Article
Engineering, Chemical
Qiang Yan, Yimin Cai, Zhipeng Wang, Xue Dong, Lihua Yuan, Wen Feng, Jing Chen, Chao Xu
Summary: A novel task-specific ionic liquid was synthesized via click chemistry and its performance in the selective separation of trivalent americium from lanthanide was studied. The results showed that the ionic liquid exhibited stronger extractability to Am(III) over Eu(III) and a cation exchange mechanism was proposed. This study provides valuable insights into the coordination chemistry of f-elements in ionic liquids and the potential of task-specific ionic liquids in actinide/lanthanide separation.
SEPARATION AND PURIFICATION TECHNOLOGY
(2022)
Article
Chemistry, Applied
Firuz A. Philip, Amr Henni
Summary: In this study, two task specific ionic liquids (TSILs) were encapsulated into Zeolite imidazolate framework-8 (ZIF-8) to enhance its CO2 capture capacity and CO2/N-2 selectivity at post-combustion conditions. The TSIL@ZIF-8 composite sorbents showed significantly higher CO2 uptake and selectivity compared to ZIF-8. These composites have the potential to be used in post-combustion CO2 capture processes.
MICROPOROUS AND MESOPOROUS MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Masauso Moses Phiri, Elmarie Davoren, Barend Christiaan Vorster
Summary: The aim of this study was to improve the extraction method for urinary organic acids by miniaturizing and automating the process. The evaluated miniaturized method was translated into an automated extraction procedure on a MicroLab (ML) Star (Hamilton Technologies) liquid handler. The automated extraction method provided comparable or even superior results compared to the current in-house method, with the potential to reduce solvent volumes used during extraction, increase sample throughput, and minimize variability and random errors in routine diagnostic settings.
Article
Chemistry, Physical
Zhang Zhang, Fang Yong, Lei Zhang, Hao Chen, Wen-Li Yuan, Dingguo Xu, Yi-Hong Shen, Xiao-Hua Wang, Ling He, Guo-Hong Tao
Summary: Designing functionalized task-specific ionic liquid is a promising way to alleviate potential second pollution in the PUREX process. The newly synthesized anion-functionalized ionic liquid shows high efficiency and selectivity in uranium extraction.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Engineering, Environmental
Xinyi Wan, Ting Wan, Chaochao Cao, Chengchun Tang, Yanming Xue, Youguo Yan, Zhen Li, Zhizhen Ye, Xinsheng Peng
Summary: A novel BN nanosheets supported magnetic ionic liquid membrane (BN-SMILM) with nanoconfined magnetic ionic liquid (MIL) in 2D nanochannels of BN membrane is developed for efficient CO2 separation. The nanoconfinement effect enhances CO2 transport, resulting in high selectivity and permeability above the Robeson upper-bound, and promising applications in CO2 separation with excellent long-term stability. This work provides a new strategy for preparing high-performance supported liquid membrane materials for practical environmental and energy applications.
CHEMICAL ENGINEERING JOURNAL
(2021)
Review
Chemistry, Applied
Alok Rout
Summary: This article summarizes the methods and suitability of using IL-based solvents for Pu(IV) solvent extraction from a nitric acid medium. Ionic liquids have high solvating capability, selectivity, and radiation stability, and selective separation of a target metal ion from other metal ions can be achieved by designing the cation-anion combination of the ionic liquid.
SEPARATION AND PURIFICATION REVIEWS
(2023)
Article
Materials Science, Multidisciplinary
Xinyi Wan, Xiao Wang, Ting Wan, Youguo Yan, Zhizhen Ye, Xinsheng Peng
Summary: Inspired by the function of AQP1 in biological membranes for gas selectivity, a thin graphene oxide/magnetic ionic liquid membrane (GO/MILM) was developed for efficient CO2 separation, exhibiting superior performance compared to most reported membranes. The membrane shows fast permeance, high selectivity, and stability, with potential applications in industrial CO2 separation.
