Article
Pharmacology & Pharmacy
Hao Yao, Jiaxin Guo, Wangyong Zhu, Yuxiong Su, Wenxue Tong, Lizhen Zheng, Liang Chang, Xinluan Wang, Yuxiao Lai, Ling Qin, Jiankun Xu
Summary: This study demonstrated the significant role of BMP-2 loaded hydrogel in promoting bone formation in mandibular defects in a rat model. BMP-2 facilitated intramembranous ossification within the defect and increased the proportion of skeletal stem cell descendants, showing potential for improving bone regeneration.
Review
Chemistry, Multidisciplinary
Jie Fang, Zhi Wang, Chao-yu Miao
Summary: Stroke is the second leading cause of death globally due to its high disability and mortality rates. Currently, there are limited clinical treatment strategies available for stroke, with tissue plasminogen activator (tPA) being the only FDA-approved drug. Angiogenesis, which promotes neural regeneration and functional recovery, is an important protective mechanism during stroke. Thus, inducing angiogenesis in the affected area can improve hemodynamics and facilitate vascular remodeling and recovery of neurovascular function. This review summarizes the cellular and molecular mechanisms affecting angiogenesis after cerebral ischemia, and provides pro-angiogenic strategies for exploring the treatment of ischemic stroke, including endothelial progenitor cells, mesenchymal stem cells, growth factors, cytokines, non-coding RNAs, etc.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Endocrinology & Metabolism
Fazal Ur Rehman Bhatti, Ushashi C. Dadwal, Conner R. Valuch, Nikhil P. Tewari, Olatundun D. Awosanya, Caio de Andrade Staut, Seungyup Sun, Stephen K. Mendenhall, Anthony J. Perugini, Rohit U. Nagaraj, Hanisha L. Battina, Murad K. Nazzal, Rachel J. Blosser, Kevin A. Maupin, Paul J. Childress, Jiliang Li, Melissa A. Kacena
Summary: This study investigated angiogenesis at fracture sites and distal locations in obesity-induced type 2 diabetic mice. The results showed that local BMP-2 treatment promoted complete bone healing at the femoral critical sized defect. High fat diet increased tube formation ability, while BMP-2 treatment decreased certain angiogenesis-related gene expression in HFD mice.
Article
Allergy
Jin Youp Kim, Suha Lim, Hee-Suk Lim, Yi-Sook Kim, Kyoung Mi Eun, Roza Khalmuratova, Yuju Seo, Joon Kon Kim, Young Seok Kim, Min-Kyung Kim, Siyeon Jin, Seung Cheol Han, Suyeon Pyo, Seung-No Hong, Jong-Wan Park, Hyun-Woo Shin, Dae Woo Kim
Summary: The role of BMPs in osteitis in patients with CRSwNPs and their associations with inflammatory markers are not fully investigated. Among the 6 BMPs studied, BMP-2 may be a novel biomarker for refractory CRSwNP with potential implications for mucosa and bone remodeling.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Chemistry, Applied
Ao Zheng, Xiao Wang, Jie Wang, Xianzhen Xin, Yuanman Yu, Yang Liu, Jing Wang, Kaige Lv, Lingyan Cao
Summary: This study explored the synergistic effect of sulfonated chitosan and BMP-2, with results showing that 26SCS can affect the structure of BMP-2 protein and enhance its biological activity.
CARBOHYDRATE POLYMERS
(2021)
Article
Hematology
Lidia M. Fernandez-Sevilla, Jaris Valencia, Paula Ortiz-Sanchez, Alberto Fraile-Ramos, Pilar Zuluaga, Eva Jimenez, Rosa Sacedon, Maria V. Martinez-Sanchez, Janez Jazbec, Marusa Debeljak, Birthe Fedders, Martin Stanulla, Denis Schewe, Gunnar Cario, Alfredo Minguela, Manuel Ramrez, Alberto Varas, Angeles Vicente
Summary: A retrospective study found that BMP4 expression levels in leukemic cells could serve as a new biomarker for prognosis in pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL). High BMP4 expression was associated with higher relapse rates and worse survival outcomes. Furthermore, BMP4 may be a potential therapeutic target for blocking leukemic central nervous system disease.
