Review
Biochemistry & Molecular Biology
Umar Mushtaq
Summary: EP1 receptor has contrasting functions in the CNS and other tissues, acting as an anti-apoptotic factor in cancer cells and a neurotoxic factor in neurological disorders. Antagonists of EP1 receptor attenuate neuroinflammation and may have therapeutic potential for neurological disorders. The receptor is also involved in the development and metastasis of different cancers through the activation of different signaling pathways.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2023)
Article
Cell Biology
Zhenkai Lou, Jinwen Zhu, Xing Li, Xingguo Li, Kaili Du, Bing Wang, Fan Zhang, Xinliang Zhang
Summary: Aging is associated with increased occurrence of DVT, possibly due to endothelial cell senescence and reduced Sirt1 expression; lncRNA Sirt1-AS can decrease expression of DVT-related biomarkers by regulating Sirt1 expression, alleviating the occurrence of DVT.
Article
Physiology
Jean-Claude Kresse, Henricus A. M. Mutsaers, Michael Schou Jensen, Stine Julie Tingskov, Mia Gebauer Madsen, Lene N. Nejsum, Helle Praetorius, Rikke Norregaard
Summary: This study evaluated the role of the PGE(2)-EP1 receptor in renal fibrosis and found that EP1 receptor inhibition can attenuate fibrogenesis, suggesting it as a promising therapeutic target.
Article
Plant Sciences
Yuejin Xue, Liyuan Zhang, Lusha Zhang, Wei Sun, Zhirui Fang, Yuze Leng, Mengyao Li, Xiuyun Ren, Rui Zhang, Yingxue Zhang, Lu Chen, Hong Wang
Summary: This study investigated the antithrombotic and antiplatelet mechanisms of Danshensu (DSS) using network pharmacology analysis and in vitro experiments. The results showed that DSS effectively inhibited platelet activation by reducing reactive oxygen species (ROS) burden and preventing the release of platelet mtDNA. Importantly, DSS did not increase bleeding risk, suggesting its potential as a promising candidate drug for thrombosis and cardiovascular disease therapeutics.
Article
Cell Biology
Juliana Bezerra Medeiros de Lima, Chidera Ubah, Lucas Kniess Debarba, Iven Ayyar, Olesya Didyuk, Marianna Sadagurski
Summary: The hypothalamus plays a key role in controlling physiological functions and whole-body metabolism. Growth hormone (GH) and the GH receptor (GHR) are expressed in hypothalamic regions involved in regulating feeding and energy balance. SIRT1, a NAD(+)-dependent protein deacetylase, interacts with GHR signaling and plays a role in sensing nutrient availability in response to caloric restriction. In the arcuate nucleus (ARC) of the hypothalamus, GHR-expressing neurons also express SIRT1 and upregulate SIRT1 expression in response to fasting, revealing a novel interaction between GH and SIRT1 in fasting responses.
Article
Medical Laboratory Technology
Wenxin Huang, Renhao Li, Jue Zhang, Yiliang Cheng, Devi P. Ramakrishnan, Roy L. Silverstein
Summary: CD36 is a receptor for oxidized LDL and other endogenous danger signals that promotes athero-thrombotic processes. It physically associates with other transmembrane proteins and the N-terminal transmembrane domain is hypothesized to be involved in these interactions. By using peptide treatments and functional experiments, it was found that CD36 nTMD peptide decreased CD36 surface associations with tetraspanin CD9 and ameliorated pathologically important CD36 mediated responses to oxLDL.
TRANSLATIONAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Bei Wang, Yuxuan Jin, Jiao Liu, Qian Liu, Yujun Shen, Shengkai Zuo, Ying Yu
Summary: Chemotherapeutic agent doxorubicin (DOX) can cause cardiomyopathy and potentially life-threatening arrhythmias in cancer patients. This study reveals that the prostaglandin E2 (PGE2)/EP1 axis plays a critical role in protecting cardiomyocytes from DOX-induced ferroptosis. EP1 activation promotes nuclear factor erythroid 2-related factor 2 (Nrf2)-driven anti-oxidative gene expression and prevents ferroptotic cell death. The findings suggest that activating EP1 may be a promising strategy for preventing and treating DOX-induced cardiomyopathy.
Article
Chemistry, Multidisciplinary
Yuan-bing Huang, Ze-gang Ma, Chao Zheng, Xiao-kuang K. Ma, Devin H. Taylor, Ming Gao, Ronald J. Lukas, Jie Wu
Summary: Nicotine, a highly addictive substance, stimulates reward circuits in the brain, while the herbal compound l-THP has been found to inhibit nicotine-induced currents, potentially contributing to blocking nicotine addiction.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Agriculture, Multidisciplinary
Yijie Yang, Bo Li
Summary: Collagen peptide DEGP was found to inhibit platelet aggregation and thrombus formation, and regulate phosphorylation processes by antagonizing TP and P2Y12 receptors. Among them, DEGI exhibited the strongest inhibitory activity against platelet aggregation and antithrombotic activity.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Reproductive Biology
Yeon Jeong Hwang, Gi-Jun Sung, Ryan Marquardt, Steven L. Young, Bruce A. Lessey, Tae Hoon Kim, Yong-Pil Cheon, Jae-Wook Jeong
Summary: This study reveals the temporal expression pattern of SIRT1 in the mouse uterus and demonstrates its important role in uterine function, decidualization, and key molecules involved in implantation.
BIOLOGY OF REPRODUCTION
(2022)
Review
Cardiac & Cardiovascular Systems
Hui-ru Zhu, Hong-yu Kuang, Qiang Li, Xiao-juan Ji
Summary: Oral targeted treatments for PAH have been shown to decrease the risk of clinical worsening events, improve exercise capacity, and ameliorate functional class. Nitric oxide exhibits the most prominent clinical effect, but drugs targeting different pathways have applicability to different populations.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cell Biology
Ping Tang, Yiting Wang, Xinrong Yang, Zhongrui Wu, Wenpei Chen, Yuxin Ye, Yong Jiang, Liuqing Lin, Bingqing Lin, Baoqin Lin
Summary: Activation of SIRT1 can alleviate DVT induced by IVC stenosis. SIRT1 plays an independent role in ameliorating hypoxia-induced endothelial dysfunction and thrombotic inflammation in DVT, and this effect is mediated by NF-κB deacetylation.
Article
Oncology
Anna Buchholz, Aurelia Vattai, Sophie Fuerst, Theresa Vilsmaier, Alaleh Zati Zehni, Alexander Steger, Christina Kuhn, Elisa Schmoeckel, Christian Dannecker, Sven Mahner, Udo Jeschke, Helene H. Heidegger
Summary: In recent years, vulvar cancer incidence has been increasing, but treatment options are limited. This study investigated the expression of EP1 in vulvar cancer and its correlation with clinicopathological parameters. The results suggest that EP1 expression is associated with tumor grading and may influence cell differentiation, providing important insights into the molecular mechanisms of carcinogenesis.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Cell Biology
Weichen Wang, Longlong Wang, Mengyue Yang, Chunwei Wu, Rui Lan, Weiwei Wang, Yuze Li
Summary: Studies have shown that circ-SIRT1 restrains cardiac hypertrophy by activating SIRT1 to promote autophagy, suggesting circ-SIRT1 as a promising target for alleviating CH.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Jie Chen, Jiao Zhang, Jie Li, Ran Qin, Na Lu, David Goltzman, Dengshun Miao, Renlei Yang
Summary: Emerging observational data suggest that vitamin D deficiency is associated with knee osteoarthritis. However, the relationship between vitamin D level and osteoarthritis, as well as the role of vitamin D supplementation in prevention, are still controversial. This study found that 1,25(OH)2D3 deficiency accelerated the development of knee osteoarthritis in mice, while supplementation with 1,25(OH)2D3 rescued the phenotypes of osteoarthritis.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Medicine, Research & Experimental
Leonardo Sandrini, Patrizia Amadio, Alessandro Ieraci, Alessandro Malara, Jose P. Werba, Paolo M. Soprano, Alessandra Balduini, Marta Zara, Alice Bonomi, Fabrizio Veglia, Gualtiero Colombo, Maurizio Popoli, Francis S. Lee, Elena Tremoli, Silvia S. Barbieri
