Strategy for selecting nanotechnology carriers to overcome immunological and hematological toxicities challenging clinical translation of nucleic acid-based therapeutics
Published 2015 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Strategy for selecting nanotechnology carriers to overcome immunological and hematological toxicities challenging clinical translation of nucleic acid-based therapeutics
Authors
Keywords
-
Journal
Expert Opinion on Drug Delivery
Volume 12, Issue 7, Pages 1163-1175
Publisher
Informa Healthcare
Online
2015-05-21
DOI
10.1517/17425247.2015.1042857
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Nanotechnological carriers for cancer chemotherapy: The state of the art
- (2015) Marilene Estanqueiro et al. COLLOIDS AND SURFACES B-BIOINTERFACES
- Preclinical Evaluation of the Toxicological Effects of a Novel Constrained Ethyl Modified Antisense Compound Targeting Signal Transducer and Activator of Transcription 3 in Mice and Cynomolgus Monkeys
- (2015) Sebastien A. Burel et al. Nucleic Acid Therapeutics
- Triggering of RNA Interference with RNA–RNA, RNA–DNA, and DNA–RNA Nanoparticles
- (2014) Kirill A. Afonin et al. ACS Nano
- Innate Immune Sensing and Signaling of Cytosolic Nucleic Acids
- (2014) Jiaxi Wu et al. Annual Review of Immunology
- AS1411 Aptamer and Folic Acid Functionalized pH-Responsive ATRP Fabricated pPEGMA–PCL–pPEGMA Polymeric Nanoparticles for Targeted Drug Delivery in Cancer Therapy
- (2014) Shantanu V. Lale et al. BIOMACROMOLECULES
- Ligand-Directed Active Tumor-Targeting Polymeric Nanoparticles for Cancer Chemotherapy
- (2014) Yinan Zhong et al. BIOMACROMOLECULES
- Multi-modal transfection agent based on monodisperse magnetic nanoparticles for stem cell gene delivery and tracking
- (2014) Wooram Park et al. BIOMATERIALS
- In vitro and in vivo Evaluation of Antitumor Drug-Loaded Aptamer Targeted Single-Walled Carbon Nanotubes System
- (2014) Huijuan Zhang et al. CURRENT PHARMACEUTICAL BIOTECHNOLOGY
- Oligonucleotide delivery: a patent review (2010 – 2013)
- (2014) Santiago Grijalvo et al. EXPERT OPINION ON THERAPEUTIC PATENTS
- A phase II trial of intraperitoneal EGEN-001, an IL-12 plasmid formulated with PEG–PEI–cholesterol lipopolymer in the treatment of persistent or recurrent epithelial ovarian, fallopian tube or primary peritoneal cancer: A Gynecologic Oncology Group study
- (2014) Ronald D. Alvarez et al. GYNECOLOGIC ONCOLOGY
- Targeting CpG Oligonucleotides to the Lymph Node by Nanoparticles Elicits Efficient Antitumoral Immunity
- (2014) C. Bourquin et al. JOURNAL OF IMMUNOLOGY
- Grafting Aptamers onto Gold Nanostars Increases in Vitro Efficacy in a Wide Range of Cancer Cell Types
- (2014) Duncan Hieu M. Dam et al. MOLECULAR PHARMACEUTICS
- Improved in Vitro Efficacy of Gold Nanoconstructs by Increased Loading of G-quadruplex Aptamer
- (2014) Duncan Hieu M. Dam et al. NANO LETTERS
- Macrophages associated with tumors as potential targets and therapeutic intermediates
- (2014) Serguei Vinogradov et al. Nanomedicine
- DNA and aptamer stabilized gold nanoparticles for targeted delivery of anticancer therapeutics
- (2014) Alfonso Latorre et al. Nanoscale
- Lipid Nanoparticles Improve Activity of Single-Stranded siRNA and Gapmer Antisense Oligonucleotides in Animals
- (2013) Thazha P. Prakash et al. ACS Chemical Biology
- pH-Responsive Nanoparticle Vaccines for Dual-Delivery of Antigens and Immunostimulatory Oligonucleotides
- (2013) John T. Wilson et al. ACS Nano
- Combined EGFR and c-Src Antisense Oligodeoxynucleotides Encapsulated with PAMAM Denderimers Inhibit HT-29 Colon Cancer Cell Proliferation
- (2013) Ali Reza Nourazarian et al. Asian Pacific Journal of Cancer Prevention
