Article
Oncology
Jing-jing Teng, Wen-jing Zhao, Xun-lei Zhang, Da-Kun Zhao, Xin-Yue Qiu, Xu-dong Chen, Lei Yang
Summary: PRDM5 is downregulated in gastric cancer and associated with poor survival and tumor progression. Methylation of PRDM5 promoter is closely related to histological types and tumor progression in gastric cancer.
Article
Cell Biology
Li-Li Ren, Zhi-Wen Wang, Ren Sen, Zhou-Tong Dai, Xing-Hua Liao, Li-Juan Shen
Summary: GRB10 and its family members GRB7 and GRB14 are important adaptor proteins that regulate cellular functions by interacting with tyrosine kinase receptors and other phosphorus-containing amino acid proteins. Abnormal expression of GRB10 is closely related to cancer occurrence and development. In gastric cancer, high expression of GRB10 is associated with poorer overall survival. Knockdown of GRB10 inhibits proliferation and migration ability in gastric cancer, and miR-379-5p can downregulate GRB10 expression to suppress gastric cancer development. Therefore, miR-379-5p and GRB10 are potential targets for gastric cancer treatment.
Review
Genetics & Heredity
Yunqing Zeng, Huimin Rong, Jianwei Xu, Ruyue Cao, Shuhua Li, Yanjing Gao, Baoquan Cheng, Tao Zhou
Summary: DNA methylation plays a significant role in the occurrence and development of gastric cancer, and research in this area is crucial for finding cancer biomarkers.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Keiji Nishibeppu, Shuhei Komatsu, Jun Kiuchi, Takuma Kishimoto, Yusuke Takashima, Katsutoshi Shoda, Tomohiro Arita, Toshiyuki Kosuga, Hirotaka Konishi, Atsushi Shiozaki, Takeshi Kubota, Kazuma Okamoto, Hitoshi Fujiwara, Hitoshi Tsuda, Eigo Otsuji
Summary: The study revealed that overexpression of TRIM37 in gastric cancer is significantly correlated with tumor invasion, T/N staging, histology, and recurrence rate, predicting worse outcomes. Knockdown of TRIM37 increased apoptosis and suppressed migration and invasion in TRIM37-overexpressing gastric cancer cells.
Article
Genetics & Heredity
Vincenza Ylenia Cusenza, Luca Braglia, Raffaele Frazzi
Summary: This study analyzed data from the TCGA database and found that colon and liver tumors consistently exhibit methylation heterogeneity, and the downregulation of the SPG20 gene suggests its role in tumor progression control.
Article
Oncology
Zehua Wang, Chenyi Wang, Bing-Hua Jiang, Litong Shi, Shan Lin, Lei Wang, Ling-Zhi Liu, Jian-Ge Qiu, Yanru Qin, Yongxu Jia
Summary: The overexpression of STK17A significantly promotes the proliferation and migration of gastric cancer cells, and is associated with the prognosis of patients with gastric cancer. STK17A may be a valuable biomarker for the prognosis of patients with gastric cancer.
Article
Oncology
Xiong Guo, Yujun Wang, Lang Zha, Hui Li, Kun Qian
Summary: In this study, a prognostic model based on DNA methylation regulator-related lncRNAs was established to predict the survival of gastric cancer patients. The study found that a high lncRNA score was associated with poor prognosis, decreased tumor mutation burden, and immunosuppression, while a low lncRNA score was associated with increased neoantigen load and increased response to immunotherapy targeting PDL1/CTLA4. Additionally, a low lncRNA score was associated with significant therapeutic advantage and clinical benefit.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Linfeng Mao, Weijie Yuan, Kaimei Cai, Chen Lai, Changhao Huang, Yi Xu, Shangwei Zhong, Chen Yang, Ran Wang, Pengwei Zeng, Heyuan Huang, Zhikang Chen, Zihua Chen
Summary: EphA2, YES1, and ANXA2 form a signaling axis that promotes gastric cancer invasion and metastasis. Overexpression of YES1 increases invasion and migration of gastric cancer cells, while knockdown of ANXA2 decreases these processes.
Article
Oncology
Xiangliu Chen, Yingying Huang, Jin Liu, Wu Lin, Chuanzhi Chen, Yiran Chen, Yongfeng Ding, Yan Yang, Yanyan Chen, Haiyong Wang, Lisong Teng
Summary: In this study, we found that EXOSC5 is upregulated in GC tissues and cell lines and is associated with poor prognosis. It promotes GC proliferation and tumorigenesis, possibly through activation of the AKT and STAT3 signaling pathways.
