Article
Microbiology
Ryosuke Adachi, Takahiko Tamura
Summary: Malaria is a global infectious disease and immunity against it can be achieved through multiple infection-cure cycles. This study investigated the impact of repeated infection-cure cycles on the functionality of conventional dendritic cells (cDCs) and found that it can significantly affect their phagocytic capacity, potentially influencing immune responses against subsequent malaria infections.
Article
Immunology
Laura C. Van Eyndhoven, Eleni Chouri, Nikita Subedi, Jurjen Tel
Summary: Plasmacytoid dendritic cells (pDCs) are a rare type of immune cells with specialized functions in producing large amounts of type I interferon (IFN-I) and exerting cytotoxic effects. Studies show that only a small percentage of pDCs respond to activation by toll-like receptors with IFN alpha secretion and upregulation of cytotoxic markers. The early IFN-producing pDCs, known as first responders, exhibit high expression of PD-L1 and TRAIL, while IFN-I primed cells increase IFN alpha production but do not significantly enhance cytotoxicity. Through droplet-based microfluidics, researchers observed that first responders play a key role in orchestrating population-wide IFN-I responses and have a high cytotoxic potential.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Abdul Muktadir Shafi, Akos Vegvari, Roman A. Zubarev, Carlos Penha-Goncalves
Summary: This study reveals the important role of the STING-INFb-CXCL10 pathway in brain microvascular endothelial cells (BECs) in the development of cerebral malaria (CM). Activation of this pathway leads to immunoproteasome activation, enhanced antigen presentation, and impairment of endothelial barrier function. These findings provide insights into the pathogenesis of CM and its lethality.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Sebastian Bruera, Thandiwe Chavula, Riya Madan, Sandeep. K. K. Agarwal
Summary: Systemic lupus erythematosus (SLE) is a complex autoimmune disease with diverse clinical manifestations. Recent studies have highlighted the important role of the type I interferon (IFN) pathway in SLE pathogenesis. Therapeutic strategies targeting type I IFN and related pathways are being developed for the treatment of SLE. This review discusses the role of type I IFN in SLE pathogenesis and its potential as a biomarker and therapeutic target for SLE patients.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Faezzah Baharom, Ramiro A. Ramirez-Valdez, Ahad Khalilnezhad, Shabnam Khalilnezhad, Marlon Dillon, Dalton Hermans, Sloane Fussell, Kennedy K. S. Tobin, Charles-Antoine Dutertre, Geoffrey M. Lynn, Soren Muller, Florent Ginhoux, Andrew S. Ishizuka, Robert A. Seder
Summary: Therapeutic cancer vaccines aim to enhance tumor-specific T cell immunity, but suppressive mechanisms within the tumor microenvironment can limit T cell function. This study investigated how different routes of vaccination impact intratumoral myeloid cells and found that intravenous administration of a nanoparticle vaccine induced tumor regression mediated by systemic type I interferon, leading to a reduction in intratumoral monocytes expressing immune-regulatory genes. In humans, these gene signatures are associated with worse outcomes. These results suggest that combining the generation of tumor-specific CD8+ T cells with remodeling of the tumor microenvironment holds promise for tumor immunotherapy.
Article
Immunology
Juan Liu, Xiaomin Zhang, Xuetao Cao
Summary: This review discusses the activation and functional changes of dendritic cells (DCs) during the development of systemic lupus erythematosus (SLE) and explores the therapeutic potential of targeting DCs in the treatment of SLE.