- Assembly of Liposomes Controlled by Triple Helix Formation
- (2013) Ulla Jakobsen et al. BIOCONJUGATE CHEMISTRY
- Drug-Induced Nanocarrier Assembly as a Strategy for the Cellular Delivery of Nucleotides and Nucleotide Analogues
- (2013) Giovanna Giacalone et al. BIOMACROMOLECULES
- Albumin-based nanoconjugates for targeted delivery of therapeutic oligonucleotides
- (2013) Xin Ming et al. BIOMATERIALS
- Systemic delivery of gemcitabine triphosphate via LCP nanoparticles for NSCLC and pancreatic cancer therapy
- (2013) Yuan Zhang et al. BIOMATERIALS
- A phase 1 study of the BCL2-targeted deoxyribonucleic acid inhibitor (DNAi) PNT2258 in patients with advanced solid tumors
- (2013) Anthony W. Tolcher et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Clinical optimization of antigen specific modulation of type 1 diabetes with the plasmid DNA platform
- (2013) Peter Gottlieb et al. CLINICAL IMMUNOLOGY
- Canonical and Non-Canonical Barriers Facing AntimiR Cancer Therapeutics
- (2013) Christopher Cheng et al. CURRENT MEDICINAL CHEMISTRY
- Charge affects the oral toxicity of poly(amidoamine) dendrimers
- (2013) Giridhar Thiagarajan et al. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
- Pluronic–PEI copolymers enhance exon-skipping of 2′-O-methyl phosphorothioate oligonucleotide in cell culture and dystrophic mdx mice
- (2013) M Wang et al. GENE THERAPY
- Phase I trial of a formulated IL-12 plasmid in combination with carboplatin and docetaxel chemotherapy in the treatment of platinum-sensitive recurrent ovarian cancer
- (2013) Khursheed Anwer et al. GYNECOLOGIC ONCOLOGY
- A phase II trial of AS1411 (a novel nucleolin-targeted DNA aptamer) in metastatic renal cell carcinoma
- (2013) Jonathan E. Rosenberg et al. INVESTIGATIONAL NEW DRUGS
- Understanding the correlation between in vitro and in vivo immunotoxicity tests for nanomedicines
- (2013) Marina A. Dobrovolskaia et al. JOURNAL OF CONTROLLED RELEASE
- Immune system targeting by biodegradable nanoparticles for cancer vaccines
- (2013) Joana M. Silva et al. JOURNAL OF CONTROLLED RELEASE
- Studying Complexes Between PPI Dendrimers and Mant-ATP
- (2013) A. Szulc et al. JOURNAL OF FLUORESCENCE
- Safety and tolerability of an intratumorally injected DNAzyme, Dz13, in patients with nodular basal-cell carcinoma: a phase 1 first-in-human trial (DISCOVER)
- (2013) Eun-Ae Cho et al. LANCET
- Nucleolin Targeting AS1411 Modified Protein Nanoparticle for Antitumor Drugs Delivery
- (2013) Jinhui Wu et al. MOLECULAR PHARMACEUTICS
- Delivery materials for siRNA therapeutics
- (2013) Rosemary Kanasty et al. NATURE MATERIALS
- Activation of different split functionalities on re-association of RNA–DNA hybrids
- (2013) Kirill A. Afonin et al. Nature Nanotechnology
- Safety and Efficacy of RNAi Therapy for Transthyretin Amyloidosis
- (2013) Teresa Coelho et al. NEW ENGLAND JOURNAL OF MEDICINE
- The Co-Delivery of Oxaliplatin Abrogates the Immunogenic Response to PEGylated siRNA-Lipoplex
- (2013) Eman Alaaeldin et al. PHARMACEUTICAL RESEARCH
- Self-Assembly of Poly-Adenine-Tailed CpG Oligonucleotide-Gold Nanoparticle Nanoconjugates with Immunostimulatory Activity
- (2013) Nan Chen et al. Small
- Multifunctional AS1411-functionalized fluorescent gold nanoparticles for targeted cancer cell imaging and efficient photodynamic therapy
- (2013) Jun Ai et al. TALANTA
- Nanoparticle-Based Vaccine Delivery for Cancer Immunotherapy
- (2013) Yeong-Min Park et al. Immune Network
- Catalytic Deoxyribozyme-Modified Nanoparticles for RNAi-Independent Gene Regulation
- (2012) Kevin Yehl et al. ACS Nano
- Gene Silencing by Gold Nanoshell-Mediated Delivery and Laser-Triggered Release of Antisense Oligonucleotide and siRNA
