Isotope Substitution of Promiscuous Alcohol Dehydrogenase Reveals the Origin of Substrate Preference in the Transition State

Modulating Enzyme Catalysis through Mutations Designed to Alter Rapid Protein Dynamics

(2016) Ioanna Zoi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Dynamic and Electrostatic Effects on the Reaction Catalyzed by HIV-1 Protease

(2016) Agnieszka Krzemińska et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Minimization of dynamic effects in the evolution of dihydrofolate reductase

(2016) J. Javier Ruiz-Pernía et al.   Chemical Science

Protein motions and dynamic effects in enzyme catalysis

(2015) Louis Y. P. Luk et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Heavy enzymes—experimental and computational insights in enzyme dynamics

(2014) Katarzyna Świderek et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Evolutionary Aspects of Enzyme Dynamics

(2014) Judith P. Klinman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Picosecond-Resolved Fluorescent Probes at Functionally Distinct Tryptophans within a Thermophilic Alcohol Dehydrogenase: Relationship of Temperature-Dependent Changes in Fluorescence to Catalysis

(2014) Corey W. Meadows et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Different Dynamical Effects in Mesophilic and Hyperthermophilic Dihydrofolate Reductases

(2014) Louis Y. P. Luk et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Picosecond-Resolved Fluorescence Studies of Substrate and Cofactor-Binding Domain Mutants in a Thermophilic Alcohol Dehydrogenase Uncover an Extended Network of Communication

(2014) Corey W. Meadows et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Protein Isotope Effects in Dihydrofolate Reductase From Geobacillus stearothermophilus Show Entropic–Enthalpic Compensatory Effects on the Rate Constant

(2014) Louis Y. P. Luk et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure ofEscherichia coliAdhP (ethanol-inducible dehydrogenase) with bound NAD

(2013) Leonard M. Thomas et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Identification of a Long-range Protein Network That Modulates Active Site Dynamics in Extremophilic Alcohol Dehydrogenases

(2013) Zachary D. Nagel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Changes in Protein Architecture and Subpicosecond Protein Dynamics Impact the Reaction Catalyzed by Lactate Dehydrogenase

(2013) Jean E. Masterson et al.   JOURNAL OF PHYSICAL CHEMISTRY A

Heavy-Enzyme Kinetic Isotope Effects on Proton Transfer in Alanine Racemase

(2013) Michael D. Toney et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Increased Dynamic Effects in a Catalytically Compromised Variant of Escherichia coli Dihydrofolate Reductase

(2013) J. Javier Ruiz-Pernia et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fast Protein Motions Are Coupled to Enzyme H-Transfer Reactions

(2013) Christopher R. Pudney et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Unraveling the role of protein dynamics in dihydrofolate reductase catalysis

(2013) L. Y. P. Luk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mass-Dependent Bond Vibrational Dynamics Influence Catalysis by HIV-1 Protease

(2011) D. Randal Kipp et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Catalysis by dihydrofolate reductase and other enzymes arises from electrostatic preorganization, not conformational motions

(2011) A. J. Adamczyk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA