Bombesin receptor subtype 3 as a potential target for obesity and diabetes

Synthesis and biological evaluation of novel chiral diazepine derivatives as bombesin receptor subtype-3 (BRS-3) agonists incorporating an antedrug approach

(2015) Tetsuyoshi Matsufuji et al.   BIOORGANIC & MEDICINAL CHEMISTRY

ML-18 is a non-peptide bombesin receptor subtype-3 antagonist which inhibits lung cancer growth

(2015) Terry W. Moody et al.   PEPTIDES

Gastrointestinal peptides and itch sensation

(2015) H. Christian Weber   Current Opinion in Endocrinology Diabetes and Obesity

Regulation of body temperature and brown adipose tissue thermogenesis by bombesin receptor subtype-3

(2014) Dalya M. Lateef et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Discovery of novel chiral diazepines as bombesin receptor subtype-3 (BRS-3) agonists with low brain penetration

(2014) Tetsuyoshi Matsufuji et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Glucagon-like peptide-1 receptor agonists for the treatment of type 2 diabetes: Differences and similarities

(2014) Asger Lund et al.   European Journal of Internal Medicine

Genome-wide Association of Single-Nucleotide Polymorphisms With Weight Loss Outcomes After Roux-en-Y Gastric Bypass Surgery

(2013) Erica S. Rinella et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Bombesin receptor subtype-3 (BRS-3), a novel candidate as therapeutic molecular target in obesity and diabetes

(2013) Irene Ramos-Álvarez et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Human BRS-3 receptor: Functions/role in cell signaling pathways and glucose metabolism in obese or diabetic myocytes

(2013) I. Ramos-Álvarez et al.   PEPTIDES

Biology and pharmacology of bombesin receptor subtype-3

(2013) Ishita D. Majumdar et al.   Current Opinion in Endocrinology Diabetes and Obesity

Gastrointestinal hormones stimulate growth of Foregut Neuroendocrine Tumors by transactivating the EGF receptor

(2012) Alessia Di Florio et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The design and synthesis of potent, selective benzodiazepine sulfonamide bombesin receptor subtype 3 (BRS-3) agonists with an increased barrier of atropisomerization

(2012) Harry R. Chobanian et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Anatomical characterization of bombesin receptor subtype-3 mRNA expression in the rodent central nervous system

(2012) Li Zhang et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Discovery of MK-7725, A Potent, Selective Bombesin Receptor Subtype-3 Agonist for the Treatment of Obesity

(2012) Harry R. Chobanian et al.   ACS Medicinal Chemistry Letters

Pyridinesulfonylureas and pyridinesulfonamides as selective bombesin receptor subtype-3 (BRS-3) agonists

(2011) Michael M.-C. Lo et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Bombesin Receptor Subtype-3 (BRS-3) Regulates Glucose-Stimulated Insulin Secretion in Pancreatic Islets across Multiple Species

(2011) Yue Feng et al.   ENDOCRINOLOGY

Pharmacokinetics and Pharmacodynamics of MK-5046, a Bombesin Receptor Subtype-3 (BRS-3) Agonist, in Healthy Patients

(2011) Marc L. Reitman et al.   JOURNAL OF CLINICAL PHARMACOLOGY

A Selective Human Bombesin Receptor Subtype-3 Peptide Agonist Mediates CREB Phosphorylation and Transactivation

(2011) Xiaoqun Qin et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Type 2 diabetes across generations: from pathophysiology to prevention and management

(2011) Christopher J Nolan et al.   LANCET

Bombesin receptor subtype-3 agonists stimulate the growth of lung cancer cells and increase EGF receptor tyrosine phosphorylation

(2011) Terry W. Moody et al.   PEPTIDES

Pharmacology and selectivity of various natural and synthetic bombesin related peptide agonists for human and rat bombesin receptors differs

(2011) Hirotsugu Uehara et al.   PEPTIDES

Bombesin-related peptides and their receptors: recent advances in their role in physiology and disease states

(2011) Nieves Gonzalez et al.   Current Opinion in Endocrinology Diabetes and Obesity

