Piecing together the puzzle of pancreatic islet adaptation in pregnancy

Connective tissue growth factor is critical for proper β-cell function and pregnancy-induced β-cell hyperplasia in adult mice

(2016) Raymond C. Pasek et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Genetics of Gestational Diabetes Mellitus and Maternal Metabolism

(2016) William L. Lowe et al.   Current Diabetes Reports

Gestational Diabetes Mellitus From Inactivation of Prolactin Receptor and MafB in Islet β-Cells

(2016) Ronadip R. Banerjee et al.   DIABETES

Maternal Serum Prolactin and Prediction of Postpartum β-Cell Function and Risk of Prediabetes/Diabetes

(2016) Ravi Retnakaran et al.   DIABETES CARE

β-Cell adaptation in pregnancy

(2016) L. Baeyens et al.   DIABETES OBESITY & METABOLISM

Serotonin competence of mouse beta cells during pregnancy

(2016) Lotte Goyvaerts et al.   DIABETOLOGIA

Impact of islet architecture on β-cell heterogeneity, plasticity and function

(2016) Sara S. Roscioni et al.   Nature Reviews Endocrinology

Role of Sex Steroids in β Cell Function, Growth, and Survival

(2016) Franck Mauvais-Jarvis   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Human Beta Cells Produce and Release Serotonin to Inhibit Glucagon Secretion from Alpha Cells

(2016) Joana Almaça et al.   Cell Reports

Critical role for adenosine receptor A2a in β-cell proliferation

(2016) Nadja Schulz et al.   Molecular Metabolism

The offspring of the diabetic mother – Short- and long-term implications

(2015) D. Mitanchez et al.   BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY

Pregnancy Hyperglycemia in Prolactin Receptor Mutant, but Not Prolactin Mutant, Mice and Feeding-Responsive Regulation of Placental Lactogen Genes Implies Placental Control of Maternal Glucose Homeostasis1

(2015) Saara M. Rawn et al.   BIOLOGY OF REPRODUCTION

Osteoprotegerin and Denosumab Stimulate Human Beta Cell Proliferation through Inhibition of the Receptor Activator of NF-κB Ligand Pathway

(2015) Nagesha Guthalu Kondegowda et al.   Cell Metabolism

Augmented Stat5 Signaling Bypasses Multiple Impediments to Lactogen-Mediated Proliferation in Human β-Cells

(2015) Hainan Chen et al.   DIABETES

Hepatokines: unlocking the multi-organ network in metabolic diseases

(2015) Alison Iroz et al.   DIABETOLOGIA

Placenta-on-a-chip: a novel platform to study the biology of the human placenta

(2015) Ji Soo Lee et al.   Journal of Maternal-Fetal & Neonatal Medicine

Noncoding RNAs in β cell biology

(2015) Ruth A. Singer et al.   Current Opinion in Endocrinology Diabetes and Obesity

Prolactin Receptors and Placental Lactogen Drive Male Mouse Pancreatic Islets to Pregnancy-Related mRNA Changes

(2015) Lotte Goyvaerts et al.   PLoS One

The transcriptional landscape of mouse beta cells compared to human beta cells reveals notable species differences in long non-coding RNA and protein-coding gene expression

(2014) Christopher Benner et al.   BMC GENOMICS

Glucagon Regulates Hepatic Kisspeptin to Impair Insulin Secretion

(2014) Woo-Jin Song et al.   Cell Metabolism

Increase of beta cell mass by beta cell replication, but not neogenesis, in the maternal pancreas in mice

(2014) Xin Zhao   ENDOCRINE JOURNAL

Menin determines K-RAS proliferative outputs in endocrine cells

(2014) Chester E. Chamberlain et al.   JOURNAL OF CLINICAL INVESTIGATION

Progesterone induces apoptosis of insulin-secreting cells: insights into the molecular mechanism

(2014) V A Nunes et al.   JOURNAL OF ENDOCRINOLOGY

The control of insulin secretion by adipokines: current evidence for adipocyte-beta cell endocrine signalling in metabolic homeostasis

(2014) James Cantley   MAMMALIAN GENOME

EGFR Signaling Promotes β-Cell Proliferation and Survivin Expression during Pregnancy

(2014) Elina Hakonen et al.   PLoS One

Contribution of a Non-β-Cell Source to β-Cell Mass during Pregnancy

(2014) Chiara Toselli et al.   PLoS One

Prevalence Estimates of Gestational Diabetes Mellitus in the United States, Pregnancy Risk Assessment Monitoring System (PRAMS), 2007–2010

