Structural Basis of a Broadly Selective Acyltransferase from the Polyketide Synthase of Splenocin

Polyketide Bioderivatization Using the Promiscuous Acyltransferase KirCII

(2017) Ewa M. Musiol-Kroll et al.   ACS Synthetic Biology

Inversion of Extender Unit Selectivity in the Erythromycin Polyketide Synthase by Acyltransferase Domain Engineering

(2016) Irina Koryakina et al.   ACS Chemical Biology

Natural Products as Sources of New Drugs from 1981 to 2014

(2016) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

Substrate Flexibility of a Mutated Acyltransferase Domain and Implications for Polyketide Biosynthesis

(2015) Kenny Bravo-Rodriguez et al.   CHEMISTRY & BIOLOGY

Uncovering the Formation and Selection of Benzylmalonyl-CoA from the Biosynthesis of Splenocin and Enterocin Reveals a Versatile Way to Introduce Amino Acids into Polyketide Carbon Scaffolds

(2015) Chenchen Chang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biochemical and Structural Basis for Controlling Chemical Modularity in Fungal Polyketide Biosynthesis

(2015) Jaclyn M. Winter et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Polyketide Synthase Acyltransferase Domain Structure Suggests a Recognition Mechanism for Its Hydroxymalonyl-Acyl Carrier Protein Substrate

(2014) Hyunjun Park et al.   PLoS One

Biosynthesis of Antimycins with a Reconstituted 3-Formamidosalicylate Pharmacophore in Escherichia coli

(2014) Joyce Liu et al.   ACS Synthetic Biology

Azaphilones: Chemistry and Biology

(2013) Jin-Ming Gao et al.   CHEMICAL REVIEWS

Engineering the acyltransferase substrate specificity of assembly line polyketide synthases

(2013) B. J. Dunn et al.   Journal of the Royal Society Interface

Industrial natural product chemistry for drug discovery and development

(2013) Armin Bauer et al.   NATURAL PRODUCT REPORTS

Enzyme-Directed Mutasynthesis: A Combined Experimental and Theoretical Approach to Substrate Recognition of a Polyketide Synthase

(2012) Uschi Sundermann et al.   ACS Chemical Biology

Bioengineering natural product biosynthetic pathways for therapeutic applications

(2012) Ming-Cheng Wu et al.   CURRENT OPINION IN BIOTECHNOLOGY

Biochemical and Structural Study of the Atypical Acyltransferase Domain from the Mycobacterial Polyketide Synthase Pks13

(2012) Fabien Bergeret et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biosynthetic Pathway for High Structural Diversity of a Common Dilactone Core in Antimycin Production

(2012) Yan Yan et al.   ORGANIC LETTERS

Reveromycin A biosynthesis uses RevG and RevJ for stereospecific spiroacetal formation

(2011) Shunji Takahashi et al.   Nature Chemical Biology

Identification of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in Streptomyces ambofaciens

(2011) L. Laureti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA