Article
Biochemistry & Molecular Biology
Christian Sirko, Matthew J. Novello, Peter B. Stathopulos
Summary: Stromal interaction molecule 1 (STIM1) is a calcium sensing protein that regulates store-operated calcium entry. S-Glutathionylation of STIM1 at Cys49 or Cys56 induces conformational changes and thermodynamic destabilization. This modification or mutation of Cys56 reduces the binding affinity to calcium ions.
JOURNAL OF MOLECULAR BIOLOGY
(2022)
Review
Cell Biology
Inbal Dagan, Raz Palty
Summary: Calcium signaling in cells plays a crucial role in regulating cell survival, proliferation, and death. Store-operated Ca2+ entry through CRAC channels is a major pathway for Ca2+ influx in non-excitable cells, regulated by a negative feedback mechanism called slow Ca2+ dependent inactivation (SCDI).
Article
Hematology
Alejandro Berna-Erro, Girish Ramesh, Elena Delgado, Antonio J. Corbacho, Francisca Ferrer-Marin, Raul Teruel, Maria P. Granados, Juan A. Rosado, Pedro C. Redondo
Summary: This study investigated the changes in Ca2+ entry through the store-operated calcium entry (SOCE) mechanism in neonatal platelets. The results showed altered TG-evoked SOCE, different molecular weight forms of STIM1, and overexpression of SARAF in neonatal platelets compared to maternal and control women platelets. It was also found that CAPN1 may cleave STIM1 in neonatal platelets, impairing SARAF coupling after SOCE activation.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Clinical Neurology
Tania Rizo, Lisa Gebhardt, Julia Riedlberger, Esther Eberhardt, Lars Fester, Dalia Alansary, Jurgen Winkler, Soeren Turan, Philipp Arnold, Barbara A. Niemeyer, Michael J. M. Fischer, Beate Winner
Summary: The study demonstrates that pathogenic variants in the SPAST gene lead to dysregulation of spastin, affecting the dynamics of the endoplasmic reticulum and resulting in aberrant calcium regulation.
Review
Cell Biology
Isaac Jardin, Jose J. Lopez, Jose Sanchez-Collado, Luis J. Gomez, Gines M. Salido, Juan A. Rosado
Summary: Cancer stem cells exhibit stemness features and their behavior is influenced by Ca2+ homeostasis and store-operated Ca2+ entry. Understanding the key components of store-operated Ca2+ entry is important for the understanding of cancer stem cell biology and tumorigenesis.
Review
Physiology
Declan Manning, Caroline Dart, Richard L. Evans
Summary: The skin is a complex organ with various functions such as protection, temperature regulation, sensation, immune surveillance, and biochemical functions. Dysfunction in store-operated channels is linked to skin pathologies, and these channels play vital roles in the normal physiology and function of the skin.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Neurosciences
Timo Fischer, Jessica Prey, Lena Eschholz, Natalie Rotermund, Christian Lohr
Summary: The study shows that norepinephrine induces a cytosolic calcium rise in olfactory bulb astrocytes, which is independent of neuronal activity and primarily mediated by PLC/IP3-dependent internal calcium release. Additionally, store-operated calcium entry (SOCE) plays a role in the late phase of the response.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Yang Ye, Xue Li, Zhihua Wang, Fen Ye, Wenrong Xu, Rongzhu Lu, Haijun Shen, Shuhan Miao
Summary: The natural compound 3,3'-Diindolylmethane (DIM) inhibits proliferation and induces apoptosis and autophagy in gastric cancer cells by activating the STIM1-mediated Store-operated calcium entry (SOCE) pathway. Inhibition of SOCE attenuates DIM-induced effects on apoptosis and autophagy, suggesting SOCE as a potential therapeutic target in gastric cancer. Further research is warranted to explore combination chemotherapy strategies targeting SOCE for clinical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Medicine, Research & Experimental
Wu Lele, Lv Lei, Qian Liting
Summary: Resveratrol can enhance the damage of radiation on lung adenocarcinoma A549 cells by suppressing SOCE and reducing the expression of both STIM1 and Orai1.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Oncology
Samriddhi Arora, Jyoti Tanwar, Nutan Sharma, Suman Saurav, Rajender K. Motiani
Summary: Orai3, a highly Ca2+ selective plasma membrane channel, is overexpressed in pancreatic cancer and is associated with poor prognosis. It modulates cell proliferation, apoptosis, and migration, playing a critical role in PC metastasis. This study suggests Orai3 as a potential therapeutic target for managing PC metastasis.
Article
Biochemistry & Molecular Biology
Joana Poejo, Yolanda Orantos-Aguilera, Francisco Javier Martin-Romero, Ana Maria Mata, Carlos Gutierrez-Merino
Summary: Dysregulation in calcium signaling pathways plays a major role in the initiation of Alzheimer's disease. This study reveals the complexation of Aβ with CaM-binding protein STIM1, leading to the dysregulation of Ca2+ signaling and enhanced amyloidogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Muhammad Yasir Asghar, Taru Lassila, Ilkka Paatero, Van Dien Nguyen, Pauliina Kronqvist, Jixi Zhang, Anna Slita, Christoffer Lof, You Zhou, Jessica Rosenholm, Kid Tornquist
Summary: Research shows that STIM1 and ORAI1 are upregulated in thyroid cancer, and their knockdown can attenuate SOCE, reduce invasion and expression of promigratory factors, inhibit cell proliferation, and increase sensitivity to chemotherapeutic drugs.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Oncology
Jose Sanchez-Collado, Jose J. Lopez, Carlos Cantonero, Isaac Jardin, Sergio Regodon, Pedro C. Redondo, Juan Gordillo, Tarik Smani, Gines M. Salido, Juan A. Rosado
Summary: The expression ratio of Orai1:Orai2 varies in different breast cancer cells, and Orai2 plays a crucial role in cell cycle progression and apoptosis resistance.
