Advances in salivary gland gene therapy – oral and systemic implications

Minicircle DNA vectors for gene therapy: advances and applications

(2014) Vítor Gaspar et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

AdLTR2EF1α-FGF2-mediated prevention of fractionated irradiation-induced salivary hypofunction in swine

(2014) L Guo et al.   GENE THERAPY

Toxicity and Biodistribution of the Serotype 2 Recombinant Adeno-Associated Viral Vector, Encoding Aquaporin-1, after Retroductal Delivery to a Single Mouse Parotid Gland

(2014) Dariya Momot et al.   PLoS One

Matriptase Deletion Initiates a Sjögren’s Syndrome-Like Disease in Mice

(2014) Hongen Yin et al.   PLoS One

Proteomic profiling of salivary gland after nonviral gene transfer mediated by conventional plasmids and minicircles

(2014) Ramaz Geguchadze et al.   Molecular Therapy-Methods & Clinical Development

Association of Bone Morphogenetic Protein 6 With Exocrine Gland Dysfunction in Patients With Sjögren's Syndrome and in Mice

(2013) Hongen Yin et al.   ARTHRITIS AND RHEUMATISM

Double-strand adeno-associated virus-mediated exendin-4 expression in salivary glands is efficient in a diabetic rat model

(2013) Junhong Wang et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Modulation of taste responsiveness by the satiation hormone peptide YY

(2013) Michael S. La Sala et al.   FASEB JOURNAL

Recombinant AAV9-TLK1B Administration Ameliorates Fractionated Radiation-Induced Xerostomia

(2013) Prakash Srinivasan Timiri Shanmugam et al.   HUMAN GENE THERAPY

Recovery of Radiation-Induced Dry Eye and Corneal Damage by Pretreatment with Adenoviral Vector-Mediated Transfer of Erythropoietin to the Salivary Glands in Mice

(2013) Eduardo M. Rocha et al.   HUMAN GENE THERAPY

Salivary Peptide Tyrosine-Tyrosine 3-36 Modulates Ingestive Behavior without Inducing Taste Aversion

(2013) M. D. Hurtado et al.   JOURNAL OF NEUROSCIENCE

Nanoparticle-mediated Gene Silencing Confers Radioprotection to Salivary Glands In Vivo

(2013) Szilvia Arany et al.   MOLECULAR THERAPY

Targeting the Splicing of mRNA in Autoimmune Diseases: BAFF Inhibition in Sjögren's Syndrome as a Proof of Concept

(2013) N. Roescher et al.   MOLECULAR THERAPY

Retrograde Ductal Administration of the Adenovirus-mediated NDRG2 Gene Leads to Improved Sialaden Hypofunction in Estrogen-deficient Rats

(2013) Yan Li et al.   MOLECULAR THERAPY

Toward gene therapy for growth hormone deficiency via salivary gland expression of growth hormone

(2013) GZ Racz et al.   ORAL DISEASES

Expression and Secretion of Human Proinsulin-B10 from Mouse Salivary Glands: Implications for the Treatment of Type I Diabetes Mellitus

(2013) Anne M. Rowzee et al.   PLoS One

Gene therapy for adenosine deaminase-deficient severe combined immune deficiency: clinical comparison of retroviral vectors and treatment plans

(2012) F. Candotti et al.   BLOOD

Pro-apoptotic gene knockdown mediated by nanocomplexed siRNA reduces radiation damage in primary salivary gland cultures

(2012) Szilvia Arany et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

An AAV2/5 Vector Enhances Safety of Gene Transfer to the Mouse Salivary Gland

(2012) R.N. Geguchadze et al.   JOURNAL OF DENTAL RESEARCH

Distribution of Y-Receptors in Murine Lingual Epithelia

(2012) Maria D. Hurtado et al.   PLoS One

Sustained Exendin-4 Secretion through Gene Therapy Targeting Salivary Glands in Two Different Rodent Models of Obesity/Type 2 Diabetes