Summary: Depression is associated with thrombotic risk and arterial events, and its management is recommended in coronary artery disease patients. The BDNF Val66Met polymorphism, related to depression, is associated with arterial thrombosis in mice and acute myocardial infarction in humans. Finding show desipramine rescues behavioral impairments and reduces arterial thrombosis risk by normalizing norepinephrine levels in BDNFMet/Met mice, suggesting the potential use of alpha(2A)-ADR inhibitors in treating depression-associated thrombotic conditions.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Cristina Banfi, Patrizia Amadio, Marta Zara, Maura Brioschi, Leonardo Sandrini, Silvia S. Barbieri
Summary: The absence of PCYOX1 leads to platelet hypo-reactivity and impaired arterial thrombosis, suggesting PCYOX1 as a potential novel target for antithrombotic drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cardiac & Cardiovascular Systems
Carla Carnovale, Cristiana Perrotta, Sara Baldelli, Dario Cattaneo, Cristina Montrasio, Silvia S. Barbieri, Giulio Pompilio, Chiara Vantaggiato, Emilio Clementi, Marco Pozzi
Summary: There is a bidirectional relationship between hypertension and psychiatric disorders, and the repurposing of antihypertensive drugs to treat mental disorders is being explored. However, the mechanisms and clinical consequences of the use of these drugs on neuropsychiatric functions are not yet fully understood. This article reviews the potential role of antihypertensive agents in psychiatric disorders, discusses their targets and mechanisms of action, and examines the extent to which specific drug classes/molecules may affect psychiatric symptoms.
CARDIOVASCULAR RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Patrizia Amadio, Chiara Macchi, Chiara Favero, Marta Zara, Giulia Solazzo, Laura Dioni, Leonardo Sandrini, Luisella Vigna, Maria Francesca Greco, Massimiliano Buoli, Cesare R. Sirtori, Angela Cecilia Pesatori, Alessandro Ieraci, Massimiliano Ruscica, Silvia Stella Barbieri, Valentina Bollati
Summary: Obesity and depression are often associated with an increased risk of cardiovascular complications. The present study investigated the relationship among peripheral Brain-Derived Neurotrophic Factor (BDNF), depression, and extracellular vesicle (EV)-derived miRNAs related to atherothrombosis in a large Italian cohort of obese individuals. The results revealed a negative association between depression and BDNF levels, which was modified by raised levels of IFN-gamma. BDNF levels were also found to be linked to an increase in EV-derived miRNAs related to atherosclerosis and thrombosis, suggesting a possible link among BDNF, depression, and miRNAs.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Maria Francesca Greco, Alessandra Stefania Rizzuto, Marta Zara, Marco Cafora, Chiara Favero, Giulia Solazzo, Ilaria Giusti, Maria Pia Adorni, Francesca Zimetti, Vincenza Dolo, Cristina Banfi, Nicola Ferri, Cesare R. Sirtori, Alberto Corsini, Silvia Stella Barbieri, Anna Pistocchi, Valentina Bollati, Chiara Macchi, Massimiliano Ruscica
Summary: This study reveals that PCSK9 plays an inflammatory role through EVs released by vascular smooth muscle cells, affecting the function and content of neighboring cells, and may have a significant role in atherosclerosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Chemistry, Medicinal
Alessandra Romandini, Damiano Baldassarre, Stefano Genovese, Stefano Capri, Giulio Pompilio, Marco Scatigna, Jose Pablo Werba
Summary: Innovative lipid-modifying agents have significant potential benefits for patients with atherogenic dyslipidemias who are intolerant or unresponsive to standard care. They can target previously unmodifiable lipid factors and provide incremental metabolic and cardiovascular improvements. However, there are real-life barriers to their prescription and patient acceptance that need to be addressed for better utilization.