JOURNAL OF AUTOIMMUNITY
(2022)
Article
Infectious Diseases
Nathella Pavan Kumar, Chandrasekaran Padmapriyadarsini, Anuradha Rajamanickam, Perumal Kannabiran Bhavani, Arul Nancy, Bharathi Jeyadeepa, Nandhini Selvaraj, Dinesh Ashokan, Rachel Mariam Renji, Vijayalakshmi Venkataramani, Srikanth Tripathy, Subash Babu
Summary: BCG vaccination in elderly individuals enhances DC subsets and increases levels of specific interferons, suggesting its ability to induce non-specific innate immune responses.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Dermatology
Kristen L. Chen, Jay Patel, Majid Zeidi, Maria Wysocka, Muhammad M. Bashir, Basil Patel, Spandana Maddukuri, Barbara White, Victoria P. Werth
Summary: The pathogenesis of dermatomyositis involves a predominant IFN-1 response, with mDCs playing an important role in IFN-beta production in the skin. Patients with dermatomyositis have increased CD4+, CD11c+, and CD69+ cells in lesional skin, and both mDCs and plasmacytoid dendritic cells are major producers of IFN-beta in their blood. Additionally, mDCs are significantly increased in the skin of hydroxychloroquine nonresponders.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Immunology
Hayley A. McNamara, Mireille H. Lahoud, Yeping Cai, Jessica Durrant-Whyte, James H. O'Connor, Irina Caminschi, Ian A. Cockburn
Summary: This study investigates the mechanisms behind B cell fate determination using a Plasmodium infection model. It finds that the organ environment plays a role in determining B cell fate, with the majority of the response derived from splenic plasmablasts. Furthermore, macrophages and CD11c(+) dendritic cells drive the plasmablast fate of CSP-specific B cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Sarah E. Fenton, Diana Saleiro, Leonidas C. Platanias
Summary: Interferons play crucial roles in activating immune responses, promoting anti-tumor effects while also potentially suppressing immune responses. Maintaining a balance is key for effective cancer surveillance and immune responses.
Review
Immunology
Xueran Guo, Chengwei He, Shuzi Xin, Han Gao, Boya Wang, Xiaohui Liu, Sitian Zhang, Fengrong Gong, Xinyi Yu, Luming Pan, Fangling Sun, Jingdong Xu
Summary: This review summarizes the latest research on the development and functional characteristics of plasmacytoid dendritic cells (pDCs). They play a crucial role in intestinal disorders and participate in intestinal immune responses through the generation of interferon and the presentation of antigens.
IMMUNITY INFLAMMATION AND DISEASE
(2023)
Article
Immunology
Ee Shan Pang, Ghazal Daraj, Katherine R. Balka, Dominic De Nardo, Christophe Macri, Hubertus Hochrein, Kelly-Anne Masterman, Peck S. Tan, Angus Shoppee, Zoe Magill, Nazneen Jahan, Mariam Bafit, Yifan Zhan, Benjamin T. Kile, Kate E. Lawlor, Kristen J. Radford, Mark D. Wright, Meredith O'Keeffe
Summary: This study compared the responses of mouse and human plasmacytoid DCs and conventional DC subsets upon STING activation. It was found that both mouse and human DC subsets were activated by STING stimulation and produced Type I interferons. However, only human DCs produced large amounts of IFN-lambda 1, which is not expressed in the mouse genome. Additionally, mouse plasmacytoid DCs underwent rapid cell death upon STING activation, while human plasmacytoid DCs did not.
FRONTIERS IN IMMUNOLOGY
(2022)
Editorial Material
Oncology
Kung-Chi Kao, Alison Jaccard, Ping-Chih Ho
Summary: Hu and colleagues demonstrate that the combination of IFN alpha administration and anti-PD-1 therapy can enhance the antitumor response of CD8(+) T-cells in hepatocellular carcinoma, suggesting a novel therapeutic strategy.
Article
Biology
Toshio Kanno, Takahiro Nakajima, Satoru Yokoyama, Hikari K. Asou, Shigemi Sasamoto, Yasuhiro Kamii, Koji Hayashizaki, Yasuo Ouchi, Taishi Onodera, Yoshimasa Takahashi, Kazutaka Ikeda, Yoshinori Hasegawa, Yuki Kinjo, Osamu Ohara, Toshinori Nakayama, Yusuke Endo
Summary: Research shows that viral infection weakens the expression of genes related to lipid metabolism in murine CD4(+) T cells, which in turn increases the expression of antiviral genes. Inhibiting the fatty acid synthesis pathway substantially boosts the basal expression of antiviral genes via the spontaneous production of type I interferon. This study demonstrates the important relationship between fatty acid biosynthesis and type I IFN responses in enhancing the antiviral response.
