Combined therapy with thrombospondin-1 type I repeats (3TSR) and chemotherapy induces regression and significantly improves survival in a preclinical model of advanced stage epithelial ovarian cancer

The Thrombospondin-1 Mimetic ABT-510 Increases the Uptake and Effectiveness of Cisplatin and Paclitaxel in a Mouse Model of Epithelial Ovarian Cancer

(2015) Nicole E. Campbell et al.   NEOPLASIA

Overexpression of Elafin in Ovarian Carcinoma Is Driven by Genomic Gains and Activation of the Nuclear Factor κB Pathway and Is Associated with Poor Overall Survival

(2015) Adam Clauss et al.   NEOPLASIA

The Effect of Bevacizumab on Human Malignant Melanoma Cells with Functional VEGF/VEGFR2 Autocrine and Intracrine Signaling Loops

(2015) Una Adamcic et al.   NEOPLASIA

Metronomic Ceramide Analogs Inhibit Angiogenesis in Pancreatic Cancer through Up-regulation of Caveolin-1 and Thrombospondin-1 and Down-regulation of Cyclin D1

(2015) Guido Bocci et al.   NEOPLASIA

Cancer statistics, 2014

(2014) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Thrombospondin-1 modulates VEGF signaling via CD36 by recruiting SHP-1 to VEGFR2 complex in microvascular endothelial cells

(2013) L.-Y. Chu et al.   BLOOD

A phase 1 trial of imatinib, bevacizumab and metronomic cyclophosphamide in advanced colorectal cancer

(2013) R K Kelley et al.   BRITISH JOURNAL OF CANCER

Phase III Trials of Standard Chemotherapy with or without Bevacizumab for Ovarian Cancer: A Meta-Analysis

(2013) Mingyi Zhou et al.   PLoS One

Correlation between TSP-1, TGF-β and PPAR-γ expression levels and glioma microvascular density

(2013) JING ZHANG et al.   Oncology Letters

A phase I study of ABT-510 plus bevacizumab in advanced solid tumors

(2013) Hope E. Uronis et al.   Cancer Medicine

Bevacizumab-induced perforation of the gastrointestinal tract: clinical and radiographic findings in 11 patients

(2012) Samuel E. Borofsky et al.   ABDOMINAL IMAGING

Combination antiangiogenic therapy in advanced breast cancer: a phase 1 trial of vandetanib, a VEGFR inhibitor, and metronomic chemotherapy, with correlative platelet proteomics

(2012) Erica L. Mayer et al.   BREAST CANCER RESEARCH AND TREATMENT

Ovarian cancer molecular pathology

(2012) Rémi Longuespée et al.   CANCER AND METASTASIS REVIEWS

Regulation of VEGF signaling by membrane traffic

(2012) Arie Horowitz et al.   CELLULAR SIGNALLING

Thrombospondin-1 (TSP-1) Analogs ABT-510 and ABT-898 Inhibit Prolactinoma Growth and Recover Active Pituitary Transforming Growth Factor-β1 (TGF-β1)

(2012) M. Victoria Recouvreux et al.   ENDOCRINOLOGY

Prospective Study of Thrombospondin-1 Mimetic Peptides, ABT-510 and ABT-898, in Dogs with Soft Tissue Sarcoma

(2012) A.I. Sahora et al.   JOURNAL OF VETERINARY INTERNAL MEDICINE

An Inside View: VEGF Receptor Trafficking and Signaling

(2012) Michael Simons   PHYSIOLOGY

ABT-898 Induces Tumor Regression and Prolongs Survival in a Mouse Model of Epithelial Ovarian Cancer

(2011) N. Campbell et al.   MOLECULAR CANCER THERAPEUTICS

Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases

(2011) Peter Carmeliet et al.   NATURE REVIEWS DRUG DISCOVERY

Molecular mechanisms of cisplatin resistance

(2011) L Galluzzi et al.   ONCOGENE

Ovarian cancer creates a suppressive microenvironment to escape immune elimination

(2010) Refika Yigit et al.   GYNECOLOGIC ONCOLOGY

A Double Hit to Kill Tumor and Endothelial Cells by TRAIL and Antiangiogenic 3TSR

(2009) B. Ren et al.   CANCER RESEARCH

METRONOMIC CHEMOTHERAPY. CHANGING THE PARADIGM THAT MORE IS BETTER

(2009) O.Graciela Scharovsky et al.   Current Oncology

Thrombospondin-1 modulates vascular endothelial growth factor activity at the receptor level

(2009) Xuefeng Zhang et al.   FASEB JOURNAL

ABT-510 induces tumor cell apoptosis and inhibits ovarian tumor growth in an orthotopic, syngeneic model of epithelial ovarian cancer

(2009) J. Greenaway et al.   MOLECULAR CANCER THERAPEUTICS

A phase 1 trial of 2 dose schedules of ABT-510, an antiangiogenic, thrombospondin-1-mimetic peptide, in patients with advanced cancer

(2008) Michael S. Gordon et al.   CANCER

Autocrine VEGF-A/KDR loop protects epithelial ovarian carcinoma cells from anoikis

(2008) Ifat Sher et al.   INTERNATIONAL JOURNAL OF CANCER

Epithelial–stromal interaction increases cell proliferation, survival and tumorigenicity in a mouse model of human epithelial ovarian cancer

(2007) James Greenaway et al.   GYNECOLOGIC ONCOLOGY