Inflammatory bowel disease: new therapies from antisense oligonucleotides

Chemokines in homeostasis and diseases

(2018) Keqiang Chen et al.   Cellular & Molecular Immunology

Effects of Mongersen (GED-0301) on Endoscopic and Clinical Outcomes in Patients With Active Crohn’s Disease

(2018) Brian G. Feagan et al.   GASTROENTEROLOGY

Knockdown of Smad7 With a Specific Antisense Oligonucleotide Attenuates Colitis and Colitis-Driven Colonic Fibrosis in Mice

(2018) Roberta Izzo et al.   INFLAMMATORY BOWEL DISEASES

Chemical modifications of nucleic acid drugs and their delivery systems for gene-based therapy

(2018) Changmai Chen et al.   MEDICINAL RESEARCH REVIEWS

Rectal Delivery of a DNAzyme That Specifically Blocks the Transcription Factor GATA3 and Reduces Colitis in Mice

(2017) Vanessa Popp et al.   GASTROENTEROLOGY

Novel Insights into the Mechanisms of Gut Homing and Antiadhesion Therapies in Inflammatory Bowel Diseases

(2017) Sebastian Zundler et al.   INFLAMMATORY BOWEL DISEASES

Crohn's disease

(2017) Joana Torres et al.   LANCET

Ulcerative colitis

(2017) Ryan Ungaro et al.   LANCET

Enhancing the Therapeutic Delivery of Oligonucleotides by Chemical Modification and Nanoparticle Encapsulation

(2017) Yating Sun et al.   MOLECULES

The chemical evolution of oligonucleotide therapies of clinical utility

(2017) Anastasia Khvorova et al.   NATURE BIOTECHNOLOGY

Current and emerging therapeutic targets for IBD

(2017) Markus F. Neurath   Nature Reviews Gastroenterology & Hepatology

Chemistry, mechanism and clinical status of antisense oligonucleotides and duplex RNAs

(2017) Xiulong Shen et al.   NUCLEIC ACIDS RESEARCH

Crystal structure of an RNA-cleaving DNAzyme

(2017) Hehua Liu et al.   Nature Communications

Advances in the delivery of RNA therapeutics: from concept to clinical reality

(2017) James C. Kaczmarek et al.   Genome Medicine

Ameliorating Active Ulcerative Colitis via an Orally Available Toll-Like Receptor-9 Modifier: A Prospective Open-Label, Multicenter Phase II Trial

(2016) Iris Dotan et al.   DIGESTIVE DISEASES AND SCIENCES

Phase 1 Clinical Study of siRNA Targeting Carbohydrate Sulphotransferase 15 in Crohn’s Disease Patients with Active Mucosal Lesions

(2016) Kenji Suzuki et al.   Journal of Crohns & Colitis

RNA cleavage products generated by antisense oligonucleotides and siRNAs are processed by the RNA surveillance machinery

(2016) Walt F. Lima et al.   NUCLEIC ACIDS RESEARCH

Pivotal Role of Carbohydrate Sulfotransferase 15 in Fibrosis and Mucosal Healing in Mouse Colitis

(2016) Kenji Suzuki et al.   PLoS One

Pharmacokinetics, biodistribution and cell uptake of antisense oligonucleotides

(2015) Richard S. Geary et al.   ADVANCED DRUG DELIVERY REVIEWS

An orally administrated nucleotide-delivery vehicle targeting colonic macrophages for the treatment of inflammatory bowel disease

(2015) Zhen Huang et al.   BIOMATERIALS

Pathogenic aspects and therapeutic avenues of intestinal fibrosis in Crohn's disease

(2015) F. Zorzi et al.   CLINICAL SCIENCE

Molecular interactions between chondroitin–dermatan sulfate and growth factors/receptors/matrix proteins

(2015) Shuji Mizumoto et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Mongersen, an Oral SMAD7 Antisense Oligonucleotide, and Crohn’s Disease

(2015) Giovanni Monteleone et al.   NEW ENGLAND JOURNAL OF MEDICINE

Biomarkers can predict potential clinical responders to DIMS0150 a toll-like receptor 9 agonist in ulcerative colitis patients

