The Multiple Depletion Curves Method Provides Accurate Estimates of Intrinsic Clearance (CLint), Maximum Velocity of the Metabolic Reaction (Vmax), and Michaelis Constant (Km): Accuracy and Robustness Evaluated through Experimental Data and Monte Carlo Simulations

Published 2008 View Full Article

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Title
The Multiple Depletion Curves Method Provides Accurate Estimates of Intrinsic Clearance (CLint), Maximum Velocity of the Metabolic Reaction (Vmax), and Michaelis Constant (Km): Accuracy and Robustness Evaluated through Experimental Data and Monte Carlo Simulations
Authors
Keywords
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Journal
DRUG METABOLISM AND DISPOSITION
Volume 37, Issue 1, Pages 47-58
Publisher
American Society for Pharmacology & Experimental Therapeutics (ASPET)
Online
2008-09-30
DOI
10.1124/dmd.108.021477

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