The potential of targeting indoleamine 2,3-dioxygenase for cancer treatment

Constitutive IDO expression in human cancer is sustained by an autocrine signaling loop involving IL-6, STAT3 and the AHR

(2015) Ulrike M. Litzenburger et al.   Oncotarget

Human indoleamine 2,3-dioxygenase-2 has substrate specificity and inhibition characteristics distinct from those of indoleamine 2,3-dioxygenase-1

(2014) Georgios Pantouris et al.   AMINO ACIDS

Indoleamine 2,3-dioxygenase (IDO) is frequently expressed in stromal cells of Hodgkin lymphoma and is associated with adverse clinical features: a retrospective cohort study

(2014) Ji-Young Choe et al.   BMC CANCER

Vitamins B2 and B6 as determinants of kynurenines and related markers of interferon-γ-mediated immune activation in the community-based Hordaland Health Study

(2014) Despoina Theofylaktopoulou et al.   BRITISH JOURNAL OF NUTRITION

Immunoregulatory Impact of Food Antioxidants

(2014) Johanna Gostner et al.   CURRENT PHARMACEUTICAL DESIGN

IDO2 is critical for IDO1-mediated T-cell regulation and exerts a non-redundant function in inflammation

(2014) Richard Metz et al.   INTERNATIONAL IMMUNOLOGY

IDO2 Is a Critical Mediator of Autoantibody Production and Inflammatory Pathogenesis in a Mouse Model of Autoimmune Arthritis

(2014) L. M. F. Merlo et al.   JOURNAL OF IMMUNOLOGY

Aryl hydrocarbon receptor control of a disease tolerance defence pathway

(2014) Alban Bessede et al.   NATURE

Antitumour agents as inhibitors of tryptophan 2,3-dioxygenase

(2013) Georgios Pantouris et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Indoleamine 2,3-dioxygenase inhibitors: a patent review (2008 – 2012)

(2013) Eduard Dolušić et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

CTLA4-Ig immunosuppressive activity at the level of dendritic cell/T cell crosstalk

(2013) Edda Mayer et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Redox regulation of the immune response

(2013) Johanna M Gostner et al.   REDOX REPORT

Immunomodulatory effects in vitro of vitamin K antagonist acenocoumarol

(2013) S. Schroecksnadel et al.   THROMBOSIS RESEARCH

The neuroimmune basis of fatigue

(2013) Robert Dantzer et al.   TRENDS IN NEUROSCIENCES

Kynurenic acid in human renal cell carcinoma: its antiproliferative and antimigrative action on Caki-2 cells

(2012) Katarzyna Walczak et al.   AMINO ACIDS

Using an Ancient Tool for Igniting and Propagating Immune Tolerance: IDO as an Inducer and Amplifier of Regulatory T Cell Functions

(2012) F. Fallarino et al.   CURRENT MEDICINAL CHEMISTRY

Indoleamine 2,3-dioxygenase, Tregs and Cancer

(2012) D. H. Munn   CURRENT MEDICINAL CHEMISTRY

New functions of protein kinase Gcn2 in yeast and mammals

(2012) José R. Murguía et al.   IUBMB LIFE

Kynurenines in the mammalian brain: when physiology meets pathology

(2012) Robert Schwarcz et al.   NATURE REVIEWS NEUROSCIENCE

Reversal of tumoral immune resistance by inhibition of tryptophan 2,3-dioxygenase

(2012) L. Pilotte et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immune changes and neurotransmitters: Possible interactions in depression?

(2012) Barbara Sperner-Unterweger et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Indoleamine 2,3 dioxygenase and metabolic control of immune responses

(2012) David H. Munn et al.   TRENDS IN IMMUNOLOGY

Antimalarial drug chloroquine counteracts activation of indoleamine (2,3)-dioxygenase activity in human PBMC

(2012) Johanna M. Gostner et al.   FEBS Open Bio

The aryl hydrocarbon receptor in tumor immunity

(2012) Michael Platten et al.   OncoImmunology

Expression of indoleamine 2,3-dioxygenase in metastatic malignant melanoma recruits regulatory T cells to avoid immune detection and affects survival

(2011) Jonathan R. Brody et al.   CELL CYCLE

Indoleamine 2,3-Dioxygenase Expression in Human Cancers: Clinical and Immunologic Perspectives

