Article
Biochemistry & Molecular Biology
Maria S. Hadjiagapiou, George Krashias, Christina Christodoulou, Marios Pantzaris, Anastasia Lambrianides
Summary: Synaptic dysfunction and disrupted communication between neuronal and glial cells are essential in the mechanisms of multiple sclerosis. Antibodies to the NR2 subunit of NMDAR were detected in MS patients and were correlated with clinical outcome. Furthermore, there may be a link between NR2 reactivity and anti-coagulant antibody levels in MS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Jilun Feng, Mu Yang, Dingge Cui, Zhi Huang, Tuo Ji, Yajun Lian
Summary: This study aimed to investigate the factors influencing or predicting the probability of recurrence of anti-NMDAR encephalitis in central China. The results showed that brainstem lesions and ≥3 abnormal sites on brain MRI were significantly associated with an increased risk of recurrence.
FRONTIERS IN NEUROLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lucas Rischka, Chrysoula Vraka, Verena Pichler, Sazan Rasul, Lukas Nics, Gregor Gryglewski, Patricia Handschuh, Matej Murgas, Godber M. Godbersen, Leo R. Silberbauer, Jakob Unterholzner, Christoph Wotawa, Ahmed Haider, Hazem Ahmed, Roger Schibli, Thomas Mindt, Markus Mitterhauser, Wolfgang Wadsak, Andreas Hahn, Rupert Lanzenberger, Marcus Hacker, Simon M. Ametamey
Summary: This study reports on the performance characteristics of (R)-C-11-Me-NB1, a radioligand used to map GluN2B-enriched NMDARs in the human brain. The radioligand demonstrated high and heterogeneous uptake and a high test-retest reliability. It shows promise in deepening our understanding of the role of GluN2B-containing NMDARs in neurodegenerative and neuropsychiatric diseases such Alzheimer's disease and major depression.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Review
Chemistry, Medicinal
Amany Digal Ladagu, Funmilayo Eniola Olopade, Adeboye Adejare, James Olukayode Olopade
Summary: N-methyl-D-aspartate receptors (NMDARs) play a crucial role in the central nervous system, affecting functions such as learning, memory, and neurodegenerative diseases. Understanding their role is important for the development of neuroprotective drugs.
Review
Neurosciences
Taylor M. Benske, Ting-Wei Mu, Ya-Juan Wang
Summary: NMDARs are crucial for synaptic development and plasticity in the mammalian CNS. Proper folding and assembly of the receptors, as well as their trafficking to the plasma membrane, are ensured by protein quality control mechanisms.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Biology
Eui-Ho Park, Nam-Soo Kim, Yeon-Kyung Lee, June-Seek Choi
Summary: Accumulating evidence suggests that the medial prefrontal cortex (mPFC) plays a crucial role in the acquisition of fear memory during trace fear conditioning. Specifically, the prelimbic (PL) subregion within the mPFC is involved in short- and long-term trace fear memory formation. Furthermore, NMDA receptor-mediated neurotransmission in PL is required for the acquisition of trace fear memory.
Article
Biochemistry & Molecular Biology
Shinhui Lee, Sanung Eom, Khoa V. A. Nguyen, Jiwon Lee, Youngseo Park, Hye Duck Yeom, Junho H. Lee
Summary: The study found that ergotamine effectively inhibits the NR1a/NR2A subunit of NMDAR, preventing excessive Ca2+ influx and neuronal death.
Article
Pharmacology & Pharmacy
Jan Voldrich, Marika Matousova, Marketa Smidkova, Barbora Slavikova, Hana Chodounska, Eva Kudova, Helena Mertlikova-Kaiserova
Summary: The goal of this study was to evaluate the efficacy of mixed cortical and hippocampal primary rat postnatal neuronal culture for identifying NMDAR antagonists. The authors found that this model is comparable to other commonly used primary rat neuronal models and is a convenient and robust tool for NMDAR antagonist screening.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ying Chen, Wenqing Xu, Yuan Yuan, Houyang Chen, Shuangyan Zheng, Yuanqiao He, Tao Luo
Summary: The study found that the N-methyl-D-aspartic acid receptor may be involved in the inhibitory effect of ketamine on human sperm function, while NMDA can reverse the inhibitory effect of ketamine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Xiaoyu Ma, Chen Chen, Yaxin Lu, Ling Fang, Baohua Cao, Xueqiang Hu, Wei Qiu, Yaqing Shu
Summary: This study found that serum levels of GSDMD are elevated in patients with anti-NMDAR encephalitis and are associated with disease prognosis. After treatment, GSDMD levels decreased and clinical symptoms improved in patients, indicating a potential role of GSDMD in monitoring and predicting disease progression of anti-NMDAR encephalitis.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Medicine, Research & Experimental
Xiao-Ting Huang, Jun-Xiao Yang, Zun Wang, Chen-Yu Zhang, Zi-Qiang Luo, Wei Liu, Si-Yuan Tang
Summary: The study highlights the role of the glutamate/NMDAR axis in obesity-related metabolic syndrome, with evidence showing that targeting NMDAR can be a promising therapeutic strategy. In obese mice, increased glutamate levels and blockade of NMDAR by Memantine improved insulin sensitivity and reduced hepatic steatosis, while NMDA treatment induced obesity and metabolic disorders. In vitro studies demonstrated that NMDAR activation promoted lipid accumulation and impaired fatty acid oxidation through PPARa signaling, suggesting a potential mechanism for NMDAR-mediated metabolic syndrome in obesity.
Review
Immunology
Fanshi Zhang, Mei Liu, Jinmei Tuo, Li Zhang, Jun Zhang, Changyin Yu, Zucai Xu
Summary: This article reviews how neuroinflammation mediates the development of levodopa-induced dyskinesia (LID) through the regulation of NMDA receptors. It also evaluates the potential of common anti-inflammatory drugs and NMDA receptor antagonists to mitigate the development of LID by regulating central neuroinflammation, providing a new theoretical basis for finding new therapeutic targets for LID.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Giovanna Casili, Marika Lanza, Alessia Filippone, Laura Cucinotta, Irene Paterniti, Alberto Repici, Anna Paola Capra, Salvatore Cuzzocrea, Emanuela Esposito, Michela Campolo
Summary: Recent research has found that the non-opioid drug DMF has therapeutic effects on post-operative pain. This is achieved by modulating NMDA receptors and inflammatory pathways, reducing pain and neuroinflammation.
Review
Neurosciences
Bin Dong, Yang Yue, Han Dong, Yuehui Wang
Summary: NMDA receptors play a critical role in synaptic transmission and plasticity, and abnormalities in their expression and function can result in neurological disorders. NMDAR hypofunction is widely implicated in several disorders and is associated with disease progression and manifestation. Targeting NMDAR hypofunction could be a promising therapeutic approach.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Clinical Neurology
Yingzhe Shao, Juan Du, Yajun Song, Yanfei Li, Lijun Jing, Zhe Gong, Ranran Duan, Yaobing Yao, Yanjie Jia, Shujie Jiao
Summary: This study aimed to explore the difference in coagulation function between healthy individuals and patients with anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis and its relationship with disease severity. The results showed that serum D-dimer and neutrophil levels were independent predictors of disease severity in patients with first-attack anti-NMDAR encephalitis.
FRONTIERS IN NEUROLOGY
(2022)