APPLIED MATERIALS TODAY
(2021)
Article
Chemistry, Analytical
Miranda N. Emaus, Jared L. Anderson
Summary: The study investigated three hydrophobic magnetic ionic liquids (MILs) as EXPAR additives and miRNA extraction solvents. The addition of MIL to the EXPAR buffer decreased non-specific amplification background signal and increased reaction rate. Reactions containing MIL could detect miRNA at concentration levels down to 10 aM.
ANALYTICA CHIMICA ACTA
(2021)
Article
Chemistry, Analytical
Xiangdong Ding, Chao Liu, Wei Yu, Zhongling Liu
Summary: A green, efficient and easy method combining magnetic ionic liquid-based liquid-liquid microextraction (MIL-based LLME) with ultraperformance liquid chromatography coupled with triple-quadrupole tandem mass spectrometry (UPLC-QqQ/ MS2) was developed for simultaneous determination of neurotransmitters (NTs) in biosamples. The selected magnetic ionic liquid [P6,6,6,14]2[CoCl4] showed advantages of visual recognition, paramagnetic behavior and higher extraction efficiency. The proposed method achieved facile magnetic separation of MIL containing analytes from matrix and successfully extracted and determined 20 NTs in human cerebrospinal fluid and plasma samples. The excellent analytical performance suggests the broad potential of this method for clinical diagnosis and therapy of neurological diseases.
Article
Engineering, Environmental
Yubin Wang, Chencan Du, Zhifei Yan, Wuhua Duan, Jian Deng, Guangsheng Luo
Summary: In this study, a miniaturized annular centrifugal device (MACD) was developed based on microscale effect and centrifugal force. Through detailed investigations, it was found that a very fast phase separation can be achieved, extraction efficiency and volume mass transfer coefficient were significantly improved. Moreover, dimensionless correlations were obtained to predict the maximum throughput of the single-phase and the volume mass transfer coefficient.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Analytical
Lamia Boulafrouh, Stephanie Boudesocque, Aminou Mohamadou, Laurent Dupont
Summary: Synthesis of a series of salts based on ethyl ester glycine-betaine derivatives and their characterization using spectroscopic methods. These salts can be used for the selective separation of Ni(II) and Co(II) in saline media. Different conditions were evaluated for the separation.
Article
Biochemistry & Molecular Biology
Hiroshi Kuroki, Hirotaka Koyama, Makoto Tsunoda
Summary: In this study, we have improved the automatic sample injection system for pillar array columns by substituting the autosampler with a syringe pump. This change has overcome the problem of sample dilution during injection, leading to increased analytical reproducibility. The improved system decreased the relative standard deviation (RSD) of peak height to the range 1.2-1.8%, and good reproducibility was confirmed through the evaluation using five types of amino acids. The developed sample injection method can be applied as a simple quantitative analysis method for biological sample analyses using pillar array columns.
Article
Chemistry, Physical
Liwei Sun, Shaokun Tang
Summary: This paper successfully synthesized a task-specific ionic liquid with high thermal stability, grafted it onto mesoporous alumina, and applied it for the chemical fixation of CO2. The catalyst showed good reusability and high yield in the cycloaddition reaction, forming 4-(chloromethyl)-1,3-dioxolan-2-one.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Biochemical Research Methods
Manlin Li, Hanxue Wang, Xiaohan Huan, Ning Cao, Huida Guan, Hongmei Zhang, Xuemei Cheng, Changhong Wang
Summary: The study aimed to improve analyte coverage by evaluating six protocols for sample pretreatment methods, with SALLE producing broader analyte coverage with satisfactory reproducibility, acceptable recovery, and low matrix interference. The developed SALLE method showed good sensitivity, linearity, precision, accuracy, and stability, making it suitable for pharmacokinetic studies of herbal medicines.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Janne J. Wiedmann, Yelda N. Demirdoegen, Stefan Schmidt, Mariia A. Kuzina, Yanchen Wu, Fei Wang, Britta Nestler, Carsten Hopf, Pavel A. Levkin
Summary: In the current drug discovery process, the synthesis of compound libraries is separated from biological screenings due to the challenge of high-throughput purification. This study demonstrates a miniaturized high-throughput liquid-liquid extraction method on a chip, with efficiency comparable to large-scale extraction. The new purification method adds an important tool to accelerate drug discovery by combining chemical combinatorial synthesis with biological screenings on a miniaturized microarray platform.
