Article
Health Care Sciences & Services
Laura B. Scheinfeldt, Andrew Brangan, Dara M. Kusic, Sudhir Kumar, Neda Gharani
Summary: Pharmacogenomics shows promise for personalized drug efficacy optimization and toxicity minimization. Research has been biased towards European participants, but the new machine learning method XGB-PGX excels in predicting pharmacogenetic variants. While there are differences in pharmacogenetic allele frequency distribution across global populations, the focus should be on identifying functional variants rather than on population differences.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Medicine, Research & Experimental
Filippo Pinto e Vairo, Jennifer L. Kemppainen, Carolyn R. Rohrer Vitek, Denise A. Whalen, Kayla J. Kolbert, Kaitlin J. Sikkink, Sarah A. Kroc, Teresa Kruisselbrink, Gabrielle F. Shupe, Alyssa K. Knudson, Elizabeth M. Burke, Elle C. Loftus, Lorelei A. Bandel, Carri A. Prochnow, Lindsay A. Mulvihill, Brittany Thomas, Dale M. Gable, Courtney B. Graddy, Giovanna G. Moreno Garzon, Idara U. Ekpoh, Eva M. Carmona Porquera, Fernando C. Fervenza, Marie C. Hogan, Mireille El Ters, Kenneth J. Warrington, John M. Davis III, Matthew J. Koster, Amir B. Orandi, Matthew L. Basiaga, Adrian Vella, Seema Kumar, Ana L. Creo, Aida N. Lteif, Siobhan T. Pittock, Peter J. Tebben, Ejigayehu G. Abate, Avni Y. Joshi, Elizabeth H. Ristagno, Mrinal S. Patnaik, Lisa A. Schimmenti, Radhika Dhamija, Sonia M. Sabrowsky, Klaas J. Wierenga, Mira T. Keddis, Niloy Jewel J. Samadder, Richard J. Presutti, Steven I. Robinson, Michael C. Stephens, Lewis R. Roberts, William A. Faubion, Sherilyn W. Driscoll, Lily C. Wong-Kisiel, Duygu Selcen, Eoin P. Flanagan, Vijay K. Ramanan, Lauren M. Jackson, Michelle L. Mauermann, Victor E. Ortega, Sarah A. Anderson, Stacy L. Aoudia, Eric W. Klee, Tammy M. McAllister, Konstantinos N. Lazaridis
Summary: Rare diseases in the United States, which affect fewer than 200,000 individuals, often have an underlying genetic cause. To better serve these patients, the Mayo Clinic has established the Program for Rare and Undiagnosed Diseases (PRaUD). Through collaboration with subspecialty providers, PRaUD has evaluated 1152 patients and achieved significant medical management changes based on genetic test results.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Biology
Leila Fattel, Dennis Psaroudakis, Colleen F. Yanarella, Kevin O. Chiteri, Haley A. Dostalik, Parnal Joshi, Dollye C. Starr, Ha Vu, Kokulapalan Wimalanathan, Carolyn J. Lawrence-Dill
Summary: Genome-wide functional annotations are crucial for studying gene function and traits in plants. By comparing functional annotation data from different species, similarities and differences can be identified, leading to the generation of novel hypotheses about gene function and evolutionary relationships.
Article
Computer Science, Artificial Intelligence
Xinxin Shan, Tai Ma, Ying Wen
Summary: This paper proposes a novel classification model called PCL for unsupervised domain adaptation, which predicts the common labels of different domains and uses the Category Separation via Clustering (CSC) method. The proposed method effectively addresses the problems of existing methods and achieves better domain alignment.
Article
Psychology, Multidisciplinary
Dan Hu, Matias Ison, Alan Johnston
Summary: Human vision has a common processing rate for motion-based visual prediction across diverse motion phenomena. Motion Induced Spatial Conflict (MISC) frequency correlates significantly with the accrual rate of the Motion Induced Position Shift (MIPS) effect, suggesting a shared perceptual rate between them.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Taesic Lee, Hyunju Lee
Summary: This study identified shared disease-related genes and common hub genes between Alzheimer's disease and cardiovascular disease, providing insights into the shared mechanisms between these two diseases.
Article
Biochemistry & Molecular Biology
Bingjian Liu, Jiasheng Li, Ying Peng, Kun Zhang, Qi Liu, Xun Jin, Sixu Zheng, Yunpeng Wang, Li Gong, Liqin Liu, Zhenming Lu, Yifan Liu
Summary: By constructing the genome of the common hairfin anchovy (Setipinna tenuifilis) and studying its adaptive diversity, we found three genetic groups of this species along the Chinese coast and identified the important role of environmental factors, such as temperature, in driving adaptive divergence. This study sheds light on the evolution and genetic variation patterns of S. tenuifilis, providing a valuable genomic resource for further research on this species and closely related Clupeiformes.
Editorial Material
Multidisciplinary Sciences
Conrad O. Iyegbe, Paul F. O'Reilly
Summary: Rare and common genetic variants associated with schizophrenia provide convergent clues about the underlying biology of this complex disorder.
Article
Biochemistry & Molecular Biology
Sean K. McKenzie, Max E. Winston, Felix Grewe, Gabriel Vargas Asensio, Natalia Rodriguez-Hernandez, Benjamin E. R. Rubin, Catalina Murillo-Cruz, Christoph von Beeren, Corrie S. Moreau, Garret Suen, Adrian A. Pinto-Tomas, Daniel J. C. Kronauer
Summary: Mass raiding evolution has made army ants dominant predators in the tropics. The genome of New World army ant Eciton burchellii is compact with a reduced gene complement, but has an expanded gene subfamily related to hydrocarbon recognition. This modification in the chemosensory system may aid in behavioral coordination and prey selection during social predation for army ants and their relatives.
Article
Multidisciplinary Sciences
Atil Bisgin, Ozge Sonmezler, Ibrahim Boga, Mustafa Yilmaz
Summary: NGS of 103 CVID patients identified 112 different rare variants, with 49.1% classified as variants of uncertain significance and 1.8% classified as pathogenic. Rare variants in different genes were found to play a prominent role in disease susceptibility and etiology. However, the frequencies of these variants differed from population frequency databases.
SCIENTIFIC REPORTS
(2021)
Article
Environmental Sciences
Andrea Barcelo, Jonathan Sandoval-Castillo, Karen A. Stockin, Kerstin Bilgmann, Catherine R. M. Attard, Nikki Zanardo, Guido J. Parra, Krista Hupman, Isabella M. Reeves, Emma L. Betty, Gabriela Tezanos-Pinto, Luciano B. Beheregaray, Luciana M. Moeller
Summary: The study reveals a complex population structure and connectivity of common dolphins in the Australasian region, involving migration and gene flow across international jurisdictions.
FRONTIERS IN MARINE SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Li-Jun Cao, Bing-Yan Li, Jin-Cui Chen, Jia-Ying Zhu, Ary A. Hoffmann, Shu-Jun Wei
Summary: Invasive species pose a increasing threat to global biodiversity and ecosystems. Differentiation in genetic flow and local adaptation between invasive and non-invasive species may play a key role in the invasiveness of the species. The study suggests that genetic differentiation and adaptation to the environment may affect the invasive potential of species such as the peach fruit moth.
Article
Biochemistry & Molecular Biology
Devon A. DeRaad, Marlon E. Cobos, Abdelghafar Alkishe, Uzma Ashraf, Koffi Mensah Ahadji-Dabla, Claudia Nunez-Penichet, A. Townsend Peterson
Summary: The concept of fundamental ecological niche is crucial for various ecological questions. This study examined the potential role of genome environment association (GEA) testing in understanding genetic basis of ecological niche using genomic data from Anopheles gambiae 1000 Genomes Consortium. The results indicated that while commonly implemented GEA methods can account for confounding patterns of genetic variation, challenges remain in discerning true signals of genome environment adaptation.
