Disease prevention and delayed aging by dietary sulfur amino acid restriction: translational implications

Homocysteine, cysteine, and body composition in the Hordaland Homocysteine Study: does cysteine link amino acid and lipid metabolism?

(2018) Amany K Elshorbagy et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Excess Dietary l-Cysteine Causes Lethal Metabolic Acidosis in Chicks

(2018) Ryan N. Dilger et al.   JOURNAL OF NUTRITION

Pleiotropic responses to methionine restriction

(2017) Gene P. Ables et al.   EXPERIMENTAL GERONTOLOGY

Lean Body Mass Harbors Sensing Mechanisms that Allow Safeguarding of Methionine Homeostasis

(2017) Yves Ingenbleek   Nutrients

Methionine restriction on lipid metabolism and its possible mechanisms

(2016) Xihong Zhou et al.   AMINO ACIDS

Methionine restriction beyond life-span extension

(2016) Gene P. Ables et al.   Annals of the New York Academy of Sciences

Methionine-restricted diet inhibits growth of MCF10AT1-derived mammary tumors by increasing cell cycle inhibitors in athymic nude mice

(2016) J. R. Hens et al.   BMC CANCER

Role of GCN2-Independent Signaling Through a Noncanonical PERK/NRF2 Pathway in the Physiological Responses to Dietary Methionine Restriction

(2016) Desiree Wanders et al.   DIABETES

Amino acid changes during transition to a vegan diet supplemented with fish in healthy humans

(2016) Amany Elshorbagy et al.   EUROPEAN JOURNAL OF NUTRITION

Methionine restriction improves renal insulin signalling in aged kidneys

(2016) Louise Grant et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Hydrogen sulfide in signaling pathways

(2015) Beata Olas   CLINICA CHIMICA ACTA

UCP1 is an essential mediator of the effects of methionine restriction on energy balance but not insulin sensitivity

(2015) Desiree Wanders et al.   FASEB JOURNAL

Cysteine dietary supplementation reverses the decrease in mitochondrial ROS production at complex I induced by methionine restriction

(2015) A. Gomez et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

l-Cysteine metabolism and its nutritional implications

(2015) Jie Yin et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Regulation of Hematopoiesis and Methionine Homeostasis by mTORC1 Inhibitor NPRL2

(2015) Paul A. Dutchak et al.   Cell Reports

Elevated Serum Levels of Cysteine and Tyrosine: Early Biomarkers in Asymptomatic Adults at Increased Risk of Developing Metabolic Syndrome

(2015) Nina Mohorko et al.   Biomed Research International

Methionine restriction restores a younger metabolic phenotype in adult mice with alterations in fibroblast growth factor 21

(2014) Emma K. Lees et al.   AGING CELL

Methionine restriction slows down senescence in human diploid fibroblasts

(2014) Rafał Kozieł et al.   AGING CELL

Mechanisms of Increased In Vivo Insulin Sensitivity by Dietary Methionine Restriction in Mice

(2014) Kirsten P. Stone et al.   DIABETES

A systems biology analysis of the unique and overlapping transcriptional responses to caloric restriction and dietary methionine restriction in rats

(2014) Sujoy Ghosh et al.   FASEB JOURNAL

Effects of N-acetyl cysteine on lipid levels and on leukocyte and platelet count in rats after splenectomy

(2014) M Sit et al.   Nigerian Journal of Clinical Practice

The physiological role of hydrogen sulfide and beyond

(2014) Hideo Kimura   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Methionine Restriction Activates the Retrograde Response and Confers Both Stress Tolerance and Lifespan Extension to Yeast, Mouse and Human Cells

(2014) Jay E. Johnson et al.   PLoS One

Dietary methionine restriction inhibits prostatic intraepithelial neoplasia in TRAMP mice

(2014) Raghu Sinha et al.   PROSTATE

Methionine restriction extends lifespan of Drosophila melanogaster under conditions of low amino-acid status

(2014) Byung Cheon Lee et al.   Nature Communications

Transcriptional impact of dietary methionine restriction on systemic inflammation: Relevance to biomarkers of metabolic disease during aging

(2013) Desiree Wanders et al.   BIOFACTORS

Remodeling the Integration of Lipid Metabolism Between Liver and Adipose Tissue by Dietary Methionine Restriction in Rats

(2013) B. E. Hasek et al.   DIABETES

Methionine restriction affects oxidative stress and glutathione-related redox pathways in the rat

(2013) Sreenivasa Maddineni et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Regulation of longevity and oxidative stress by nutritional interventions: Role of methionine restriction

(2013) Ines Sanchez-Roman et al.   EXPERIMENTAL GERONTOLOGY

S-Adenosylmethionine Is Associated with Fat Mass and Truncal Adiposity in Older Adults

(2013) Amany K. Elshorbagy et al.   JOURNAL OF NUTRITION

Methionine restriction prevents the progression of hepatic steatosis in leptin-deficient obese mice

