Review
Allergy
Ludger Klimek, William E. Berger, Jean Bousquet, Paul K. Keith, Peter Smith, Dirceu Sole, Glenis Scadding, Hans Christian Kuhl, Duc Tung Nguyen, Ferdinand Kopietz, Arkady Koltun
Summary: The study systematically reviewed the efficacy and safety of MP-AzeFlu for treating allergic rhinitis, finding that it provides effective relief of nasal and ocular symptoms, acts quickly, and controls allergic rhinitis faster. Long-term use is safe and beneficial for children, adults, and those over 65 years old.
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Ali Asghar Askari, Parisa Feizollahi, Alireza Rezaiemanesh, Farhad Salari, Ali Gorgin Karaji
Summary: This study evaluated the effects of fexofenadine and fluticasone propionate on gene expression levels in AR patients, finding that these medications decreased the expression levels of IRF4 and BATF genes but had no significant impact on PU.1 gene expression. Further research is needed to understand the exact mechanism of action of these treatments.
Article
Surgery
Ayush Agrawal, Kumar Shubhanshu, Mohammad Shakeel Ahmad
Summary: This study compared the effectiveness of combined use of Fluticasone propionate and Azelastine nasal spray versus standalone Fluticasone propionate nasal spray in patients with persistent allergic rhinitis (PER). The results showed that the combination therapy achieved better results with significant reduction of symptoms compared to the standalone therapy.
INDIAN JOURNAL OF OTOLARYNGOLOGY AND HEAD & NECK SURGERY
(2023)
Article
Spectroscopy
Michael Gamal Fawzy, Hanaa Saleh, Alaa Reda, Eman A. Bahgat
Summary: This study employed various UV spectrophotometric and chemo-metric methods for the quantitative analysis of FLU and AZE. The methods were found to be environmentally friendly and showed similar accuracy and precision as the official or reported HPLC methods.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Multidisciplinary Sciences
Amal A. El-Masry, Dalia R. El-Wasseef, Manal Eid, Ihsan A. Shehata, Abdallah M. Zeid
Summary: A facile, rapid, accurate, and selective H-1-qNMR method was developed for the simultaneous determination of fluticasone propionate and azelastine hydrochloride in pharmaceutical nasal spray for the first time. The method was validated efficiently according to the International Council on Harmonisation guidelines, demonstrating high linearity, precision, stability, specificity, and selectivity.
ROYAL SOCIETY OPEN SCIENCE
(2021)
Article
Allergy
Bruce M. Prenner, Niran J. Amar, Frank C. Hampel, Cynthia F. Caracta, Wen Wu
Summary: The study evaluated the efficacy, safety, and tolerability of GSP301 in pediatric patients with seasonal allergic rhinitis. The results showed that GSP301 significantly improved nasal symptoms and had a favorable safety profile, with positive effects on ocular symptoms and quality of life.
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Par Stjarne, Duc Tung Nguyen, Hans Christian Kuhl
Summary: This study assessed the effectiveness of MP-AzeFlu in relieving symptoms of allergic rhinitis. The results showed that MP-AzeFlu provided rapid and effective symptom control, improved sleep quality, and significantly improved the quality of life of patients.
PRAGMATIC AND OBSERVATIONAL RESEARCH
(2023)
Article
Allergy
Wenyuan Qi, Yue Liu, Wei Xue, Kexin Li, J. Christopher Gorski, Mark Liu, Tieliang Yan, Duc Tung Nguyen, Rajesh Kumar Ramalingam
Summary: To confirm that there was no pharmacokinetic drug interaction between AZE and FLU in MP-AzeFlu, two studies (Study I and Study II) were conducted in healthy Chinese volunteers. The secondary objective was to evaluate the pharmacokinetic parameters of MP-AzeFlu compared with the commercially available mono-components. The study results showed that there were no significant potential impacts on the systemic exposure of AZE or FLU in Chinese subjects due to the existing qualitative and quantitative differences in the formulation between the currently marketed AZE and FLU mono-product.