Article
Evolutionary Biology
Xinyu Ge, Jianfeng Jin, Lang Peng, Haoming Zang, Beixin Wang, Changhai Sun
Summary: Trichoptera is a group of freshwater insects that are highly sensitive to water quality, making them reliable indicators of water quality. In this study, we assembled the genome of C. charites and identified gene families involved in detoxification metabolism, digestive absorption, and resistance to viruses or bacteria.
GENOME BIOLOGY AND EVOLUTION
(2022)
Article
Plant Sciences
Samuel G. S. Hibdige, Pauline Raimondeau, Pascal-Antoine Christin, Luke T. Dunning
Summary: Research on 17 diverse grass species found LGT to be a widespread phenomenon, with the amount and success of transfers depending on species growth habits and phylogenetic relatedness.
Article
Genetics & Heredity
Fernando L. Mendez, G. David Poznik, Sergi Castellano, Carlos D. Bustamantel
AMERICAN JOURNAL OF HUMAN GENETICS
(2016)
Article
Biochemistry & Molecular Biology
Vadim N. Gladyshev, Elias S. Arner, Marla J. Berry, Regina Brigelius-Flohe, Elspeth A. Bruford, Raymond F. Burk, Bradley A. Carlson, Sergi Castellano, Laurent Chavatte, Marcus Conrad, Paul R. Copeland, Alan M. Diamond, Donna M. Driscoll, Ana Ferreiro, Leopold Flohe, Fiona R. Green, Roderic Guigo, Diane E. Handy, Dolph L. Hatfield, John Hesketh, Peter R. Hoffmann, Arne Holmgren, Robert J. Hondal, Michael T. Howard, Kaixun Huang, Hwa-Young Kim, Ick Young Kim, Josef Koehrle, Alain Krol, Gregory V. Kryukov, Byeong Jae Lee, Byung Cheon Lee, Xin Gen Lei, Qiong Liu, Alain Lescure, Alexei V. Lobanov, Joseph Loscalzo, Matilde Maiorino, Marco Mariotti, K. Sandeep Prabhu, Margaret P. Rayman, Sharon Rozovsky, Gustavo Salinas, Edward E. Schmidt, Lutz Schomburg, Ulrich Schweizer, Miljan Simonovic, Roger A. Sunde, Petra A. Tsuji, Susan Tweedie, Fulvio Ursini, Philip D. Whanger, Yan Zhang
JOURNAL OF BIOLOGICAL CHEMISTRY
(2016)
Article
Multidisciplinary Sciences
Martin Kuhlwilm, Ilan Gronau, Melissa J. Hubisz, Cesare de Filippo, Javier Prado-Martinez, Martin Kircher, Qiaomei Fu, Hernan A. Burbano, Carles Lalueza-Fox, Marco de la Rasilla, Antonio Rosas, Pavao Rudan, Dejana Brajkovic, Zeljko Kucan, Ivan Gusic, Tomas Marques-Bonet, Aida M. Andres, Bence Viola, Svante Paeaebo, Matthias Meyer, Adam Siepel, Sergi Castellano
Article
Biochemistry & Molecular Biology
Michael D. Martin, Flora Jay, Sergi Castellano, Montgomery Slatkin
Article
Biochemistry & Molecular Biology
Gaurab K. Sarangi, Frederic Romagne, Sergi Castellano
MOLECULAR BIOLOGY AND EVOLUTION
(2018)
Editorial Material
Microbiology
Sergi Castellano
NATURE MICROBIOLOGY
(2019)
Article
Genetics & Heredity
Joshua M. Schmidt, Marc de Manuel, Tomas Marques-Bonet, Sergi Castellano, Aida M. Andres
Review
Genetics & Heredity
Jasmin S. Rees, Sergi Castellano, Aida M. Andres
TRENDS IN GENETICS
(2020)
Article
Multidisciplinary Sciences
Louis du Plessis, John T. McCrone, Alexander E. Zarebski, Verity Hill, Christopher Ruis, Bernardo Gutierrez, Jayna Raghwani, Jordan Ashworth, Rachel Colquhoun, Thomas R. Connor, Nuno R. Faria, Ben Jackson, Nicholas J. Loman, Aine O'Toole, Samuel M. Nicholls, Kris Parag, Emily Scher, Tetyana Vasylyeva, Erik M. Volz, Alexander Watts, Isaac I. Bogoch, Kamran Khan, David M. Aanensen, Moritz U. G. Kraemer, Andrew Rambaut, Oliver G. Pybus
Summary: The study analyzed the genetic lineage structure of the early UK COVID-19 epidemic through genomic sampling, identifying that virus lineages introduced before the national lockdown tended to be larger and more dispersed. After the lockdown, lineage importation and regional diversity decreased, while lineage elimination depended on lineage size. The research emphasizes the impact of genetic perspective on transmission dynamics for COVID-19 epidemiology and control.
