes ferroptosis in these cancer cells. Clinical studies are needed to further investigate the potential of lidocaine in treating ovarian and breast cancer.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Shuai Zhang, Yuan Lu, Hong-Yu Jiang, Zhi-Mei Cheng, Zi-Jing Wei, Yun-Hao Wei, Ting Liu, Bai-Juan Xia, Xu-Ya Zhao, Yu Huang, Xun Zou, Rong Liu, Shi Zhou
Summary: CircC16orf62 acts as an oncogene in HCC progression, promoting cancer development through the miR-138-5p/PTK2/Akt pathway. It functions as a molecular sponge for miR-138-5p and a competitive endogenous RNA for PTK2, activating the AKT/mTOR pathway.
CELL DEATH & DISEASE
(2021)
Article
Multidisciplinary Sciences
Xu Zhao, Jizhao Wang, Rui Zhu, Jing Zhang, Yunfeng Zhang
Summary: DLX6-AS1 regulates cisplatin sensitivity of lung squamous cell carcinoma cells through the miR-181a-5p/miR-382-5p/CELF1 axis, playing a key role in promoting secondary cisplatin resistance. Targeting DLX6-AS1 may be a novel approach to overcome cisplatin resistance in lung squamous cell carcinoma.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Yachong Liu, Jia Song, Hongwei Zhang, Zhibin Liao, Furong Liu, Chen Su, Weijian Wang, Mengzhen Han, Lu Zhang, He Zhu, Zhanguo Zhang, Huifang Liang, Lei Zhang, Bixiang Zhang, Xiaoping Chen
Summary: In this study, it was found that EIF4A3-induced circTOLLIP promotes the progression of HCC through the circTOLLIP/miR-516a-5p/PBX3/EMT axis.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Cell Biology
Shuang Wu, Shihai Liu, Yongxian Cao, Geng Chao, Peng Wang, Huazheng Pan
Summary: This study identifies ZC3H13 as a potential tumor suppressor gene in hepatocellular carcinoma (HCC) and reveals the miR-362-3p/miR-425-5p-ZC3H13 axis as a regulatory pathway. The expression of ZC3H13 is closely associated with the prognosis and tumor immune infiltration in HCC.
Article
Biotechnology & Applied Microbiology
Xinghao Zhu, Shiqing Jiang, Zongyao Wu, Tonghua Liu, Wei Zhang, Lili Wu, Lijun Xu, Mingliang Shao
Summary: In this study, it was found that the expression levels of TTN-AS1 and SPOCK1 were significantly increased in HCC, while the expression level of miR-139-5p was markedly reduced. Functional experiments demonstrated that TTN-AS1 can promote the proliferation, migration, invasion, and EMT of HCC cells by regulating the miR-139-5p/SPOCK1 axis.
Article
Gastroenterology & Hepatology
Ji-Hye Choi, So M. Kwon, Sung U. Moon, Sarah Yoon, Masaud Shah, Byoung G. Lee, Jieun Yang, Young N. Park, Hee-Jung Wang, Hyun G. Woo
Summary: Through RNA-Seq analysis, the study identified TPRG1-AS1 as a potential driver noncoding RNA that promotes heterogeneous progression of liver cancer. TPRG1-AS1 induces tumor suppressor RBM24, activating apoptotic tumor cell death to suppress tumor growth, and acts as a ceRNA interfering with the binding of miR-4691-5p and miR-3659 to RBM24.
LIVER INTERNATIONAL
(2021)
Article
Oncology
Weizhi Li, Yingchao Li, Peijie Li, Fuquan Ma, Mengying Liu, Shuzhen Kong, Hui Xue
Summary: The upregulation of HOXB5 in HCC is associated with tumor progression by activating EGFR. miR-200a-3p and miR-181-5p regulate the expression of HOXB5, affecting HCC cell proliferation and migration.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Rafal Badacz, Pawel Kleczynski, Jacek Legutko, Krzysztof Zmudka, Jacek Gacon, Tadeusz Przewlocki, Anna Kablak-Ziembicka
Summary: The study investigated circulating microRNAs as potential predictors of subsequent ischemic events in patients with symptomatic coronary or carotid artery involvement. Specific microRNAs were found to be associated with different risks of cardiovascular events, providing new insights for risk assessment in these patients.
