Review
Oncology
Parisa Maleki Dana, Fatemeh Sadoughi, Zatollah Asemi, Bahman Yousefi
Summary: Osteosarcoma is a common primary bone tumor in children with unfavorable outcomes despite advances in treatment. Quercetin, a phytochemical compound, has shown promising anti-cancer effects in various cancers, including osteosarcoma, by affecting cell proliferation, apoptosis, invasion, and chemotherapy resistance through regulating protein expression and signaling pathways.
CANCER CELL INTERNATIONAL
(2021)
Article
Oncology
Zhi-Qiang Li, Wei-Jie Liao, Bo-Lin Sun, Zhi-Wen Luo, Nan-Shan Zhong, Jia-Bao Wu, Zhi-Li Liu, Jia-Ming Liu
Summary: LRIG2 is highly expressed in osteosarcoma tissues and cells, and its knockdown inhibits cell proliferation and migration while promoting apoptosis. Silencing LRIG2 also suppresses tumor growth in vivo.
Article
Oncology
Peng Xu, Xiaoxi Li, Chao Tang, Tao Wang, Jiaming Xu
Summary: This study found that CDC42EP3 is highly expressed in osteosarcoma and is associated with the progression of the disease. Knockdown of CDC42EP3 can inhibit tumor growth by suppressing proliferation, migration, and inducing apoptosis. Furthermore, CDC42EP3 knockdown can regulate the expression of epithelial and interstitial markers, as well as the PI3K/AKT/mTOR signaling pathway. Therefore, CDC42EP3 may be a potential target for osteosarcoma therapy.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Oncology
Wei Xu, Yifan Li, Xiaojian Ye, Yunhan Ji, Yu Chen, Xiangyang Zhang, Zhikun Li
Summary: TMED3 is significantly upregulated in osteosarcoma and its knockdown inhibits tumor progression by suppressing proliferation, migration, and promoting apoptosis. TMED3 also promotes osteosarcoma progression by inhibiting RPS15A.
CANCER CELL INTERNATIONAL
(2021)
Article
Oncology
Jian Fan, Yi Yang, Ji-kui Qian, Xin Zhang, Jia-qing Ji, Li Zhang, Shan-zhu Li, Feng Yuan
Summary: Osteosarcoma is a major malignant tumor characterized by early metastasis and a high mortality rate. PAFAH1B3, a cancer-relevant molecular, was found to be overexpressed in osteosarcoma tissues and cell lines. Knockdown of PAFAH1B3 inhibited osteosarcoma cell proliferation, promoted apoptosis in vitro, and suppressed osteosarcoma growth in vivo by regulating the expression of EIF4EBP1, MYC, PTGS2, and RPS6KB1. This study suggests that PAFAH1B3 could be a potential therapeutic target for osteosarcoma patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Pharmacology & Pharmacy
Bin He, Wenkan Zhang, Jiaming He
Summary: The study demonstrated that fraxinellone (FRA) isolated from the D. dasycarpus plant inhibited the proliferation and migration of osteosarcoma cells, induced cell apoptosis, and increased autophagy flux. The pro-apoptotic effect of FRA was achieved through excessive autophagy flux, providing new ideas for future osteosarcoma treatment and offering theoretical support for the anti-cancer mechanism of FRA.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Kai Chen, Yifu Hou, Rui Liao, Youzan Li, Hongji Yang, Jun Gong
Summary: Studies have shown that lncRNA SNHG6 is upregulated in HCC, promoting cell proliferation and inhibiting the targeting of E2F1 by competitively binding miR-204-5p.
Article
Oncology
Songjia Ni, Jianjun Li, Sujun Qiu, Yingming Xie, Kaiqin Gong, Yang Duan
Summary: The study revealed that KIF21B is upregulated in osteosarcoma and may regulate the proliferation and apoptosis of osteosarcoma cells through the PI3K/AKT pathway.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Bangmin Wang, Zheping Hong, Chen Zhao, Qing Bi, Junhui Yuan, Jihang Chen, Yi Shen
Summary: This study confirmed the overexpression of MEX3A in osteosarcoma tissues and demonstrated the inhibitory effects of MEX3A knockdown on osteosarcoma progression. It was further revealed that MEX3A may be involved in osteosarcoma development by regulating apoptosis-related factors.