Article
Microbiology
Ana da Silva Filipe, James G. Shepherd, Thomas Williams, Joseph Hughes, Elihu Aranday-Cortes, Patawee Asamaphan, Shirin Ashraf, Carlos Balcazar, Kirstyn Brunker, Alasdair Campbell, Stephen Carmichael, Chris Davis, Rebecca Dewar, Michael D. Gallagher, Rory Gunson, Verity Hill, Antonia Ho, Ben Jackson, Edward James, Natasha Jesudason, Natasha Johnson, E. Carol McWilliam Leitch, Kathy Li, Alasdair MacLean, Daniel Mair, David A. McAllister, John T. McCrone, Sarah E. McDonald, Martin P. McHugh, A. Keith Morris, Jenna Nichols, Marc Niebel, Kyriaki Nomikou, Richard J. Orton, Aine O'Toole, Massimo Palmarini, Benjamin J. Parcell, Yasmin A. Parr, Andrew Rambaut, Stefan Rooke, Sharif Shaaban, Rajiv Shah, Joshua B. Singer, Katherine Smollett, Igor Starinskij, Lily Tong, Vattipally B. Sreenu, Elizabeth Wastnedge, Matthew T. G. Holden, David L. Robertson, Kate Templeton, Emma C. Thomson
Summary: Genomic epidemiology analysis revealed multiple introductions of SARS-CoV-2 into Scotland from mainland Europe, especially Italy and Spain, during the first wave of COVID-19. Early introductions led to community outbreaks, healthcare facility transmission, and an outbreak at an international conference. Earlier implementation of travel restrictions and quarantine measures could have reduced the number of COVID-19 cases in Scotland.
NATURE MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Emma C. Thomson, Laura E. Rosen, James G. Shepherd, Roberto Spreafico, Ana da Silva Filipe, Jason A. Wojcechowskyj, Chris Davis, Luca Piccoli, David J. Pascall, Josh Dillen, Spyros Lytras, Nadine Czudnochowski, Rajiv Shah, Marcel Meury, Natasha Jesudason, Anna De Marco, Kathy Li, Jessica Bassi, Aine O'Toole, Dora Pinto, Rachel M. Colquhoun, Katja Culap, Ben Jackson, Fabrizia Zatta, Andrew Rambaut, Stefano Jaconi, Vattipally B. Sreenu, Jay Nix, Ivy Zhang, Ruth F. Jarrett, William G. Glass, Martina Beltramello, Kyriaki Nomikou, Matteo Pizzuto, Lily Tong, Elisabetta Cameroni, Tristan Croll, Natasha Johnson, Julia Di Iulio, Arthur Wickenhagen, Alessandro Ceschi, Aoife M. Harbison, Daniel Mair, Paolo Ferrari, Katherine Smollett, Federica Sallusto, Stephen Carmichael, Christian Garzoni, Jenna Nichols, Massimo Galli, Joseph Hughes, Agostino Riva, Antonia Ho, Marco Schiuma, Malcolm G. Semple, Peter J. M. Openshaw, Elisa Fadda, J. Kenneth Baillie, John D. Chodera, Suzannah J. Rihn, Samantha J. Lycett, Herbert W. Virgin, Amalio Telenti, Davide Corti, David L. Robertson, Gyorgy Snell
Summary: SARS-CoV-2 virus can mutate and evade immunity, with mutations like N439K conferring resistance against neutralizing monoclonal antibodies and enhancing binding affinity to hACE2 receptor. Despite similar in vitro replication fitness and clinical outcomes compared to wild type, N439K mutation highlights the importance of ongoing molecular surveillance for guiding vaccine and therapeutic development and usage.