Article
Oncology
Lili Han, Chen Huang, Xiaofei Wang, Dongdong Tong
Summary: This study revealed the interaction network among GRSF1, YY1, and miR-30e-5p, providing new insights into the pathogenesis of HCC. It also identified VE-821 as a potential novel agent for HCC treatment through inhibition of the GRSF1/YY1 axis.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Gastroenterology & Hepatology
Andong Ju, Yuhou Shen, Aimin Yue
Summary: This study found that circ_0011232 plays an important role in the progression of hepatocellular carcinoma (HCC) by promoting HCC development through the miR-503-5p/AKT3 axis. These findings may provide a novel treatment strategy for HCC.
HEPATOLOGY RESEARCH
(2022)
Article
Biology
Yun Liu, Jia Cao, Qi Yang, Linqi Zhu, Wenjun Zhao, Xiuping Wang, Jun Yao, Yong Zhou, Shihe Shao
Summary: This study demonstrates the inhibitory role of circRNA_15430 in gastric cancer (GC) and its regulation in the progression of Helicobacter pylori (HP) infection-related GC. CircRNA_15430 is primarily located in the cytoplasm of GC cells, downregulated in GC cell lines and tissues, and negatively correlated with tumor size. The downregulation of circRNA_15430 promotes proliferation and migration while suppressing apoptosis and autophagy in GC cells.
Article
Cell Biology
Baoshan Cai, Jian Zhao, Yuling Zhang, Yaxing Liu, Chunhong Ma, Fan Yi, Yi Zheng, Lei Zhang, Tian Chen, Huiqing Liu, Bingyu Liu, Chengjiang Gao
Summary: USP5 acts as a key scaffold protein in recruiting the E3 ligase MARCHF7 for autophagic degradation of NLRP3 independently of its deubiquitinating enzyme activity. Knockdown of USP5 promotes inflammatory signaling release, while overexpression has inhibitory effects.
Article
Cell Biology
Shuai Tan, Junhao Zhang, Yang Sun, Anton Gistera, Zi Sheng, Rickard E. Malmstrom, Ming Hou, Jun Peng, Chunhong Ma, Wangjun Liao, Nailin Li
Summary: Platelets enhance Th1 and Treg cell responses of CD4(+) central memory T cells through PF4-dependent mitochondrial biogenesis and proliferation of Tcm cells.
Article
Chemistry, Physical
Zhiyue Zhao, Yinghong Li, Jilei Wu, Zhenyu Shi, Peiqing Zhao, Hui Su, Qinghai Wang, Lili Jin
Summary: The study successfully prepared composite nanofibers using CM-CD to improve curdlan solubility, incorporating a drug for cardiovascular diseases. The resulting NOFs demonstrated improved mechanical properties, disintegration behavior, dissolution performance, and higher bioavailability compared to commercial tablets, suggesting potential for buccal mucosa drug delivery.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Article
Biotechnology & Applied Microbiology
Tixiao Wang, Jie Zhang, Na Li, Mengzhen Li, Shuaiya Ma, Siyu Tan, Xiaowei Guo, Zehua Wang, Zhuanchang Wu, Lifen Gao, Chunhong Ma, Xiaohong Liang
Summary: The spatial organization of immune cells within the tumor microenvironment (TME) plays a crucial role in anti-tumor immunity, tumor progression, and therapeutic response. Tim-3 is an immune checkpoint with potential as an immunotherapy target. This study examined the spatial distribution of Tim-3/Tim-3L in the TME and found that CD4 T cells were more accumulated in the tumor region and had a closer association with patient survival. CD4 T cells surrounding Tim-3L(+) cells expressed higher levels of Tim-3. Depletion of CD4 T cells abrogated the inhibition of tumor growth and metastasis mediated by Tim-3 blockade. These findings highlight the importance of CD4 T cells in Tim-3/Tim-3L-mediated immunosuppression and provide insights for Tim-3 targeted cancer immunotherapy.
Article
Oncology
Yunwei Lou, Miaomiao Song, Meijuan Han, Jiateng Zhong, Xueqin Tian, Yahan Ren, Yaru Song, Liangwei Duan, Peiqing Zhao, Xiangfeng Song, Wen Zhang, Youhai H. Chen, Hui Wang
CANCER IMMUNOLOGY RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Yang Sun, Yan Teng, Liyuan Wang, Zhaoying Zhang, ChaoJia Chen, Yingchun Wang, Xiaodong Zhang, Peng Xiang, Xiaojia Song, Jinghui Lu, Nailin Li, Lifen Gao, Xiaohong Liang, Yuchen Xia, Zhuanchang Wu, Chunhong Ma
Summary: This study identifies LINC01431 as a novel host restriction factor for HBV transcription. It competitively binds with PRMT1 to inhibit the ubiquitination and degradation of PRMT1 mediated by HBx, thus repressing cccDNA transcription. In turn, HBV transcriptionally suppresses LINC01431 expression by inhibiting the transcription factor ZHX2.
