Article
Chemistry, Analytical
Yunhong Zheng, Hang Yin, Chengxian Zhou, Wei Zhou, Zhijie Huan, Weicheng Ma
Summary: The swine fever virus seriously affects pork production. To improve pig breeding efficiency and diagnose sperm activity, researchers designed a microfluidic chip and a miniature microscope system, which can be used with smartphones. An intelligent diagnostic app allows for the automatic identification and tracking of boar sperm. The proposed smartphone-based hand-held platform effectively replaces the traditional microscope compound computer and offers smaller size, ease of use, and flexibility in testing scenarios.
Article
Biochemical Research Methods
Kaisong Yuan, Rui Huang, Kaishuo Gong, Ziyi Xiao, Jialin Chen, Siyao Cai, Jiayi Shen, Zuer Xiong, Zhexuan Lin
Summary: Smartphone-based hand-held polarized light microscope is a compact, portable, and low-cost method for pharmaceutical crystallinity characterization. It has high resolution, imaging quality, and flexibility for on-site applications. This device has great potential in helping pharmacists for both research purposes and on-site drug testing.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Article
Orthopedics
Haimiti Abudouaini, Tingkui Wu, Yang Meng, Beiyu Wang, Hao Liu
Summary: Anterior cervical surgery is a widely accepted surgical procedure for treating cervical radiculopathy and myelopathy. However, the traditional polyetheretherketone cage used in the surgery has concerns regarding adjacent segment degeneration and implant subsidence. To address these concerns, a novel polyurethane cervical implant was designed to provide continuous load-sharing through elastic deformation and reduce postoperative stress concentration. Mechanical tests showed that the implant remained intact under high loads, had a minimum push-out load higher than the maximum compressive shear load experienced by a human cervical intervertebral disc, and exhibited similar behavior to natural intervertebral discs under daily activity loads. These findings demonstrate the reasonable and stable design of the elastically deformable implant, making it a promising option for certain patients in clinical practice after further research on bone formation and stress distribution after implantation.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Chemistry, Analytical
Nan Xiang, Zhonghua Ni
Summary: A low-cost, portable hand-held inertial microfluidic cell sorter has been developed for high-efficiency sorting of differently sized cells in low-resource settings. Utilizing compression springs and mechanical syringe drivers to provide fluid driving force, the sorter enables high-efficiency separation of rare cells and different-sized particles.
Article
Computer Science, Artificial Intelligence
Hao Wang, Yue Zhang, Chao Liu, Honghai Liu
Summary: This study proposes a deformable convolutional network (DCN) for sEMG gesture recognition to optimize the conventional convolution kernels and achieve better performance. Experimental results show that the DCN outperforms traditional CNN in terms of recognition accuracy.
INTERNATIONAL JOURNAL OF MACHINE LEARNING AND CYBERNETICS
(2022)
Article
Chemistry, Analytical
Ane Arrizabalaga-Larranaga, Michel W. F. Nielen, Marco H. Blokland
Summary: A hand-held laser diode thermal desorption electrospray ionization (LDTD-ESI) mass spectrometry method was developed for rapid screening of illegal substances in solid samples. By optimizing ESI parameters and combining with a transportable single quadrupole mass spectrometer, rapid identification of selective androgen receptor modulators in drug samples was achieved.
ANALYTICAL CHEMISTRY
(2021)
Article
Biochemical Research Methods
Jinpeng Liao, Shufan Yang, Tianyu Zhang, Chunhui Li, Zhihong Huang
Summary: Optical coherence tomography angiography (OCTA) has been successfully applied in clinical dermatology, but extracting high-quality OCTA images from skin tissues requires at least six repeated scans due to the skin's high optical scattering property. The motion artifacts from the patient and the free hand-held probe can lead to low-quality OCTA images. Our deep-learning-based scan pipeline enables fast and high-quality OCTA imaging with 0.3-s data acquisition.
