Organic solute transporter OSTα/β is overexpressed in nonalcoholic steatohepatitis and modulated by drugs associated with liver injury

Identification of novel MRP3 inhibitors based on computational models and validation using an in vitro membrane vesicle assay

(2017) Izna Ali et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Effect of Liver Disease on Hepatic Transporter Expression and Function

(2017) Nilay Thakkar et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Nuclear receptors and nonalcoholic fatty liver disease 1 1This article is part of a Special Issue entitled: Xenobiotic nuclear receptors: New Tricks for An Old Dog, edited by Dr. Wen Xie.

(2016) Matthew C. Cave et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Amoxicillin–Clavulanate-Induced Liver Injury

(2016) Andrew S. deLemos et al.   DIGESTIVE DISEASES AND SCIENCES

DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans

(2016) Minjun Chen et al.   DRUG DISCOVERY TODAY

EASL–EASD–EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease

(2016)   JOURNAL OF HEPATOLOGY

NAFLD and liver transplantation: Current burden and expected challenges

(2016) Raluca Pais et al.   JOURNAL OF HEPATOLOGY

A Novel Di-Leucine Motif at the N-Terminus of Human Organic Solute Transporter Beta Is Essential for Protein Association and Membrane Localization

(2016) Shuhua Xu et al.   PLoS One

Age-Related Changes of Plasma Bile Acid Concentrations in Healthy Adults—Results from the Cross-Sectional KarMeN Study

(2016) Lara Frommherz et al.   PLoS One

Altered Bile Acid Metabolome in Patients with Nonalcoholic Steatohepatitis

(2015) Brian C. Ferslew et al.   DIGESTIVE DISEASES AND SCIENCES

Features and Outcomes of 899 Patients With Drug-Induced Liver Injury: The DILIN Prospective Study

(2015) Naga Chalasani et al.   GASTROENTEROLOGY

Categorization of drugs implicated in causing liver injury: Critical assessment based on published case reports

(2015) Einar S. Björnsson et al.   HEPATOLOGY

Major involvement of Na+-dependent multivitamin transporter (SLC5A6/SMVT) in uptake of biotin and pantothenic acid by human brain capillary endothelial cells

(2015) Yasuo Uchida et al.   JOURNAL OF NEUROCHEMISTRY

Hepatic Expression of Detoxification Enzymes Is Decreased in Human Obstructive Cholestasis Due to Gallstone Biliary Obstruction

(2015) Jin Chai et al.   PLoS One

Differentiation of liver progenitor cell line to functional organotypic cultures in 3D nanofibrillar cellulose and hyaluronan-gelatin hydrogels

(2014) Melina M. Malinen et al.   BIOMATERIALS

Synergistic interaction between genetics and disease on pravastatin disposition

(2014) John D. Clarke et al.   JOURNAL OF HEPATOLOGY

The organic solute transporters alpha and beta are induced by hypoxia in human hepatocytes

(2014) Carlos A. Schaffner et al.   LIVER INTERNATIONAL

Potency of Individual Bile Acids to Regulate Bile Acid Synthesis and Transport Genes in Primary Human Hepatocyte Cultures

(2014) Jie Liu et al.   TOXICOLOGICAL SCIENCES

A novel RARα/CAR-mediated mechanism for regulation of human organic solute transporter-β gene expression

(2013) Shuhua Xu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Rapid Measurement of Intracellular Unbound Drug Concentrations

(2013) André Mateus et al.   MOLECULAR PHARMACEUTICS

A Multifactorial Approach to Hepatobiliary Transporter Assessment Enables Improved Therapeutic Compound Development

(2013) Ryan E. Morgan et al.   TOXICOLOGICAL SCIENCES

Decreased hepatotoxic bile acid composition and altered synthesis in progressive human nonalcoholic fatty liver disease

(2013) April D. Lake et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Classification of Inhibitors of Hepatic Organic Anion Transporting Polypeptides (OATPs): Influence of Protein Expression on Drug–Drug Interactions

(2012) Maria Karlgren et al.   JOURNAL OF MEDICINAL CHEMISTRY

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Safety and efficacy of fidaxomicin in the treatment of Clostridium difficile-associated diarrhea

(2012) Yoav Golan et al.   Therapeutic Advances in Gastroenterology

Variations in ATP-Binding Cassette Transporter Regulation during the Progression of Human Nonalcoholic Fatty Liver Disease

(2011) R. N. Hardwick et al.   DRUG METABOLISM AND DISPOSITION

Functional Pleiotropy of Organic Anion Transporting Polypeptide OATP2B1 Due to Multiple Binding Sites

(2011) Yoshiyuki Shirasaka et al.   Drug Metabolism and Pharmacokinetics

Hypoxia and hypoxia inducible factors: Diverse roles in liver diseases

(2011) Bharath Nath et al.   HEPATOLOGY

In Vitro and In Silico Strategies to Identify OATP1B1 Inhibitors and Predict Clinical Drug–Drug Interactions

(2011) Maria Karlgren et al.   PHARMACEUTICAL RESEARCH

Neurosteroid transport by the organic solute transporter OSTα-OSTβ

(2010) Fang Fang et al.   JOURNAL OF NEUROCHEMISTRY

Interference with Bile Salt Export Pump Function Is a Susceptibility Factor for Human Liver Injury in Drug Development

(2010) Ryan E. Morgan et al.   TOXICOLOGICAL SCIENCES

Expression and regulation of the bile acid transporter, OSTα-OSTβin rat and human intestine and liver

(2009) Ansar A. Khan et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Endogenous Gene and Protein Expression of Drug-Transporting Proteins in Cell Lines Routinely Used in Drug Discovery Programs

(2009) G. Ahlin et al.   DRUG METABOLISM AND DISPOSITION

Hepatobiliary Disposition of Troglitazone and Metabolites in Rat and Human Sandwich-Cultured Hepatocytes: Use of Monte Carlo Simulations to Assess the Impact of Changes in Biliary Excretion on Troglitazone Sulfate Accumulation

(2009) J. K. Lee et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Computational Models for Drug Inhibition of the Human Apical Sodium-Dependent Bile Acid Transporter

(2009) Xiaowan Zheng et al.   MOLECULAR PHARMACEUTICS

Ostα-Ostβ is required for bile acid and conjugated steroid disposition in the intestine, kidney, and liver

(2008) Nazzareno Ballatori et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

High expression of the bile salt-homeostatic hormone fibroblast growth factor 19 in the liver of patients with extrahepatic cholestasis

(2008) Frank G. Schaap et al.   HEPATOLOGY