JOURNAL OF ASTHMA AND ALLERGY
(2023)
Article
Oncology
Qiling Zheng, Dijiang Ma, Qi Zhu, Shenjun Tang, Chengbo Chen
Summary: The combination therapy of azelastine hydrochloride and montelukast sodium significantly improves clinical symptoms and inflammatory reactions in patients with allergic rhinitis, showing higher effectiveness compared to using azelastine hydrochloride alone. The clinical therapeutic effect and symptom scores were significantly improved after treatment, as well as a noticeable decrease in serum levels of inflammatory factors.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Review
Otorhinolaryngology
Nadim Khoueir, Michel G. Khalaf, Ralph Assily, Simon Rassi, Walid Abou Hamad
Summary: This systematic review and meta-analysis examined the effects of intranasal antihistamines (INAH) on idiopathic rhinitis (IR). The study found that INAH had a beneficial effect on improving nasal symptoms compared to placebo. No significant difference in efficacy was observed between different types of INAH. The most commonly reported adverse event was bitter taste sensation.
Article
Allergy
Alexander Karaulov, Natalia I. Ilina, Natalia Shartanova, Aleksandr Maslakov, Luiz Lucio
Summary: This post hoc analysis demonstrated that TAA is effective in improving perennial allergic rhinitis symptoms, providing significant and long-lasting relief for patients. No significant differences were observed between TAA and FP, indicating that TAA may be a comparable treatment option for PAR.
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
(2022)
Article
Cell Biology
Ewa Trybus, Wojciech Trybus, Teodora Krol
Summary: This study focused on the cytological analysis of nasal mucosa swabs from patients with allergic rhinitis (AR) and nonallergic/vasomotor rhinitis (NAR/VMR) who received azelastine therapy for 4 weeks. The results demonstrated therapeutic benefits of azelastine, including regeneration of ciliated cells and induction of autophagy and apoptosis in epithelial cells. The study provides new insights into the mechanisms of action of azelastine and contributes to the understanding of prognostic indicators in different types of rhinitis.
Article
Otorhinolaryngology
Hossein Esmaeilzadeh, Nasrin Mortazavi Far, Seyed Hesamedin Nabavizadeh, Masroor Babaeian, Maryam Hadipour, Soheila Alyasin
Summary: This study investigates the efficacy of Montelukast and intranasal antihistamine in combination with intranasal corticosteroid in treating moderate to severe allergic rhinitis. The findings suggest that the combination of Azelastine and intranasal corticosteroid is recommended for the treatment of moderate to severe allergic rhinitis. Montelukast has no greater impact than intranasal corticosteroid in managing moderate to severe allergic rhinitis or asthma.
AMERICAN JOURNAL OF RHINOLOGY & ALLERGY
(2022)
Article
Respiratory System
Bing Zhou, Lei Cheng, Jing Pan, Huizhong Wang, Yongde Jin, Changqing Zhao, Peng Lin, Guolin Tan, Hongyan Fang, Hua Zhang, Huifang Zhou, Yaowu Dong, Hans Christian Kuhl, Rajesh Kumar Ramalingam, Duc Tung Nguyen
Summary: The objective of this study was to evaluate the efficacy and safety of MP-AzeFlu nasal spray in Chinese patients with moderate-to-severe allergic rhinitis. The results showed that MP-AzeFlu group had significantly higher symptom reduction compared to the AZE group and the FLU group. The incidence of adverse events in the MP-AzeFlu group was comparable or even lower than in other groups, except for dysgeusia (bitter taste).
Article
Gastroenterology & Hepatology
Evan S. Dellon, Alfredo J. Lucendo, Christoph Schlag, Alain M. Schoepfer, Gary W. Falk, Gina Eagle, James Nezamis, Gail M. Comer, Karol Knoop, Ikuo Hirano
Summary: This study demonstrates that APT-1011 (fluticasone propionate oral disintegrating tablet) is an effective and well-tolerated treatment for eosinophilic esophagitis (EoE). Different doses of APT-1011 showed superior histologic and endoscopic responses, as well as a reduction in dysphagia frequency, compared to placebo. The once daily 3 mg dose at bedtime showed the most favorable risk-benefit profile.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Letter
Medicine, Research & Experimental
Andrew Menzies-Gow, Flavia L. Hoyte, David B. Price, David Cohen, Peter Barker, James Kreindler, Maria Jison, Christopher L. Brooks, Peggy Papeleu, Rohit Katial
ADVANCES IN THERAPY
(2022)
Letter
Allergy
Peter K. Smith, Olivia Lesslar, David B. Price
Article
Respiratory System
Seyi Soremekun, Liam G. Heaney, Derek Skinner, Lakmini Bulathsinhala, Victoria Carter, Isha Chaudhry, Naeimeh Hosseini, Neva Eleangovan, Ruth Murray, Trung N. Tran, Benjamin Emmanuel, Esther Garcia Gil, Andrew Menzies-Gow, Matthew Peters, Njira Lugogo, Rupert Jones, David B. Price
Summary: This study, based on a large nationwide cohort of asthma patients, found that asthma exacerbations are associated with faster decline in lung function, especially in younger patients.
Article
Computer Science, Information Systems
Elsie M. F. Horne, Susannah McLean, Mohammad A. Alsallakh, Gwyneth A. Davies, David B. Price, Aziz Sheikh, Athanasios Tsanas
Summary: This study defined and validated asthma subtypes using large longitudinal primary care electronic health records (EHRs). The results showed that asthma subtypes were primarily defined by the level of steroid use, level of healthcare utilization, and the presence of comorbidities. This has important clinical implications for defining asthma subtypes, facilitating patient stratification, and developing more personalized monitoring and treatment strategies.
INTERNATIONAL JOURNAL OF MEDICAL INFORMATICS
(2023)
Article
Respiratory System
Heath Heatley, Trung N. Tran, Arnaud Bourdin, Andrew Menzies-Gow, David Joshua Jackson, Ekaterina Maslova, Jatin Chapaneri, Derek Skinner, Victoria Carter, Jeffrey Shi Kai Chan, Con Ariti, John Haughney, David B. Price
Summary: Intermittent oral corticosteroid (OCS) use for asthma is associated with increased risks of adverse outcomes. More frequent prescribing patterns of OCS are associated with higher risks of adverse outcomes, particularly pneumonia and sleep apnea. Mitigation strategies are needed to minimize intermittent OCS prescription in primary care.
Article
Allergy
Ian D. Pavord, Trung N. Tran, Rupert C. Jones, Javier Nuevo, Maarten van den Berge, Guy G. Brusselle, Andrew N. Menzies-Gow, Derek Skinner, Victoria Carter, Janwillem W. H. Kocks, David B. Price
Summary: A historic cohort study was conducted to determine the effectiveness of stepping up to high-dose inhaled corticosteroids (ICSs) in patients with asthma. The study found no evidence that increasing the dose to high-dose ICSs is effective in preventing future asthma exacerbations.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Article
Allergy
Paul E. Pfeffer, Nasloon Ali, Ruth Murray, Charlotte Ulrik., Trung N. Tran, Jorge Maspero, Matthew Peters, George C. Christoff, Mohsen Sadatsafavi, Carlos A. Torres-Duque, Alan Altraja, Lauri Lehtimaki, Nikolaos G. Papadopoulos, Sundeep Salvi, Richard W. Costello, Breda Cushen, Enrico Heffler, Takashi Iwanaga, Mona Al-Ahmad, Desiree Larenas-Linnemann, Piotr Kuna, Joao A. Fonseca, Riyad Al-Lehebi, Chin Kook Rhee, Luis Perez-de-Llano, Diahn-Warng Perng Steve, Bassam Mahboub, Eileen Wang, Celine Goh, Juntao Lyu, Anthony Newell, Marianna Alacqua, Andrey S. Belevskiy, Mohit Bhutani, Leif Bjermer, Unnur Bjornsdottir, Arnaud Bourdin, Anna von Boulow, John Busby, Giorgio Walter Canonica, Borja G. Cosio, Delbert R. Dorscheid, Mariana Munoz-Esquerre, J. Mark FitzGerald, Esther Garcia Gil, Peter G. Gibson, Liam G. Heaney, Mark Hew, Ole Hilberg, Flavia Hoyte, David J. Jackson, Mariko Siyue Koh, Hsin-Kuo Bruce Ko, Jae Ha Lee, Sverre Lehmann, Claudia Chaves Loureiro, Dora Ludviksdottir, Andrew N. Menzies-Gow, Patrick Mitchell, Andriana I. Papaioannou, Todor A. Popov, Celeste M. Porsbjerg, Laila Salameh, Concetta Sirena, Camille Taille, Christian Taube, Yuji Tohda, Michael E. Wechsler, David B. Price
Summary: This study aimed to describe the profile of severe asthma patients eligible for both anti-IgE and anti-IL5/5R and compare the effectiveness of these two treatments in real-life settings. The results showed that anti-IL5/5R was superior to anti-IgE in reducing asthma exacerbations and long-term oral corticosteroid use, while there was some evidence suggesting a decrease in asthma-related hospitalizations with anti-IL5/5R treatment.
Article
Developmental Biology
Rana Fetit, Michela Ilaria Barbato, Thomas Theil, Thomas Pratt, David J. Price
Summary: Inhibitory interneurons play a key role in regulating cortical circuit activity and their dysfunction is associated with autism spectrum disorder (ASD). This study investigates the effects of a genetic microdeletion, 16p11.2, which is linked to ASD, on the development of interneurons. Using human induced pluripotent stem cells, the researchers found that the microdeletion leads to increased variability in organoid size, neural rosette area, and expression of specific markers. The microdeletion also lengthens the cell cycle of ventral progenitors, promoting premature differentiation into interneurons.
Article
Medicine, General & Internal
Tae Yoon Lee, Mohsen Sadatsafavi, Chandra Prakash Yadav, David B. Price, Richard Beasley, Christer Janson, Mariko Siyue Koh, Rupsa Roy, Wenjia Chen
Summary: This study aims to develop and validate a novel risk prediction model for severe exacerbations in patients with severe asthma, and to examine the potential clinical utility of this tool.
Article
Primary Health Care
Francis J. Gilchrist, William D. Carroll, Sadie Clayton, David Price, Ian Jarrold, Iain Small, Emma J. Sutton, Warren Lenney
Summary: Despite guidelines, asthma is frequently misdiagnosed and control is poor. Large scale management programmes can improve outcomes. This study developed a primary care asthma management quality improvement programme and found modest but statistically significant improvements in asthma outcomes.
NPJ PRIMARY CARE RESPIRATORY MEDICINE
(2023)
Article
Allergy
Rod Hughes, Eleni Rapsomaniki, Aruna T. Bansal, Jorgen Vestbo, David Price, Alvar Agusti, Richard Beasley, Malin Fageras, Marianna Alacqua, Alberto Papi, Hana Mullerova, Helen K. Reddel
Summary: Cluster analysis in patients with asthma and/or COPD identified distinct clusters with characteristics that differed from conventional diagnostic features. The overlap between clusters suggests that they do not reflect discrete underlying mechanisms.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Article
Medicine, Research & Experimental
Ashraf Alzaabi, John P. Bell, Felicia Montero-Arias, David B. Price, David J. Jackson, Hao-Chien Wang, Nigel Budgen, Hisham Farouk, Ekaterina Maslova
Summary: This study retrospectively quantified the carbon footprint of short-acting beta 2-agonist (SABA) and controller inhalers in respiratory care, and found that SABA overuse is the main contributor to the carbon footprint of respiratory treatment. This is important for healthcare systems to reduce carbon emissions and improve patient outcomes.
ADVANCES IN THERAPY
(2023)
Editorial Material
Allergy
G. Walter Canonica, Ioana Agache, Holger J. Schunemann, Nicolas Roche, David Price, Stefano del Giacco
Article
Respiratory System
Christian Domingo, Klaus F. Rabe, David Price, Guy Brusselle, Michael E. Wechsler, Changming Xia, Nami Pandit-Abid, Rebecca Gall, Paul J. Rowe, Yamo Deniz, Juby A. Jacob-Nara, Amr Radwan
Summary: This post hoc analysis evaluates the long-term effects of dupilumab on severe OCS-dependent asthma, and finds that it improves clinical outcomes and reduces OCS dose irrespective of baseline disease severity.
Article
Allergy
Luke Daines, Eddie Donaghy, Anne Canny, Victoria Murray, Leo Campbell, Carol Stonham, Andrew Bush, Brian Mckinstry, Heather Milne, David Price, Aziz Sheikh, Hilary Pinnock
Summary: ObjectiveAsthma diagnosis can be challenging in primary care. This study aimed to explore health professionals' perspectives on the value of a clinical decision support system (CDSS) for asthma diagnosis and the barriers and facilitators for its use in UK primary care. Qualitative interviews were conducted with doctors and nurses who had experience diagnosing asthma, and the findings revealed that participants recognized the potential benefits of a CDSS in structuring consultations, extracting relevant information from health records, and visually communicating findings to patients. Key factors for successful implementation included evidence-based content, regular updates, integration with existing software, and ease of use. Experienced clinicians expressed skepticism about the usefulness of a CDSS in routine practice, but believed it would be beneficial for trainees or less experienced colleagues.