GM-CSF as a target in inflammatory/autoimmune disease: current evidence and future therapeutic potential

Juvenile Myelomonocytic Leukemia

(2015) Prakash Satwani et al.   PEDIATRIC CLINICS OF NORTH AMERICA

Granulocyte macrophage colony-stimulating factor and the intestinal innate immune cell homeostasis in Crohn's disease

(2014) Jan Däbritz   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

A Positive Feedback Loop between Mesenchymal-like Cancer Cells and Macrophages Is Essential to Breast Cancer Metastasis

(2014) Shicheng Su et al.   CANCER CELL

STAT5 programs a distinct subset of GM-CSF-producing T helper cells that is essential for autoimmune neuroinflammation

(2014) Wanqiang Sheng et al.   CELL RESEARCH

Innate Response Activator B Cells Aggravate Atherosclerosis by Stimulating T Helper-1 Adaptive Immunity

(2014) Ingo Hilgendorf et al.   CIRCULATION

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

Cardiac fibroblasts mediate IL-17A–driven inflammatory dilated cardiomyopathy

(2014) Lei Wu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pleural innate response activator B cells protect against pneumonia via a GM-CSF-IgM axis

(2014) Georg F. Weber et al.   JOURNAL OF EXPERIMENTAL MEDICINE

GM-CSF but Not IL-17 Is Critical for the Development of Severe Interstitial Lung Disease in SKG Mice

(2014) Aoi Shiomi et al.   JOURNAL OF IMMUNOLOGY

GM-CSF-Responsive Monocyte-Derived Dendritic Cells Are Pivotal in Th17 Pathogenesis

(2014) H.-J. Ko et al.   JOURNAL OF IMMUNOLOGY

Innate lymphoid cells integrate stromal and immunological signals to enhance antibody production by splenic marginal zone B cells

(2014) Giuliana Magri et al.   NATURE IMMUNOLOGY

The Closely Related CD103+ Dendritic Cells (DCs) and Lymphoid-Resident CD8+ DCs Differ in Their Inflammatory Functions

(2014) Zhijun Jiao et al.   PLoS One

A GM-CSF/IL-33 Pathway Facilitates Allergic Airway Responses to Sub-Threshold House Dust Mite Exposure

(2014) Alba Llop-Guevara et al.   PLoS One

Microbiota-Dependent Crosstalk Between Macrophages and ILC3 Promotes Intestinal Homeostasis

(2014) A. Mortha et al.   SCIENCE

IL-17 and GM-CSF Expression Are Antagonistically Regulated by Human T Helper Cells

(2014) R. Noster et al.   Science Translational Medicine

Transgenic Expression of GM-CSF in T Cells Causes Disseminated Histiocytosis

(2013) Annemarie E. van Nieuwenhuijze et al.   AMERICAN JOURNAL OF PATHOLOGY

Tumor-Derived GM-CSF Promotes Inflammatory Colon Carcinogenesis via Stimulating Epithelial Release of VEGF

(2013) Y. Wang et al.   CANCER RESEARCH

GM-CSF contributes to aortic aneurysms resulting from SMAD3 deficiency

(2013) Ping Ye et al.   JOURNAL OF CLINICAL INVESTIGATION

GM-CSF Modulates Autoantibody Production and Skin Blistering in Experimental Epidermolysis Bullosa Acquisita

(2013) U. K. S. R. L. Samavedam et al.   JOURNAL OF IMMUNOLOGY

GM-CSF as a therapeutic target in inflammatory diseases

(2013) Annemarie van Nieuwenhuijze et al.   MOLECULAR IMMUNOLOGY

Granulocyte-macrophage colony-stimulating factor is a key mediator in inflammatory and arthritic pain

(2012) Andrew D Cook et al.   ANNALS OF THE RHEUMATIC DISEASES

Efficacy and safety of mavrilimumab in subjects with rheumatoid arthritis

(2012) Gerd R Burmester et al.   ANNALS OF THE RHEUMATIC DISEASES

Regulation of dendritic cell development by GM-CSF: molecular control and implications for immune homeostasis and therapy

(2012) L. van de Laar et al.   BLOOD

GM-CSF Controls Nonlymphoid Tissue Dendritic Cell Homeostasis but Is Dispensable for the Differentiation of Inflammatory Dendritic Cells

(2012) Melanie Greter et al.   IMMUNITY

Dysregulated Hematopoietic Stem and Progenitor Cell Activity Promotes Interleukin-23-Driven Chronic Intestinal Inflammation

(2012) Thibault Griseri et al.   IMMUNITY

Sargramostim (GM-CSF) for Induction of Remission in Crohnʼs Disease: A Cochrane Inflammatory Bowel Disease and Functional Bowel Disorders Systematic Review of Randomized Trials

(2012) Lee Roth et al.   INFLAMMATORY BOWEL DISEASES

Interleukin-1α controls allergic sensitization to inhaled house dust mite via the epithelial release of GM-CSF and IL-33

(2012) Monique A.M. Willart et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Defining GM-CSF- and Macrophage-CSF-Dependent Macrophage Responses by In Vitro Models

(2012) D. C. Lacey et al.   JOURNAL OF IMMUNOLOGY

The regulation of the development and function of dendritic cell subsets by GM-CSF: More than a hematopoietic growth factor

