1,2-Benzisoxazole compounds: a patent review (2009 – 2014)

Second-generation antipsychotic effect on cognition in patients with schizophrenia-a meta-analysis of randomized clinical trials

(2015) R. E. Nielsen et al.   ACTA PSYCHIATRICA SCANDINAVICA

No Gain, No Pain: NaV1.7 as an Analgesic Target

(2014) Glenn F. King et al.   ACS Chemical Neuroscience

Scaffold hopping towards potent and selective JAK3 inhibitors: Discovery of novel C-5 substituted pyrrolopyrazines

(2014) Javier de Vicente et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and evaluation of new coumarin derivatives as potential atypical antipsychotics

(2014) Yin Chen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Orexin receptor antagonists – a patent review (2010 to August 2014)

(2014) Christoph Boss   EXPERT OPINION ON THERAPEUTIC PATENTS

Discovery of Dual Death-Associated Protein Related Apoptosis Inducing Protein Kinase 1 and 2 Inhibitors by a Scaffold Hopping Approach

(2014) Ling-Jie Gao et al.   JOURNAL OF MEDICINAL CHEMISTRY

Novel Arylsulfonamide Derivatives with 5-HT6/5-HT7 Receptor Antagonism Targeting Behavioral and Psychological Symptoms of Dementia

(2014) Marcin Kołaczkowski et al.   JOURNAL OF MEDICINAL CHEMISTRY

Novel DNA Gyrase Inhibiting Spiropyrimidinetriones with a Benzisoxazole Scaffold: SAR and in Vivo Characterization

(2014) Gregory S. Basarab et al.   JOURNAL OF MEDICINAL CHEMISTRY

ADN-1184 a monoaminergic ligand with 5-HT6/7receptor antagonist activity: pharmacological profile and potential therapeutic utility

(2013) M Kołaczkowski et al.   BRITISH JOURNAL OF PHARMACOLOGY

Synthesis and Biological Investigation of Coumarin Piperazine (Piperidine) Derivatives as Potential Multireceptor Atypical Antipsychotics

(2013) Yin Chen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Adenosine A2A Receptor as a Drug Discovery Target

(2013) Manuel de Lera Ruiz et al.   JOURNAL OF MEDICINAL CHEMISTRY

Metabolism of a Serotonin-4 Receptor Partial Agonist 4-{4-[4-Tetrahydrofuran-3-yloxy)-Benzo[d]Isoxazol-3-yloxymethyl]-Piperidin-1-ylmethyl}-Tetrahydropyran-4-ol (TBPT): Identification of an Unusual Pharmacologically Active Cyclized Oxazolidine Metabolite in Human

(2013) Aarti Sawant-Basak et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Synthesis and Evaluation of a Series of Piperidine-2,6-dione-piperazine (piperidine) Derivatives as Multireceptor Atypical Antipsychotics

(2012) Yin Chen et al.   ARCHIV DER PHARMAZIE

Exploration of diverse hinge-binding scaffolds for selective Aurora kinase inhibitors

(2012) Zhiqin Ji et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Extended-Release Intramuscular Paliperidone Palmitate

(2012) Natalie J. Carter   DRUGS

Identification of Multiple 5-HT4 Partial Agonist Clinical Candidates for the Treatment of Alzheimer’s Disease

(2012) Michael A. Brodney et al.   JOURNAL OF MEDICINAL CHEMISTRY

Negative allosteric modulation of metabotropic glutamate receptor 5 results in broad spectrum activity relevant to treatment resistant depression

(2012) Z.A. Hughes et al.   NEUROPHARMACOLOGY

Aryl Piperazinyl Ureas as Inhibitors of Fatty Acid Amide Hydrolase (FAAH) in Rat, Dog, and Primate

(2012) John M. Keith et al.   ACS Medicinal Chemistry Letters

Translational receptor occupancy for the 5-HT4 partial agonist PF-04995274 in rats, non-human primates and healthy volunteers

(2011) Sarah Grimwood et al.   Alzheimers & Dementia

Positive allosteric modulators as an approach to nicotinic acetylcholine receptor-targeted therapeutics: Advantages and limitations

(2011) Dustin K. Williams et al.   BIOCHEMICAL PHARMACOLOGY

Indolin-2-one p38α inhibitors III: Bioisosteric amide replacement

(2011) Paul Eastwood et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Potential atypical antipsychotics: synthesis, binding affinity and SAR of new heterocyclic bioisosteric butyrophenone analogues as multitarget ligands

(2011) María Barceló et al.   MedChemComm

Discovery of a novel TLR2 signaling inhibitor with anti-viral activity

(2010) Shenghua Zhou et al.   ANTIVIRAL RESEARCH

Recent advances in the discovery and evaluation of fatty acid amide hydrolase inhibitors

(2010) Hongfeng Deng   Expert Opinion on Drug Discovery

Risperidone long-acting injectable (Risperdal Consta®) for maintenance treatment in patients with bipolar disorder

(2010) William V Bobo et al.   Expert Review of Neurotherapeutics

Spinal hyperpolarization-activated cyclic nucleotide-gated cation channels at primary afferent terminals contribute to chronic pain

(2010) Keiko Takasu et al.   PAIN

Synthesis and antimicrobial studies of novel methylene bridged benzisoxazolyl imidazo[2,1-b][1,3,4]thiadiazole derivatives

(2008) Ravi S. Lamani et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Zonisamide: review of pharmacology, clinical efficacy, tolerability, and safety

(2008) Sanjeev V Kothare et al.   Expert Opinion on Drug Metabolism & Toxicology

Synthesis and Biological Evaluation ofd-Amino Acid Oxidase Inhibitors

(2008) Dana Ferraris et al.   JOURNAL OF MEDICINAL CHEMISTRY

Prodrugs: design and clinical applications

(2008) Jarkko Rautio et al.   NATURE REVIEWS DRUG DISCOVERY