The Immune System in Stroke: Clinical Challenges and Their Translation to Experimental Research

Reduced release and binding of perforin at the immunological synapse underlies the age-related decline in natural killer cell cytotoxicity

(2012) Jon Hazeldine et al.   AGING CELL

Carotid plaque inflammation on 18F-fluorodeoxyglucose positron emission tomography predicts early stroke recurrence

(2012) Michael Marnane et al.   ANNALS OF NEUROLOGY

Leptin action on nonneuronal cells in the CNS: potential clinical applications

(2012) Weihong Pan et al.   Annals of the New York Academy of Sciences

Mechanisms of Inflammatory Responses in Obese Adipose Tissue

(2012) Shengyi Sun et al.   Annual Review of Nutrition

Previous Infection and Stroke: A Prospective Study

(2012) Jaume Roquer et al.   CEREBROVASCULAR DISEASES

Interleukin-1 receptor antagonist reverses stroke-associated peripheral immune suppression

(2012) Craig J. Smith et al.   CYTOKINE

Stress Augments Insulin Resistance and Prothrombotic State: Role of Visceral Adipose-Derived Monocyte Chemoattractant Protein-1

(2012) Y. Uchida et al.   DIABETES

Obesity and Metabolic Syndrome: An Inflammatory Condition

(2012) E. Scarpellini et al.   DIGESTIVE DISEASES

Introduction: Stress and neurological disease

(2012) James P. Herman   EXPERIMENTAL NEUROLOGY

Body mass index and mortality in China: a 15-year prospective study of 220 000 men

(2012) Zhengming Chen et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Delayed Administration of Interleukin-1 Receptor Antagonist Reduces Ischemic Brain Damage and Inflammation in Comorbid Rats

(2012) Jesus M Pradillo et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Is psycho-physical stress a risk factor for stroke? A case-control study

(2012) Jose Antonio Egido et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

The Immunopathology of Sepsis: Pathogen Recognition, Systemic Inflammation, the Compensatory Anti-Inflammatory Response, and Regulatory T Cells

(2012) D.H. Lewis et al.   JOURNAL OF VETERINARY INTERNAL MEDICINE

Recombinant tissue plasminogen activator for acute ischaemic stroke: an updated systematic review and meta-analysis

(2012) Joanna M Wardlaw et al.   LANCET

The immunology of acute stroke

(2012) Ángel Chamorro et al.   Nature Reviews Neurology

High Fat Diet-Induced Gut Microbiota Exacerbates Inflammation and Obesity in Mice via the TLR4 Signaling Pathway

(2012) Kyung-Ah Kim et al.   PLoS One

Circulating cytokine signatures in healthy medical students exposed to academic examination stress

(2012) Yoshiko Kamezaki et al.   PSYCHOPHYSIOLOGY

Interleukin‐1 Mediates Neuroinflammatory Changes Associated With Diet‐Induced Atherosclerosis

(2012) Adam Denes et al.   Journal of the American Heart Association

Stroke prevention: an update

(2012) Marie-Germaine Bousser   Frontiers of Medicine

Liver Ischemia and Reperfusion Injury: New Insights into Mechanisms of Innate-Adaptive Immune-Mediated Tissue Inflammation

(2011) Y. Zhai et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Soluble CXCL16 and long-term outcome in acute ischemic stroke

(2011) T. Ueland et al.   ATHEROSCLEROSIS

Interleukin-1 in the pathogenesis and treatment of inflammatory diseases

(2011) C. A. Dinarello   BLOOD

Post-stroke infection: A systematic review and meta-analysis

(2011) Willeke F Westendorp et al.   BMC Neurology

Brain inflammation is induced by co-morbidities and risk factors for stroke

(2011) Caroline Drake et al.   BRAIN BEHAVIOR AND IMMUNITY

The impact of acute-stressor exposure on splenic innate immunity: A gene expression analysis

(2011) Thomas Maslanik et al.   BRAIN BEHAVIOR AND IMMUNITY

Glucocorticoids mediate stress-induced priming of microglial pro-inflammatory responses

(2011) Matthew G. Frank et al.   BRAIN BEHAVIOR AND IMMUNITY

Body Mass Index, Initial Neurological Severity and Long-Term Mortality in Ischemic Stroke

(2011) Wi-Sun Ryu et al.   CEREBROVASCULAR DISEASES

Two-Year Vascular Event Rates in Patients with Symptomatic Cerebrovascular Disease: The REACH Registry

(2011) Narayanaswamy Venketasubramanian et al.   CEREBROVASCULAR DISEASES

Interleukin-1 and Stroke: Biomarker, Harbinger of Damage, and Therapeutic Target

(2011) Adam Denes et al.   CEREBROVASCULAR DISEASES

Vascular Mechanisms in the Pathogenesis of Stroke

(2011) Cristina Sierra et al.   CURRENT HYPERTENSION REPORTS

The role of intima-media-thickness, ankle-brachial-index and inflammatory biochemical parameters for stroke risk prediction: a systematic review