JOURNAL OF BIOPHOTONICS
(2023)
Article
Geochemistry & Geophysics
Tomohiro Kondo, Kazutaka Kikuta, Motoyuki Sato
Summary: This letter proposes a method for handheld ground penetrating radar (GPR) sensor in landmine detection to compensate for the irregularities in ground reflection arrival time. By selecting the frequency with the highest power of the ground surface reflection and equalizing the phase of the received signal at that frequency, the irregular reflection can be compensated, resulting in a uniform ground reflection signal and improved quality of the target shape.
IEEE GEOSCIENCE AND REMOTE SENSING LETTERS
(2022)
Article
Environmental Sciences
Bang Wu, Chengqi Ma, Stefan Poslad, David R. Selviah
Summary: The study introduces a novel adaptive human activity-aided PDR indoor positioning system, which enhances accuracy through human activity recognition and PDR optimization.
Article
Chemistry, Multidisciplinary
Lei Cao, Xiaojin Guo, Ping Mao, Yulin Ren, Zedong Li, Minli You, Jie Hu, Miao Tian, Chunyan Yao, Fei Li, Feng Xu
Summary: A portable digital loop-mediated isothermal amplification (dLAMP) platform was developed, integrating a microscale hydrogel (microgel) array chip, a miniaturized heater, and a hand-held reader for DNA sample partition, amplification, and digital readout. The platform allows for absolute quantification of DNA, showing great potential for nucleic acid point-of-care testing (POCT).
Article
Biophysics
Jiang Liu, Wei Lu, Lu Zhang, Jiao Yang, Zhong-Ping Yao, Yongcheng He, Yingchun Li
Summary: This paper presented a tip-like electrochemical sensor prototype that integrated with a commercial pipettor, allowing semi-automatic assay procedure for sampling, detection, and rinsing. It introduced a novel multi-component sensing strategy for detection of UA, urea, and pH in urine samples using one single working electrode. This development may open new opportunities for electrochemical technology in point-of-care testing.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Chemistry, Analytical
Jin Hyeong Choi, Jun Ho Noh, Changsoon Choi
Summary: This paper presents a stretchable yarn/fiber electronics that utilizes coil structure-based carbon nanotube (CNT)/polymer fibers with adjustable piezoresistivity. The composite fibers are highly stretchable and can be used for strain sensors or supercapacitors depending on the type of polymeric core fiber. The CNT/spandex composite fiber sensor responds sensitively to tensile strain, while the CNT/nylon composite fiber functions as an elastic supercapacitor with excellent capacitance retention at 300% strain.
Article
Optics
Yifeng Tang, Wanrong Gao
Summary: This study presents an improved handheld FFOCT system based on the tandem structure of Michelson interferometer and Fizeau interferometer. The impact of wave aberrations and refractive index difference on the system point spread function (PSF) is analyzed, and the limitations of orientation deviation and measuring depth are studied. Experimental results validate the theoretical analyses, showing that reducing the refractive index difference can increase the imaging depth of the handheld FFOCT system.
OPTICS AND LASERS IN ENGINEERING
(2022)
Article
Engineering, Mechanical
Chuhan Wu, Liangchi Zhang, Peilei Qu, Shanqing Li, Zhenglian Jiang
Summary: This research investigates the effects of elastic work rolls on the hydrodynamic lubrication of high-speed rolling of hard steel strips using an innovative numerical method and finite element analysis. The analysis demonstrates that the hydrodynamic pressure is more affected by the yield strength of the metal strip and roll radius in lubricated strip rolling with a fixed rolling gap.
