Evolutionary Aspects of Enzyme Dynamics

Hydrogen Tunneling in a Prokaryotic Lipoxygenase

(2014) Cody A. Marcus Carr et al.   BIOCHEMISTRY

Picosecond-Resolved Fluorescent Probes at Functionally Distinct Tryptophans within a Thermophilic Alcohol Dehydrogenase: Relationship of Temperature-Dependent Changes in Fluorescence to Catalysis

(2014) Corey W. Meadows et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Extension and Limits of the Network of Coupled Motions Correlated to Hydride Transfer in Dihydrofolate Reductase

(2014) Priyanka Singh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Protein Mass-Modulated Effects in the Catalytic Mechanism of Dihydrofolate Reductase: Beyond Promoting Vibrations

(2014) Zhen Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Hydrogen Tunneling Links Protein Dynamics to Enzyme Catalysis

(2013) Judith P. Klinman et al.   Annual Review of Biochemistry

Identification of a Long-range Protein Network That Modulates Active Site Dynamics in Extremophilic Alcohol Dehydrogenases

(2013) Zachary D. Nagel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Preservation of Protein Dynamics in Dihydrofolate Reductase Evolution

(2013) Kevin Francis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased Dynamic Effects in a Catalytically Compromised Variant of Escherichia coli Dihydrofolate Reductase

(2013) J. Javier Ruiz-Pernia et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fast Protein Motions Are Coupled to Enzyme H-Transfer Reactions

(2013) Christopher R. Pudney et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Water Networks Contribute to Enthalpy/Entropy Compensation in Protein–Ligand Binding

(2013) Benjamin Breiten et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Functional significance of evolving protein sequence in dihydrofolate reductase from bacteria to humans

(2013) C. T. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Active Site Hydrophobic Residues Impact Hydrogen Tunneling Differently in a Thermophilic Alcohol Dehydrogenase at Optimal versus Nonoptimal Temperatures

(2012) Zachary D. Nagel et al.   BIOCHEMISTRY

Evidence that a ‘dynamic knockout’ in Escherichia coli dihydrofolate reductase does not affect the chemical step of catalysis

(2012) E. Joel Loveridge et al.   Nature Chemistry

Effects of the Donor–Acceptor Distance and Dynamics on Hydride Tunneling in the Dihydrofolate Reductase Catalyzed Reaction

(2011) Vanja Stojković et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Impaired protein conformational landscapes as revealed in anomalous Arrhenius prefactors

(2011) Z. D. Nagel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Catalysis by dihydrofolate reductase and other enzymes arises from electrostatic preorganization, not conformational motions

(2011) A. J. Adamczyk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Dynamic Knockout Reveals That Conformational Fluctuations Influence the Chemical Step of Enzyme Catalysis

(2011) G. Bhabha et al.   SCIENCE

Update 1 of: Tunneling and Dynamics in Enzymatic Hydride Transfer

(2010) Zachary D. Nagel et al.   CHEMICAL REVIEWS

Choreographing an enzyme's dance

(2010) Janice Villali et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

An integrated model for enzyme catalysis emerges from studies of hydrogen tunneling

(2009) Judith P. Klinman   CHEMICAL PHYSICS LETTERS

The hydrophobic effect and its role in cold denaturation

(2009) Cristiano L. Dias et al.   CRYOBIOLOGY

Hidden alternative structures of proline isomerase essential for catalysis

(2009) James S. Fraser et al.   NATURE

A 21st century revisionist's view at a turning point in enzymology

(2009) Zachary D Nagel et al.   Nature Chemical Biology

Free-Energy Landscape of Enzyme Catalysis†

(2008) Stephen J. Benkovic et al.   BIOCHEMISTRY