(2014) Carla L. DeSisto et al.   Preventing Chronic Disease

Advancements and challenges in generating accurate animal models of gestational diabetes mellitus

(2013) Raymond C. Pasek et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Circulating Prolactin Associates With Diabetes and Impaired Glucose Regulation: A population-based study

(2013) T. Wang et al.   DIABETES CARE

CISH has no non-redundant functions in glucose homeostasis or beta cell proliferation during pregnancy in mice

(2013) Yang Jiao et al.   DIABETOLOGIA

Prolactin Receptor Gene Polymorphisms Are Associated with Gestational Diabetes

(2013) Trang N. Le et al.   Genetic Testing and Molecular Biomarkers

The role of aging upon β cell turnover

(2013) Jake A. Kushner   JOURNAL OF CLINICAL INVESTIGATION

No evidence for β cell neogenesis in murine adult pancreas

(2013) Xiangwei Xiao et al.   JOURNAL OF CLINICAL INVESTIGATION

Multiple endocrine neoplasia type 1 (MEN1) and type 4 (MEN4)

(2013) Rajesh V. Thakker   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Mutant Prolactin Receptor and Familial Hyperprolactinemia

(2013) Paul J. Newey et al.   NEW ENGLAND JOURNAL OF MEDICINE

Epigenetic programming of obesity and diabetes by in utero exposure to gestational diabetes mellitus

(2013) Stephanie-May Ruchat et al.   NUTRITION REVIEWS

Beta-Cell ARNT Is Required for Normal Glucose Tolerance in Murine Pregnancy

(2013) Sue Mei Lau et al.   PLoS One

Serotonin regulates glucose-stimulated insulin secretion from pancreatic   cells during pregnancy

(2013) M. Ohara-Imaizumi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Placental hormones and the control of maternal metabolism and fetal growth

(2013) Dorothee Newbern et al.   Current Opinion in Endocrinology Diabetes and Obesity

Human β Cell Transcriptome Analysis Uncovers lncRNAs That Are Tissue-Specific, Dynamically Regulated, and Abnormally Expressed in Type 2 Diabetes

(2012) Ignasi Morán et al.   Cell Metabolism

Loss of HGF/c-Met Signaling in Pancreatic β-Cells Leads to Incomplete Maternal β-Cell Adaptation and Gestational Diabetes Mellitus

(2012) Cem Demirci et al.   DIABETES

A Genome-Wide Association Study of Gestational Diabetes Mellitus in Korean Women

(2012) S. H. Kwak et al.   DIABETES

Glucose metabolism: key endogenous regulator of β-cell replication and survival

(2012) D. Dadon et al.   DIABETES OBESITY & METABOLISM

Bimodal impact of skeletal muscle on pancreatic β-cell function in health and disease

(2012) P. Plomgaard et al.   DIABETES OBESITY & METABOLISM

Molecular Mechanisms of Prolactin and Its Receptor

(2012) Charles L. Brooks   ENDOCRINE REVIEWS

MicroRNAs contribute to compensatory β cell expansion during pregnancy and obesity

(2012) Cécile Jacovetti et al.   JOURNAL OF CLINICAL INVESTIGATION

Research Resource: RNA-Seq Reveals Unique Features of the Pancreatic β-Cell Transcriptome

(2012) Gregory M. Ku et al.   MOLECULAR ENDOCRINOLOGY

Gestational diabetes mellitus: risks and management during and after pregnancy

(2012) Thomas A. Buchanan et al.   Nature Reviews Endocrinology

Importance of oestrogen receptors to preserve functional β-cell mass in diabetes

(2012) Joseph P. Tiano et al.   Nature Reviews Endocrinology

Adenosine kinase inhibition selectively promotes rodent and porcine islet  -cell replication

(2012) J. P. Annes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Novel Mechanism for Regulating Hepatic Glycogen Synthesis Involving Serotonin and Cyclin-Dependent Kinase-5

(2011) S. J. Tudhope et al.   DIABETES

Islet-enriched gene expression and glucose-induced insulin secretion in human and mouse islets

(2011) C. Dai et al.   DIABETOLOGIA

Differential and Complementary Effects of Glucose and Prolactin on Islet DNA Synthesis and Gene Expression

(2011) Ramamani Arumugam et al.   ENDOCRINOLOGY

Loss of Foxd3 Results in Decreased β-Cell Proliferation and Glucose Intolerance During Pregnancy

(2011) Jennifer L. Plank et al.   ENDOCRINOLOGY

Participation of Akt, Menin, and p21 in Pregnancy-Induced β-Cell Proliferation

(2011) Elizabeth Hughes et al.   ENDOCRINOLOGY

Growth hormone receptor regulates β cell hyperplasia and glucose-stimulated insulin secretion in obese mice

(2011) Yingjie Wu et al.   JOURNAL OF CLINICAL INVESTIGATION

Association of Variations in TPH1 and HTR2B with Gestational Weight Gain and Measures of Obesity

(2011) Soo Heon Kwak et al.   Obesity

Reexpression of oncoprotein MafB in proliferative β-cells and Men1 insulinomas in mouse

(2011) J Lu et al.   ONCOGENE

Non-β-cell progenitors of β-cells in pregnant mice

(2011) Sylvie Abouna et al.   Organogenesis

MafA and MafB Regulate Genes Critical to  -Cells in a Unique Temporal Manner

(2010) I. Artner et al.   DIABETES

Disruption of Hepatocyte Growth Factor/c-Met Signaling Enhances Pancreatic  -Cell Death and Accelerates the Onset of Diabetes

(2010) J. Mellado-Gil et al.   DIABETES

The suppressor of cytokine signalling 2 (SOCS2) is a key repressor of insulin secretion

(2010) P. Lebrun et al.   DIABETOLOGIA

mRNA expression analysis of cell cycle genes in islets of pregnant mice

(2010) A. Schraenen et al.   DIABETOLOGIA

Placental lactogens induce serotonin biosynthesis in a subset of mouse beta cells during pregnancy

(2010) A. Schraenen et al.   DIABETOLOGIA

Adaptive changes in pancreatic beta cell fractional area and beta cell turnover in human pregnancy

(2010) A. E. Butler et al.   DIABETOLOGIA

Regulation of pancreatic islet gene expression in mouse islets by pregnancy

(2010) B T Layden et al.   JOURNAL OF ENDOCRINOLOGY

FoxM1 Is Up-Regulated by Obesity and Stimulates β-Cell Proliferation

(2010) Dawn Belt Davis et al.   MOLECULAR ENDOCRINOLOGY

Serotonin regulates pancreatic beta cell mass during pregnancy

(2010) Hail Kim et al.   NATURE MEDICINE

Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin

(2010) William L Holland et al.   NATURE MEDICINE

Gestational Diabetes Mellitus Resulting From Impaired  -Cell Compensation in the Absence of FoxM1, a Novel Downstream Effector of Placental Lactogen

(2009) H. Zhang et al.   DIABETES

The Transcriptional Response of the Islet to Pregnancy in Mice

(2009) Sebastian Rieck et al.   MOLECULAR ENDOCRINOLOGY

Transcriptional analysis of intracytoplasmically stained, FACS-purified cells by high-throughput, quantitative nuclease protection

(2009) Susanne Pechhold et al.   NATURE BIOTECHNOLOGY

Expansion of β-cell mass in response to pregnancy

(2009) Sebastian Rieck et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Epigenetic mechanisms in the development of type 2 diabetes

(2009) Sara E. Pinney et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Intracellular Serotonin Modulates Insulin Secretion from Pancreatic β-Cells by Protein Serotonylation

(2009) Nils Paulmann et al.   PLOS BIOLOGY

The Interplay of Prolactin and the Glucocorticoids in the Regulation of β-Cell Gene Expression, Fatty Acid Oxidation, and Glucose-Stimulated Insulin Secretion: Implications for Carbohydrate Metabolism in Pregnancy

(2008) Ramamani Arumugam et al.   ENDOCRINOLOGY

Prolactin Receptor Is Required for Normal Glucose Homeostasis and Modulation of β-Cell Mass during Pregnancy

(2008) Carol Huang et al.   ENDOCRINOLOGY

Prolactin Treatment Improves Engraftment and Function of Transplanted Pancreatic Islets

(2008) Magnus Johansson et al.   ENDOCRINOLOGY

The function of serotonin within the liver

(2008) Richard G. Ruddell et al.   JOURNAL OF HEPATOLOGY

Hyperglycemia and Adverse Pregnancy Outcomes

(2008)   NEW ENGLAND JOURNAL OF MEDICINE

Normal and abnormal maternal metabolism during pregnancy

(2008) David R. Hadden et al.   Seminars in Fetal & Neonatal Medicine