- (2012) Ryan Huschka et al. ACS Nano
- Cationic PAMAM Dendrimers Aggressively Initiate Blood Clot Formation
- (2012) Clinton F. Jones et al. ACS Nano
- c-Src Antisense Complexed with PAMAM Denderimes Decreases of c-Src Expression and EGFR-Dependent Downstream Genes in the Human HT-29 Colon Cancer Cell Line
- (2012) Ali Reza Nourazarian et al. Asian Pacific Journal of Cancer Prevention
- Poly(propylene imine) dendrimers modified with maltose or maltotriose protect phosphorothioate oligodeoxynucleotides against nuclease activity
- (2012) Joanna Drzewińska et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- A mesoporous silica nanoparticle – PEI – Fusogenic peptide system for siRNA delivery in cancer therapy
- (2012) Xu Li et al. BIOMATERIALS
- SiO2 nanoparticles as platform for delivery of nucleoside triphosphate analogues into cells
- (2012) Svetlana V. Vasilyeva et al. BIOORGANIC & MEDICINAL CHEMISTRY
- AS1411 aptamer tagged PLGA-lecithin-PEG nanoparticles for tumor cell targeting and drug delivery
- (2012) Athulya Aravind et al. BIOTECHNOLOGY AND BIOENGINEERING
- Targeted nanoparticle delivery overcomes off-target immunostimulatory effects of oligonucleotides and improves therapeutic efficacy in chronic lymphocytic leukemia
- (2012) B. Yu et al. BLOOD
- Bacterial exopolysaccharide based nanoparticles for sustained drug delivery, cancer chemotherapy and bioimaging
- (2012) Sreejith Raveendran et al. CARBOHYDRATE POLYMERS
- Systemic delivery of triplex-forming PNA and donor DNA by nanoparticles mediates site-specific genome editing of human hematopoietic cells in vivo
- (2012) N A McNeer et al. GENE THERAPY
- Common pitfalls in nanotechnology: lessons learned from NCI's Nanotechnology Characterization Laboratory
- (2012) Rachael M. Crist et al. Integrative Biology
- Efficient down-regulation of PKC-α gene expression in A549 lung cancer cells mediated by antisense oligodeoxynucleotides in dendrosomes
- (2012) Sara Movassaghian et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Factors affecting the pharmacokinetics and pharmacodynamics of liposomal drugs
- (2012) Gina Song et al. JOURNAL OF LIPOSOME RESEARCH
- Pharmacokinetics of CPX-351; a nano-scale liposomal fixed molar ratio formulation of cytarabine:daunorubicin, in patients with advanced leukemia
- (2012) E.J. Feldman et al. LEUKEMIA RESEARCH
- Cationic PAMAM Dendrimers Disrupt Key Platelet Functions
- (2012) Clinton F. Jones et al. MOLECULAR PHARMACEUTICS
- Co-transcriptional Assembly of Chemically Modified RNA Nanoparticles Functionalized with siRNAs
- (2012) Kirill A. Afonin et al. NANO LETTERS
- Nanobiopolymer for Direct Targeting and Inhibition of EGFR Expression in Triple Negative Breast Cancer
- (2012) Satoshi Inoue et al. PLoS One
- Activation of complement by therapeutic liposomes and other lipid excipient-based therapeutic products: Prediction and prevention
- (2011) Janos Szebeni et al. ADVANCED DRUG DELIVERY REVIEWS
- Modulation of biological processes in the nucleus by delivery of DNA oligonucleotides conjugated with gold nanoparticles
- (2011) Dong-Wook Kim et al. BIOMATERIALS
- The packaging of siRNA within the mesoporous structure of silica nanoparticles
- (2011) Xu Li et al. BIOMATERIALS
- Enantiospecific adjuvant activity of cationic lipid DOTAP in cancer vaccine
- (2011) Elizabeth A. Vasievich et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Polymalic Acid–Based Nanobiopolymer Provides Efficient Systemic Breast Cancer Treatment by Inhibiting both HER2/neu Receptor Synthesis and Activity
- (2011) Satoshi Inoue et al. CANCER RESEARCH
- Development and optimization of nanosomal formulations for siRNA delivery to the liver