Review
Biochemistry & Molecular Biology
Silvia M. G. Trivigno, Gianni Francesco Guidetti, Silvia Stella Barbieri, Marta Zara
Summary: Platelets play a crucial role in hemostasis and thrombosis, but they are also involved in various physiological and pathological processes, including infection. They are among the first responders recruited to sites of inflammation and infection, actively cooperating with the immune system to exert their antimicrobial response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Lena Tschiderer, Lisa Seekircher, Raffaele Izzo, Costantino V. Mancusi, Maria Manzi, Damiano Baldassarre, Mauro Amato, Elena Tremoli, Fabrizio Veglia, Tomi-Pekka Tuomainen, Jussi Kauhanen, Ari Voutilainen, Bernhard Iglseder, Lars Lind, Tatjana Rundek, Moise Desvarieux, Akihiko Kato, Eric de Groot, Guelay Asci, Ercan Ok, Stefan Agewall, Joline W. J. D. Beulens, Christopher C. Byrne, Philip C. Calder, Hertzel Gerstein, Paolo Gresele, Gerhard Klingenschmid, Michiaki H. Nagai, Michael Olsen, Grace S. Parraga, Maya Safarova, Naveed Sattar, Michael Skilton, Coen D. A. Stehouwer, Heiko A. Uthoff, Michiel A. van Agtmael, Amber A. van der Heijden, Dorota Zozulinska-Ziolkiewicz, Hyun-Woong Park, Moo-Sik Lee, Jang-Ho Bae, Oscar F. Beloqui, Manuel Landecho, Matthieu Plichart, Pierre Ducimetiere, Jean Philippe Empana, Lena Bokemark, Goeran Bergstroem, Caroline Schmidt, Samuela Castelnuovo, Laura D. Calabresi, Giuseppe Norata, Liliana Grigore, Alberico Catapano, Dong Zhao, Miao Wang, Jing Liu, M. Arfan Ikram, Maryam L. Kavousi, Michiel J. Bots, Michael W. Sweeting, Matthias Lorenz, Peter Willeit
Summary: This study conducted a meta-analysis of individual participant data from 20 prospective studies and found that common carotid artery intima-media thickness (CCA-IMT) is associated with the risk of developing carotid plaque, independent of traditional cardiovascular risk factors.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Buamina Maitusong, Federica J. Laguzzi, Rona Strawbridge, Damiano Baldassarre, Fabrizio E. Veglia, Steve Humphries, Kai Savonen, Sudhir Kurl, Matteo J. Pirro, Andries Smit, Philippe Giral, Angela Silveira, Elena Tremoli, Anders Hamsten, Ulf de Faire, Bruna Gigante, Karin Leander, IMPROVE Study Grp
Summary: The study found that certain genetic variants may modify the effect of smoking on carotid intima-media thickness, increasing the risk of atherosclerosis.
CIRCULATION-GENOMIC AND PRECISION MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Qiao Sen Chen, Otto Bergman, Louise Ziegler, Damiano Baldassarre, Fabrizio Veglia, Elena Tremoli, Rona J. Strawbridge, Antonio Gallo, Matteo Pirro, Andries J. Smit, Sudhir Kurl, Kai Savonen, Lars Lind, Per Eriksson, Bruna Gigante, IMPROVE Study Grp
Summary: This study aimed to define the endotypes of carotid subclinical atherosclerosis using demographic, clinical, and molecular data. Four endotypes were identified, and they were associated with the progression of atherosclerosis and the risk of atherosclerotic cardiovascular disease (ASCVD) in two different populations.
