Review
Pharmacology & Pharmacy
Daniela Maria Tanase, Alina Georgiana Apostol, Claudia Florida Costea, Claudia Cristina Tarniceriu, Ionut Tudorancea, Minela Aida Maranduca, Mariana Floria, Ionela Lacramioara Serban
Summary: Arterial hypertension is a prevalent disease characterized by increased incidence and heterogeneous pathophysiology. Oxidative stress plays an important role in its development, with excessive levels causing vascular cell damage and promoting hypertension. Transcription factors such as Nrf2 mediate antioxidant response pathways and provide protection.
Article
Fisheries
Yun Wang, Yafei Duan, Jianhua Huang, Jun Wang, Chuanpeng Zhou, Shigui Jiang, Heizhao Lin, Zhe Zhang
Summary: PmNrf2, a member of CNC-bZIP transcription factor family, is constitutively expressed in various tissues of shrimp and responds to bacterial challenge. Knockdown of PmNrf2 results in decreased expression of PmGPx gene, indicating its role in regulating the transcription of antioxidant enzyme genes in shrimp.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Review
Genetics & Heredity
Cui-Lan Meng, Wei Zhao, Dan-Ni Zhong
Summary: UDP-glucuronosyltransferases are important drug-metabolizing enzymes in the human body, with UGT1A family being crucial in glucuronidation reactions. Differences in the distribution and expression of UGT1As among individuals contribute to disease occurrence and metabolic variations. Additionally, epigenetics and miRNAs play a role in regulating UGT1As and impacting sex expression and in vivo distribution, with early life epigenetic changes affecting gene expression throughout life.
Review
Medicine, Research & Experimental
Marjan Talebi, Mohammad Mehdi Sadoughi, Seyed Abdulmajid Ayatollahi, Elaheh Ainy, Roghayeh Kiani, Alireza Zali, Mirmohammad Miri
Summary: CBD, a non-psychoactive cannabinoid, has been found to have numerous therapeutic benefits and is closely associated with the Nrf2 signaling pathway. Nrf2 is linked to various health issues including cardiovascular dysfunctions, cancers, and neurodegenerative conditions. Understanding the relationship between CBD and Nrf2 is of great interest in the medical field and could significantly impact the treatment and prevention of a wide range of health conditions.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Pharmacology & Pharmacy
Congjian Ma, Yanjun Deng, Ran Xiao, Fan Xu, Mobai Li, Qihai Gong, Jianmei Gao
Summary: The study found that Phlorizin (PHZ) has positive effects on fatigue, as it can alleviate fatigue and improve exercise endurance. PHZ achieves these effects by reducing reactive oxygen species, enhancing antioxidant enzyme activity, and regulating apoptosis-related factors.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Review
Cell Biology
Rabab S. Hamad, Hayder M. Al-kuraishy, Athanasios Alexiou, Marios Papadakis, Eman A. Ahmed, Hebatallah M. Saad, Gaber El-Saber Batiha
Summary: COVID-19 is a recent pandemic caused by SARS-CoV-2, leading to pulmonary and extra-pulmonary manifestations. Inhibition of Nrf2 may contribute to oxidative stress and hyperinflammation in COVID-19. Nrf2 pathway suppresses pro-inflammatory cytokines, reducing pulmonary symptoms. Nrf2 activators can improve endothelial dysfunction, RAS dysregulation, immune thrombosis, and coagulopathy.