- (2011) Anup K. Kundu et al. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
- Anti-PEG IgM production by siRNA encapsulated in a PEGylated lipid nanocarrier is dependent on the sequence of the siRNA
- (2011) Tatsuaki Tagami et al. JOURNAL OF CONTROLLED RELEASE
- Size-Dependent Attenuation of TLR9 Signaling by Gold Nanoparticles in Macrophages
- (2011) C.-Y. Tsai et al. JOURNAL OF IMMUNOLOGY
- Nanoparticle Size and Surface Charge Determine Effects of PAMAM Dendrimers on Human Platelets in Vitro
- (2011) Marina A. Dobrovolskaia et al. MOLECULAR PHARMACEUTICS
- Interaction of nanoparticles with immunocompetent cells: nanosafety considerations
- (2011) Diana Boraschi et al. Nanomedicine
- Dendrimer-induced leukocyte procoagulant activity depends on particle size and surface charge
- (2011) Marina A Dobrovolskaia et al. Nanomedicine
- Liposome-induced complement activation and related cardiopulmonary distress in pigs: factors promoting reactogenicity of Doxil and AmBisome
- (2011) János Szebeni et al. Nanomedicine-Nanotechnology Biology and Medicine
- Size and surface charge significantly influence the toxicity of silica and dendritic nanoparticles
- (2011) Khaled Greish et al. Nanotoxicology
- Design and self-assembly of siRNA-functionalized RNA nanoparticles for use in automated nanomedicine
- (2011) Kirill A Afonin et al. Nature Protocols
- Nanoparticles and modulation of immune responses
- (2011) Igor Pantic SCIENCE PROGRESS
- Liver-targeted siRNA delivery by polyethylenimine (PEI)-pullulan carrier
- (2010) Jeong-Hun Kang et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Phase I and Pharmacokinetic Studies of CYT-6091, a Novel PEGylated Colloidal Gold-rhTNF Nanomedicine
- (2010) S. K. Libutti et al. CLINICAL CANCER RESEARCH
- Breaking down the barriers: siRNA delivery and endosome escape
- (2010) M. Dominska et al. JOURNAL OF CELL SCIENCE
- Delivery of Immunostimulatory RNA Oligonucleotides by Gelatin Nanoparticles Triggers an Efficient Antitumoral Response
- (2010) Carole Bourquin et al. JOURNAL OF IMMUNOTHERAPY
- Mechanistically Probing Lipid-siRNA Nanoparticle-associated Toxicities Identifies Jak Inhibitors Effective in Mitigating Multifaceted Toxic Responses
- (2010) Weikang Tao et al. MOLECULAR THERAPY
- Mesoporous Silica Nanoparticles Facilitate Delivery of siRNA to Shutdown Signaling Pathways in Mammalian Cells
- (2010) Christopher Hom et al. Small
- Lipidic Systems for In Vivo siRNA Delivery
- (2009) Sherry Y. Wu et al. AAPS Journal
- Functional Delivery of siRNA in Mice Using Dendriworms
- (2009) Amit Agrawal et al. ACS Nano
- Increased levels of tissue factor activity and procoagulant phospholipids during treatment of children with acute lymphoblastic leukaemia
- (2009) Pascale Schneider et al. BRITISH JOURNAL OF HAEMATOLOGY
- The First Targeted Delivery of siRNA in Humans via a Self-Assembling, Cyclodextrin Polymer-Based Nanoparticle: From Concept to Clinic
- (2009) Mark E. Davis MOLECULAR PHARMACEUTICS
- Evaluation of Efficacy, Biodistribution, and Inflammation for a Potent siRNA Nanoparticle: Effect of Dexamethasone Co-treatment
- (2009) Marc T Abrams et al. MOLECULAR THERAPY
- Drug delivery of siRNA therapeutics: potentials and limits of nanosystems
- (2008) Daniela Reischl et al. Nanomedicine-Nanotechnology Biology and Medicine
- Preparation of chitosan-polyaspartic acid-5-fluorouracil nanoparticles and its anti-carcinoma effect on tumor growth in nude mice
- (2008) Dan-Ying Zhang et al. WORLD JOURNAL OF GASTROENTEROLOGY
- Innate immune response induced by gene delivery vectors
- (2007) Haruna Sakurai et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started