(2011) D. Sander et al.   EUROPEAN JOURNAL OF NEUROLOGY

Intravenous administration of pravastatin immediately after middle cerebral artery occlusion reduces cerebral oedema in spontaneously hypertensive rats

(2011) Giuseppina Mariucci et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Incident Stroke and Mortality Associated With New-Onset Atrial Fibrillation in Patients Hospitalized With Severe Sepsis

(2011) Allan J. Walkey et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Obesity is associated with hypothalamic injury in rodents and humans

(2011) Joshua P. Thaler et al.   JOURNAL OF CLINICAL INVESTIGATION

Tissue plasminogen activator prevents white matter damage following stroke

(2011) Fernando Correa et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Increased cerebral matrix metalloprotease-9 activity is associated with compromised recovery in the diabetic db/db mouse following a stroke

(2011) Rashmi Kumari et al.   JOURNAL OF NEUROCHEMISTRY

Systemic inflammatory challenges compromise survival after experimental stroke via augmenting brain inflammation, blood- brain barrier damage and brain oedema independently of infarct size

(2011) Ádám Dénes et al.   Journal of Neuroinflammation

Endothelial and inflammatory markers in relation to progression of ischaemic cerebral small-vessel disease and cognitive impairment: a 6-year longitudinal study in patients with type 2 diabetes mellitus

(2011) T. Umemura et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

C-reactive protein in the Heart Protection Study – Authors' reply

(2011) Jonathan Emberson et al.   LANCET

Ischemic hippocampal cell death induces glucose dysregulation by attenuating glucose-stimulated insulin secretion which is exacerbated by a high fat diet

(2011) Sunmin Park et al.   LIFE SCIENCES

The immunology of stroke: from mechanisms to translation

(2011) Costantino Iadecola et al.   NATURE MEDICINE

Long-term exposure to high fat diet is bad for your brain: exacerbation of focal ischemic brain injury

(2011) K.D. Langdon et al.   NEUROSCIENCE

Niaspan reduces high-mobility group box 1/receptor for advanced glycation endproducts after stroke in type-1 diabetic rats

(2011) X. Ye et al.   NEUROSCIENCE

Stroke Epidemiology: Advancing Our Understanding of Disease Mechanism and Therapy

(2011) Bruce Ovbiagele et al.   Neurotherapeutics

Stress Worsens Endothelial Function and Ischemic Stroke via Glucocorticoids

(2011) Mustafa Balkaya et al.   STROKE

Increased Blood–Brain Barrier Permeability and Brain Edema After Focal Cerebral Ischemia Induced by Hyperlipidemia

(2011) Ayman ElAli et al.   STROKE

Hospitalization for Infection and Risk of Acute Ischemic Stroke

(2011) Mitchell S.V. Elkind et al.   STROKE

Influenza Virus Infection Aggravates Stroke Outcome

(2011) Sajjad Muhammad et al.   STROKE

Obesity Paradox and Stroke

(2011) Michael Katsnelson et al.   STROKE

Predictors of Early and Late Case-Fatality in a Nationwide Danish Study of 26 818 Patients With First-Ever Ischemic Stroke

(2011) Klaus Kaae Andersen et al.   STROKE

Link between leptin and interleukin-6 levels in the initial phase of obesity related inflammation

(2011) Ingeborg Stelzer et al.   Translational Research

Inflammatory pathways underlying atrial fibrillation

(2011) Kai Friedrichs et al.   TRENDS IN MOLECULAR MEDICINE

Rapid brain penetration of interleukin-1 receptor antagonist in rat cerebral ischaemia: pharmacokinetics, distribution, protection

(2010) AD Greenhalgh et al.   BRITISH JOURNAL OF PHARMACOLOGY

Central and Peripheral Mechanisms of T-Lymphocyte Activation and Vascular Inflammation Produced by Angiotensin II–Induced Hypertension

(2010) Paul J. Marvar et al.   CIRCULATION RESEARCH

Carotid Plaque Inflammation Is Associated With Cerebral Microembolism in Patients With Recent Transient Ischemic Attack or Stroke

(2010) Ramez Reda Moustafa et al.   Circulation-Cardiovascular Imaging

ACE Inhibition Reduces Infarction in Normotensive but Not Hypertensive Rats: Correlation with Cortical ACE Activity

(2010) Michelle J Porritt et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Exacerbated brain damage, edema and inflammation in type-2 diabetic mice subjected to focal ischemia

(2010) Kudret Tureyen et al.   JOURNAL OF NEUROCHEMISTRY

Incidence of aetiological subtypes of stroke in a multi-ethnic population based study: the South London Stroke Register