Review
Chemistry, Analytical
Maria J. Trujillo-Rodriguez, Maria Rosende, Manuel Miro
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2020)
Article
Environmental Sciences
Maria J. Trujillo-Rodriguez, Rosa M. Gomila, Gabriel Martorell, Manuel Miro
Summary: The unified bioaccessibility method (UBM) was utilized to assess the in vitro oral bioaccessibility pools of plastic compounds in contaminated beach sand, with DLLME method chosen for efficient extraction. The majority of compounds were found to be released mainly in gastric fluids, with potential risks for human health.
ENVIRONMENTAL POLLUTION
(2021)
Article
Chemistry, Multidisciplinary
Kevin D. Clark, Colin Lee, Rhanor Gillette, Jonathan Sweedler
Summary: The study suggests that subtle changes in post-transcriptional modifications may regulate central nervous system plasticity and activity-induced protein synthesis. Using mass spectrometry, researchers found unique RNA modification patterns in neurons during learning processes, with two tRNA modifications showing significantly higher levels in trained animals. This indicates a link between noncoding RNA modifications and non-associative learning.
ACS CENTRAL SCIENCE
(2021)
Article
Chemistry, Analytical
Kevin D. Clark, Stanislav S. Rubakhin, Jonathan Sweedler
Summary: SNRMA-MS is the first analytical approach capable of simultaneously quantifying numerous RNA modifications in single neurons and revealing cell-specific modification profiles.
ANALYTICAL CHEMISTRY
(2021)
Article
Environmental Sciences
Javier Lopez-Vazquez, Rosario Rodil, Maria J. Trujillo-Rodriguez, Jose Benito Quintana, Rafael Cela, Manuel Miro
Summary: Little effort has been made to study the impact of chemical additives in microplastics on human health. This study investigated the oral bioaccessibility of plastic additives and monomers in low-density polyethylene (LDPE) and polyvinyl chloride (PVC) microplastics using standardized bioaccessibility tests. It was found that the gastric and gastrointestinal bioaccessibility of certain additives and monomers was highest under fed-state gastrointestinal extraction conditions.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Genetics & Heredity
Madeline E. Melzer, Jonathan Sweedler, Kevin D. Clark
Summary: The reversible and substoichiometric modification of RNA has been recognized as an additional layer of translational regulation. A nuclease protection assay coupled with MALDI-MS was developed to rapidly characterize the modification stoichiometry of consensus motifs, providing a promising approach for studying RNA modifications.
Article
Multidisciplinary Sciences
Kevin D. Clark, Stanislav S. Rubakhin, Jonathan Sweedler
Summary: Post-transcriptional modifications (PTMs) of RNA play a role in regulating translation in the central nervous system (CNS). A protocol called single-neuron RNA modification analysis by mass spectrometry (SNRMA-MS) is described, which can detect and quantify multiple RNA modifications in individual neurons. This method has been validated in A. californica, and has revealed the diverse RNA modification patterns in identified neurons.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2022)
Review
Biochemical Research Methods
Raul Gonzalez-Martin, Eduardo Lodoso-Ruiz, Maria J. Trujillo-Rodriguez, Veronica Pino
Summary: Magnetic ionic liquids (MILs) are materials with unique properties and magnetism that can be manipulated with an external magnetic field. This tutorial review fills the gap in providing details and tips for the experimental setup of MILs in analytical microextraction, and discusses their proper handling and hyphenation with analytical techniques.