Article
Multidisciplinary Sciences
Katrina A. Lythgoe, Matthew Hall, Luca Ferretti, Mariateresa de Cesare, George MacIntyre-Cockett, Amy Trebes, Monique Andersson, Newton Otecko, Emma L. Wise, Nathan Moore, Jessica Lynch, Stephen Kidd, Nicholas Cortes, Matilde Mori, Rebecca Williams, Gabrielle Vernet, Anita Justice, Angie Green, Samuel M. Nicholls, M. Azim Ansari, Lucie Abeler-Dorner, Catrin E. Moore, Timothy E. A. Peto, David W. Eyre, Robert Shaw, Peter Simmonds, David Buck, John A. Todd, Thomas R. Connor, Shirin Ashraf, Ana da Silva Filipe, James Shepherd, Emma C. Thomson, David Bonsall, Christophe Fraser, Tanya Golubchik
Summary: The study found that SARS-CoV-2 infections in clinical samples in the UK are characterized by low levels of within-host diversity and a narrow bottleneck at transmission. Most variants are either lost or occasionally fixed at the point of transmission, with shared diversity not persisting.
Article
Biochemistry & Molecular Biology
Matthew D. Parker, Benjamin B. Lindsey, Shay Leary, Silvana Gaudieri, Abha Chopra, Matthew Wyles, Adrienn Angyal, Luke R. Green, Paul Parsons, Rachel M. Tucker, Rebecca Brown, Danielle Groves, Katie Johnson, Laura Carrilero, Joe Heffer, David G. Patridge, Cariad Evans, Mohammad Raza, Alexander J. Keeley, Nikki Smith, Ana Da Silva Filipe, James G. Shepherd, Chris Davis, Sahan Bennett, Vattipally B. Sreenu, Alain Kohl, Elihu Aranday-Cortes, Lily Tong, Jenna Nichols, Emma C. Thomson, Dennis Wang, Simon Mallal, Thushan I. de Silva
Summary: The researchers developed a tool called "periscope" for detecting and quantifying subgenomic RNA (sgRNA) in SARS-CoV-2 genomic sequence data. By using this tool on 1155 SARS-CoV-2 genomes, they were able to identify and quantify various sgRNAs, including recurrent noncanonical sgRNAs.
Review
Nutrition & Dietetics
Ashley N. Ogawa-Wong, Marla J. Berry, Lucia A. Seale
Article
Biochemistry & Molecular Biology
A. Prabakaran, Amit Alexander
Summary: The molecular interactions and mucoadhesive nature of chitosan-coated liposomes with mucin are crucial for the development of an effective drug delivery system. The positively charged SA-CH-LPs showed stronger interaction and better mucoadhesive properties compared to negatively charged SALPs, thereby improving drug retention in the nasal cavity and enhancing therapeutic efficacy.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Maryam Noei-Khesht Masjedi, Esmaeil Sadroddiny, Jafar Ai, Saeed Balalaie, Yazdan Asgari
Summary: This study discovered an effective strategy for cargo sorting within exosomes by incorporating an appropriate cleavage site, providing further insight into the potential of exosomes as nano-shuttles bearing therapeutic biomolecules.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Pei -Gee Yap, Chee-Yuen Gan
Summary: This study collected the sequences of 128 tyrosinase inhibitory peptides and analyzed their hydrophobicity/hydrophilicity properties and amino acid profiles. Molecular docking analysis was used to investigate the binding interactions between peptides and tyrosinase. The study found that hydrophobic and/or polar neutral properties facilitate or stabilize peptide binding with tyrosinase, and short peptides with cysteine and tyrosine tend to bind to the active site of tyrosinase. These findings provide detailed explanations for the relationship between peptide/amino acid structures and tyrosinase inhibition, as well as potential anti-melanogenesis mechanisms for peptide-based treatments against skin hyperpigmentation.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Ye Yang, Hai-Lian Chen, Su Fang Wu, Wei Bao
Summary: The study found that CHMP4B and VPS4A play an important role in reversing GSDMD-mediated pyroptosis by facilitating cell membrane remodeling in endometrial carcinoma.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Aya Al Othman, Dmitry Bagrov, Julian M. Rozenberg, Olga Glazova, Gleb Skryabin, Elena Tchevkina, Alexandre Mezentsev, Mikhail Durymanov