(2010) C. Hajat et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

The Neurotoxic Effects of Estrogen on Ischemic Stroke in Older Female Rats Is Associated with Age-Dependent Loss of Insulin-Like Growth Factor-1

(2010) A. Selvamani et al.   JOURNAL OF NEUROSCIENCE

Glucocorticoids Exacerbate Lipopolysaccharide-Induced Signaling in the Frontal Cortex and Hippocampus in a Dose-Dependent Manner

(2010) C. D. Munhoz et al.   JOURNAL OF NEUROSCIENCE

Chronic Systemic Infection Exacerbates Ischemic Brain Damage via a CCL5 (Regulated on Activation, Normal T-Cell Expressed and Secreted)-Mediated Proinflammatory Response in Mice

(2010) A. Denes et al.   JOURNAL OF NEUROSCIENCE

Major Stress Hormones Suppress the Response of Macrophages Through Down-Regulation of TLR2 and TLR4

(2010) Quan Du et al.   JOURNAL OF SURGICAL RESEARCH

Imaging Atherosclerotic Plaque Inflammation by Fluorodeoxyglucose With Positron Emission Tomography

(2010) James H.F. Rudd et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Risk factors for ischaemic and intracerebral haemorrhagic stroke in 22 countries (the INTERSTROKE study): a case-control study

(2010) Martin J O'Donnell et al.   LANCET

Common infections and the risk of stroke

(2010) Armin J. Grau et al.   Nature Reviews Neurology

Age exaggerates proinflammatory cytokine signaling and truncates signal transducers and activators of transcription 3 signaling following ischemic stroke in the rat

(2010) V.A. DiNapoli et al.   NEUROSCIENCE

Vascular Cellular Adhesion Molecule-1 (VCAM-1) Expression in Mice Retinal Vessels Is Affected by Both Hyperglycemia and Hyperlipidemia

(2010) Carin Gustavsson et al.   PLoS One

Infectious Burden and Carotid Plaque Thickness

(2010) Mitchell S.V. Elkind et al.   STROKE

Excess Body Weight and Incidence of Stroke

(2010) Pasquale Strazzullo et al.   STROKE

Association Between Obesity and Mortality After Acute First-Ever Stroke

(2010) Konstantinos Vemmos et al.   STROKE

White Matter Damage and the Effect of Matrix Metalloproteinases in Type 2 Diabetic Mice After Stroke

(2010) Jieli Chen et al.   STROKE

C-Reactive Protein Elicits White Blood Cell Activation in Humans

(2009) Radjesh J. Bisoendial et al.   AMERICAN JOURNAL OF MEDICINE

Colonic bacterial translocation as a possible factor in stress-worsening experimental stroke outcome

(2009) Javier R. Caso et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Multimodal microglia imaging of fiber tracts in acute subcortical stroke

(2009) Basia A. Radlinska et al.   ANNALS OF NEUROLOGY

Infectious Burden and Risk of Stroke

(2009) Mitchell S. V. Elkind   ARCHIVES OF NEUROLOGY

Interplay Between Human Adipocytes and T Lymphocytes in Obesity

(2009) Carine Duffaut et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Natural Killer T Cells Are Involved in Adipose Tissues Inflammation and Glucose Intolerance in Diet-Induced Obese Mice

(2009) Kazue Ohmura et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Inflammation and brain injury: Acute cerebral ischaemia, peripheral and central inflammation

(2009) A. Denes et al.   BRAIN BEHAVIOR AND IMMUNITY

INTRACEREBROVENTRICULAR INJECTION OF EPIDERMAL GROWTH FACTOR REDUCES NEUROLOGICAL DEFICIT AND INFARCT VOLUME AND ENHANCES NESTIN EXPRESSION FOLLOWING FOCAL CEREBRAL INFARCTION IN ADULT HYPERTENSIVE RATS

(2009) Jian Yu et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Treating inflammation in atherosclerotic cardiovascular disease: emerging therapies

(2009) Roland Klingenberg et al.   EUROPEAN HEART JOURNAL

The PPAR-γ Agonist, Darglitazone, Restores Acute Inflammatory Responses to Cerebral Hypoxia–Ischemia in the Diabetic ob/ob Mouse

(2009) Rashmi Kumari et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Changes in Experimental Stroke Outcome across the Life Span

(2009) Fudong Liu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Increased Brain Microvascular MMP-9 and Incidence of Haemorrhagic Transformation in Obese Mice after Experimental Stroke

(2009) Barry W McColl et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Monocytes from Patients with Type 1 Diabetes Spontaneously Secrete Proinflammatory Cytokines Inducing Th17 Cells