COMMUNICATIONS BIOLOGY
(2021)
Article
Virology
Isshu Kojima, Koji Onomoto, Wenjie Zuo, Makoto Ozawa, Kosuke Okuya, Kiyotada Naitou, Fumiki Izumi, Misuzu Okajima, Takuro Fujiwara, Naoto Ito, Mitsutoshi Yoneyama, Kentaro Yamada, Akira Nishizono, Makoto Sugiyama, Takashi Fujita, Tatsunori Masatani
Summary: Rabies virus (RABV) can induce the formation of stress granules (SGs), but the relationship between SG formation capacity and pathogenicity of RABV has been unclear. By comparing two RABV strains with completely different levels of virulence, we found that an amino acid mutation from valine to alanine at position 95 of matrix protein (M95), known to determine the difference in virulence, plays a major role in SG formation. Importantly, M95 is involved in the accumulation of RIG-I in SGs and in promoting interferon induction. These findings are the first report of the effect of a single amino acid substitution associated with SGs on viral virulence.
JOURNAL OF VIROLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Takahiko Tamura, Chiaki Kawabata, Shunsuke Matsushita, Miako Sakaguchi, Shigeto Yoshida
JOURNAL OF GENE MEDICINE
(2016)
Article
Infectious Diseases
Mitsuhiro Iyori, Daisuke S. Yamamoto, Miako Sakaguchi, Masanori Mizutani, Sota Ogata, Hidesato Nishiura, Takahiko Tamura, Hiroyuki Matsuoka, Shigeto Yoshida
Article
Immunology
Takahiko Tamura, Kazumi Kimura, Masao Yuda, Katsuyuki Yui
INFECTION AND IMMUNITY
(2011)
Article
Medicine, Research & Experimental
Takahiko Tamura, Joe Chiba
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2009)
Article
Biotechnology & Applied Microbiology
Takahiko Tamura, Joe Chiba
JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY
(2009)
Article
Immunology
Rika Kamei, Mana Miyakoda, Takahiko Tamura, Daisuke Kimura, Kiri Honma, Kazumi Kimura, Katsuyuki Yui
MICROBIOLOGY AND IMMUNOLOGY
(2013)
Article
Immunology
T. Tamura, M. Akbari, K. Kimura, D. Kimura, K. Yui
PARASITE IMMUNOLOGY
(2014)
Article
Pharmacology & Pharmacy
Yusuke Kawai, Chiaki Kawabata, Miako Sakaguchi, Takahiko Tamura
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2018)
Article
Immunology
Ryosuke Adachi, Takahiko Tamura
MICROBIOLOGY AND IMMUNOLOGY
(2020)
Article
Pharmacology & Pharmacy
Chiaki Kawabata, Yusuke Kawai, Takahiko Tamura
Summary: The study investigated the combination of CSP and CRPs in a BV system to enhance transduction efficacy and resist complement attack. By infecting CSP type BV to insect Sf9 cells stably expressing CRPs, the resulting CSP-CD46-DAF-CD59 BV showed significantly improved transduction efficacy in human hepatoma HepG2 cells under intact serum exposure, indicating the potential for generating BVs with novel functions through stable protein expression in cells.
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2021)
Article
Microbiology
Ryosuke Adachi, Takahiko Tamura
Summary: Malaria is a global infectious disease and immunity against it can be achieved through multiple infection-cure cycles. This study investigated the impact of repeated infection-cure cycles on the functionality of conventional dendritic cells (cDCs) and found that it can significantly affect their phagocytic capacity, potentially influencing immune responses against subsequent malaria infections.
Article
Pharmacology & Pharmacy
Chiaki Kawabata, Ryosuke Adachi, Benoit Gamain, Takahiko Tamura
Summary: A BV displaying malarial var2CSA molecules was developed to improve the transduction efficiency in human cancer cells. The var2CSA BV showed significantly higher gene transduction in hepatic and pancreatic cancer cells, suggesting its potential as an improved vector for cancer gene therapies.
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2023)
Meeting Abstract
Public, Environmental & Occupational Health
Mitsuhiro Iyori, Andrew M. Blagborough, Sota Ogata, Hidesato Nishiura, Miako Sakaguchi, Masanori Mizutani, Takahiko Tamura, Kento Genshi, Satoshi Shimada, Daisuke S. Yamamoto, Hiroyuki Matsuoka, Shigeto Yoshida
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2017)
Article
Multidisciplinary Sciences
Mikael J. Pittet, Jan Grimm, Cedric R. Berger, Takahiko Tamura, Gregory Wojtkiewicz, Matthias Nahrendorf, Pedro Romero, Filip K. Swirski, Ralph Weissleder
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2007)