(2011) J. Godin-Ethier et al.   CLINICAL CANCER RESEARCH

High expression of indoleamine 2,3-dioxygenase in the tumour is associated with medullary features and favourable outcome in basal-like breast carcinoma

(2011) Jocelyne Jacquemier et al.   INTERNATIONAL JOURNAL OF CANCER

Tryptophan 2,3-Dioxygenase (TDO) Inhibitors. 3-(2-(Pyridyl)ethenyl)indoles as Potential Anticancer Immunomodulators

(2011) Eduard Dolušić et al.   JOURNAL OF MEDICINAL CHEMISTRY

An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor

(2011) Christiane A. Opitz et al.   NATURE

Psychoneuroimmunology Meets Neuropsychopharmacology: Translational Implications of the Impact of Inflammation on Behavior

(2011) Ebrahim Haroon et al.   NEUROPSYCHOPHARMACOLOGY

Kynurenic acid synthesis and kynurenine aminotransferases expression in colon derived normal and cancer cells

(2011) Katarzyna Walczak et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Influence of immunosuppressive agents on tryptophan degradation and neopterin production in human peripheral blood mononuclear cells

(2011) Sebastian Schroecksnadel et al.   TRANSPLANT IMMUNOLOGY

Macrophage Diversity Enhances Tumor Progression and Metastasis

(2010) Bin-Zhi Qian et al.   CELL

Association between increased tryptophan degradation and depression in cancer patients

(2010) Katharina Kurz et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation

(2010) Jiangbin Ye et al.   EMBO JOURNAL

Possible roles of excess tryptophan metabolites in cancer

(2010) King-Thom Chung et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Inhibitors of indoleamine 2,3-dioxygenase: a review of novel patented lead compounds

(2010) Tiziana Di Pucchio et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Tryptophan metabolite 3-hydroxyanthranilic acid selectively induces activated T cell death via intracellular GSH depletion

(2010) Sun-Mi Lee et al.   IMMUNOLOGY LETTERS

In vitro testing for anti-inflammatory properties of compounds employing peripheral blood mononuclear cells freshly isolated from healthy donors

(2010) M. Jenny et al.   INFLAMMATION RESEARCH

An Interaction between Kynurenine and the Aryl Hydrocarbon Receptor Can Generate Regulatory T Cells

(2010) J. D. Mezrich et al.   JOURNAL OF IMMUNOLOGY

Rational Design of Indoleamine 2,3-Dioxygenase Inhibitors

(2010) Ute F. Röhrig et al.   JOURNAL OF MEDICINAL CHEMISTRY

Prognostic value of indoleamine 2,3-dioxygenase expression in high grade osteosarcoma

(2009) Hiroshi Urakawa et al.   CLINICAL & EXPERIMENTAL METASTASIS

Interferon-γ-mediated pathways are induced in human CD34+ haematopoietic stem cells

(2009) Katharina Kurz et al.   IMMUNOBIOLOGY

IDO Activates Regulatory T Cells and Blocks Their Conversion into Th17-Like T Cells

(2009) B. Baban et al.   JOURNAL OF IMMUNOLOGY

IDO1 and IDO2 are expressed in human tumors: levo- but not dextro-1-methyl tryptophan inhibits tryptophan catabolism

(2008) Stefan Löb et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

High INDO (indoleamine 2,3-dioxygenase) mRNA level in blasts of acute myeloid leukemic patients predicts poor clinical outcome

(2008) M. E.D. Chamuleau et al.   HAEMATOLOGICA

Indoleamine 2,3-dioxygenase-2; a new enzyme in the kynurenine pathway

(2008) Helen J. Ball et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Expression and prognosis role of indoleamine 2,3-dioxygenase in hepatocellular carcinoma

(2008) Ke Pan et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins

(2008) Marc Veldhoen et al.   NATURE

Control of Treg and TH17 cell differentiation by the aryl hydrocarbon receptor

(2008) Francisco J. Quintana et al.   NATURE

Nutrient transporters in cancer: Relevance to Warburg hypothesis and beyond

(2008) Vadivel Ganapathy et al.   PHARMACOLOGY & THERAPEUTICS