Letter
Oncology
Yuming Ding, Chaojia Chen, Shuaiya Ma, Xue Sheng, Fangcheng Zhao, Jiali Peng, Haoqing Dong, Chunhong Ma, Chunyang Li
CANCER COMMUNICATIONS
(2022)
Article
Chemistry, Analytical
Yamei Li, Zhaosong Li, Haibo Tan, Yueyuan Li, Feng Tang, Ping Wang, Yueyun Li, Hui Liu, Peiqing Zhao, Qing Liu
Summary: Developing heterojunctions with high visible light absorption capability, fast e(-)/h(+) separation and sufficient chemical stability is crucial for developing efficient photoelectrochemical (PEC) biosensing systems. In this work, we developed an intercalated ZnCdS/NiS/ZnCdS dual heterojunction based on the hydrophilicity of bimetallic sulfides ZnCdS solid solution to construct a PEC immunosensor for PD-L1 detection. The constructed dual heterojunction sensing platform exhibits high sensitivity and selectivity in detecting PD-L1, showing a good linear range and low detection limit.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Analytical
Yamei Li, Shujun Wang, Yan Zhao, Yueyuan Li, Ping Wang, Hongqiang Xie, Peiqing Zhao, Yueyun Li, Qing Liu, Qin Wei
Summary: In this study, a double-photoelectrode PEC sensing platform was fabricated by integrating a p-type metal-organic framework (MIL-68-(In)-NH2) photocatalyst as a photocathode and CdSe/MgIn2S4 type-II heterojunction as a photoanode using an antenna-like strategy. The platform exhibited 2.5 times stronger photocurrent response compared to traditional heterojunction single electrode. Based on this strategy, a PEC biosensor for the detection of PD-L1 was constructed, which showed sensitive and precise detection capability with a detection range of 1 x10(-5) to 1 x 10(3) ng/mL.
ANALYTICAL CHEMISTRY
(2023)
Article
Cell Biology
Wei Hu, Wenxiang Zheng, Jianxin Du, Zhaobing Tian, Yixin Zhao, Peiqing Zhao, Junsheng Li
Summary: Drug resistance is a major challenge in breast cancer treatment, and drug-induced autophagy and cancer stem cells play important roles in this process. However, the inhibitory role of TIPE2 in paclitaxel resistance in breast cancer cells has not been fully understood. This study demonstrated that TIPE2 can sensitize breast cancer cells to paclitaxel by suppressing drug-induced autophagy and cancer stem cell properties, suggesting that TIPE2 may be a potential target for breast cancer chemotherapy.
Article
Genetics & Heredity
Yongting Lan, Qing Jia, Min Feng, Peiqing Zhao, Min Zhu
Summary: This study aimed to develop a novel prognostic signature for pancreatic cancer (PC) patients by analyzing NK cell-related genes (NKGs). A total of 32 prognostic NKGs were identified and used to generate three distinct clusters. PC patients were divided into high and low risk groups based on the risk signature, which showed differences in prognosis, clinicopathological features, immune infiltration, immunotherapy response, and drug sensitivity. A decision tree and nomogram model were successfully constructed for prognostic prediction.
FRONTIERS IN GENETICS
(2023)
Article
Medicine, Research & Experimental
Ziying Jiang, Xinyu Wang, Haoqiang Zhang, Jian Yin, Peiqing Zhao, Qingqing Yin, Zhenfu Wang
Summary: The ketogenic diet, a low-carbohydrate, high-fat regime, can protect against neurodegenerative diseases like Parkinson's disease by regulating the gut microbiota and reducing inflammation.
Letter
Biochemistry & Molecular Biology
Zhuanchang Wu, Xiaobo Lei, Xin Wang, Zhaoying Zhang, Yuming Li, Lifen Gao, Xiaohong Liang, Peihui Wang, Jianwei Wang, Chunhong Ma
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Materials Science, Multidisciplinary
Na Yang, Lan Yang, Xiang Zhu, Peiqing Zhao, Honglai Liu, Chungu Xia, Sheng Dai, Chengcheng Tian
Summary: Highly crystalline covalent triazine frameworks (CTFs) were synthesized for the first time using a solvent-and catalyst-free approach. The CTFs were then transformed into isolated single-atom catalysts (SACs) through a new condensation reaction. These SACs exhibited efficient performance in electrochemical carbon dioxide reduction.
ACS MATERIALS LETTERS
(2022)
Article
Oncology
Haixia Shan, Bo Wang, Xiaodong Zhang, Hui Song, Xi Li, Yongxin Zou, Baichun Jiang, Huili Hu, Hao Dou, Changshun Shao, Lifen Gao, Chunhong Ma, Xiaoyun Yang, Xiaohong Liang, Yaoqin Gong
Summary: The study found that CUL4B enhances HBV replication by interacting with HBx and disrupting its ubiquitin-dependent proteasomal degradation. The results of this study are of great significance for the development of potential targets for anti-HBV therapy.
CANCER BIOLOGY & MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
G. F. Senguel, R. Mishra, E. Candiello, P. Schu
Summary: AP2 forms AP2 CCV with clathrin and other coat proteins, and synapses contain different types of CCV. The stability and composition of CCV are regulated by various factors, including Hsc70 and phosphorylation patterns. The knockout of the AP1/O1B complex disrupts synaptic vesicle recycling and endosomal protein sorting, leading to upregulation of endocytosis. Stable CCV, termed stCCV, have distinct characteristics and specialized functions in synaptic plasticity. The phosphorylation of Hsc70 and the levels of kinases play a crucial role in regulating the stability and disassembly of clathrin in CCV.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Martin Fluck, Colline Sanchez, Vincent Jacquemond, Christine Berthier, Marie-Noelle Giraud, Daniel Jacko, Kathe Bersiner, Sebastian Gehlert, Guus Baan, Richard T. Jaspers
Summary: Enhancing CaMKII signaling improves fatigue resistance and contractile characteristics of skeletal muscle by enhancing calcium release.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Letter
Biochemistry & Molecular Biology
Federica Coppola, Sara Monaci, Alessandro Falsini, Carlo Aldinucci, Irene Filippi, Daniela Rossi, Fabio Carraro, Antonella Naldini
Summary: The adaptor protein p62 plays a crucial role in maintaining the survival of dendritic cells (DCs) under hypoxic conditions by preserving Erk1/2 phosphorylation and reducing AMPK activation, thus extending their lifespan to ensure their functions in hypoxic microenvironments.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Jenifer Pendiuk Goncalves, Jorvani Cruz Villarreal, Sierra A. Walker, Xuan Ning Sharon Tan, Chad Borges, Joy Wolfram
Summary: This study used a mass spectrometry-based approach to assess the differences in glycan features between extracellular vesicles (EVs) and originating cells. The results showed that EVs selectively enriched specific glycan features, particularly those associated with binding to the extracellular matrix. The study also found differences in EV glycan sorting between different metastatic cell lines and mouse models, indicating a potential role of glycan diversity in the metastatic process.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
De-ao Gong, Peng Zhou, Wen-yi Chang, Jia-yao Yang, Yan-lai Zhang, Ai-long Huang, Ni Tang, Kai Wang
Summary: Liver cancer, ranked sixth globally, is a major contributor to cancer-related mortality. Metastasis is the main cause of treatment failure and deaths in liver cancer. The SPOP-CREB5-MET axis plays a significant role in liver cancer metastasis.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Ning Huang, Jun Tang, Xiaoyao Yi, Maoxin Zhang, Bin Li, Yuan Cheng, Jin Chen
Summary: This study reveals that glioma-derived S100A9 can induce microglial M2 polarization, inhibit CD8+ T lymphocytes, and promote immunosuppression. The mechanism is related to the interaction with alpha v133 integrin and subsequent activation of AKT1 in microglia. The expression of S100A9 is positively associated with CD206 expression and negatively correlated with CD8+ T lymphocyte accumulation in the TME, suggesting a potential role of S100A9 in regulating the tumor microenvironment and immune evasion in glioma.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Yomna S. Abd El-Aziz, Matthew J. McKay, Mark P. Molloy, Betty McDowell, Elizabeth Moon, Loretta Sioson, Amy Sheen, Angela Chou, Anthony J. Gill, Patric J. Jansson, Sumit Sahni
Summary: This study identified a novel combination of autophagy inhibitors that can effectively inhibit the proliferation of oral squamous cell carcinoma (OSCC) cells, including both chemosensitive and chemoresistant cells. This research is important for the development of new therapies for advanced OSCC tumors.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Luojia Liu, Xiaoqiang Liu, Ying Chen, Meng Kong, Jinghong Zhang, Min Jiang, Hongling Zhou, Jinrui Yang, Xu Chen, Ze Zhang, Chao Wu, Xupin Jiang, Jiaping Zhang
