Advances in phage display technology for drug discovery

An Improved Single-Chain Fab Platform for Efficient Display and Recombinant Expression

(2015) James T. Koerber et al.   JOURNAL OF MOLECULAR BIOLOGY

Molecular basis for antagonistic activity of anifrolumab, an anti-interferon–α receptor 1 antibody

(2015) Li Peng et al.   mAbs

Subunit disassembly and inhibition of TNFα by a semi-synthetic bicyclic peptide

(2015) Stefan Luzi et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Epitope mapping via selection of anti-FVIII antibody-specific phagepresented peptide ligands that mimic the antibody binding sites

(2015) Joerg Kahle et al.   THROMBOSIS AND HAEMOSTASIS

DNA-Encoded Chemical Libraries: Advancing beyond Conventional Small-Molecule Libraries

(2014) Raphael M. Franzini et al.   ACCOUNTS OF CHEMICAL RESEARCH

A phase 1 study investigating DX-2930 in healthy subjects

(2014) Yung Chyung et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

Phage display discovery of novel molecular targets in glioblastoma-initiating cells

(2014) J K Liu et al.   CELL DEATH AND DIFFERENTIATION

Generation and characterization of nanobodies targeting PSMA for molecular imaging of prostate cancer

(2014) Mehdi Evazalipour et al.   Contrast Media & Molecular Imaging

Inhibition of Plasma Kallikrein by a Highly Specific Active Site Blocking Antibody

(2014) Jon A. Kenniston et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

First-in-Human Molecular Imaging of HER2 Expression in Breast Cancer Metastases Using the 111In-ABY-025 Affibody Molecule

(2014) J. Sorensen et al.   JOURNAL OF NUCLEAR MEDICINE

Ramucirumab plus paclitaxel versus placebo plus paclitaxel in patients with previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (RAINBOW): a double-blind, randomised phase 3 trial

(2014) Hansjochen Wilke et al.   LANCET ONCOLOGY

An electrochemical immunosensor for digoxin using core–shell gold coated magnetic nanoparticles as labels

(2014) Anita Ahmadi et al.   MOLECULAR BIOLOGY REPORTS

Phase I Study of GC1008 (Fresolimumab): A Human Anti-Transforming Growth Factor-Beta (TGFβ) Monoclonal Antibody in Patients with Advanced Malignant Melanoma or Renal Cell Carcinoma

(2014) John C. Morris et al.   PLoS One

A systematic approach to identify novel cancer drug targets using machine learning, inhibitor design and high-throughput screening

(2014) Jouhyun Jeon et al.   Genome Medicine

Bacteria Screening, Viability, And Confirmation Assays Using Bacteriophage-Impedimetric/Loop-Mediated Isothermal Amplification Dual-Response Biosensors

(2013) Chaker Tlili et al.   ANALYTICAL CHEMISTRY

New analytical applications of gold nanoparticles as label in antibody based sensors

(2013) Kobra Omidfar et al.   BIOSENSORS & BIOELECTRONICS

Phage display and molecular imaging: expanding fields of vision in living subjects

(2013) Frank V. Cochran et al.   Biotechnology & Genetic Engineering Reviews

Phage display as a technology delivering on the promise of peptide drug discovery

(2013) Maryam Hamzeh-Mivehroud et al.   DRUG DISCOVERY TODAY

Nanoscale bacteriophage biosensors beyond phage display

(2013) Kwan Hyi Lee et al.   International Journal of Nanomedicine

Novel phage display-derived neuroblastoma-targeting peptides potentiate the effect of drug nanocarriers in preclinical settings

(2013) Monica Loi et al.   JOURNAL OF CONTROLLED RELEASE

Drugs derived from phage display

(2013) Andrew E Nixon et al.   mAbs

Efficient growth inhibition of EGFR over-expressing tumor cells by an anti-EGFR nanobody

(2013) Kobra Omidfar et al.   MOLECULAR BIOLOGY REPORTS

Recent Advances in Bacteriophage Based Biosensors for Food-Borne Pathogen Detection

(2013) Amit Singh et al.   SENSORS

Novel Antiplatelet Agents: ALX-0081, a Nanobody Directed towards von Willebrand Factor

(2013) Jozef Bartunek et al.   Journal of Cardiovascular Translational Research

Development of Anti-Infectives Using Phage Display: Biological Agents against Bacteria, Viruses, and Parasites

(2012) Johnny X. Huang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

An efficient strategy for cell-based antibody library selection using an integrated vector system

(2012) Hyerim Yoon et al.   BMC BIOTECHNOLOGY

Single Domain Antibodies: A New Concept for Epidermal Growth Factor Receptor and EGFRvIII Targeting