CARDIOVASCULAR RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Federico Ravanelli, Laura Musazzi, Silvia Stella Barbieri, Gianenrico Rovati, Maurizio Popoli, Alessandro Barbon, Alessandro Ieraci
Summary: Alzheimer's disease is a neurodegenerative disease that causes memory loss and cognitive impairment in elderly people. The causes of this disease are not well understood and involve genetic, environmental, and epigenetic factors. In the study, SAMP8 mice were used as a model to investigate epigenetic changes in the dorsal hippocampus. The results showed differential regulation of epigenetic markers between male and female SAMP8 mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Damiano Baldassarre, Licia Iacoviello, Roberta Baetta, Maria Carla Roncaglioni, Gianluigi Condorelli, Giuseppe Remuzzi, Gianfranco Gensini, Luigi Frati, Walter Ricciardi, Pier Giulio Conaldi, Antonio Uccelli, Fabio Blandini, Silvano Bosari, Giovanni Scambia, Massimo Fini, Antonio Di Malta, Mauro Amato, Fabrizio Veglia, Alice Bonomi, Catherine Klersy, Francesca Colazzo, Martino Pengo, Francesca Gorini, Luciana Auteri, Giuseppe Ferrante, Marta Baviera, Giuseppe Ambrosio, Alberico Catapano, Alessandro Gialluisi, Alexis Elias Malavazos, Serenella Castelvecchio, Massimiliano Marco Corsi-Romanelli, Rosanna Cardani, Maria Teresa La Rovere, Valentina Agnese, Bianca Pane, Daniele Prati, Laura Spinardi, Giovanna Liuzzo, Eloisa Arbustini, Maurizio Volterrani, Marco Visconti, Jose Pablo Werba, Stefano Genovese, Grzegorz Bilo, Cecilia Invitti, Anna Di Blasio, Carolina Lombardi, Andrea Faini, Debora Rosa, Luisa Ojeda-Fernandez, Andreana Foresta, Amalia De Curtis, Augusto Di Castelnuovo, Simonetta Scalvini, Antonia Pierobon, Alessandra Gorini, Luca Valenti, Livio Luzi, Annarosa Racca, Manuela Bandi, Elena Tremoli, Lorenzo Menicanti, Gianfranco Parati, Giulio Pompilio
Summary: The CV-PREVITAL study is a multicentre, prospective, randomised, controlled, open-label interventional trial aiming to compare the effectiveness of an educational and motivational mobile health intervention with usual care in reducing cardiovascular risk. The trial plans to enrol approximately 80,000 subjects without overt cardiovascular diseases and evaluate the short-term endpoints, as well as conduct a long-term follow-up to assess the incidence of major adverse cardiovascular events.
Article
Biochemistry & Molecular Biology
Marta Zara, Andrea Baggiano, Patrizia Amadio, Jeness Campodonico, Sebastiano Gili, Andrea Annoni, Gianluca De Dona, Maria Ludovica Carerj, Francesco Cilia, Alberto Formenti, Laura Fusini, Cristina Banfi, Paola Gripari, Calogero Claudio Tedesco, Maria Elisabetta Mancini, Mattia Chiesa, Riccardo Maragna, Francesca Marchetti, Marco Penso, Luigi Tassetti, Alessandra Volpe, Alice Bonomi, Giancarlo Marenzi, Gianluca Pontone, Silvia Stella Barbieri
Summary: This study found that the expression of CD41-CD61 in sEVs can reflect the CMR-assessed ischemic damage after STEMI, providing a new strategy for the timely identification of high-risk patients and their treatment optimization.
Letter
Biochemistry & Molecular Biology
Silvia Stella Barbieri, Franca Cattani, Leonardo Sandrini, Magda Maria Grillo, Alessandra Amendola, Carmen Valente, Carmine Talarico, Daniela Iaconis, Gabriele Turacchio, Miriam Lucariello, Lucia Lione, Erika Salvatori, Patrizia Amadio, Gloria Garoffolo, Mariano Maffei, Francesca Galli, Andrea Rosario Beccari, Giuseppe Sberna, Emanuele Marra, Marica Zoppi, Michael Michaelides, Giuseppe Roscilli, Luigi Aurisicchio, Riccardo Bertini, Marcello Allegretti, Maurizio Pesce
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)