Estimating the Bioconcentration Factors of Hydrophobic Organic Compounds from Biotransformation Rates Using Rainbow Trout Hepatocytes

Comparison of trout hepatocytes and liver S9 fractions as in vitro models for predicting hepatic clearance in fish

(2016) Kellie A. Fay et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Optimizing the use of rainbow trout hepatocytes for bioaccumulation assessments with fish

(2013) Kellie A. Fay et al.   XENOBIOTICA

In vitromodels of xenobiotic metabolism in trout for use in environmental bioaccumulation studies

(2012) Chibuzor Uchea et al.   XENOBIOTICA

Physiologically Based Pharmacokinetic (PBPK) Models for Lifetime Exposure to PCB 153 in Male and Female Harbor Porpoises (Phocoena phocoena): Model Development and Evaluation

(2010) Liesbeth Weijs et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Revisiting Bioaccumulation Criteria for POPs and PBT Assessments

(2009) Frank A.P.C. Gobas et al.   Integrated Environmental Assessment and Management

Energy intake affects the biotransformation rate, scope for induction, and metabolite profile of benzo[a]pyrene in rainbow trout

(2008) Christopher J. Kennedy et al.   AQUATIC TOXICOLOGY

Xenobiotic intrinsic clearance in freshly isolated hepatocytes from rainbow trout (Oncorhynchus mykiss): Determination of trout hepatocellularity, optimization of cell concentrations and comparison of serum and serum-free incubations

(2008) Xing Han et al.   AQUATIC TOXICOLOGY

Functional and energetic characterization of P-gp-mediated doxorubicin transport in rainbow trout (Oncorhynchus mykiss) hepatocytes

(2008) Jennifer L. Hildebrand et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY

The Multiple Depletion Curves Method Provides Accurate Estimates of Intrinsic Clearance (CLint), Maximum Velocity of the Metabolic Reaction (Vmax), and Michaelis Constant (Km): Accuracy and Robustness Evaluated through Experimental Data and Monte Carlo Simulations

(2008) E. Sjogren et al.   DRUG METABOLISM AND DISPOSITION

A DATABASE OF FISH BIOTRANSFORMATION RATES FOR ORGANIC CHEMICALS

(2008) Jon A. Arnot et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

A FUGACITY APPROACH FOR ASSESSING THE BIOACCUMULATION OF HYDROPHOBIC ORGANIC COMPOUNDS FROM ESTUARINE SEDIMENT

(2008) Christopher J. Golding et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

LIVER MICROSOMES AND S9 FROM RAINBOW TROUT (ONCORHYNCHUS MYKISS): COMPARISON OF BASAL-LEVEL ENZYME ACTIVITIES WITH RAT AND DETERMINATION OF XENOBIOTIC INTRINSIC CLEARANCE IN SUPPORT OF BIOACCUMULATION ASSESSMENT

(2008) Xing Han et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

THE STATE OF IN VITRO SCIENCE FOR USE IN BIOACCUMULATION ASSESSMENTS FOR FISH

(2008) Anne V. Weisbrod et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Guidance for Evaluating In Vivo Fish Bioaccumulation Data

(2008) Thomas F. Parkerton et al.   Integrated Environmental Assessment and Management

Approach for extrapolating in vitro metabolism data to refine bioconcentration factor estimates

(2007) Christina E. Cowan-Ellsberry et al.   CHEMOSPHERE

The uptake and metabolism of benzo[a]pyrene from a sample food substrate in an in vitro model of digestion

(2007) Luba Vasiluk et al.   FOOD AND CHEMICAL TOXICOLOGY