Article
Biophysics
Morteza Azizi, Benyamin Davaji, Ann Nguyen, Amir Mokhtare, Shiying Zhang, Belgin Dogan, Patrick A. Gibney, Kenneth W. Simpson, Alireza Abbaspourrad
Summary: The study introduces a microfluidics platform for efficient and precise biological testing, demonstrating the potential for high-throughput and automated operation.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Biochemistry & Molecular Biology
Beatriz Vieira-da-Silva, Miguel A. R. B. Castanho
Summary: Cell viability and metabolic activity are important parameters in biochemical and biotechnological studies, and resazurin reduction is a commonly used method to assess cell metabolic activity. However, the fundamentals of the resazurin assay and its limitations are not well understood. This work revisits the basics of metabolic activity assays using resazurin and proposes a reliable approach using low concentrations of resazurin for fluorescence ratio assays.
Article
Chemistry, Multidisciplinary
Nailiang Qiu, Chunyan Liu, Haijiao Lang, Jingyang Xu, Rui Su, Jie Jiang, Jiaqi Tian, Jisen Li
Summary: A new small-molecule donor, BTEHR-FT, has been designed and synthesized for the fabrication of all-small-molecule organic solar cells (ASM-OSCs). It exhibits excellent solubility and thermal stability. By introducing fluorine atoms, it achieves a low-lying highest occupied molecular orbital energy level. After thermal annealing treatment, the solar cell shows a significant enhancement in power conversion efficiency.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Biochemical Research Methods
Arkadeep Mukherjee, Young-Ho Ahn
Summary: A refined colorimetric assay using the redox dye resazurin was developed to assess viable microorganisms in water treatment plants. The assay accurately predicted the level of microbial contamination using a mixed bacterial suspension of multi-drug-resistant coliform bacteria isolated from hospital wastewater and a resazurin reduction calibration curve. Combination of ultrasonication and heat disinfection treatments showed a synergistic effect on raw and secondary wastewater effluent. The results of the resazurin microbial viability test were highly comparable with conventional colony plate count, suggesting its appropriateness for quick and reliable wastewater sample microbial viability monitoring.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Review
Materials Science, Multidisciplinary
Bin Kan, Yuanyuan Kan, Lijian Zuo, Xueliang Shi, Ke Gao
Summary: Recent breakthroughs have been made in solution-processed organic solar cells combining small-molecule donor and nonfullerene acceptor, with certified efficiency over 15%. By modifying materials and optimizing morphology, researchers have achieved impressive progress in this area. Small-molecule materials with easily tuned properties will be a key focus for future developments.
Article
Chemistry, Applied
Suha Lee, Hee Su Kim, Hea Jung Park, Ning Yang, Bogyu Lim, Do-Hoon Hwang
Summary: This study synthesized and characterized two small-molecule donors, BDT-IDTT-ORH and BDT-C8IDTT-ORH, based on highly fused indacenodithiophene (IDTT). The different side chains of these molecules led to different crystallinities in the film state. These two synthesized molecules showed absorption in the long wavelength range and demonstrated potential as small-molecule donors in donor:Y6 blend for SM-OSCs. The BDT-C8IDTT-ORH:Y6 blend exhibited the highest power conversion efficiency (PCE) of 6.33% due to its tighter molecular packing compared to the BDT-IDTT-ORH blend.
Article
Biochemistry & Molecular Biology
Kathleen Molyneaux, Christian Laggner, Susann M. Brady-Kalnay
Summary: PTPmu, a member of receptor protein tyrosine phosphatase IIb family, plays a role in cell-cell adhesion and signaling. Proteolytic downregulation of PTPmu in glioblastoma generates fragments that promote cancer cell growth and migration. Using deep learning neural network AtomNet(R), 76 potential compounds were identified to target PTPmu-mediated cell adhesion. Among them, four compounds inhibited Sf9 cell aggregation and six compounds inhibited glioma sphere formation, while two compounds were effective in both assays. One of the compounds demonstrated interaction with PTPmu fragments and presented a promising starting point for developing PTPmu-targeting agents for glioblastoma treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Polymer Science
Ja Eun Lee, Yoon Kim, Yang Ho Na, Nam Seob Baek, Jae Woong Jung, Yura Choi, Namchul Cho, Tae-Dong Kim
Summary: The study synthesized medium-band-gap donor-acceptor (D-A) type conjugated polymers and a small conjugated molecule, and found that the efficiency of inverted solar cell devices using BTZCZ-2 significantly improved, possibly due to high energy transfer and excellent film morphologies.