Summary: Our study revealed that the Paxillin/HDAC6 signaling pathway regulates microtubule acetylation in electric field-guided keratinocyte migration.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Julia Weikum, Jeroen F. van Dyck, Saranya Subramani, David P. Klebl, Merete Storflor, Stephen P. Muench, Soren Abel, Frank Sobott, J. Preben Morth
Summary: The study reveals the complex interaction between bacterial magnesium transporter A (MgtA) and cardiolipin 18:1 and cardiolipin 16:0, highlighting the importance of lipid environment in protein activity and stability. Further understanding of Mg2+ homeostasis in bacteria will provide insights into bacterial infections.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Sumit Kinger, Yuvraj Anandrao Jagtap, Ankur Rakesh Dubey, Prashant Kumar, Akash Choudhary, Rohan Dhiman, Vijay Kumar Prajapati, Deepak Chitkara, Krishna Mohan Poluri, Amit Mishra
Summary: Efficient protein synthesis and quality control mechanisms are crucial for maintaining proteostasis and preventing neurodegeneration. This study demonstrates that treating cells with Lanosterol can enhance the proteolytic activity of Proteasome and promote the removal of misfolded proteins, suggesting a potential therapeutic approach for abnormal protein accumulation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Karolina Stepien, Adrianna Skoneczna, Monika Kula-Maximenko, Lukasz Jurczyk, Mateusz Molon
Summary: The replication of DNA requires a complex machinery called the replisome, which is highly conserved across species. One crucial component of the replisome is the CMG helicase complex, which unwinds DNA and coordinates the assembly and function of other replisome components. In this study, the impact of the absence of one copy of the CMG complex genes on the physiology and aging of yeast cells was investigated. The findings showed disruptions in the cell cycle, extended doubling times, and alterations in the biochemical profile of these cells. Importantly, it was found that heterozygous cells for CMG helicase genes exhibited increased reproductive potential and delayed aging. The study also highlighted potential therapeutic targets for cancer treatment using yeast.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Nishadh Rathod, Guadalupe Guerrero-Serna, Howard S. Young, L. Michel Espinoza-Fonseca
Summary: This study reveals that replacing Lys27 with Asn enhances the inhibitory potency of MLN without affecting SERCA's affinity for Ca2+. The findings suggest that the SERCA site modulating Ca2+ affinity also functions as a catalytic activity switch.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Can Jiang, Chunyang Zhang, Min Dai, Fuyan Wang, Sa Xu, Dan Han, Yanyan Wang, Yajie Cao, Yanyan Liang, Ziyu Zhang, Lina Yan, Yujun Shen, Kewu He, Yuxian Shen, Jun Liu
Summary: The phosphorylation of p65 and the expression of SUMO1 are increased in cancer tissues of HCC patients, and there is a positive correlation between SUMO1 and phosphorylated p65. SUMOylation of p65 by SUMO1 promotes p65 nuclear import and enhances NF-xB activity. Both SUMOylation and phosphorylation of p65 increase the viability and invasion of hepatoma cells, and decrease cell apoptosis.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Ming-Fo Hsu, Yoshihiro Ito, Jai Prakash Singh, Shu-Fang Hsu, Alan Wells, Kuang-Yu Jen, Tzu-Ching Meng, Fawaz G. Haj
Summary: This study identified alpha-actinin4 as a novel substrate of PTP1B in podocytes and demonstrated their interaction in regulating podocyte function. Targeting PTP1B and alpha-actinin4 could be a potential therapeutic approach for podocyte injury.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Paulo F. V. Bizerra, Eduardo H. Gilglioni, Hang Lam Li, Simei Go, Ronald P. J. Oude Elferink, Arthur J. Verhoeven, Jung -Chin Chang
Summary: This study investigates the role of cyclic AMP (cAMP) in glycogen metabolism and reveals that cAMP regulates glycogenolysis in opposite directions depending on its site of synthesis within cells and downstream effectors. The canonical tmAC-cAMP-PKA signaling promotes glycogenolysis, while the non-canonical sAC-cAMP-Epac1 signaling suppresses glycogenolysis. This highlights the importance of cAMP microdomain organization for distinct metabolic regulation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)