CELL STRESS & CHAPERONES
(2023)
Article
Critical Care Medicine
Eilise M. Ryan, Pranvera Sadiku, Patricia Coelho, Emily R. Watts, Ailiang Zhang, Andrew J. M. Howden, Manuel A. Sanchez-Garcia, Martin Bewley, Joby Cole, Brian J. McHugh, Wesley Vermaelen, Bart Ghesquiere, Peter Carmeliet, Giovanny Rodriguez Blanco, Alex Von Kriegsheim, Yolanda Sanchez, William Rumsey, James F. Callahan, George Cooper, Nicholas Parkinson, Kenneth Baillie, Doreen A. Cantrell, John McCafferty, Gourab Choudhury, Dave Singh, David H. Dockrell, Moira K. B. Whyte, Sarah R. Walmsley
Summary: Chronic obstructive pulmonary disease (COPD) is characterized by persistent airway inflammation and impaired macrophage function. This study found that COPD alveolar macrophages (AMs) and peripheral monocyte-derived macrophages (MDMs) exhibit metabolic deficiencies and impairments in redox balance. Activation of the NRF2 pathway can rescue these defects and improve macrophage function in COPD.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Liqiang Qiu, Xiaoxiong Liu, Hao Xia, Changwu Xu
Summary: Increasing evidence suggests that PCAF plays a key role in vascular aging. Downregulation of PCAF can alleviate vascular aging by activating Nrf2 and reducing oxidative stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Qian Zeng, Tingting Zhou, Feiyan Zhao, Dayan Xiong, Bin He, Qingzhong Hua, Miao Lin, Lang Deng, Xiaoxue Sang, Weixi Xie, Jia Chen, Zun Wang, Lu Ren, Ziqiang Luo, Xiaoting Huang, Wei Liu, Siyuan Tang
Summary: Bergenin can alleviate pulmonary fibrosis by relieving oxidative stress, reducing extracellular matrix deposition, and inhibiting the formation of myofibroblasts. Furthermore, a regulatory loop between p62 and Nrf2 is formed, which is important for the therapeutic effects of bergenin on pulmonary fibrosis.
Article
Genetics & Heredity
Yusuf Ayikgoz, Mehmet Salih Aydin, Nazim Kankilic, Ebru Temiz
Summary: During cardiopulmonary bypass, TNF-alpha, Nrf2, and HO-1 gene expressions increase, and these values decrease postoperatively. This indicates that oxidative stress and inflammatory processes start with cardiopulmonary bypass, and antioxidant processes start similarly.
Article
Medicine, Research & Experimental
Dawei Cai, Huyong Yan, Jun Liu, Sichun Chen, Longhai Jiang, Xiaoxu Wang, Jian Qin
Summary: The study demonstrated that ergosterol (ER) effectively alleviated cartilage degradation and played a role in cartilage protection against osteoarthritis (OA) through activation of the Nrf2-heme oxygenase 1 pathway.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Medicine, Research & Experimental
Huanhuan Wang, Bin Wang, Jinlong Wei, Zhuangzhuang Zheng, Jing Su, Chenbin Bian, Ying Xin, Xin Jiang
Summary: This study found that sulforaphane (SFN) has certain efficacy in preventing radiation-induced muscle fibrosis (RIMF), and the mechanism may involve the antioxidant stress mediated by nuclear factor erythroid 2-related factor 2 (Nrf2) and the activation of the AKT/GSK-3 beta/Fyn pathway.
Article
Pharmacology & Pharmacy
Shoji Nakamura, Ryohei Yamashita, Yuu Miyauchi, Yoshitaka Tanaka, Yuji Ishii
Summary: Adenine-related compounds act as allosteric inhibitors of UDP-glucuronosyltransferase (UGT) in rat and human liver microsomes treated with detergent or pore-forming peptide. In this study, adenine-related compounds were found to inhibit 4-methylumbelliferone (4-MU) glucuronidation in mouse liver microsomes in a non-competitive manner, with AMP counteracting the inhibitory effects of ATP and ADP. Additionally, NAD(+) and NADP(+) were potent inhibitors of 4-MU glucuronidation, while the reduced forms NADH and NADPH did not show inhibitory effects.
Article
Biochemistry & Molecular Biology
Xiaozhen Dai, Kai Wang, Jiawei Fan, Hanjie Liu, Xia Fan, Qian Lin, Yuhang Chen, Hu Chen, Yao Li, Hairong Liu, Oscar Chen, Jing Chen, Xiaohong Li, Di Ren, Ji Li, Daniel J. Conklin, Kupper A. Wintergerst, Yu Li, Lu Cai, Zhongbin Deng, Xiaoqing Yan, Yi Tan
Summary: Endothelial progenitor cells (EPCs) are reduced in number and impaired in function in diabetic patients. The expression of Nrf2 and its downstream genes were also decreased in EPCs from diabetic patients and db/db mice. Knockdown of Nrf2 increased apoptosis and impaired tube formation in EPCs, while Nrf2 overexpression decreased apoptosis and rescued tube formation. Mechanistic studies demonstrated that diabetes induced mitochondrial fragmentation and dysfunction of EPCs, which was attenuated by upregulating Nrf2 expression. Further analysis showed that Nrf2 specifically upregulated the transcription of IDH2 and improving mitochondrial function. Overall, Nrf2 is a potential therapeutic target for improving diabetic EPC function.
Article
Biochemistry & Molecular Biology
Lee E. Neilson, Joseph F. Quinn, Nora E. Gray
Summary: NRF2, a transcription factor critical in maintaining cellular redox balance, has been identified as a therapeutic target in various human diseases. PBMCs can serve as a convenient source of biomarkers to monitor NRF2 activation and disease progression in clinical trials, indicating their potential as exploratory markers for targeting NRF2 activation.
Review
Respiratory System
Shaodong Tong, Zhaohui Qin, Minghui Wan, Longzhen Zhang, Yan Cui, Yuanhu Yao
JOURNAL OF THORACIC DISEASE
(2018)
Article
Engineering, Biomedical
Xi Tian, Michael E. Werner, Kyle C. Roche, Ariel D. Hanson, Henry P. Foote, Stephanie K. Yu, Samuel B. Warner, Jonathan A. Copp, Haydee Lara, Eliane L. Wauthier, Joseph M. Caster, Laura E. Herring, Longzhen Zhang, Joel E. Tepper, David S. Hsu, Tian Zhang, Lola M. Reid, Andrew Z. Wang
NATURE BIOMEDICAL ENGINEERING
(2018)
Article
Oncology
Qian Cheng, Debao Qu, Zheng Lu, Longzhen Zhang
Article
Pharmacology & Pharmacy
Zhenkun Zong, Lei Hua, Zhen Wang, Haoyue Xu, Chengkun Ye, Bomin Pan, Zongren Zhao, Longzhen Zhang, Jun Lu, Liu Hong Mei, Yu Rutong
Article
Cell Biology
Nianli Liu, Zhiyuan Wu, Aoxing Chen, Dafei Chai, Liantao Li, Longzhen Zhang, Junnian Zheng
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2019)
Article
Cell Biology
Nianli Liu, Zhiyuan Wu, Aoxing Chen, Yuqi Wang, Dafei Cai, Junian Zheng, Yong Liu, Longzhen Zhang
CELL DEATH & DISEASE
(2019)
Article
Multidisciplinary Sciences
Hao Cui, Hongjian Shan, Michael Zhe Miao, Zhiguo Jiang, Yuanyuan Meng, Ran Chen, Longzhen Zhang, Yong Liu
SCIENTIFIC REPORTS
(2020)
Article
Biotechnology & Applied Microbiology
Nianli Liu, Jiayin Ji, Hui Qiu, Zhiying Shao, Xin Wen, Aoxing Chen, Senbang Yao, Xingying Zhang, Hong Yao, Longzhen Zhang
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2020)
Article
Medicine, General & Internal
Quanquan Guo, Zhiying Shao, Dan Xu, Lili Fan, Huiru Xiong, Xin Ding, Chuanwen You, Longzhen Zhang
Article
Genetics & Heredity
Qiuwen Sun, Xia Li, Muchen Xu, Li Zhang, Haiwei Zuo, Yong Xin, Longzhen Zhang, Ping Gong
FRONTIERS IN GENETICS
(2020)
Article
Genetics & Heredity
Xin Wen, Zhiying Shao, Shuyi Chen, Wei Wang, Yan Wang, Jinghua Jiang, Qinggong Ma, Longzhen Zhang
Summary: By analyzing RBPs in PAAD, we constructed an RBP-associated prognostic risk model, including 453 differentially expressed RBPs and 28 prognostic-associated RBPs. This model can predict the prognosis of PAAD patients and serve as an independent prognostic indicator.
FRONTIERS IN GENETICS
(2021)
Correction
Nanoscience & Nanotechnology
Yuanzeng Min, Kyle C. Roche, Shaomin Tian, Michael J. Eblan, Karen P. McKinnon, Joseph M. Caster, Shengjie Chai, Laura E. Herring, Longzhen Zhang, Tian Zhang, Joseph M. DeSimone, Joel E. Tepper, Benjamin G. Vincent, Jonathan S. Serody, Andrew Z. Wang
NATURE NANOTECHNOLOGY
(2021)
Article
Health Care Sciences & Services
Zheng Chen, Shu Jiang, Xuechun Li, Jingyao Zhang, Liu Liu, Juan Li, Peiyu Cao, Yong Xin, Longzhen Zhang
Summary: The meta-analysis results showed that combination therapy of anti-angiogenic drugs with erlotinib significantly improved progression-free survival (PFS) in patients with advanced non-small cell lung cancer. Particularly, patients with epidermal growth factor receptor (EGFR) mutations, adenocarcinoma, and Asian populations benefited the most from the treatment.