Regulation and signaling of human bombesin receptors and their biological effects

(2011) H Christian Weber   Current Opinion in Endocrinology Diabetes and Obesity

Biology of mammalian bombesin-like peptides and their receptors

(2011) Ishita D Majumdar et al.   Current Opinion in Endocrinology Diabetes and Obesity

Discovery of Benzodiazepine Sulfonamide-Based Bombesin Receptor Subtype 3 Agonists and Their Unusual Chirality

(2011) Ping Liu et al.   ACS Medicinal Chemistry Letters

Body temperature as a mouse pharmacodynamic response to bombesin receptor subtype-3 agonists and other potential obesity treatments

(2010) Joseph M. Metzger et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Synthesis and SAR of heterocyclic carboxylic acid isosteres based on 2-biarylethylimidazole as bombesin receptor subtype-3 (BRS-3) agonists for the treatment of obesity

(2010) Mark Hadden et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of substituted biphenyl imidazoles as potent, bioavailable bombesin receptor subtype-3 agonists

(2010) Shuwen He et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and SAR of derivatives based on 2-biarylethylimidazole as bombesin receptor subtype-3 (BRS-3) agonists for the treatment of obesity

(2010) Jian Liu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Treating Obesity? It's in the Bag!

(2010) Anthony P. Coll   Cell Metabolism

Regulation of Energy Homeostasis by Bombesin Receptor Subtype-3: Selective Receptor Agonists for the Treatment of Obesity

(2010) Xiao-Ming Guan et al.   Cell Metabolism

Neuromedin B receptors regulate EGF receptor tyrosine phosphorylation in lung cancer cells

(2010) Terry W. Moody et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Prevalence and Trends in Obesity Among US Adults, 1999-2008

(2010) Katherine M. Flegal   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Activation of Bombesin Receptor Subtype-3 Influences Activity of Orexin Neurons by Both Direct and Indirect Pathways

(2010) Naoki Furutani et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Antiobesity Effect of MK-5046, a Novel Bombesin Receptor Subtype-3 Agonist

(2010) X.-M. Guan et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Female mice target deleted for the neuromedin B receptor have partial resistance to diet-induced obesity

(2010) Gabriela Silva Monteiro Paula et al.   JOURNAL OF PHYSIOLOGY-LONDON

Pharmacology of putative selective hBRS-3 receptor agonists for human bombesin receptors (BnR): Affinities, potencies and selectivity in multiple native and BnR transfected cells

(2010) Veronica Sancho et al.   PEPTIDES

Discovery of MK-5046, a Potent, Selective Bombesin Receptor Subtype-3 Agonist for the Treatment of Obesity

(2010) Iyassu K. Sebhat et al.   ACS Medicinal Chemistry Letters

Bombesin Receptor-Mediated Imaging and Cytotoxicity: Review and Current Status

(2010) Veronica Sancho et al.   Current Drug Delivery

Pharmacological characterization of a selective agonist for bombesin receptor subtype-3

(2009) Li Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Influence of maternal educational level on the association between the rs3809508 neuromedin B gene polymorphism and the risk of obesity in the HELENA study

(2009) M Pigeyre et al.   INTERNATIONAL JOURNAL OF OBESITY

Characterization of putative GRP- and NMB-receptor antagonist's interaction with human receptors

(2009) Nieves González et al.   PEPTIDES

Discovery of small molecule agonists for the bombesin receptor subtype 3 (BRS-3) based on an omeprazole lead

(2008) David L. Carlton et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Full Accounting of Diabetes and Pre-Diabetes in the U.S. Population in 1988-1994 and 2005-2006

(2008) C. C. Cowie et al.   DIABETES CARE

International Union of Pharmacology. LXVIII. Mammalian Bombesin Receptors: Nomenclature, Distribution, Pharmacology, Signaling, and Functions in Normal and Disease States

(2008) R. T. Jensen et al.   PHARMACOLOGICAL REVIEWS

Factors Contributing to Obesity in Bombesin Receptor Subtype-3-Deficient Mice

(2007) Ellen E. Ladenheim et al.   ENDOCRINOLOGY