Article
Multidisciplinary Sciences
Gusty R. T. Ryanto, Koji Ikeda, Kazuya Miyagawa, Ly Tu, Christophe Guignabert, Marc Humbert, Tomoyuki Fujiyama, Masashi Yanagisawa, Ken-ichi Hirata, Noriaki Emoto
Summary: The dysregulation of the activin A-bone morphogenetic protein receptor type 2 link in endothelium plays a critical role in the progression of pulmonary arterial hypertension. Inhibin-beta -A/activin-A in endothelial cells could be a potential pharmacotherapeutic target for the treatment of pulmonary arterial hypertension.
NATURE COMMUNICATIONS
(2021)
Article
Cell Biology
Kui Huang, Shuyu Cai, Ting Fu, Qiang Zhu, Lin Liu, Zhihao Yao, Pengcheng Rao, Xiaorong Lan, Qing Li, Jingang Xiao
Summary: It was found that the expression of Wnt10b RNA in OP-ASCs was significantly lower than that in ASCs. The upregulation of Wnt10b can enhance the osteogenic ability of OP-ASCs and promote bone defect healing.
CELL PROLIFERATION
(2023)
Review
Biochemistry & Molecular Biology
Zay Yar Soe, Eun Jeong Park, Motomu Shimaoka
Summary: Integrins play a crucial role in cell adhesion, intercellular communication, and functions of tumor and immune cell exosomes, with potential implications in tumor microenvironment modulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Letter
Peripheral Vascular Disease
Yara Onetti, Roland E. Kaelin, Bettina Pitter, Mengzhuo Hou, Victor Arribas, Rainer Glass, Eloi Montanez
Summary: Endothelial alpha-pv is necessary for tumor angiogenesis and progression. Using an inducible knockout approach, researchers found that loss of endothelial alpha-pv reduces vessel density and vascular complexity in the pathological neo-vasculature of brain tumor-bearing mice. This reduction in tumor vascularization is associated with increased tumor cell apoptosis and decreased tumor volume.
Article
Pharmacology & Pharmacy
Alexandru Filippi, Alina Constantin, Nicoleta Alexandru, Cristina Ana Mocanu, Mihaela Loredana Vlad, Ioana Madalina Fenyo, Agneta Simionescu, Dan Teodor Simionescu, Ileana Manduteanu, Adriana Georgescu
Summary: The number and function of endothelial progenitor cells (EPCs) are reduced in diabetes. Genetically modified EPCs can be a safe treatment option for dyslipidemia and diabetes, preserving aortic valve function.
Article
Engineering, Biomedical
Kevin T. Campbell, Matthew B. Curtis, Joshua M. Massey, Kajetan Wysoczynski, Dustin J. Hadley, Steve C. George, Eduardo A. Silva
Summary: Lymphatic dysfunction is associated with the progression of several vascular disorders, and there are limited strategies currently available to promote new lymphatic vasculature. This study isolated lymphatic endothelial progenitor cells from human umbilical cord blood and found that they have the potential to promote lymphatic sprouts, highlighting the therapeutic potential of these cells. Delivery of lymphatic EPCs using alginate hydrogels also showed promise for possible therapeutic applications.
ACTA BIOMATERIALIA
(2021)
Review
Cell Biology
Cheng Huang, Zeqin Wen, Junjie Niu, Subin Lin, Weiguo Wang
Summary: SONFH is characterized by the collapse of the femoral head, often caused by the overuse of glucocorticoids in patients with immune-related diseases. Impaired blood vessels, specifically bone endothelial cells, play a crucial role in the pathogenesis of SONFH. Despite candidate reagents showing promise in improving SONFH, they are still in the preclinical stage. Bone tissue engineering, such as co-transplantation of bone endothelial cells and bone marrow mesenchymal stem cells, may offer another feasible therapeutic strategy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Michael Warkala, Dongying Chen, AnnJosette Ramirez, Ali Jubran, Michael Schonning, Xia Wang, Huaning Zhao, Sophie Astrof
Summary: The development of the fourth pharyngeal arch arteries involves a multistep process with contributions from SHF-derived ECs, remodeling of endothelial plexus into PAAs, and remodeling of PAAs into the aortic arch artery and its major branches. Cell-ECM interactions regulated by integrin alpha 5 beta 1 and Fn1 are essential at each developmental stage.
