Article
Toxicology
Hengyang Shen, Yixuan Meng, Tao Hu, Shuwei Li, Mulong Du, Junyi Xin, Dongying Gu, Meilin Wang, Zan Fu
Summary: The study identified a novel colorectal cancer susceptibility locus, SCRIB rs13251492, associated with a decreased risk of colorectal cancer and longer recurrence-free survival time. Functional analyses revealed the influence of rs13251492 on the expression of SCRIB mRNA in colorectal tumors and its enhancer activity. High expression levels of SCRIB mRNA in colorectal cancer tissues compared to normal tissues further supported its functional relevance in cancer.
ARCHIVES OF TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Maria I. Aroca-Siendones, Sara Moreno-SanJuan, Jose D. Puentes-Pardo, Michela Verbeni, Javier Arnedo, Julia Escudero-Feliu, Maria Garcia-Costela, Adelina Garcia-Robles, Angel Carazo, Josefa Leon
Summary: Low expression of PER2 and BMAL1 is associated with metastasis at the time of CRC diagnosis, high expression of CRY1 is an independent prognostic factor for metastasis development, and high expression of NR1D2 is an independent prognostic factor for local recurrence development. Patients with low BMAL1 expression and high CRY1 expression show lower overall survival and disease-free survival at five years.
Review
Genetics & Heredity
Saiedeh Razi Soofiyani, Hossein Ahangari, Alireza Soleimanian, Ghader Babaei, Tohid Ghasemnejad, Seyed Esmaeil Safavi, Shirin Eyvazi, Vahideh Tarhriz
Summary: Colorectal cancer is the third most common cancer in humans, with unclear development mechanisms but known associations with genetic, environmental, and epigenetic risk factors. The circadian rhythm, controlled by circadian clock genes, cytokines, and hormones, regulates various biological processes and disruptions in this rhythm have been linked to diseases such as cancer. The pathways of circadian genes in the pathogenesis of CRC are still underexplored, but understanding them may lead to new therapeutic approaches.
Article
Genetics & Heredity
Yucheng Qian, Jingsun Wei, Wei Lu, Fangfang Sun, Maxwell Hwang, Kai Jiang, Dongliang Fu, Xinyi Zhou, Xiangxing Kong, Yingshuang Zhu, Qian Xiao, Yeting Hu, Kefeng Ding
Summary: This study focused on immune-related genes (IRGs) to establish a prognostic model for colorectal cancer patients, providing recommendations for clinical treatment. The 18-IRG signature was identified as an independent prognostic factor for overall survival in CRC patients, reflecting the state of tumor immune microenvironment (TIME) to a certain extent.
FRONTIERS IN GENETICS
(2021)
Article
Oncology
Alireza Basti, Deeksha Malhan, Malti Dumbani, Mathias Dahlmann, Ulrike Stein, Angela Relogio
Summary: The study investigates the interaction between the biological clock and metastasis-associated gene MACC1 in colorectal cancer (CRC). Results show a reciprocal interplay between the circadian clock and MACC1, suggesting a potential regulation of CRC invasiveness through the circadian clock.
Article
Biochemistry & Molecular Biology
Maria Radanova, Mariya Levkova, Galya Mihaylova, Rostislav Manev, Margarita Maneva, Rossen Hadgiev, Nikolay Conev, Ivan Donev
Summary: There is a growing interest in studying single nucleotide polymorphisms (SNPs) in microRNA (miRNA) genes, as they may be associated with susceptibility, prognosis, and treatment response in colorectal cancer (CRC). These miRNA-SNPs could serve as non-invasive biomarkers for early detection of CRC. However, contradictory findings have been reported when different research groups investigated the same SNP in a gene for a specific miRNA, highlighting the need for more case-control studies involving participants from different ethnic backgrounds. According to our review, three miRNA-SNPs - miR-146a rs2910164, miR-27a rs895819, and miR-608 rs4919510 - appear to be promising prognostic, diagnostic, and predictive biomarkers for CRC.
Article
Oncology
Muege Yalcin, Deeksha Malhan, Alireza Basti, Ana Rita Peralta, Joaquim J. Ferreira, Angela Relogio
Summary: The study reveals that cancer and neurodegenerative diseases, despite being two aging-related pathologies, are both influenced by disruptions in the biological clock, which can lead to alterations in cellular pathways that may significantly impact patient survival.
Article
Oncology
Yang Li, Ru-yao Wang, Yu-jiao Deng, Shao-hua Wu, Xinti Sun, Hong Mu
Summary: This study systematically analyzed the expression and impact of cuproptosis and ferroptosis genes in colorectal cancer patients. By evaluating gene expression, transcriptional patterns, and clinical features, the study identified molecular subtypes associated with prognosis. Furthermore, a scoring system was established to predict prognosis and immunotherapy efficacy, providing valuable guidance for clinical treatment.
FRONTIERS IN ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Yeshwanth Reddy Vedire, Sarbajit Mukherjee, Sumedha Dondapati, Sai Yendamuri
Summary: This study aimed to investigate the association between visceral obesity and disease recurrence and survival in early-stage colorectal cancer (CRC) patients. The researchers also examined if this association is influenced by metformin use. The results showed that visceral obesity, but not BMI, is associated with recurrence risk and poorer survival in stage I/II CRC. Interestingly, this association is influenced by metformin use.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Shenshen Wu, Xi Yang, Weiyan Tang, Giuseppe Familiari, Michela Relucenti, Michael Aschner, Xiaobo Li, Rui Chen
Summary: Recent studies have found an association between the PVT1 rs2278176 CT/TT genotypes and a better chemotherapy response, overall survival, and progression-free survival in metastatic colorectal cancer patients. In vivo experiments showed that the rs2278176 C to T mutation inhibited tumor growth and increased apoptosis in colorectal cancer cells treated with 5-Fu. Functional studies revealed that the rs2278176 C to T mutation altered the binding site for hsa-miR-297, leading to downregulation of GSTA2 expression. High GSTA2 expression predicted poor clinical outcomes in metastatic colorectal cancer treated with FOLFOX.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Sara M. Ortega-Campos, Eva M. Verdugo-Sivianes, Ana Amiama-Roig, Jose R. Blanco, Amancio Carnero
Summary: The molecular machinery of the circadian clock regulates gene expression and cellular activities to adapt to daily light-dark cycles. Disruption of the circadian rhythm is an independent risk factor for cancer and circadian genes may play dual roles as tumor suppressors and oncogenes. Understanding the molecular basis of the circadian clock can help identify new markers and targets for cancer prognosis and therapy.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2023)
Article
Multidisciplinary Sciences
Irawan Yusuf, Bens Pardamean, James W. Baurley, Arif Budiarto, Upik A. Miskad, Ronald E. Lusikooy, Arham Arsyad, Akram Irwan, George Mathew, Ivet Suriapranata, Rinaldy Kusuma, Muhamad F. Kacamarga, Tjeng W. Cenggoro, Christopher McMahan, Chase Joyner, Carissa Pardamean
Summary: The study conducted a genome-wide association study on colorectal cancer in Indonesians, identifying SNP associated with colorectal cancer risk and establishing a polygenic risk model. The findings help characterize the relationship between genetic variants and colorectal cancer risk in diverse Indonesian populations.
SCIENTIFIC REPORTS
(2021)
Article
Genetics & Heredity
Weiqiang Wu, Jingqing Dong, Yang Lv, Dongmin Chang
Summary: Cuproptosis is related to the clinical characteristics and prognosis of colorectal cancer (CRC), and is closely associated with the levels of immune cells and stromal cells in the tumor microenvironment.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Meizhi Du, Yu Wang, Jillian Vallis, Matin Shariati, Patrick S. Parfrey, John R. Mclaughlin, Peizhong Peter Wang, Yun Zhu
Summary: This study investigated the association between genetic variants of LEP and LEPR and colorectal cancer (CRC) survival. The results showed that variations in the LEP and LEPR genes were associated with disease-free survival and CRC-specific survival in patients with CRC. It was also found that the association between LEPR single-nucleotide polymorphisms and survival was modified by red meat intake and BMI status.
CANCER BIOLOGY & MEDICINE
(2023)
Article
Genetics & Heredity
Qianru Zhu, Xingxing Huang, Shuxian Yu, Lan Shou, Ruonan Zhang, Han Xie, Zimao Liang, Xueni Sun, Jiao Feng, Ting Duan, Mingming Zhang, Yu Xiang, Xinbing Sui, Weiwei Jin, Lili Yu, Qibiao Wu
Summary: The study identified three distinct m(6)A modification patterns in CRC patients, with the pattern exhibiting longer RFS showing robust immune responses. CRC patients were divided into high- and low-score subgroups based on m(6)A score, with patients in the low-score group having longer RFS and altered immune cell infiltration.