(2009) E. M. Bradshaw et al.   JOURNAL OF IMMUNOLOGY

Plasma levels of inflammatory and thrombotic/fibrinolytic markers in acute ischemic strokes: Relationship with TOAST subtype, outcome and infarct site

(2009) Antonino Tuttolomondo et al.   JOURNAL OF NEUROIMMUNOLOGY

Cognitive impairment following high fat diet consumption is associated with brain inflammation

(2009) Paul J. Pistell et al.   JOURNAL OF NEUROIMMUNOLOGY

Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies

(2009) Prospective Studies Collaboration   LANCET

C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis

(2009)   LANCET

The Stressed CNS: When Glucocorticoids Aggravate Inflammation

(2009) Shawn F. Sorrells et al.   NEURON

Innate and adaptive immunity in atherosclerosis

(2009) René R. S. Packard et al.   Seminars in Immunopathology

Monocytes Are Major Players in the Prognosis and Risk of Infection After Acute Stroke

(2009) Xabier Urra et al.   STROKE

The Impact of Body Mass Index on Mortality After Stroke

(2009) Amytis Towfighi et al.   STROKE

Infarct Volume is a Major Determiner of Post-Stroke Immune Cell Function and Susceptibility to Infection

(2009) Andreas Hug et al.   STROKE

Inflammatory Biomarkers of Vascular Risk as Correlates of Leukoariosis

(2009) Clinton B. Wright et al.   STROKE

Update of the Stroke Therapy Academic Industry Roundtable Preclinical Recommendations

(2009) Marc Fisher et al.   STROKE

Sex Differences in Stroke Epidemiology

(2009) Peter Appelros et al.   STROKE

Inflammatory Markers and Poor Outcome after Stroke: A Prospective Cohort Study and Systematic Review of Interleukin-6

(2009) William Whiteley et al.   PLOS MEDICINE

Cytokines and atherosclerosis: a comprehensive review of studies in mice

(2008) R. Kleemann et al.   CARDIOVASCULAR RESEARCH

Matrix Metalloproteinase-2 and -9 Levels in Obese Patients

(2008) G. Derosa et al.   ENDOTHELIUM-JOURNAL OF ENDOTHELIAL CELL RESEARCH

Molecular Pathology in Vulnerable Carotid Plaques: Correlation with [18]-Fluorodeoxyglucose Positron Emission Tomography (FDG-PET)

(2008) M. Græbe et al.   EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY

Aspirin Attenuates Cerebral Ischemic Injury in Diabetic Rats

(2008) T. Wang et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Elevated soluble intercellular adhesion molecule-1 levels are associated with poor short-term prognosis in middle-aged patients with acute ischaemic stroke

(2008) Loukianos S. Rallidis et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Role of CX3CR1 (Fractalkine Receptor) in Brain Damage and Inflammation Induced by Focal Cerebral Ischemia in Mouse

(2008) Ádám Dénes et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Systemic Inflammation Alters the Kinetics of Cerebrovascular Tight Junction Disruption after Experimental Stroke in Mice

(2008) B. W. McColl et al.   JOURNAL OF NEUROSCIENCE

Vascular Protection with Candesartan after Experimental Acute Stroke in Hypertensive Rats: A Dose-Response Study

(2008) W. Kozak et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Acute ischaemic stroke and infection: recent and emerging concepts

(2008) Hedley CA Emsley et al.   LANCET NEUROLOGY

Intestinal, adipose, and liver inflammation in diet-induced obese mice

(2008) Hong Li et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Reproductive age modulates the impact of focal ischemia on the forebrain as well as the effects of estrogen treatment in female rats

(2008) Amutha Selvamani et al.   NEUROBIOLOGY OF AGING

Body Mass Index and Poststroke Mortality

(2008) Tom Skyhøj Olsen et al.   NEUROEPIDEMIOLOGY

Psychological distress, major depressive disorder, and risk of stroke

(2008) P. G. Surtees et al.   NEUROLOGY

Systemic infection, inflammation and acute ischemic stroke

(2008) B.W. McColl et al.   NEUROSCIENCE

Rosuvastatin to Prevent Vascular Events in Men and Women with Elevated C-Reactive Protein

(2008) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Body Mass Index, Blood Pressure, and Mortality From Stroke

(2008) Maigeng Zhou et al.   STROKE

Inflammatory and Injury Responses to Ischemic Stroke in Obese Mice

(2008) Satoshi Terao et al.   STROKE

Early disruptions of the blood–brain barrier may contribute to exacerbated neuronal damage and prolonged functional recovery following stroke in aged rats

(2007) Vincent A. DiNapoli et al.   NEUROBIOLOGY OF AGING

Role of nonsynaptic communication in regulating the immune response

(2007) Zsolt Selmeczy et al.   NEUROCHEMISTRY INTERNATIONAL