CIRCULATION RESEARCH
(2021)
Article
Multidisciplinary Sciences
Mi Gyeom Kim, Che Lin Kim, Young Sik Kim, Ju Woong Jang, Gyun Min Lee
Summary: Cell surface HSPG-mediated endocytosis leads to low yields of recombinant human bone morphogenetic proteins (rhBMPs) in CHO cell cultures, but blocking internalization significantly increases the production of rhBMP-2.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Tur-Fu Huang, Shih-Wei Wang, Yu-Wei Lai, Shih-Chia Liu, Yu-Jen Chen, Thomas Y. Hsueh, Chih-Chung Lin, Chun-Hsuan Lin, Ching-Hu Chung
Summary: The compound 4-acetylantroquinonol B (4AAQB) has shown inhibitory effects on cancer growth and angiogenesis, making it a potential candidate for prostate cancer therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Correction
Agriculture, Multidisciplinary
Chien-Hsin Chang, Tur-Fu Huang, Kung-Tin Lin, Chun-Chieh Hsu, Wei-Luen Chang, Shih-Wei Wang, Feng-Nien Ko, Hui-Chin Peng, Ching-Hu Chung
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
David Achudhan, Shan-Chi Liu, Yen-You Lin, Hsiang-Ping Lee, Shih-Wei Wang, Wei-Chien Huang, Yang-Chang Wu, Yueh-Hsiung Kuo, Chih-Hsin Tang
Summary: Antcin K, a phytosterol isolated from Antrodia cinnamomea, exhibits anti-inflammatory and anti-angiogenic activities that may have potential therapeutic effects in rheumatoid arthritis by suppressing VEGF expression and inhibiting endothelial progenitor cell migration and tube formation. Further research is needed to explore its effects in other angiogenesis-related disorders.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Article
Endocrinology & Metabolism
Huai-Ching Tai, Shih-Wei Wang, Sanskruti Swain, Liang-Wei Lin, Hsiao-Chi Tsai, Shan-Chi Liu, Hsi-Chin Wu, Jeng-Hung Guo, Chun-Lin Liu, Yu-Wei Lai, Tien-Huang Lin, Shun-Fa Yang, Chih-Hsin Tang
Summary: Melatonin has been found to inhibit the migratory and invasive abilities of osteoblastic prostate cancer cells by targeting kinases and transcriptional activity, suggesting its potential as a therapeutic option for treating osteoblastic bone lesions in prostate cancer.
JOURNAL OF PINEAL RESEARCH
(2022)
Article
Chemistry, Medicinal
Safwan Safwan, Shih-Wei Wang, George Hsiao, Sui-Wen Hsiao, Su-Jung Hsu, Tzong-Huei Lee, Ching-Kuo Lee
Summary: In this study, eight trichothecenes and one cyclonerane were isolated and identified from the solid-state fermentation of Trichoderma brevicompactum NTU439 isolated from the marine alga Mastophora rosea. Compound 8 showed promising cytotoxic activity against multiple cancer cell lines, and other compounds also exhibited certain biological activities.
Article
Multidisciplinary Sciences
Shih-Wei Wang, Leong-Perng Chan, Ling-Feng Wang, Che-Wei Wu, Sheng-Hsuan Lin, Tzu-Yen Huang, Ka-Wo Lee
Summary: The survival rate of head and neck squamous cell carcinoma (HNSCC) patients with secondary primary malignancy (SPM) has not significantly improved over the years, but the advances in diagnostic tools have enabled more patients to receive appropriate treatment.
Article
Biochemistry & Molecular Biology
Wei-Cheng Chen, Shih-Wei Wang, Cai-Wei Li, Hsiang-Ru Lin, Chang-Syun Yang, Yi-Cheng Chu, Tzong-Huei Lee, Jih-Jung Chen
Summary: Portulaca oleracea has potential medicinal value and can be used to treat various disorders and as a natural antioxidant.
Article
Biochemistry & Molecular Biology
Mingli Hsieh, Pei-Ju Huang, Pei-Yu Chou, Shih-Wei Wang, Hsi-Chi Lu, Wei-Wen Su, Yuan-Chiang Chung, Min-Huan Wu
Summary: Research has shown that CAVIII is overexpressed in colorectal cancer tissues and more aggressive cancer cells. It may facilitate the release of VEGF by inhibiting miRNA16-5p. The CAVIII/miR-16-5p signaling pathway appears to function as a metastasis suppressor in CRC.