(2013) Virginia L. Malloy et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Effects of aging and methionine restriction applied at old age on ROS generation and oxidative damage in rat liver mitochondria

(2012) Inés Sanchez-Roman et al.   BIOGERONTOLOGY

A review of methionine dependency and the role of methionine restriction in cancer growth control and life-span extension

(2012) Paul Cavuoto et al.   CANCER TREATMENT REVIEWS

Metabolic adaptations to methionine restriction that benefit health and lifespan in rodents

(2012) Carmen E. Perrone et al.   EXPERIMENTAL GERONTOLOGY

Resurgence of Serine: An Often Neglected but Indispensable Amino Acid

(2012) Satish C. Kalhan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genomic and Metabolic Responses to Methionine-Restricted and Methionine-Restricted, Cysteine-Supplemented Diets in Fischer 344 Rat Inguinal Adipose Tissue, Liver and Quadriceps Muscle

(2012) Carmen E. Perrone et al.   Journal of Nutrigenetics and Nutrigenomics

The effect of taurine on cholesterol metabolism

(2012) Wen Chen et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Sulfur amino acid metabolism and requirements

(2012) Glenda Courtney-Martin et al.   NUTRITION REVIEWS

The Association of Cysteine with Obesity, Inflammatory Cytokines and Insulin Resistance in Hispanic Children and Adolescents

(2012) Amany K. Elshorbagy et al.   PLoS One

Methionine-Restricted C57BL/6J Mice Are Resistant to Diet-Induced Obesity and Insulin Resistance but Have Low Bone Density

(2012) Gene P. Ables et al.   PLoS One

The oxidative stress-inducible cystine/glutamate antiporter, system x c − : cystine supplier and beyond

(2011) Marcus Conrad et al.   AMINO ACIDS

Forty percent methionine restriction lowers DNA methylation, complex I ROS generation, and oxidative damage to mtDNA and mitochondrial proteins in rat heart

(2011) Ines Sanchez-Roman et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Dietary Methionine Restriction Increases Fat Oxidation in Obese Adults with Metabolic Syndrome

(2011) Eric P. Plaisance et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Vegetarianism produces subclinical malnutrition, hyperhomocysteinemia and atherogenesis

(2011) Yves Ingenbleek et al.   NUTRITION

Cysteine and Obesity

(2011) Amany K. Elshorbagy et al.   Obesity

Dietary methionine restriction enhances metabolic flexibility and increases uncoupled respiration in both fed and fasted states

(2010) Barbara E. Hasek et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Role of β-adrenergic receptors in the hyperphagic and hypermetabolic responses to dietary methionine restriction

(2010) Eric P. Plaisance et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Plasma Homocysteine and Cysteine and Risk of Breast Cancer in Women

(2010) J. Lin et al.   CANCER RESEARCH

Dealing with methionine/homocysteine sulfur: cysteine metabolism to taurine and inorganic sulfur

(2010) Martha H. Stipanuk et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Cysteine supplementation reverses methionine restriction effects on rat adiposity: significance of stearoyl-coenzyme A desaturase

(2010) Amany K. Elshorbagy et al.   JOURNAL OF LIPID RESEARCH

S-Adenosylmethionine decarboxylase

(2009) Anthony E. Pegg   Essays in Biochemistry

Life-Span Extension in Mice by Preweaning Food Restriction and by Methionine Restriction in Middle Age

(2009) L. Sun et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Forty Percent Methionine Restriction Decreases Mitochondrial Oxygen Radical Production and Leak at Complex I During Forward Electron Flow and Lowers Oxidative Damage to Proteins and Mitochondrial DNA in Rat Kidney and Brain Mitochondria

(2009) Pilar Caro et al.   REJUVENATION RESEARCH

L-Cysteine Down-Regulates SREBP-1c-Regulated Lipogenic Enzymes Expression via Glutathione in HepG2 Cells

(2008) Anja Bettzieche et al.   ANNALS OF NUTRITION AND METABOLISM

Elevated Gamma-Glutamyltransferase Activity and Perturbed Thiol Profile Are Associated With Features of Metabolic Syndrome

(2008) Philippe Giral et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Forty percent and eighty percent methionine restriction decrease mitochondrial ROS generation and oxidative stress in rat liver

(2008) Pilar Caro et al.   BIOGERONTOLOGY

Effect of 40% restriction of dietary amino acids (except methionine) on mitochondrial oxidative stress and biogenesis, AIF and SIRT1 in rat liver

(2008) Pilar Caro et al.   BIOGERONTOLOGY

The low-methionine content of vegan diets may make methionine restriction feasible as a life extension strategy

(2008) Mark F. McCarty et al.   MEDICAL HYPOTHESES

Oxidative and nitrosative stress and apoptosis in the liver of rats fed on high methionine diet: Protective effect of taurine

(2008) Seda Yalçınkaya et al.   NUTRITION