(2012) Yifan Zhan et al.   MOLECULAR IMMUNOLOGY

Innate Response Activator B Cells Protect Against Microbial Sepsis

(2012) P. J. Rauch et al.   SCIENCE

Colony stimulating factors and myeloid cell biology in health and disease

(2012) John A. Hamilton et al.   TRENDS IN IMMUNOLOGY

Mavrilimumab, a human monoclonal antibody targeting GM-CSF receptor- , in subjects with rheumatoid arthritis: a randomised, double-blind, placebo-controlled, phase I, first-in-human study

(2011) G. R. Burmester et al.   ANNALS OF THE RHEUMATIC DISEASES

TNFα inhibits the development of osteoclasts through osteoblast-derived GM-CSF

(2011) Elvis Atanga et al.   BONE

GM-CSF is not essential for optimal fertility or for weight control

(2011) John A. Hamilton et al.   CYTOKINE

GM-CSF increases cross-presentation and CD103 expression by mouse CD8+ spleen dendritic cells

(2011) Yifan Zhan et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

IL-33 Shifts the Balance from Osteoclast to Alternatively Activated Macrophage Differentiation and Protects from TNF- -Mediated Bone Loss

(2011) M. M. Zaiss et al.   JOURNAL OF IMMUNOLOGY

Differentiation of Inflammatory Dendritic Cells Is Mediated by NF- B1-Dependent GM-CSF Production in CD4 T Cells

(2011) I. K. Campbell et al.   JOURNAL OF IMMUNOLOGY

Granulocyte-macrophage colony-stimulating factor (GM-CSF): a chemoattractive agent for murine leukocytes in vivo

(2011) Maitham Khajah et al.   JOURNAL OF LEUKOCYTE BIOLOGY

IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses

(2011) Thomas Krausgruber et al.   NATURE IMMUNOLOGY

RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation

(2011) Laura Codarri et al.   NATURE IMMUNOLOGY

The encephalitogenicity of TH17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF

(2011) Mohamed El-Behi et al.   NATURE IMMUNOLOGY

Batf3-Dependent CD11blow/− Peripheral Dendritic Cells Are GM-CSF-Independent and Are Not Required for Th Cell Priming after Subcutaneous Immunization

(2011) Brian T. Edelson et al.   PLoS One

Systematic cytokine receptor profiling reveals GM-CSF as a novel TLR-independent activator of human plasmacytoid predendritic cells

(2010) C. Ghirelli et al.   BLOOD

GM-CSF–dependent, CD103+dermal dendritic cells play a critical role in Th effector cell differentiation after subcutaneous immunization

(2010) Irah L. King et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Granulocyte-Macrophage Colony-Stimulating Factor Is the Major CD8+ T Cell-Derived Licensing Factor for Dendritic Cell Activation

(2010) L. Min et al.   JOURNAL OF IMMUNOLOGY

GM-CSF: a role in immune and inflammatory reactions in the intestine

(2010) Laia Egea et al.   Expert Review of Gastroenterology & Hepatology

The granulocyte-macrophage colony-stimulating factor receptor: linking its structure to cell signaling and its role in disease

(2009) T. R. Hercus et al.   BLOOD

Origin of the Lamina Propria Dendritic Cell Network

(2009) Milena Bogunovic et al.   IMMUNITY

GM-CSF Regulates Fusion of Mononuclear Osteoclasts into Bone-Resorbing Osteoclasts by Activating the Ras/ERK Pathway

(2009) M. S. Lee et al.   JOURNAL OF IMMUNOLOGY

GM-CSF- and M-CSF-dependent macrophage phenotypes display differential dependence on Type I interferon signaling

(2009) Andrew J. Fleetwood et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Hematopoietic colony–stimulating factors mediate tumor-nerve interactions and bone cancer pain

(2009) Matthias Schweizerhof et al.   NATURE MEDICINE

G-CSF and GM-CSF as therapeutic targets in rheumatoid arthritis

(2009) Ann L. Cornish et al.   Nature Reviews Rheumatology

The role of GM-CSF in adipose tissue inflammation

(2008) Dong-Hoon Kim et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Inflammatory osteoclastogenesis can be induced by GM-CSF and activated under TNF immunity

(2008) Koji Nomura et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Structure of the GM-CSF Receptor Complex Reveals a Distinct Mode of Cytokine Receptor Activation

(2008) Guido Hansen et al.   CELL

Toll-like receptor-induced granulocyte-macrophage colony-stimulating factor secretion is impaired in Crohn's disease by nucleotide oligomerization domain 2-dependent and -independent pathways

(2008) A. Brosbøl-Ravnborg et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

GM-CSF mediates autoimmunity by enhancing IL-6–dependent Th17 cell development and survival

(2008) Ivo Sonderegger et al.   JOURNAL OF EXPERIMENTAL MEDICINE

GRANULOCYTE-MACROPHAGE-COLONY-STIMULATING FACTOR-DEPENDENT PERITONEAL MACROPHAGE RESPONSES DETERMINE SURVIVAL IN EXPERIMENTALLY INDUCED PERITONITIS AND SEPSIS IN MICE

(2008) Donn Spight et al.   SHOCK