ANNALS OF PALLIATIVE MEDICINE
(2021)
Article
Oncology
Yang Wu, Longzhen Zhang, Tianyou Tang, Liantao Li, Liang Li, Hongmin Yu
Summary: The study found that excluding cervical lymph node radiotherapy after surgery does not have a significant impact on recurrence, survival, and radiation complications in patients with locally advanced supraglottic and glottic laryngeal carcinoma.
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2021)
Article
Medicine, Research & Experimental
Xingying Zhang, Xin Wen, Ning Feng, Aoxin Chen, Senbang Yao, Xin Ding, Longzhen Zhang
MEDICAL SCIENCE MONITOR
(2020)
Article
Pharmacology & Pharmacy
Paola Orlandi, Marta Banchi, Francesca Vaglini, Marco Carli, Stefano Aringhieri, Arianna Bandini, Carla Pardini, Cristina Viaggi, Michele Lai, Greta Ali, Alessandra Ottani, Eleonora Vandini, Patrizia Guidi, Margherita Bernardeschi, Veronica La Rocca, Giulio Francia, Gabriella Fontanini, Mauro Pistello, Giada Frenzilli, Daniela Giuliani, Marco Scarselli, Guido Bocci
Summary: This study investigates the role of MC4R in melanoma and the use of the selective antagonist ML in combination with vemurafenib. The results show that ML can inhibit melanoma cell proliferation and induce apoptosis through the inhibition of ERK1/2 phosphorylation and reduction of BCL-XL expression. The combination of vemurafenib and ML exhibits a synergistic effect in vitro and inhibits tumor growth in vivo without causing adverse effects.
BIOCHEMICAL PHARMACOLOGY
(2024)
Article
Pharmacology & Pharmacy
Conor J. Bloxham, Katina D. Hulme, Fabrizio Fierro, Christian Fercher, Cassandra L. Pegg, Shannon L. O'Brien, Simon R. Foster, Kirsty R. Short, Sebastian G. B. Furness, Melissa E. Reichelt, Masha Y. Niv, Walter G. Thomas
Summary: Bitter taste receptors (T2Rs) are a type of G protein-coupled receptors that allow humans to detect aversive and toxic substances. This study characterized the functional properties of previously identified T2Rs in human cardiac tissues and their naturally occurring polymorphisms. The results showed differences in signaling among different T2R variants, and revealed a potential association between the T2R50 Tyr203 variant and cardiovascular disease.
BIOCHEMICAL PHARMACOLOGY
(2024)
Article
Pharmacology & Pharmacy
Lu Chen, Huanying Shi, Wenxin Zhang, Yongjun Zhu, Haifei Chen, Zimei Wu, Huijie Qi, Jiafeng Liu, Mingkang Zhong, Xiaojin Shi, Tianxiao Wang, Qunyi Li
Summary: This study demonstrates that Carfilzomib exhibits potent anti-tumor activity against esophageal squamous cell carcinoma (ESCC) by triggering mitochondrial apoptosis and reprogramming cellular metabolism. It has been identified that activating transcription factor 3 (ATF3) plays a crucial role as a cellular target in ESCC cells treated with Carfilzomib. Overexpression of ATF3 effectively counteracts the effects of Carfilzomib on ESCC cell proliferation, apoptosis, and metabolic reprogramming. Furthermore, ATF3 mediates the anti-tumor activity of Carfilzomib, suggesting its potential as a therapeutic agent for ESCC.
BIOCHEMICAL PHARMACOLOGY
(2024)
Review
Pharmacology & Pharmacy
Xing Zhang, Xiang Li, Ran Xia, Hong-Sheng Zhang
Summary: This review summarizes recent progress on the mechanisms of ferroptosis resistance in cancer and highlights the role of redox status and metabolism. Combination therapy for ferroptosis has great potential in treating resistant malignant tumors.
BIOCHEMICAL PHARMACOLOGY
(2024)