(2014) Nikolai V Kuznetsov et al.   BMC GASTROENTEROLOGY

Overexpression of GATA-3 in T Cells Accelerates Dextran Sulfate Sodium-Induced Colitis

(2014) Midori Okamura et al.   EXPERIMENTAL ANIMALS

GATA-3 Function in Innate and Adaptive Immunity

(2014) Irma Tindemans et al.   IMMUNITY

Phosphorothioates, Essential Components of Therapeutic Oligonucleotides

(2014) Fritz Eckstein   Nucleic Acid Therapeutics

Crohn's disease complicated by strictures: a systematic review

(2013) Florian Rieder et al.   GUT

A phase 1 open-label trial shows that smad7 antisense oligonucleotide (GED0301) does not increase the risk of small bowel strictures in Crohn's disease

(2012) F. Zorzi et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Molecular function of macrophage migration inhibitory factor and a novel therapy for inflammatory bowel disease

(2012) Jun Nishihira   Annals of the New York Academy of Sciences

Topical Treatment with the Toll-like Receptor Agonist DIMS0150 Has Potential for Lasting Relief of Symptoms in Patients with Chronic Active Ulcerative Colitis by Restoring Glucocorticoid Sensitivity

(2012) Eugen Musch et al.   INFLAMMATORY BOWEL DISEASES

Phase I Clinical Trial of Smad7 Knockdown Using Antisense Oligonucleotide in Patients With Active Crohn's Disease

(2012) Giovanni Monteleone et al.   MOLECULAR THERAPY

A New Therapeutic Approach Using a Schizophyllan-based Drug Delivery System for Inflammatory Bowel Disease

(2012) Hidetoshi Takedatsu et al.   MOLECULAR THERAPY

Transcript levels of Toll-Like receptors 5, 8 and 9 correlate with inflammatory activity in Ulcerative Colitis

(2011) Fausto Sánchez-Muñoz et al.   BMC GASTROENTEROLOGY

An Overview of Sugar-Modified Oligonucleotides for Antisense Therapeutics

(2011) Thazha P. Prakash   CHEMISTRY & BIODIVERSITY

Regulation of Homeostasis and Inflammation in the Intestine

(2011) Thomas T. MacDonald et al.   GASTROENTEROLOGY

Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity

(2011) Taro Kawai et al.   IMMUNITY

Intestinal homeostasis and its breakdown in inflammatory bowel disease

(2011) Kevin J. Maloy et al.   NATURE

Inflammation meets cancer, with NF-κB as the matchmaker

(2011) Yinon Ben-Neriah et al.   NATURE IMMUNOLOGY

Mechanisms of single-stranded phosphorothioate modified antisense oligonucleotide accumulation in hepatocytes

(2011) Erich Koller et al.   NUCLEIC ACIDS RESEARCH

Oral nuclear factor-κB decoy oligonucleotides delivery system with chitosan modified poly(d,l-lactide-co-glycolide) nanospheres for inflammatory bowel disease

(2010) Kohei Tahara et al.   BIOMATERIALS

T cell-dependent protective effects of CpG motifs of bacterial DNA in experimental colitis are mediated by CD11c+ dendritic cells

(2010) C. Hofmann et al.   GUT

Homing of immune cells: Role in homeostasis and intestinal inflammation

(2010) Ailsa L. Hart et al.   INFLAMMATORY BOWEL DISEASES

Long-term complications, extraintestinal manifestations, and mortality in adult Crohnʼs disease in population-based cohorts

(2010) Laurent Peyrin-Biroulet et al.   INFLAMMATORY BOWEL DISEASES

G3139, an Anti-Bcl-2 Antisense Oligomer That Binds Heparin-Binding Growth Factors and Collagen I, Alters In vitro Endothelial Cell Growth and Tubular Morphogenesis

(2009) C.A. Stein et al.   CLINICAL CANCER RESEARCH

Targeting delivery of anti-TNF  oligonucleotide into activated colonic macrophages protects against experimental colitis

(2009) L. Zuo et al.   GUT

The Effects of Cytokines on Suppression of Lymphocyte Proliferation by Dexamethasone

(2009) T. J. Creed et al.   JOURNAL OF IMMUNOLOGY

Inflammatory Bowel Disease

(2009) Clara Abraham et al.   NEW ENGLAND JOURNAL OF MEDICINE