Article
Peripheral Vascular Disease
Xiaohan Lu, Jiandong Zhang, Yi Wen, Jiafa Ren, Robert Griffiths, Nathan P. Rudemiller, Shintaro Ide, Tomokazu Souma, Steven D. Crowley
Summary: In this study, the researchers investigated the role of AT(1) receptors on CD11c(+) cells in the development of hypertension. They found that AT(1) receptor stimulation on dendritic cells (DCs) suppresses renal DC maturation and T cell activation, resulting in protection from sodium retention and blood pressure elevation. These findings provide insights into the pathogenesis of hypertension and offer new possibilities for its treatment.
Article
Immunology
Lifei Hou, Koichi Yuki
Summary: This study reveals the importance of CD11c in maintaining T cell survival by showing that CD11c deficiency leads to defects in T cell development in mice.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Jiayuan Zhou, Guo-Min Deng
Summary: Bacterial DNA containing CpG motifs contributes to the development of arthritis by activating immune cells, especially macrophages, and inducing proinflammatory cytokines. Therapeutic strategies for bacterial arthritis involve systemic anti-inflammatory treatment, antibiotic therapy, and efforts to minimize bacterial growth while blocking the proinflammatory effects of bacterial DNA. CpG ODN-mediated Th1 immune activation shows significant therapeutic efficiency in mouse models of various diseases.
JOURNAL OF LEUKOCYTE BIOLOGY
(2021)
Article
Immunology
Yu-Qin He, Yue-Long Qiao, Shan Xu, Wo-Er Jiao, Rui Yang, Yong-Gang Kong, Ze-Zhang Tao, Shi-Ming Chen
Summary: This study found that allergens can induce autophagy in CD11c+ dendritic cells in a dose dependent manner, and promote immune imbalance of downstream T cells towards a proinflammatory phenotype. Autophagy plays an important regulatory role in allergic inflammatory response.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Immunology
Hinda Najem, Anantha Marisetty, Craig Horbinski, James Long, Jason T. Huse, Isabella C. Glitza Oliva, Sherise D. Ferguson, Priya U. Kumthekar, Derek A. Wainwright, Peiwen Chen, Maciej S. Lesniak, Jared K. Burks, Amy B. Heimberger
Summary: The TME of LMD lacks CD3+ T cells but is enriched in immune suppression and innate immunity.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Fisheries
Marta Maruszewska-Cheruiyot, Katarzyna Donskow-Lysoniewska, Katarzyna Krawczak, Maja Machcinska, Maria Doligalska
Summary: In an inflammatory environment, the mouse intestinal parasite adaptively affects dendritic cell function, exacerbating inflammatory colitis symptoms.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
Article
Microbiology
B. Shoshana Zha, Ludovic Desvignes, Tawania J. Fergus, Amber Cornelius, Tan-Yun Cheng, D. Branch Moody, Joel D. Ernst
Summary: In the early stages of tuberculosis infection, the interactions between different strains of Mycobacterium tuberculosis and lung leukocytes can shape the adaptive immune responses.
Article
Parasitology
Anshul Anand, Rajan Singh, Shashi Saini, Baishakhi Mahapatra, Abhishek Singh, Samer Singh, Rakesh K. Singh
Summary: CD8+ T cells are important for adaptive immunity and play a decisive role in eliminating Leishmania parasites from the host. In visceral leishmaniasis, the loss of CD8+ T cell function is associated with worsened disease progression.
Article
Immunology
Lianghui Diao, Alexandra Maximiliane Hierweger, Agnes Wieczorek, Petra Clara Arck, Kristin Thiele
Summary: The specific cross talk between pregnancy hormone progesterone and dendritic cells plays a crucial role in regulating the generation of regulatory T cells which are important for fetal development. Knockout of glucocorticoid receptor on dendritic cells improves placental function and fetal development, indicating a disrupted communication between glucocorticoids and dendritic cells favors a tolerant immune microenvironment.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Microbiology
Margaret Alexander, Qi Yan Ang, Renuka R. Nayak, Annamarie E. Bustion, Moriah Sandy, Bing Zhang, Vaibhav Upadhyay, Katherine S. Pollard, Susan Lynch, Peter J. Turnbaugh
Summary: The activation of Th17 cells by human gut bacteria Eggerthella lenta exacerbates inflammatory bowel disease. Variations in E. lenta strains and the Cgr2 enzyme contribute to Th17 cell activation. Blocking E. lenta-induced intestinal inflammation is crucial for preventing the development of autoimmune diseases.
CELL HOST & MICROBE
(2022)
Article
Multidisciplinary Sciences
Lu Lu, Toshinobu Kuroishi, Yukinori Tanaka, Mutsumi Furukawa, Tomonori Nochi, Shunji Sugawara
Summary: The study identified CD11c(+) and CD11c(-) subsets among CD64(+) macrophages in steady-state salivary glands (SGs). CD11c(-) macrophages were predominant in embryonic and newborn mice SGs, while CD11c(+) macrophages rapidly expanded after birth. CD11c(+) macrophages accumulate from bone marrow-derived progenitors in a CCR2-dependent manner, whereas CD11c(-) macrophages were derived from embryonic progenitors in SGs. SG macrophages have weak phagocytic activity but regulate gland development and functions in SGs based on their gene expression profile.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
So Young Kim, Purva Gupta, Scott C. Johns, Elina Zuniga, John R. Teijaro, Mark M. Fuster
Summary: This study demonstrates that genetic alteration of glycan heparan sulfate in CD11c + cells can reduce lung inflammation and inhibit lung infiltration by regulatory T cells during influenza A virus infection. Furthermore, decreasing heparan sulfate sulfation can increase the expression of the antiviral cytokine interferon beta.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Hae-Bin Park, So-Jung Kim, Dhananjay Yadav, Eun-Koung An, Wei Zhang, Hee-Yun Eom, Minseok Kwak, Tatsuya Oda, Peter Chang-Whan Lee, Jun-O Jin
Summary: This study found that porphyran derived from Pyropia yezoensis has an inhibitory effect on dextran sodium sulfate (DSS)-induced colitis in mice. Oral or intraperitoneal administration of porphyran can inhibit the progression of colitis and prevent immune cell infiltration in the colon. Porphyran inhibits T cell activation by suppressing dendritic cells and macrophages and attenuates chronic colitis caused by long-term DSS administration.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Dermatology
Mathias Hochgerner, Thomas Bauer, Victoria Zyulina, Elisabeth Glitzner, Sarah Warsi, Joanne E. Konkel, Carmen Tam-Amersdorfer, Wanjun Chen, Stefan Karlsson, Maria Sibilia, Herbert Strobl
Summary: TGF beta 1-BMPR1a signaling is essential for the efficient induction of CD207 during LC differentiation in the steady state, and it plays a role in promoting the expansion and differentiation of LCs, as well as being upregulated in psoriatic skin lesions.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Immunology
Lei Zhang, Wei Zhao, Jinke Huang, Fangxuan Li, Jindong Sheng, Hualin Song, Ying Chen
Summary: A new tumor vaccine, FCM-NPs, was developed by fusing DCs and OC cells and coating them onto nanoparticles, showing promising results in promoting immune responses and inhibiting tumor metastasis.
FRONTIERS IN IMMUNOLOGY
(2022)