Palladium-Catalyzed Enantioselective Reductive Heck Reactions: Convenient Access to 3,3-Disubstituted 2,3-Dihydrobenzofuran

Palladium/PC-Phos-Catalyzed Enantioselective Arylation of General Sulfenate Anions: Scope and Synthetic Applications

(2018) Lei Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

An Integrated Continuous-Flow Synthesis of a Key Oxazolidine Intermediate to Noroxymorphone from Naturally Occurring Opioids

(2017) Alejandro Mata et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

First deuterated drug approved

(2017) Charles Schmidt   NATURE BIOTECHNOLOGY

Chiral ligands designed in China

(2017) Yuanyuan Liu et al.   National Science Review

Diastereo- and Enantioselective Copper(I)-Catalyzed Intermolecular [3+2] Cycloaddition of Azomethine Ylides with β-Trifluoromethyl β,β-Disubstituted Enones

(2016) Zhan-Ming Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Total syntheses of (±)-spiroindimicins B and C enabled by a late-stage Schöllkopf–Magnus–Barton–Zard (SMBZ) reaction

(2016) Lachlan M. Blair et al.   CHEMICAL COMMUNICATIONS

Iron-catalysed tritiation of pharmaceuticals

(2016) Renyuan Pony Yu et al.   NATURE

Copper(I)/Ming-Phos-Catalyzed Asymmetric Intermolecular [3 + 2] Cycloaddition of Azomethine Ylides with α-Trifluoromethyl α, β-Unsaturated Esters

(2016) Bing Xu et al.   ACS Catalysis

Enantioselective gold-catalyzed intermolecular [2 + 2]-cycloadditions of 3-styrylindoles with N-allenyl oxazolidinone

(2016) Haoxiang Hu et al.   Organic Chemistry Frontiers

Palladium-Catalyzed Asymmetric Reductive Heck Reaction of Aryl Halides

(2015) Guizhou Yue et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Palladium(0)/NHC-Catalyzed Reductive Heck Reaction of Enones: A Detailed Mechanistic Study

(2015) Saeed Raoufmoghaddam et al.   CHEMISTRY-A EUROPEAN JOURNAL

Palladium-Catalyzed Enantioselective Domino Heck/Intermolecular C–H Bond Functionalization: Development and Application to the Synthesis of (+)-Esermethole

(2015) Wangqing Kong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Arylative Dearomatization of Indoles via Pd-Catalyzed Intramolecular Reductive Heck Reactions

(2015) Chong Shen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Efficient Synthesis of (P-Chirogenic) o-Boronated Phosphines from sec-Phosphine Boranes

(2015) Jérôme Bayardon et al.   ORGANIC LETTERS

Polymer-Bound Chiral Gold-Based Complexes as Efficient Heterogeneous Catalysts for Enantioselectivity Tunable Cycloaddition

(2015) Mingjin Chen et al.   ACS Catalysis

A New Type of Chiral Sulfinamide Monophosphine Ligands: Stereodivergent Synthesis and Application in Enantioselective Gold(I)-Catalyzed Cycloaddition Reactions

(2014) Zhan-Ming Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Total Synthesis of (±)-Gelsemoxonine

(2013) Stefan Diethelm et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Heavy drugs draw heavy interest from pharma backers

(2013) Alla Katsnelson   NATURE MEDICINE

Use of Radiolabeled Compounds in Drug Metabolism and Pharmacokinetic Studies

(2012) Emre M. Isin et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Recent advances in organocatalytic methods for the synthesis of disubstituted 2- and 3-indolinones

(2012) Renato Dalpozzo et al.   CHEMICAL SOCIETY REVIEWS

Stereoselective Synthesis of o-Bromo (or Iodo)aryl P-Chirogenic Phosphines Based on Aryne Chemistry

(2012) Jérôme Bayardon et al.   JOURNAL OF ORGANIC CHEMISTRY

Total Synthesis of (−)-Galanthamine and (−)-Lycoramine via Catalytic Asymmetric Hydrogenation and Intramolecular Reductive Heck Cyclization

(2012) Ji-Qiang Chen et al.   ORGANIC LETTERS

Synthesis of New 4,5-Dihydrofuranoindoles and Their Evaluation as HCV NS5B Polymerase Inhibitors

(2012) Francisco Velázquez et al.   ORGANIC LETTERS

A synthetic approach for (S)-(3-benzyl-3-methyl-2,3-dihydro-benzofuran-6-yl)-piperidin-1-yl-methanone, a selective CB2 receptor agonist

(2012) Zhushou Luo et al.   TETRAHEDRON LETTERS

Large-Scale Applications of Transition Metal-Catalyzed Couplings for the Synthesis of Pharmaceuticals

(2011) Javier Magano et al.   CHEMICAL REVIEWS

Pd-NHC Catalyzed Conjugate Addition versus the Mizoroki-Heck Reaction

(2011) Aditya L. Gottumukkala et al.   CHEMISTRY-A EUROPEAN JOURNAL

Kinetic Isotope Effects in Asymmetric Reactions

(2010) Thomas Giagou et al.   CHEMISTRY-A EUROPEAN JOURNAL

A new model for the origin of kinetic hydrogen isotope effects

(2010) Judith P. Klinman   JOURNAL OF PHYSICAL ORGANIC CHEMISTRY

Isotope effect in spin response of π-conjugated polymer films and devices

(2010) Tho D. Nguyen et al.   NATURE MATERIALS

2,3-Dihydro-1-Benzofuran Derivatives as a Series of Potent Selective Cannabinoid Receptor 2 Agonists: Design, Synthesis, and Binding Mode Prediction through Ligand-Steered Modeling

(2009) Philippe Diaz et al.   ChemMedChem

Potent, nonpeptide inhibitors of human mast cell tryptase. Synthesis and biological evaluation of novel spirocyclic piperidine amide derivatives

(2008) Michael J. Costanzo et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

1,3-Diaxially Substitutedtrans-Decalins: Potential Nonsteroidal Human Progesterone Receptor Inhibitors

(2008) Ze Li et al.   JOURNAL OF ORGANIC CHEMISTRY

Total Synthesis of the Strychnos Alkaloid (+)-Minfiensine: Tandem Enantioselective Intramolecular Heck−Iminium Ion Cyclization

(2008) Amy B. Dounay et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY