Recent advances in fluorination techniques and their anticipated impact on drug metabolism and toxicity

Novel fluorinated lipopeptides from Bacillus sp. CS93 via precursor-directed biosynthesis

(2014) Neil K. O’Connor et al.   AMINO ACIDS

A Convenient Photocatalytic Fluorination of Unactivated CH Bonds

(2014) Shira D. Halperin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Identification of Fluorinases fromStreptomycessp MA37,Norcardia brasiliensis, andActinoplanessp N902-109 by Genome Mining

(2014) Hai Deng et al.   CHEMBIOCHEM

Targeted Fluorination of a Nonsteroidal Anti-inflammatory Drug to Prolong Metabolic Half-Life

(2014) Maxwell J. Shaughnessy et al.   ChemMedChem

Fluoroacetate biosynthesis from the marine-derived bacterium Streptomyces xinghaiensis NRRL B-24674

(2014) Sheng Huang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Microbial biotransformation of aryl sulfanylpentafluorides

(2013) Emma Kavanagh et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Fluorouracil in the environment: Analysis, occurrence, degradation and transformation

(2013) Tina Kosjek et al.   JOURNAL OF CHROMATOGRAPHY A

Data-Mining for Sulfur and Fluorine: An Evaluation of Pharmaceuticals To Reveal Opportunities for Drug Design and Discovery

(2013) Elizabeth A. Ilardi et al.   JOURNAL OF MEDICINAL CHEMISTRY

A convenient chemical-microbial method for developing fluorinated pharmaceuticals

(2013) Tara V. Bright et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Expanding the Fluorine Chemistry of Living Systems Using Engineered Polyketide Synthase Pathways

(2013) M. C. Walker et al.   SCIENCE

Cunninghamella as a Microbiological Model for Metabolism of Histamine H3 Receptor Antagonist 1-[3-(4-tert-Butylphenoxy)propyl]piperidine

(2012) Elżbieta Pękala et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Discovery of practical production processes for arylsulfur pentafluorides and their higher homologues, bis- and tris(sulfur pentafluorides): Beginning of a new era of “super-trifluoromethyl” arene chemistry and its industry

(2012) Teruo Umemoto et al.   Beilstein Journal of Organic Chemistry

Production of the novel lipopeptide antibiotic trifluorosurfactin via precursor-directed biosynthesis

(2012) Neil K. O’Connor et al.   JOURNAL OF FLUORINE CHEMISTRY

Synthetic chemistry and biological activity of pentafluorosulphanyl (SF5) organic molecules

(2012) Stefano Altomonte et al.   JOURNAL OF FLUORINE CHEMISTRY

Unique Gene-Silencing and Structural Properties of 2′-Fluoro-Modified siRNAs

(2011) Muthiah Manoharan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Continuous gas/liquid–liquid/liquid flow synthesis of 4-fluoropyrazole derivatives by selective direct fluorination

(2011) Jessica R Breen et al.   Beilstein Journal of Organic Chemistry

Fluoride Excess and Periostitis in Transplant Patients Receiving Long-Term Voriconazole Therapy

(2011) R. A. Wermers et al.   CLINICAL INFECTIOUS DISEASES

Innate C-H trifluoromethylation of heterocycles

(2011) Y. Ji et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular mechanisms of fluoride toxicity

(2010) Olivier Barbier et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Engineering Fluorometabolite Production: Fluorinase Expression inSalinispora tropicaYields Fluorosalinosporamide†

(2010) Alessandra S. Eustáquio et al.   JOURNAL OF NATURAL PRODUCTS

Discovery of 4-tert-Butyl-2,6-dimethylphenylsulfur Trifluoride as a Deoxofluorinating Agent with High Thermal Stability as Well as Unusual Resistance to Aqueous Hydrolysis, and Its Diverse Fluorination Capabilities Including Deoxofluoro-Arylsulfinylation with High Stereoselectivity

(2010) Teruo Umemoto et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of an 8-pentafluorosulfanyl analog of the antimalarial agent mefloquine

(2010) Tingting Mo et al.   TETRAHEDRON LETTERS

ENVIRONMENTAL PROPERTIES OF PENTAFLUOROSULFANYL COMPOUNDS: PHYSICAL PROPERTIES AND PHOTODEGRADATION

(2009) Derek A. Jackson et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Snapshots of the Fluorosalinosporamide/20S Complex Offer Mechanistic Insights for Fine Tuning Proteasome Inhibition

(2009) Michael Groll et al.   JOURNAL OF MEDICINAL CHEMISTRY

Precursor-directed biosynthesis of fluorinated iturin A in Bacillus spp.

(2009) Stephen Moran et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis and biological evaluation of the first pentafluorosulfanyl analogs of mefloquine

(2009) Peter Wipf et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Mutasynthesis of Fluorosalinosporamide, a Potent and Reversible Inhibitor of the Proteasome

(2008) Alessandra S. Eustáquio et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structural and Functional Analysis of the Human HDAC4 Catalytic Domain Reveals a Regulatory Structural Zinc-binding Domain

(2008) Matthew J. Bottomley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chemo-enzymatic fluorination of unactivated organic compounds

(2008) Andrea Rentmeister et al.   Nature Chemical Biology

Fluorination in Medicinal Chemistry: Methods, Strategies, and Recent Developments

(2008) Kenneth L. Kirk   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Fluorine in medicinal chemistry

(2007) Sophie Purser et al.   CHEMICAL SOCIETY REVIEWS