Article
Chemistry, Multidisciplinary
Shu-Rong Chen, Shih-Wei Wang, Ching-Yeu Chen, Tzu-Yi Ke, Jue-Jun Lin, Tsong-Long Hwang, Yi-Ting Huang, Yu-Ching Huang, Yuan-Bin Cheng
Summary: Sixteen azaphilone derivatives, including four new compounds, were isolated from the algae-derived fungus Penicillium sclerotiorum. These compounds showed anti-angiogenic effects on human endothelial progenitor cells. The structure-activity relationships (SAR) for the anti-angiogenic effects of these azaphilones were deduced.
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN
(2023)
Article
Pharmacology & Pharmacy
Sunny Li-Yun Chang, Chiang-Wen Lee, Chen-Yu Yang, Zih-Chan Lin, Kuo-Ti Peng, Shih-Chia Liu, Shih-Wei Wang, Hsiao-Chi Tsai, Yi-Chin Fong, Chao-Yang Lai, Yuan-Li Huang, Chun-Hao Tsai, Chih-Yuan Ko, Ju-Fang Liu, Chih-Hsin Tang
Summary: Despite low survival rates of metastatic osteosarcoma (OS) with surgery and chemotherapy, new therapeutic approaches are needed. Epigenetic changes like histone H3 methylation play crucial roles in various cancers including OS, although the underlying mechanisms are unclear. Treating OS cells with the histone lysine demethylase inhibitor IOX-1 increased histone H3 methylation, suppressed migration and invasion, reversed epithelial-to-mesenchymal transition, and reduced stemness properties.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Plant Sciences
Tzu-Yi Ke, Shih-Wei Wang, Shu-Rong Chen, Dong-Ming Huang, Yun-Sheng Lin, Tsong-Long Hwang, Wen-Chun Sun, Yuan-Bin Cheng
Summary: Four new alkaloids and three new polyacetylenes were isolated from Hippobroma longiflora. The structures of the compounds were determined using mass and NMR spectroscopic data, as well as X-ray and ECD analyses. The compounds exhibited weak antiangiogenic activity against human endothelial progenitor cells.
JOURNAL OF NATURAL PRODUCTS
(2023)
Article
Cell Biology
Liang-Wei Lin, Shih-Wei Wang, Wei-Chien Huang, Thanh Kieu Huynh, Chao-Yang Lai, Chih-Yuan Ko, Yi-Chin Fong, Jie-Jen Lee, Shun-Fa Yang, Chih-Hsin Tang
Summary: Neovascular age-related macular degeneration (AMD) is a disease characterized by abnormal blood vessel growth in the retina, leading to severe vision loss. The presence of certain markers in the retinas of AMD patients suggests a contribution of endothelial progenitor cells (EPCs) in this pathogenesis. This study explores the potential of melatonin, a hormone produced in the retina, to inhibit EPC angiogenesis in neovascular AMD. The results demonstrate that melatonin can effectively inhibit the formation of EPC blood vessels and shows promise as a potential treatment for neovascular AMD.
Article
Chemistry, Multidisciplinary
Cong-Min Peng, Shih-Wei Wang, Yi-Lin Hwang, Wen-Chun Sun, Li-Pin Chiu, Yi-Ting Liu, Yu-Wei Lai, Hsueh-Yun Lee
Summary: The in situ CuI-mediated cyclization methodology was used to synthesize benzimidazoles with different substitution manner. Structure-activity relationship (SAR) study confirmed the significance of the 5,6,7-trimethoxybenzimidazole moiety. Representative derivatives exhibited potent antiproliferative activity against A549, HCT-116, and PC-3 cells, as well as inhibition of tubulin polymerization. Compound 10 showed the most promising activity with an IC50 value of 0.07 μM against cancer cell growth and 0.26 μM against tubulin polymerization.
Article
Cell Biology
Po- Liu, Ya-Jing Jiang, An-Chen Chang, Chang-Lun Huang, Yi-Chin Fong, Jeng-Hung Guo, Chun-Lin Liu, Shih-Wei Wang, Ju-Fang Liu, Sunny Li-Yu Chang, Chih-Hsin Tang
Summary: Lung cancer is common and metastatic lung cancer has a low survival rate. Lymphangiogenesis plays a crucial role in the development and metastasis of lung cancer. The adipokine angiopoietin-like protein 2 (ANGPTL2) is involved in tumor progression and metastasis, but its role in lung cancer is unknown. Analysis of data from multiple sources revealed a correlation between high levels of ANGPTL2 expression and disease progression and lymph node metastasis in lung cancer. ANGPTL2 promotes lymphatic endothelial cell tube formation and migration through integrin alpha 5 beta 1, p38, and nuclear factor (NF)-KB signaling. In vivo studies showed that overexpression of ANGPTL2 enhances tumor growth and lymphangiogenesis. Therefore, ANGPTL2 is a potential therapeutic target for treating lung cancer.