Summary: Arc protein is found in glutamatergic neurons of vertebrates and can be transferred between neurons in extracellular vesicles (EVs). In glioma cells, Arc protein is also present in EVs and can facilitate the transfer of mRNA, potentially contributing to tumor progression and affecting synaptic plasticity in cancer patients.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Nan Zhang, Meng-yu Shen, Qing-li Meng, Hao-ping Sun, Fang-yi Fan, Hai Yi, Yong-jian Yang
Summary: In this study, it was demonstrated for the first time that FAT1 inhibited AML proliferation by reducing autophagy level. FAT1 achieved this by decreasing the expression of ATG4B, which is related to autophagy. Mechanistically, FAT1 decreased the levels of phosphorylated and intranuclear smad2/3, thus decreasing the activity of the ATG4B gene promoter. It was also found that FAT1 competitively bound to TGF-beta R II, leading to reduced phosphorylation of TGF-beta R I and smad2/3. Knockdown of FAT1 promoted AML autophagy and proliferation in vivo.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Oleh Demianchuk, Myroslava Vatashchuk, Dmytro Gospodaryov, Viktoria Hurza, Marian Ivanochko, Vitalii Derkachov, Vladyslav Berezovskyi, Oleh Lushchak, Kenneth B. Storey, Maria Bayliak, Volodymyr I. Lushchak
Summary: This study investigated the effects of a high-fat high-fructose diet (HFFD) on the behavior, energy metabolism, and oxidative stress markers in the cerebral cortex of mice. The results showed that HFFD stimulated locomotion and defecation, while an AKG-supplemented diet had a tendency to promote anxiety-like behavior. Additionally, there were significant differences in glutathione-dependent detoxification and processes related to autophagy between the two diets.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Yusaku Chukai, Ginga Ito, Yasuo Miki, Koichi Wakabayashi, Ken Itoh, Eriko Sugano, Hiroshi Tomita, Tomokazu Fukuda, Taku Ozaki
Summary: The study found that mitochondrial calpain-5 plays an important role in the occurrence and development of ischemia-reperfusion injury and is expressed in the human and mouse brains. Targeting the expression or activity of mitochondrial calpain-5 may have significant implications for suppressing inflammation during I/R injuries such as cerebrovascular diseases.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Aline Dias da Purificaca, Victor Debbas, Leonardo Yuji Tanaka, Gabriele Veronica de Mello Gabriel, Joao Wosniak Junior, Tiphany Coralie De Bessa, Sheila Garcia-Rosa, Francisco Rafael Martins Laurindo, Percillia Victoria Santos Oliveira
Summary: The ER transmembrane chaperones DNAJB12 and DNAJB14 play important roles in protein folding and ER stress response. They are regulated by thiol redox processes and are involved in ER protein reflux.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Ekaterina O. Bryanskaya, Andrey Y. Vinokurov, Angelina I. Dolgikh, Andrey Dunaev, Plamena R. Angelova, Andrey Y. Abramov
Summary: FAD autofluorescence in cells can assess enzymatic activity, and its intensity variations may be related to different cell types and tissues. High levels of FAD autofluorescence can indicate cell pathology and potentially predict the occurrence of apoptosis and necrosis.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Rumei Luan, Manyu Luo, Dongyan Ding, Xin Su, Junling Yang
Summary: Zinc deficiency can worsen obesity-related lung damage, and Nrf2 activation is one of the important mechanisms of this protective effect. Regulating zinc homeostasis can contribute to the prevention and treatment of obesity-related lung injury.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