(2012) Giovanni Di Pasquale et al.   PLoS One

Local Administration of Soluble CD40:Fc to the Salivary Glands of Non-Obese Diabetic Mice Does Not Ameliorate Autoimmune Inflammation

(2012) Nienke Roescher et al.   PLoS One

Early responses to adenoviral-mediated transfer of the aquaporin-1 cDNA for radiation-induced salivary hypofunction

(2012) B. J. Baum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Local delivery of AAV2-CTLA4IgG decreases sialadenitis and improves gland function in the C57BL/6.NOD-Aec1Aec2 mouse model of Sjögren's syndrome

(2012) Hongen Yin et al.   ARTHRITIS RESEARCH & THERAPY

Alterations in type I hemidesmosome components suggestive of epigenetic control in the salivary glands of patients with Sjögren's syndrome

(2011) Sergio González et al.   ARTHRITIS AND RHEUMATISM

Changes in Rab3D expression and distribution in the acini of Sjögren's syndrome patients are associated with loss of cell polarity and secretory dysfunction

(2011) Verónica Bahamondes et al.   ARTHRITIS AND RHEUMATISM

Gene delivery in salivary glands: From the bench to the clinic

(2011) Yuval Samuni et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Prevention of Radiation-Induced Salivary Hypofunction Following hKGF Gene Delivery to Murine Submandibular Glands

(2011) C. Zheng et al.   CLINICAL CANCER RESEARCH

TACI-Fc gene therapy improves autoimmune sialadenitis but not salivary gland function in non-obese diabetic mice

(2011) JL Vosters et al.   ORAL DISEASES

Salivary PYY: A Putative Bypass to Satiety

(2011) Andres Acosta et al.   PLoS One

Adenoviral delivery of Tousled kinase for the protection of salivary glands against ionizing radiation damage

(2010) S Palaniyandi et al.   GENE THERAPY

Ultrasound-assisted non-viral gene transfer to the salivary glands

(2010) M J Passineau et al.   GENE THERAPY

α-Galactosidase A Expressed in the Salivary Glands Partially Corrects Organ Biochemical Deficits in the Fabry Mouse Through Endocrine Trafficking

(2010) Michael J. Passineau et al.   HUMAN GENE THERAPY

Salivary epithelial cells: An unassuming target site for gene therapeutics

(2010) Paola Perez et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Clinical Management of Salivary Gland Hypofunction and Xerostomia in Head-and-Neck Cancer Patients: Successes and Barriers

(2010) Arjan Vissink et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Aberrant localization of ezrin correlates with salivary acini disorganization in Sjögren’s Syndrome

(2010) Paola Pérez et al.   RHEUMATOLOGY

Long-term transduction of miniature pig parotid glands using serotype 2 adeno-associated viral vectors

(2009) Bo Hai et al.   JOURNAL OF GENE MEDICINE

Transient detection of E1-containing adenovirus in saliva after the delivery of a first-generation adenoviral vector to human parotid gland

(2009) Changyu Zheng et al.   JOURNAL OF GENE MEDICINE

Lack of efficacy of etanercept in Sjogren syndrome correlates with failed suppression of tumour necrosis factor   and systemic immune activation

(2008) N M Moutsopoulos et al.   ANNALS OF THE RHEUMATIC DISEASES

Sorting of Transgenic Secretory Proteins in Rhesus Macaque Parotid Glands After Adenovirus-Mediated Gene Transfer

(2008) Antonis Voutetakis et al.   HUMAN GENE THERAPY

Safety and Efficacy of Gene Transfer for Leber's Congenital Amaurosis

(2008) Albert M. Maguire et al.   NEW ENGLAND JOURNAL OF MEDICINE

Human gene therapy for RPE65 isomerase deficiency activates the retinoid cycle of vision but with slow rod kinetics

(2008) A. V. Cideciyan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gene Therapy: Some History, Applications, Problems, and Prospects

(2008) Ana P. Cotrim et al.   TOXICOLOGIC PATHOLOGY