Article
Cell Biology
Julia Hermes, Vesela Borisova, Jens Kockskaemper
Summary: This study investigates the mechanisms of store-operated calcium entry (SOCE) in cardiomyocytes and its potential role in cardiac remodeling. The results show that SOCE can increase nuclear calcium levels and alter gene expression through calcium/calmodulin-dependent enzyme signaling. Both TRPC and Orai channels may contribute to SOCE in adult cardiomyocytes, with larger SOCE amplitudes observed in atrial myocytes compared to ventricular myocytes.
Article
Physiology
Declan Manning, Richard Barrett-Jolley, Richard L. Evans, Caroline Dart
Summary: Skin is the largest organ in the human body, mainly composed of keratinocytes which maintain a healthy skin barrier through regulated differentiation driven by Ca2+-transcriptional coupling. Disruption of this process leads to various skin conditions. Our study suggests that TRPC2 and Orai1 channels do not insert into the plasma membrane during store-operated Ca2+ entry.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Joshua R. Sheak, Simin Yan, Laura Weise-Cross, Rosstin Ahmadian, Benjimen R. Walker, Nikki L. Jernigan, Thomas C. Resta
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Jessica B. Snow, Charles E. Norton, Michelle A. Sands, Laura Weise-Cross, Simin Yan, Lindsay M. Herbert, Joshua R. Sheak, Laura Gonzalez Bosc, Benjimen R. Walker, Nancy L. Kanagy, Nikki L. Jernigan, Thomas C. Resta
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Charles E. Norton, Laura Weise-Cross, Rosstin Ahmadian, Simin Yan, Nikki L. Jernigan, Michael L. Paffett, Jay S. Naik, Benjimen R. Walker, Thomas C. Resta
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2020)
Article
Multidisciplinary Sciences
Selina M. Garcia, Alexander G. Obukhov, Lindsay M. Herbert, Benjimen R. Walker, Thomas C. Resta, Nikki L. Jernigan
Review
Biochemistry & Molecular Biology
Simin Yan, Thomas C. Resta, Nikki L. Jernigan
Article
Cardiac & Cardiovascular Systems
Huanan Shi, Bojun Zhang, Taylor Abo-Hamzy, James W. Nelson, Chandra Shekar R. Ambati, Joseph F. Petrosino, Robert M. Jr Jr Bryan, David J. Durgan
Summary: Recent studies have shown that intermittent fasting can alter the gut microbiota and reduce blood pressure, while identifying microbial influenced metabolites as potential mediators in the regulation of host blood pressure.
CIRCULATION RESEARCH
(2021)
Article
Neurosciences
Nikki L. Jernigan, Jay S. Naik, Thomas C. Resta
Summary: Pulmonary hypertension is characterized by sustained vasoconstriction and remodeling of the small pulmonary arteries. Acid-sensing ion channel 1 (ASIC1) plays a role in chronic hypoxia-induced pulmonary hypertension and contributes to the depolarization of pulmonary arterial smooth muscle cells. Na+ influx, mediated by ASIC1, is essential for the persistent depolarization in PASMCs during chronic hypoxia.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Physiology
Selina M. Garcia, Benjamin Matheson, Juan H. Morales-Loredo, Nikki L. Jernigan, Nancy L. Kanagy, Thomas C. Resta, Ross M. Clark, Reza Shekarriz, Laura V. Gonzalez Bosc
Summary: This article discusses the symptoms and physiological responses to hypoxia, and proposes the hypothesis of hypoxia-induced biomarkers. The authors found that ET-1 levels return to normal after returning to normal oxygen levels, while the levels of miR-21 and H2S remain decreased.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Selina M. Garcia, Tracy R. Yellowhair, Neil D. Detweiler, Rosstin Ahmadian, Lindsay M. Herbert, Laura V. Gonzalez Bosc, Thomas C. Resta, Nikki L. Jernigan
Summary: This study using specific Asic1a knockout mice models demonstrated that SM-Asic1a contributes to the development of chronic hypoxia-induced pulmonary hypertension and vascular remodeling, while EC-Asic1a opposes the development of chronic hypoxia-induced pulmonary hypertension. These findings provide evidence for the therapeutic potential of ASIC1a inhibition to reverse pulmonary hypertension.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Physiology
Selina M. Garcia, Jay S. Naik, Thomas C. Resta, Nikki L. Jernigan
Summary: This study demonstrates that ASIC1a activates IKCa/SKCa channels in mesenteric resistance arteries, which are crucial mediators of endothelium-dependent hyperpolarization and vasodilation. This novel evidence suggests that ASIC1a is an important contributor to endothelium-dependent vasodilation.
JOURNAL OF GENERAL PHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Sriram Ayyaswamy, Huanan Shi, Bojun Zhang, Robert M. M. Bryan, David J. J. Durgan
Summary: Obstructive sleep apnea (OSA) is an independent risk factor for hypertension. OSA induces gut dysbiosis, which contributes to hypertension. This study explores the mechanisms linking gut dysbiosis to blood pressure regulation, demonstrating that OSA induces inflammation in the gut and brain, which involves interleukin-17a signaling.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Charles E. Norton, Nikki L. Jernigan, Benjimen R. Walker, Thomas C. Resta
PULMONARY CIRCULATION
(2020)