FRONTIERS IN GENETICS
(2022)
Article
Biochemistry & Molecular Biology
Junyi Xin, Dongying Gu, Silu Chen, Shuai Ben, Huiqin Li, Zhengdong Zhang, Mulong Du, Meilin Wang
Summary: This study systematically evaluated the genetic effects on cancer survival using GWAS dataset and assessed the causal effects of risk factors and biomarkers using Mendelian randomization. Several genetic factors were found to be associated with cancer prognosis, and an online database was developed to facilitate accessing cancer survival results.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Oncology
Silu Chen, Xiangming Cao, Shuai Ben, Lingjun Zhu, Dongying Gu, Yuan Wu, Shuwei Li, Qiang Yu
Summary: The study identified that genetic variations in m(5)C modification genes are associated with the prognosis of colorectal cancer after chemotherapy, potentially affecting the therapeutic efficacy through the regulation of YBX1 gene expression.
Article
Toxicology
Fang Gao, Huiqin Li, Zhenguang Mao, Yanping Xiao, Mulong Du, Shizhi Wang, Rui Zheng, Zhengdong Zhang, Meilin Wang
Summary: This study identified smoking-related genes using weighted correlation network analysis (WGCNA) and investigated their genetic effects on bladder cancer risk. The results showed that among 14 smoking-related genes, 24 SNPs were associated with bladder cancer risk, and the interaction between CDKAL1 rs9348451 and smoking status increased the risk of bladder cancer.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Genetics & Heredity
Junyi Xin, Mulong Du, Dongying Gu, Kewei Jiang, Mengyun Wang, Mingjuan Jin, Yeting Hu, Shuai Ben, Silu Chen, Wei Shao, Shuwei Li, Haiyan Chu, Linjun Zhu, Chen Li, Kun Chen, Kefeng Ding, Zhengdong Zhang, Hongbing Shen, Meilin Wang
Summary: Researchers developed a polygenic risk score (PRS) incorporating East Asian and European ancestry groups to assess colorectal cancer risk across different populations. The study also found that a healthy lifestyle can reduce the impact of genetics on colorectal cancer risk.
Article
Oncology
Shuwei Li, Mulong Du, Kaili Xu, Shuai Ben, Tianru Zhu, Mengfan Guo, Junyi Xin, Lingjun Zhu, Dongying Gu, Zhengdong Zhang, Meilin Wang
Summary: Genetic variant rs11245997 in the 3'UTR of the BET1L gene is significantly associated with colorectal cancer risk. This variant promotes BET1L expression by disrupting miR-140-3p binding and reducing BET1L m6A modification. Higher BET1L expression is linked to advanced tumor stages and poor patient prognosis. This study provides insights into the role of genetic variants of BET1L in the development and progression of colorectal cancer.
Article
Engineering, Environmental
Shuwei Li, Shenya Xu, Yehua Chen, Jieyu Zhou, Shuai Ben, Mengfan Guo, Haiyan Chu, Dongying Gu, Zhengdong Zhang, Meilin Wang
Summary: Using an elementomics approach, we found that thallium (Tl) was positively correlated with toxic metals and associated with an increased risk of colorectal cancer. Acute exposure to Tl led to cytotoxicity and cell death by increasing reactive oxygen species and DNA damage. Chronic exposure to Tl inhibited cell death, leading to the malignant transformation of normal colon cells and tumor formation in mice. We also identified a significant metal quantitative trait locus for a novel colorectal cancer susceptibility locus. Mechanistically, Tl increased the level of aberrant N6-methyladenosine modification of ATP13A3 to promote colorectal tumorigenesis via the METLL3/METTL14/ALKBH5-ATP13A3 axis. This study provides a basis for developing public health strategies to reduce metal exposure in high-risk populations for colorectal cancer.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Nutrition & Dietetics
Giulia Collatuzzo, Eva Negri, Claudio Pelucchi, Rossella Bonzi, Federica Turati, Charles S. Rabkin, Linda M. Liao, Rashmi Sinha, Domenico Palli, Monica Ferraroni, Lizbeth Lopez-Carrillo, Nuno Lunet, Samantha Morais, Demetrius Albanes, Stephanie J. Weinstein, Dominick Parisi, David Zaridze, Dmitry Maximovitch, Trinidad Dierssen-Sotos, Jose Juan Jimenez-Moleon, Jesus Vioque, Manoli Garcia de la Hera, Maria Paula Curado, Emmanuel Dias-Neto, Raul Ulises Hernandez-Ramirez, Malaquias Lopez-Cervantes, Mary H. Ward, Shoichiro Tsugane, Akihisa Hidaka, Areti Lagiou, Pagona Lagiou, Zuo-Feng Zhang, Antonia Trichopoulou, Anna Karakatsani, Maria Constanza Camargo, Carlo La Vecchia, Paolo Boffetta
Summary: A meta-analysis of 16 studies found no significant association between yoghurt consumption and gastric cancer risk.