Article
Biochemistry & Molecular Biology
Cheng Zhang, Yong-Zhi Li, Dong-Qiu Dai
Summary: This study revealed that FOXF2 is downregulated in gastric cancer due to aberrant DNA methylation, and the degree of methylation in the FOXF2 promoter region is related to patient prognosis. Additionally, FOXF2 may play a vital biological regulation role in gastric cancer through the FOXF2/miRNAs/target genes axis.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Mathematical & Computational Biology
Yuan Yang, Yuwei Ye, Min Liu, Ya Zheng, Guozhi Wu, Zhaofeng Chen, Yuping Wang, Qinghong Guo, Rui Ji, Yongning Zhou
Summary: This study discovers that FAM153B is downregulated in gastric cancer tissues and positively associated with unfavorable survival. Enrichment pathways of FAM153B involve regulation of signaling receptor activity, DNA replication, cell cycle transition, and chromosomal regulation. Additionally, the protein expression level of FAM153B is related to the degree of immune cell infiltration.
MATHEMATICAL BIOSCIENCES AND ENGINEERING
(2022)
Article
Genetics & Heredity
Donghui Liu, Long Li, Liru Wang, Chao Wang, Xiaowei Hu, Qingxin Jiang, Xuyao Wang, Guiqin Xue, Yu Liu, Dongbo Xue
Summary: The study integrated GC DNA methylation data from public databases to identify reliable diagnostic and prognostic markers, and constructed corresponding models. These models can assist in accurate and individualized treatment of GC.
FRONTIERS IN GENETICS
(2021)
Article
Cell Biology
Lingjun Ge, Gaichao Zhao, Chao Lan, Houji Song, Dan Qi, Pan Huang, Xiaoxue Ke, Hongjuan Cui
Summary: Gastric cancer is a deadly disease with high incidence and mortality rates. MESP2, a transcription factor, is found to be decreased in gastric cancer tissue and cell lines. Overexpression of MESP2 can suppress the growth, migration, and invasion of gastric cancer cells, and it achieves this by regulating the SKP2/p27 axis.
CELL DEATH DISCOVERY
(2023)
Article
Anatomy & Morphology
Yu Chen, Biling Wang, Zihao Zhao, Ming Li, Fei Wang
Summary: Overexpression of PRSS2 in gastric cancer is associated with poor prognosis and can serve as a potential biomarker for assessing the prognosis of gastric cancer. Knockdown of PRSS2 reduces the proliferation, migration, and invasion of GC cells.
Article
Biochemistry & Molecular Biology
Haejeong Heo, Hee-Jin Kim, Keeok Haam, Hyun Ahm Sohn, Yang-Ji Shin, Hanyong Go, Hyo-Jung Jung, Jong-Hwan Kim, Sang-Il Lee, Kyu-Sang Song, Min-Ju Kim, Haeseung Lee, Eun-Soo Kwon, Seon-Young Kim, Yong Sung Kim, Mirang Kim
Summary: Gastric cancer is influenced by genetic and epigenetic factors, with chronic inflammation and dietary risk factors playing a role in promoting the disease. Upregulation of TNS4, a protein involved in cell adhesion, was observed in gastric cancer tumors. Depletion of TNS4 in certain gastric cancer cell lines reduced cell proliferation and migration, while overexpression of TNS4 in other cell lines increased colony formation and cell migration. The promoter region of TNS4 had lower methylation levels in gastric cancer cell lines with upregulated TNS4 expression. This study sheds light on the epigenetic mechanism and functional roles of TNS4 in gastric cancer development and suggests potential avenues for future treatments.