TRIBOLOGY INTERNATIONAL
(2022)
Review
Biotechnology & Applied Microbiology
Zahra Pazhouhnia, Nima Beheshtizadeh, Mojdeh Salehi Namini, Nasrin Lotfibakhshaiesh
Summary: This review discusses the advantages and challenges of portable hand-held bioprinters for in situ tissue regeneration. It covers various tissues that have been investigated using this approach, as well as the design and applications of hand-held bioprinters. The review also highlights the potential of these devices in translating regenerative medicine science from the laboratory to the clinic.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2022)
Article
Nanoscience & Nanotechnology
Gopal Ammanath, Carla Giorgia Delachi, Soner Karabacak, Yusuf Ali, Bernhard O. Boehm, Umit Hakan Yildiz, Palaniappan Alagappan, Bo Liedberg
Summary: A simple method for colorimetric and fluorometric profiling of AGEs was reported in this study, utilizing changes in optical properties of PTs and Apts to estimate the concentrations of AGEs in plasma, and achieving distinct profiling of different AGEs through PCA analysis. The approach allows for rapid analysis of spiked AGEs in plasma samples without the need for preanalytical processing and advanced instrumentation, facilitating on-site diagnosis.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Polymer Science
Ozgun Daglar, Burcu Alkan, Ufuk Saim Gunay, Gurkan Hizal, Umit Tunca, Hakan Durmaz
Summary: The study presents a new method for the synthesis of phosphorus-containing polymers through the ultrafast thiol-yne reaction, resulting in fourteen phosphothioester-containing polythioethers with reasonable molecular weights and high yields. The proposed approach offers a rational, robust, time- and energy-saving solution for the preparation of phosphorus-containing polymers without needing harsh conditions, metal, acid, or base additives.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
James C. S. Ho, Wan-Chih Su, Xuan Chun Wang, Atul N. Parikh, Bo Liedberg
Summary: When certain amphiphiles encounter water, they form fingerlike tubular protrusions called myelin figures. In mixtures of unsaturated lipid, cholesterol, and sphingomyelin, myelins break symmetry and create gradients of cholesterol and unsaturated lipid, resulting in unusual morphologies. These findings suggest that kinetic differences in hydration characteristics dictate the behavior of lipid mixtures.
Article
Polymer Science
Serter Luleburgaz, Gurkan Hizal, Umit Tunca, Hakan Durmaz
Summary: Polyethers have been widely used in polymer chemistry, but their synthesis often requires harsh conditions. In this study, a versatile strategy using chlorodimethylsilane-mediated reductive etherification reaction was introduced to synthesize polyethers under milder conditions. The proposed method allows for the synthesis of high alternating unit polyethers from various diols.
Article
Polymer Science
Burcu Alkan, Ozgun Daglar, Serter Luleburgaz, Begum Gungor, Ufuk Saim Gunay, Gurkan Hizal, Umit Tunca, Hakan Durmaz
Summary: A novel one-pot cascade reaction was proposed for the synthesis and simultaneous modification of polyesters, utilizing the Passerini three-component reaction. The study emphasized the significance of temperature in achieving high molecular weight polymers and efficient reactions.
Article
Chemistry, Multidisciplinary
Gaurav Sinsinbar, Alagappan Palaniappan, Umit Hakan Yildiz, Bo Liedberg
Summary: Poly(3-alkylthiophene) (PT)-based conjugated poly-electrolytes (CPEs) are responsive polymers with excellent optical properties, making them ideal for detection of various analytes. The advancements and future applications of PTs as reporters have been discussed.
Article
Chemistry, Multidisciplinary
Ugur Parlatan, Mehmet Ozgun Ozen, Ibrahim Kecoglu, Batuhan Koyuncu, Hulya Torun, Davod Khalafkhany, Irem Loc, Mehmet Giray Ogut, Fatih Inci, Demir Akin, Ihsan Solaroglu, Nesrin Ozoren, Mehmet Burcin Unlu, Utkan Demirci
Summary: Researchers have developed a method that combines surface-enhanced Raman spectroscopy (SERS) with machine learning algorithms to classify extracellular vesicles (EVs) derived from different cell lines and determine their cellular origins. This machine learning-assisted SERS method allows for label-free investigation of EV preparations and differentiation between cancer cell-derived exosomes and healthy cell-derived exosomes, offering new avenues for early detection and monitoring of diseases.
Article
Chemistry, Multidisciplinary
Ismail Es, Abdullah Kafadenk, M. Burak Gormus, Fatih Inci
Summary: This study explores an isotropic XeF2 dry etching process to fabricate silicon-based solid microneedles (MNs). By modifying the CAD designs, photolithographic process, and etching conditions, the fabrication of dense MNs (up to 1452 MNs cm(-2)) with varying heights (80-300 μm) is achieved. The coated MNs show improved surface roughness and less displacement upon applied force, making them suitable for real-life applications without fracture.