Article
Plant Sciences
Ho-Cheng Wu, Lung-Lin Shiu, Shih-Wei Wang, Chia-Ying Huang, Tzong-Huei Lee, Ping-Jyun Sung, Yueh-Hsiung Kuo
Summary: This study investigated the chemical profiles and anti-lymphangiogenic activity of Juniperus chinensis var. tsukusiensis, a type of Taiwan juniper. Several new compounds were successfully isolated and evaluated for their anti-lymphangiogenic effects in human lymphatic endothelial cells. The results showed that one compound, totarolone, displayed the most potent anti-lymphangiogenic activity. These findings suggest the promising potential of Juniperus chinensis var. tsukusiensis in developing therapeutics targeting tumor lymphangiogenesis.
Article
Pharmacology & Pharmacy
Paola Orlandi, Marta Banchi, Francesca Vaglini, Marco Carli, Stefano Aringhieri, Arianna Bandini, Carla Pardini, Cristina Viaggi, Michele Lai, Greta Ali, Alessandra Ottani, Eleonora Vandini, Patrizia Guidi, Margherita Bernardeschi, Veronica La Rocca, Giulio Francia, Gabriella Fontanini, Mauro Pistello, Giada Frenzilli, Daniela Giuliani, Marco Scarselli, Guido Bocci
Summary: This study investigates the role of MC4R in melanoma and the use of the selective antagonist ML in combination with vemurafenib. The results show that ML can inhibit melanoma cell proliferation and induce apoptosis through the inhibition of ERK1/2 phosphorylation and reduction of BCL-XL expression. The combination of vemurafenib and ML exhibits a synergistic effect in vitro and inhibits tumor growth in vivo without causing adverse effects.
BIOCHEMICAL PHARMACOLOGY
(2024)
Article
Pharmacology & Pharmacy
Conor J. Bloxham, Katina D. Hulme, Fabrizio Fierro, Christian Fercher, Cassandra L. Pegg, Shannon L. O'Brien, Simon R. Foster, Kirsty R. Short, Sebastian G. B. Furness, Melissa E. Reichelt, Masha Y. Niv, Walter G. Thomas
Summary: Bitter taste receptors (T2Rs) are a type of G protein-coupled receptors that allow humans to detect aversive and toxic substances. This study characterized the functional properties of previously identified T2Rs in human cardiac tissues and their naturally occurring polymorphisms. The results showed differences in signaling among different T2R variants, and revealed a potential association between the T2R50 Tyr203 variant and cardiovascular disease.
BIOCHEMICAL PHARMACOLOGY
(2024)
Article
Pharmacology & Pharmacy
Lu Chen, Huanying Shi, Wenxin Zhang, Yongjun Zhu, Haifei Chen, Zimei Wu, Huijie Qi, Jiafeng Liu, Mingkang Zhong, Xiaojin Shi, Tianxiao Wang, Qunyi Li
Summary: This study demonstrates that Carfilzomib exhibits potent anti-tumor activity against esophageal squamous cell carcinoma (ESCC) by triggering mitochondrial apoptosis and reprogramming cellular metabolism. It has been identified that activating transcription factor 3 (ATF3) plays a crucial role as a cellular target in ESCC cells treated with Carfilzomib. Overexpression of ATF3 effectively counteracts the effects of Carfilzomib on ESCC cell proliferation, apoptosis, and metabolic reprogramming. Furthermore, ATF3 mediates the anti-tumor activity of Carfilzomib, suggesting its potential as a therapeutic agent for ESCC.
BIOCHEMICAL PHARMACOLOGY
(2024)
Review
Pharmacology & Pharmacy
Xing Zhang, Xiang Li, Ran Xia, Hong-Sheng Zhang
Summary: This review summarizes recent progress on the mechanisms of ferroptosis resistance in cancer and highlights the role of redox status and metabolism. Combination therapy for ferroptosis has great potential in treating resistant malignant tumors.
BIOCHEMICAL PHARMACOLOGY
(2024)