Article
Neurosciences
Min Tang, Jin Liu, Chesong Zhao, Chengming Wang, Qian Zhang, Mulong Du, Xiaoxin Meng, Pu Li
Summary: This study retrospectively compared the efficacy and safety of micro-RF therapy through the urethra with oral tolterodine for newly diagnosed OAB. The results showed that although both treatments improved symptoms, micro-RF therapy was safer and more effective in the short term.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Medicine, General & Internal
Junyi Xin, Xia Jiang, Huiqin Li, Silu Chen, Zhengdong Zhang, Meilin Wang, Dongying Gu, Mulong Du, David C. Christiani
Summary: The study found that the cancer risk-specific polygenic risk score (PRS) is not a clinically useful tool in cancer prognosis prediction.
Article
Cell Biology
Mulong Du, Dongying Gu, Junyi Xin, Ulrike Peters, Mingyang Song, Guoshuai Cai, Shuwei Li, Shuai Ben, Yixuan Meng, Haiyan Chu, Lianmin Chen, Qianghu Wang, Lingjun Zhu, Zan Fu, Zhengdon Zhang, Meilin Wang
Summary: In this study, the genome, epigenome, transcriptome, and proteome of tumors from Chinese colorectal cancer patients were analyzed. The findings showed that early-onset colorectal cancer has a high tumor mutation burden, increased DNA repair features, and immune infiltration. The study also identified LMTK3 as a potential biomarker and functional modulator in the development and immunotherapy of early-onset colorectal cancer. This integrative omics study provides valuable knowledge for precision oncology of colorectal cancer.
CELL REPORTS MEDICINE
(2023)
Article
Environmental Sciences
Silu Chen, Junyi Xin, Zhutao Ding, Lingyan Zhao, Shuai Ben, Rui Zheng, Shuwei Li, Huiqin Li, Wei Shao, Yifei Cheng, Zhengdong Zhang, Mulong Du, Meilin Wang
Summary: This study aimed to assess human internal exposure to pollutants by constructing a genetically relevant environmental surrogate. The results showed that the constructed polygenic risk scores (EpPRSs) can serve as a proxy for assessing pollutant internal exposure and improve disease risk assessment. The study also revealed the toxic pathway and mode of action linking exposure and disease, providing a basis for environmental pollutant control strategies.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Critical Care Medicine
Shurui Cao, Huiqin Li, Junyi Xin, Zhenghao Jin, Zhengyu Zhang, Jiawei Li, Yukun Zhu, Li Su, Peipei Huang, Lei Jiang, Mulong Du, David Christiani
Summary: This study profiles genetic causal factors of acute respiratory distress syndrome (ARDS) and develops a promising prediction model for early clinical management and intervention of ARDS development.
INTENSIVE CARE MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Rui Zheng, Fang Gao, Zhenguang Mao, Yanping Xiao, Lin Yuan, Zhengkai Huang, Qiang Lv, Chao Qin, Mulong Du, Zhengdong Zhang, Meilin Wang
Summary: This study identifies the rs62483508 G > A variant in microRNA response elements (MREs) of lncRNA BCCE4 as significantly associated with decreased bladder cancer risk in the Chinese population. Further experiments reveal that this variant disrupts the binding affinity of miR-328-3p to facilitate USP18 from miRNA-mediated degradation and attenuates the downstream PD-L1/PD-1 interaction. The study also finds that lncRNA BCCE4 is enriched in exosomes from bladder cancer plasma, tissues, and cells.
Article
Oncology
Giulia Collatuzzo, Claudio Pelucchi, Eva Negri, Manolis Kogevinas, Jose Maria Huerta, Jesus Vioque, Manoli Garcia de la Hera, Shoichiro Tsugane, Gerson Shigueaki Hamada, Akihisa Hidaka, Zuo-Feng Zhang, M. Constanza Camargo, Maria Paula Curado, Nuno Lunet, Carlo La Vecchia, Paolo Boffetta
Summary: The association between sleep duration and stress with gastric cancer (GC) was examined. Long sleep duration (=9 h) was found to be associated with GC, while stress was associated with noncardia GC.
Article
Cell Biology
Mengfan Guo, Jie Lin, Xiangming Cao, Jieyu Zhou, Shuai Ben, Silu Chen, Haiyan Chu, Lin Miao, Shuwei Li, Dongying Gu
Summary: Genetic variants in hypoxia-related genes are associated with colorectal cancer risk, and EPAS1 may serve as a promising predictor of colorectal cancer susceptibility and immune status.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)