JOURNAL OF CHROMATOGRAPHY A
(2022)
Article
Chemistry, Analytical
Victor Vallez-Gomis, Maria J. Trujillo-Rodriguez, Juan L. Benede, Jorge Pasan, Veronica Pino, Alberto Chisvert
Summary: An analytical method combining stir bar sorptive dispersive microextraction (SBSDME) and liquid chromatography coupled to tandem mass spectrometry detection (LC-MS/MS) was developed for the determination of twelve endocrine disrupting compounds (EDCs) in urine samples. The PCN-250(Fe2Mn) metal-organic framework (MOF) was used as the sorbent, with cobalt ferrite (CoFe2O4) magnetic nanoparticles for magnetic retrieval. The method showed good validation parameters and successfully applied to human urine samples.
MICROCHEMICAL JOURNAL
(2023)
Article
Biochemical Research Methods
Arya Patel, Kevin D. Clark
Summary: Post-transcriptional modifications to RNA play a crucial role in regulating translation in the CNS. Analytical methods such as RNA sequencing and LC-MS/MS have provided insights into the landscape of RNA modifications in bulk CNS tissues. However, recent advancements in techniques for single-cell and subcellular detection have revealed heterogeneity in RNA modification profiles, raising questions about cell-specific distributions and functions of modified nucleosides in the brain.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Diego W. Allgaier-Diaz, Maria J. Trujillo-Rodriguez, Juan H. Ayala, David Diaz Diaz, Veronica Pino
Summary: This study proposed a strategy using unmodified biopolymers as sorbents in dispersive micro-solid-phase extraction (mu-dSPE) for sample preparation. After optimization and validation, the method showed high extraction efficiency and analytical performance for the determination of polycyclic aromatic hydrocarbons (PAHs) in environmental waters and the monitoring of personal care products (PCPs).
MICROCHEMICAL JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Raul Gonzalez-Martin, Francisca A. e Silva, Maria J. Trujillo-Rodriguez, David Diaz Diaz, Jacob Lorenzo-Morales, Mara G. Freire, Veronica Pino
Summary: This study proposes the use of aqueous biphasic systems as a tool for clean-up, microextraction, and preconcentration of biomarkers in saliva. This innovative approach improves the analysis of saliva in terms of simplicity and environmental friendliness.
Article
Physics, Atomic, Molecular & Chemical
Max D. Sharin, Gabriella M. Floro, Kevin D. Clark
Summary: Electrospray ionization (ESI) and matrix-assisted laser desorption ionization (MALDI) have revolutionized nucleic acid analysis by mass spectrometry. However, complex biological samples and large nucleic acids pose challenges for these techniques. Over the past two decades, innovations in sample preparation methods have been vital in overcoming these challenges and advancing high-throughput, sensitive, and broadly applicable MS methods for nucleic acid analysis.
INTERNATIONAL JOURNAL OF MASS SPECTROMETRY
(2023)
Article
Chemistry, Analytical
Kevin D. Clark
Summary: This article discusses the challenges and opportunities in the field of RNA modifications, with a focus on advancements in sample preparation and microextraction methods. These techniques enable the analysis of RNA modifications in single cells, providing new insights into their function in the brain and biological systems.
LC GC NORTH AMERICA
(2022)
Article
Chemistry, Analytical
Alexandra Sixto, Bilal El-Morabit, Maria Jose Trujillo-Rodriguez, Enrique Javier Carrasco-Correa, Manuel Miro
Summary: This study investigated the leaching rates of plastic-borne contaminants in the human gastrointestinal tract using physiologically relevant body fluids for the first time. The results showed that different contaminants were released from high-density polyethylene pellets at slightly different apparent leaching rates under various conditions, but there were no significant differences in oral bioaccessibility pools.