Review
Pharmacology & Pharmacy
Eylul Gulsen Yilmaz, Emre Ece, Ozgecan Erdem, Ismail Es, Fatih Inci
Summary: The skin, as the largest epithelial surface of the human body, is susceptible to various skin diseases. Dermal and transdermal patches or microneedles made of biocompatible and biodegradable materials offer controlled and effective delivery of medications, but their synthetic nature may have harmful environmental effects. This review explores the use of natural materials in eco-friendly patches and discusses their implementation in wound healing, skin cancer, inflammations, and infections, highlighting the importance of these studies for future perspectives.
Review
Chemistry, Analytical
Emre Ece, Nedim Haciosmanoglu, Fatih Inci
Summary: Microplastic pollution is increasing rapidly and causing significant problems for the ecosystem. The impact of microplastics on life and environmental cycles has reached a irreversible point, but global awareness and regulations can help address this issue for human health. Deploying detection and separation methods for different types of microplastics is crucial to reversing their effects. Microfluidics, with its low cost and high efficiency, has immense potential to tackle the challenges of microplastics. This review discusses conventional detection and separation technologies, along with state-of-the-art examples of microfluidic platforms, and provides insights into future directions for microfluidics to eradicate microplastic pollution more efficiently.
Review
Chemistry, Analytical
Yusuf Aslan, Maryam Atabay, Hussain Kawsar Chowdhury, Ilgim Gokturk, Yeseren Saylan, Fatih Inci
Summary: Recent innovations in POC diagnostic technologies have paved the way for improved application of biomedicine in resource-scarce settings. The usage of antibodies as bio-recognition elements is limited due to cost and production obstacles, but aptamers offer a promising alternative. Aptamers, short sequences of DNA and RNA structures, possess advantageous properties that make them critical in the development of sensitive and portable POC systems. The integration of computational tools can help overcome deficiencies in biosensor schematics and provide insights into aptamer modeling for POC integration.
Article
Materials Science, Multidisciplinary
Emre Ece, Ismail Es, Fatih Inci
Summary: Preventing plant loss and improving their health are crucial for the agricultural industry. Microneedles have emerged as a innovative tool with numerous applications in agriculture, offering advantages such as non-invasiveness, speed, and precision. This review highlights recent advancements in the use of microneedles in agriculture, including DNA extraction, gene expression, and compound detection.
Article
Multidisciplinary Sciences
Ozgecan Erdem, Ismail Es, Yeseren Saylan, Maryam Atabay, Murat Alp Gungen, Kadriye Olmez, Adil Denizli, Fatih Inci
Summary: The current synthesis methods for molecularly imprinted polymers face challenges such as lengthy process, low productivity, the need for expensive and sophisticated equipment, and inability for in situ synthesis. In this study, a micro-reactor was developed for in situ and continuous production of molecularly imprinted polymer nanoparticles that contain specific molecular fingerprints. The micro-reactor showed significantly improved productivity compared to conventional methods.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Physical
Mina Askun, Kutay Sagdic, Fauh Inci, Bengi Ozgun Ozturk
Summary: This study demonstrates that encapsulating homogeneous catalysts in hollow silica gels is an efficient approach to improve the performance and recyclability of ruthenium catalysts in ring-closing metathesis reactions. The resulting catalytic system shows enhanced stability even under an air atmosphere and can maintain its activity for up to 6 months of storage time on the benchtop.
CATALYSIS SCIENCE & TECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Zeynep Tunali, Kutay Sagdic, Fatih Inci, Bengi Ozgun Ozturk
Summary: In this study, nano-sized mesoporous carbon-supported HG2 and magnetic gamma-Fe2O3 nanoparticles were encapsulated within calcium alginate gels using a one-pot procedure. The encapsulated HG2 catalyst showed improved performance in water, achieving quantitative yields in ring-closing metathesis reactions even in tap water under an air atmosphere. The catalyst can be easily separated and reused multiple times.
REACTION CHEMISTRY & ENGINEERING
(2022)