Review
Chemistry, Multidisciplinary
Wanru Xu, Yilin Chang, Xiangwei Zhu, Zhenhua Wei, Xiaoli Zhang, Xiangnan Sun, Kun Lu, Zhixiang Wei
Summary: Small molecule donor/polymer acceptor (SD/PA)-type organic solar cells (OSCs) have attracted attention for their high efficiency and thermal stability. However, their development lags behind polymer donor/small molecule acceptor (PD/SA)-type OSCs. This review analyzes the key factors affecting the photovoltaic performances of SD/PA-type OSCs and provides insights on their future development.
CHINESE CHEMICAL LETTERS
(2022)
Article
Chemistry, Analytical
Tianyi Qin, Bin Liu, Zhongyong Xu, Guangkai Yao, Hanhong Xu, Chen Zhao
Summary: Flavonols, as important natural botanical functional pigments, exhibit unique environmental-sensitive dual emissions as fluorophore skeleton for probe design. This review summarizes recent progress of flavonol-based fluorescent probes for diverse sensing applications, including detection of anions, cations, proteins, DNA, etc.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Nanoscience & Nanotechnology
Weiya Wang, Jin Wu, Zunquan Zhao, Qiaofeng Li, Bingyang Huo, Xuan Sun, Dianpeng Han, Mingzhu Liu, Ling Chao Cai, Yuan Peng, Jialei Bai, Zhixian Gao
Summary: This article presents a strategy called smSimoa for detecting trace amounts of small molecules. The strategy utilizes an aptamer as a recognition element and a DNA Nanoflower attached to magnetic beads as the output signal. With digital imaging and automated counting analysis, E2 can be measured at the attomolar level.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Physical
Ziqi Zhang, Dan Deng, Yi Li, Jianwei Ding, Qiong Wu, Lili Zhang, Guangjie Zhang, Muhammad Junaid Iqbal, Rui Wang, Jianqi Zhang, Xiaohui Qiu, Zhixiang Wei
Summary: The study introduces a polymerized small-molecule acceptor (PJ1) as an interface modulator to optimize the morphology of all-small-molecule organic solar cells (ASM-OSCs) and improve power conversion efficiency. Adding a small amount of PJ1 effectively condenses the morphology, enhances crystallinity, and decreases domain sizes in ASM-OSCs, ultimately leading to accelerated hole transfer and enhanced charge transport.
ADVANCED ENERGY MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Yan Zheng, Sunan Bao, Hang Yang, Hongyu Fan, Dongdong Fan, Chaohua Cui, Yongfang Li
Summary: IDT units have great potential in designing efficient small-molecule donors.
CHEMICAL COMMUNICATIONS
(2021)
Article
Materials Science, Multidisciplinary
Jing Guo, Ke Hu, Beibei Qiu, Dengchen Yang, Xiaojun Li, Jinyuan Zhang, Lei Meng, Zhanjun Zhang, Yongfang Li
Summary: Reducing energy loss is a crucial challenge in organic photovoltaic cells. In this study, two small-molecule donors with high open-circuit voltage and high mobility were synthesized by introducing a BTz pi-bridge unit and terminal regulation. The organic solar cells based on one of the donors achieved a high power conversion efficiency, indicating the potential of the BTz pi-bridge unit in improving mobility and reducing energy loss.
SCIENCE CHINA-MATERIALS
(2022)
Article
Chemistry, Analytical
Alen Albreht, Humma Hussain, Beatriz Jimenez, Ada H. Y. Yuen, Luke Whiley, Matthias Witt, Matthew R. Lewis, Elena Chekmeneva
Summary: Liquid chromatography-mass spectrometry (LC-MS) is widely used in metabolomics to analyze complex biological samples. However, interference signals are often observed in LC-MS metabolic profiles. In this study, two interfering metabolites, L,L-TMAP and L,L-DMPP, were identified and their chemical and spectroscopic characteristics were analyzed. Proposed strategies to mitigate interference effects include modifying column temperature and pH, as well as sample dilution and internal standardization methods.
ANALYTICAL CHEMISTRY
(2022)