CANCER CELL INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Jing Zhao, Peifeng Li, Hua Zhu, Fengqin Ge, Jie Liu, Jingjun Xia, Pengzhou Hang
Summary: Recent studies have shown that 7,8-dihydroxyflavone (7,8-DHF) can inhibit the development of osteosarcoma by regulating Akt/Bad and MAPK signaling pathways. This study demonstrated that 7,8-DHF reduced cell viability, promoted apoptosis, inhibited migration, and induced oxidative stress in osteosarcoma cells. The findings suggest potential pharmacological effects of 7,8-DHF for improving drug therapy in osteosarcoma patients.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2021)
Article
Biotechnology & Applied Microbiology
Xian Tao, Jiansheng Cheng, Xinghua Wang
Summary: Overexpression of miR-200a can inhibit proliferation and increase radiosensitivity of osteosarcoma cells, possibly through regulating BMPR2.
Article
Cell Biology
Yafang Zhang, Junqiang Wei, Lingwei Kong, Mingze Song, Yange Zhang, Xiangyu Xiao, Haiying Cao, Zhehong Li, Ning Yang, Yu Jin
Summary: This study aimed to explore the antitumor effects of angelicin on osteosarcoma and its underlying mechanism. The researchers used network pharmacology, molecular docking, and in vitro experiments to investigate the potential targets and molecular mechanism of angelicin in osteosarcoma treatment. The results showed that angelicin promotes osteosarcoma cell apoptosis and inhibits cell proliferation and migration by activating a signaling network involving hub targets. Angelicin could potentially be developed as an alternative drug for the treatment of osteosarcoma.
Article
Integrative & Complementary Medicine
Liu Na, Song Mei-Na, Zhang Qian-Qian, Wu Cong, Zhu Kong-Kai, Sun Yu-Lin, Li Meng-Ru, Yang Feng-Ying, Feng Run-Liang, Zhang Yu-Ying, Zhang Hua
Summary: This study identified chemical components of an endophytic Penicillium from Dendrobium officinale, including nine citrinin derivatives and one peptide-polyketide hybrid. Among them, GKK1032B exhibited significant cytotoxicity against human osteosarcoma cells, inducing apoptosis through caspase pathway activation.
CHINESE JOURNAL OF NATURAL MEDICINES
(2022)
Article
Cell Biology
Lu Ding, Rongxin Sun, Qi Yan, Chengwei Wang, Xiaoping Han, Yong Cui, Rong Li, Jiwen Liu
Summary: In osteosarcoma, miR-506 directly targets Skp2 to inhibit cell proliferation, induce apoptosis, and reduce migration and invasion abilities. Upregulation of Skp2 reverses the tumor suppressive effects of miR-506, while downregulation of Skp2 enhances the anticancer activity of miR-506 mimic transfection in osteosarcoma cells.
Article
Medicine, Research & Experimental
Liangyu Guo, Kangwen Xiao, Yuanlong Xie, Zhiqiang Yang, Jun Lei, Lin Cai
Summary: This study validated the effect of HSPB6 on osteosarcoma through experiments and found that HSPB6 overexpression can inhibit cell proliferation, increase apoptosis, reduce cell migration and invasion in osteosarcoma. These effects are mediated through the ERK signaling pathway.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Yuri Nagaoka, Kotone Oshiro, Yuta Yoshino, Toshiyuki Matsunaga, Satoshi Endo, Akira Ikari
Summary: This study investigated the effect of intercellular adhesion molecule CLDN1 on the anticancer drug sensitivity of small-cell lung cancer (SCLC) cells. It was found that overexpression of CLDN1 decreased the sensitivity of SCLC cells to anticancer drugs and enhanced their migratory capacity through the activation of the TGF-81/EMT signaling pathway. Treatment with EMT inhibitors showed potential in overcoming the reduced sensitivity to anticancer drugs in CLDN1-overexpressing SCLC cells.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2024)