(2012) Kobra Omidfar et al.   DNA AND CELL BIOLOGY

Phage Display-based Strategies for Cloning and Optimization of Monoclonal Antibodies Directed against Human Pathogens

(2012) Nicola Clementi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Antibody Phage Display Libraries: Contributions to Oncology

(2012) Carmela Dantas-Barbosa et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Phase I Trial of Anti-CD22 Recombinant Immunotoxin Moxetumomab Pasudotox (CAT-8015 or HA22) in Patients With Hairy Cell Leukemia

(2012) Robert J. Kreitman et al.   JOURNAL OF CLINICAL ONCOLOGY

A Phase I/II Study of Erlotinib in Combination with the Anti-Insulin-Like Growth Factor-1 Receptor Monoclonal Antibody IMC-A12 (Cixutumumab) in Patients with Advanced Non-small Cell Lung Cancer

(2012) Andrew Weickhardt et al.   Journal of Thoracic Oncology

Peptibodies: A flexible alternative format to antibodies

(2012) Grant Shimamoto et al.   mAbs

Development of an enhanced chemiluminescence immunoassay (CLIA) for detecting urinary albumin

(2012) Elham Sadat Aghaei Meibodi et al.   MOLECULAR BIOLOGY REPORTS

The use of phage display to generate conformation-sensor recombinant antibodies

(2012) Aftabul Haque et al.   Nature Protocols

A Safety Review and Meta-Analyses of Bevacizumab and Ranibizumab: Off-Label versus Goldstandard

(2012) Christine Schmucker et al.   PLoS One

A high-sensitivity electrochemical immunosensor based on mobile crystalline material-41–polyvinyl alcohol nanocomposite and colloidal gold nanoparticles

(2011) Kobra Omidfar et al.   ANALYTICAL BIOCHEMISTRY

Development of urinary albumin immunosensor based on colloidal AuNP and PVA

(2011) Kobra Omidfar et al.   BIOSENSORS & BIOELECTRONICS

Modified phages: Novel antimicrobial agents to combat infectious diseases

(2011) Zahra Moradpour et al.   BIOTECHNOLOGY ADVANCES

Antithrombotic drug candidate ALX-0081 shows superior preclinical efficacy and safety compared with currently marketed antiplatelet drugs

(2011) H. Ulrichts et al.   BLOOD

Necitumumab in the treatment of advanced non-small cell lung cancer: translation from preclinical to clinical development

(2011) Rodrigo Dienstmann et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Cyclotides: a patent review

(2011) Amanda B Smith et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Development of a Colloidal Gold-based Immunochromatographic Test Strip for Screening of Microalbuminuria

(2011) Kobra Omidfar et al.   HYBRIDOMA

Development of Antidrug Antibodies Against Adalimumab and Association With Disease Activity and Treatment Failure During Long-term Follow-up

(2011) Geertje M. Bartelds   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

PET with the 89Zr-Labeled Transforming Growth Factor-  Antibody Fresolimumab in Tumor Models

(2011) T. H. Oude Munnink et al.   JOURNAL OF NUCLEAR MEDICINE

Recent advances in bacteriophage therapy: how delivery routes, formulation, concentration and timing influence the success of phage therapy

(2011) Elizabeth M. Ryan et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Isolation and characterisation of Ebolavirus-specific recombinant antibody fragments from murine and shark immune libraries

(2011) Sarah A. Goodchild et al.   MOLECULAR IMMUNOLOGY

Phage Display for the Generation of Antibodies for Proteome Research, Diagnostics and Therapy

(2011) Thomas Schirrmann et al.   MOLECULES

High Affinity, Developability and Functional Size: The Holy Grail of Combinatorial Antibody Library Generation

(2011) Dirk Ponsel et al.   MOLECULES

Peptide Phage Display as a Tool for Drug Discovery: Targeting Membrane Receptors

(2011) Peter Molek et al.   MOLECULES

Diversity of Phage-Displayed Libraries of Peptides during Panning and Amplification

(2011) Ratmir Derda et al.   MOLECULES

Rise and Fall of an Anti-MUC1 Specific Antibody

(2011) Holger Thie et al.   PLoS One

Phage display: Concept, innovations, applications and future

(2010) Jyoti Pande et al.   BIOTECHNOLOGY ADVANCES

A Phase 1b/2 trial of mapatumumab in patients with relapsed/refractory non-Hodgkin's lymphoma

(2010) A Younes et al.   BRITISH JOURNAL OF CANCER

Phase II trial of mapatumumab, a fully human agonistic monoclonal antibody that targets and activates the tumour necrosis factor apoptosis-inducing ligand receptor-1 (TRAIL-R1), in patients with refractory colorectal cancer