MOLECULES AND CELLS
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Haitian Liu, Zhangjian Zhou, Xiang Li, Chenxia Li, Rong Wang, Yuelang Zhang, Gang Niu
BRITISH JOURNAL OF RADIOLOGY
(2018)
Article
Medicine, General & Internal
Zhangjian Zhou, Xin Xie, Nan Hao, Dongmei Diao, Yongchun Song, Peng Xia, Chengxue Dang, Hao Zhang
CURRENT MEDICAL RESEARCH AND OPINION
(2018)
Article
Oncology
Xin Xie, Zhangjian Zhou, Yongchun Song, Wei Wang, Chengxue Dang, Hao Zhang
INTERNATIONAL JOURNAL OF ONCOLOGY
(2018)
Article
Oncology
Zhi Wang, Zhangjian Zhou, Wenxing Li, Wei Wang, Xin Xie, Jincheng Liu, Yongchun Song, Chengxue Dang, Hao Zhang
CANCER MANAGEMENT AND RESEARCH
(2018)
Article
Oncology
Zhangjian Zhou, Heng Lu, Shoumin Zhu, Ahmed Gomaa, Zheng Chen, Jin Yan, Kay Washington, Wael El-Rifai, Chengxue Dang, Dunfa Peng
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2019)
Article
Oncology
Dunfa Peng, Heng Lu, Shoumin Zhu, Zhangjian Zhou, Tianling Hu, Zheng Chen, Alexander Zaika, Wael El-Rifai
Article
Oncology
Xin Xie, Jianhao Yin, Zhangjian Zhou, Chengxue Dang, Hao Zhang, Yong Zhang
Article
Genetics & Heredity
Zhangjian Zhou, Xin Xie, Xuan Wang, Xin Zhang, Wenxin Li, Tuanhe Sun, Yifan Cai, Jianhua Wu, Chengxue Dang, Hao Zhang
Summary: This study investigated the patterns and prognostic roles of TMB and immune infiltration in colon cancer, providing new insights into the tumor microenvironment and immunotherapies. A novel nomogram prognostic prediction model for patients with colon cancer was developed, integrating TMB, immune infiltration, and clinical parameters with better calibration and predictive ability.
FRONTIERS IN GENETICS
(2021)
Article
Obstetrics & Gynecology
Wei Wang, Xin Xie, Ting Yuan, Yanyan Wang, Fei Zhao, Zhangjian Zhou, Hao Zhang
Summary: Global studies on hypertensive disorders of pregnancy show an increase in incidence but a decrease in age-standardized incidence rates. Deaths due to hypertensive disorders of pregnancy decreased by 30.05% in 2019 compared to 1990. The highest incidence and mortality rates were observed in the 25-29 age group, with higher rates in countries and regions with lower sociodemographic indices and human development indices.
BMC PREGNANCY AND CHILDBIRTH
(2021)
Article
Medicine, General & Internal
Wei Wang, Xin Xie, Zhangjian Zhou, Hao Zhang
Summary: Our study revealed that Mist1 may act as an oncogene in cervical squamous cell carcinoma and could serve as a potential biomarker. High expression of Mist1 was significantly associated with poor overall survival, while overexpression of Mist1 resulted in downregulation of E-cadherin and upregulation of N-cadherin and Twist, suggesting a potential role in epithelial-mesenchymal transition.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Article
Medicine, Research & Experimental
Yifan Cai, Xuan Wang, Nan Wang, Jianhua Wu, Li Ma, Xin Xie, Hao Zhang, Chengxue Dang, Huafeng Kang, Shuqun Zhang, Zhangjian Zhou
Summary: The study investigated the patterns and prognostic roles of tumor mutation burden (TMB) and immune microenvironment in pancreatic cancer. Results showed differences in gene expression, immune cell infiltration, and immune gene expression between high and low TMB groups, leading to the establishment of a nomogram integrating TMB and immune infiltration with good predictive ability for survival rates.
Article
Oncology
Jianhua Wu, Xuan Wang, Nan Wang, Li Ma, Xin Xie, Hao Zhang, Huafeng Kang, Zhangjian Zhou
Summary: This study established an antioxidant-related gene signature and nomogram that effectively predicted gastric cancer prognosis, providing novel tools for patient management. The model performed well in assessing prognoses and showed good consistency in internal validation.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Genetics & Heredity
Xueting Ren, Li Ma, Nan Wang, Ruina Zhou, Jianhua Wu, Xin Xie, Hao Zhang, Di Liu, Xiaobin Ma, Chengxue Dang, Huafeng Kang, Zhangjian Zhou
Summary: By utilizing the TCGA database, six antioxidant genes were identified as prognostic indicators in KIRC patients, dividing them into high- and low-risk groups with different clinical outcomes and immune infiltration patterns. The established nomogram model showed promising performance in predicting survival outcomes and guiding potential patient selection for immunotherapy.
FRONTIERS IN GENETICS
(2021)
Article
Oncology
Xin Xie, Zhangjian Zhou, Yongchun Song, Xin Zhang, Chengxue Dang, Hao Zhang
Summary: The study showed that overexpression of Mist1 could inhibit tumor growth and distant metastasis in gastric cancer by suppressing the Wnt/beta-catenin signaling pathway, suggesting Mist1 as a potential tumor suppressor and a novel marker for early gastric cancer screening.
Article
Cell Biology
Huafeng Kang, Nan Wang, Xuan Wang, Yu Zhang, Shuai Lin, Guochao Mao, Di Liu, Chengxue Dang, Zhangjian Zhou
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)