(2010) T Trarbach et al.   BRITISH JOURNAL OF CANCER

Phage Display in Molecular Imaging and Diagnosis of Cancer

(2010) Susan L. Deutscher   CHEMICAL REVIEWS

Peptides and Peptide Hormones for Molecular Imaging and Disease Diagnosis

(2010) Seulki Lee et al.   CHEMICAL REVIEWS

A Phase I Pharmacologic Study of Necitumumab (IMC-11F8), a Fully Human IgG1 Monoclonal Antibody Directed Against EGFR in Patients with Advanced Solid Malignancies

(2010) B. Kuenen et al.   CLINICAL CANCER RESEARCH

Peptidic Tumor Targeting Agents: The Road from Phage Display Peptide Selections to Clinical Applications

(2010) Kathlynn Brown   CURRENT PHARMACEUTICAL DESIGN

Affibody molecules: Engineered proteins for therapeutic, diagnostic and biotechnological applications

(2010) J. Löfblom et al.   FEBS LETTERS

A human scFv antibody generation pipeline for proteome research

(2010) Michael Hust et al.   JOURNAL OF BIOTECHNOLOGY

Phase I Pharmacologic and Biologic Study of Ramucirumab (IMC-1121B), a Fully Human Immunoglobulin G1Monoclonal Antibody Targeting the Vascular Endothelial Growth Factor Receptor-2

(2010) Jennifer L. Spratlin et al.   JOURNAL OF CLINICAL ONCOLOGY

Targeting of HER2-Expressing Tumors Using 111In-ABY-025, a Second-Generation Affibody Molecule with a Fundamentally Reengineered Scaffold

(2010) S. Ahlgren et al.   JOURNAL OF NUCLEAR MEDICINE

Raxibacumab

(2010) Sohini Mazumdar   mAbs

Identification of Ligand-Selective Peptide Antagonists of the Mineralocorticoid Receptor Using Phage Display

(2010) Jun Yang et al.   MOLECULAR ENDOCRINOLOGY

Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo

(2010) Nathalia Holt et al.   NATURE BIOTECHNOLOGY

Development trends for human monoclonal antibody therapeutics

(2010) Aaron L. Nelson et al.   NATURE REVIEWS DRUG DISCOVERY

Combining phage and staphylococcal surface display for generation of ErbB3-specific Affibody molecules

(2010) N. Kronqvist et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Colloidal Nanogold-Based Immunochromatographic Strip Test for the Detection of Digoxin Toxicity

(2009) Kobra Omidfar et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

A phase II, randomized, double-blind, placebo-controlled, dose-ranging study of belimumab in patients with active systemic lupus erythematosus

(2009) Daniel J. Wallace et al.   ARTHRITIS AND RHEUMATISM

Engineered affinity proteins for tumour-targeting applications

(2009) Mikaela Friedman et al.   BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY

Isolation of a human-like antibody fragment (scFv) that neutralizes ricin biological activity

(2009) Thibaut Pelat et al.   BMC BIOTECHNOLOGY

Progress in phage display: evolution of the technique and its applications

(2009) Tomaž Bratkovič   CELLULAR AND MOLECULAR LIFE SCIENCES

Engineered protein scaffolds as next-generation antibody therapeutics

(2009) Michaela Gebauer et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Engineered Zinc Finger Protein-Mediated VEGF-A Activation Restores Deficient VEGF-A in Sensory Neurons in Experimental Diabetes

(2009) E. J. Pawson et al.   DIABETES

A polysialic acid mimetic peptide promotes functional recovery in a mouse model of spinal cord injury

(2009) Philippe Marino et al.   EXPERIMENTAL NEUROLOGY

Therapeutic peptides for cancer therapy. Part II – cell cycle inhibitory peptides and apoptosis-inducing peptides

(2009) Drazen Raucher et al.   Expert Opinion on Drug Delivery

Therapeutic peptides for cancer therapy. Part I – peptide inhibitors of signal transduction cascades

(2009) Gene L Bidwell et al.   Expert Opinion on Drug Delivery

Cixutumumab

(2009) Kevin P McKian et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Expression of EGFRvIII in Thyroid Carcinoma: Immunohistochemical Study by Camel Antibodies

(2009) Kobra Omidfar et al.   IMMUNOLOGICAL INVESTIGATIONS

Mapatumumab and lexatumumab induce apoptosis in TRAIL-R1 and TRAIL-R2 antibody-resistant NSCLC cell lines when treated in combination with bortezomib

(2009) T. A. Luster et al.   MOLECULAR CANCER THERAPEUTICS

Efficient one-cycle affinity selection of binding proteins or peptides specific for a small-molecule using a T7 phage display pool

(2008) Yoichi Takakusagi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Phage Display Derived Therapeutic Antibodies

(2008) Holger Thie et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY