Article
Oncology
Yumeng Zhang, Shu Liu, Shu Zhou, Dandan Yu, Junjie Gu, Qin Qin, Yu Cheng, Xinchen Sun
Summary: Oesophageal cancer is highly invasive and prone to recurrence and metastasis, with a low five-year survival rate, making the development of new therapeutic interventions crucial. Focal adhesion kinase (FAK) plays a key role in survival, proliferation, and migration of cancer cells, making it a potential therapeutic target for oesophageal cancer. The combination of FAK inhibitors with other treatments is expected to improve patient survival.
Article
Biochemistry & Molecular Biology
Hongshan Guo, Joanna A. Vuille, Ben S. Wittner, Emily M. Lachtara, Yu Hou, Maoxuan Lin, Ting Zhao, Ayush T. Raman, Hunter C. Russell, Brittany A. Reeves, Haley M. Pleskow, Chin-Lee Wu, Andreas Gnirke, Alexander Meissner, Jason A. Efstathiou, Richard J. Lee, Mehmet Toner, Martin J. Aryee, Michael S. Lawrence, David T. Miyamoto, Shyamala Maheswaran, Daniel A. Haber
Summary: Cancer is characterized by hypomethylation-associated silencing of large chromatin domains, but its contribution to tumorigenesis is uncertain. Through single-cell DNA methylation sequencing, researchers identify core domains that are hypomethylated in prostate malignancy from early stages to metastatic circulating tumor cells (CTCs). Some smaller loci within these domains have preserved methylation and contain cell proliferation genes. Transcriptionally silenced genes within the hypomethylated domains are enriched for immune-related genes, including a gene cluster harboring CD1 genes and IFI16-related genes linked to innate immunity. Restoring CD1 or IFI16 expression in mice with intact immune systems inhibits tumorigenesis and activates anti-tumor immunity. Hypomethylation domains can be detected in blood samples enriched for CTCs.
Review
Biochemistry & Molecular Biology
Xiao-Jing Pang, Xiu-Juan Liu, Yuan Liu, Wen-Bo Liu, Yin-Ru Li, Guang-Xi Yu, Xin-Yi Tian, Yan-Bing Zhang, Jian Song, Cheng-Yun Jin, Sai-Yang Zhang
Summary: FAK, a nonreceptor intracellular tyrosine kinase, is overexpressed in many human cancer cell lines, promoting tumor growth by controlling various cellular functions. Targeting FAK with small molecule inhibitors is considered a promising cancer therapy, with several FAK inhibitors undergoing clinical trials in different phases. Additionally, the development of novel FAK inhibitors, including FAK degraders through PROTAC technology, provides potential for new anticancer agents.
Article
Pathology
Yijie Tang, Yingda Wang, Xiaodong Xu, Hongxia Sun, Weidong Tang
Summary: This study identified STEAP4 as a tumor suppressor gene in hepatocellular carcinoma (HCC), with its expression regulated by promoter methylation. STEAP4 inhibited the proliferation and metastasis of HCC cells by inhibiting the PI3K/AKT/mTOR pathway. These findings reveal the important role of STEAP4 and methylation regulation in HCC progression.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Oncology
Nicklas Pihlstrom, Yang Jin, Zeynep Nenseth, Omer F. Kuzu, Fahri Saatcioglu
Summary: Prostate cancer is one of the most common non-skin cancers among men, with no curative treatment currently available. STAMP2, an important factor for prostate cancer growth and survival, is regulated by inflammatory signaling which may affect disease progression. Inflammatory events and dysregulated cytokine expression are implicated in prostate cancer, and STAMP2 knockdown increases the sensitivity of prostate cancer cells to cytokine treatment.
Article
Medicine, Research & Experimental
Hung-Chih Lo, Wei-Jyun Hua, Hsin Yeh, Zhi-Hu Lin, Li-Chen Huang, Yi -Ru Ciou, Runcheng Ruan, Kai-Fan Lin, Ai -Jung Tseng, Alexander T. H. Wu, Wei-Hung Hsu, Chi -Hong Chao, Tung-Yi Lin
Summary: This study demonstrates that GMI protein inhibits lung cancer metastasis by suppressing cell migration and disrupting cell adhesion. GMI also induces degradation of integrins and increases expression of epithelial markers, leading to reduced pulmonary lesions in mice.
Review
Biochemistry & Molecular Biology
Akshita Chauhan, Tabassum Khan
Summary: The article discusses the critical role of FAK in cancer cell adhesion, motility, proliferation, and survival, and the potential of small molecule FAK inhibitors in modulating cancer progression. Development of FAK inhibitors, including hybrid scaffolds, is being actively pursued, with some already in clinical trials showing promise in reducing metastasis and inducing tumor cell apoptosis. The future prospects in the development of FAK inhibitors for cancer therapeutics are highlighted, with a growing interest in targeting FAK-mediated signaling pathways.
CHEMICAL BIOLOGY & DRUG DESIGN
(2021)
Article
Oncology
Siddesh Southekal, Nitish Kumar Mishra, Chittibabu Guda
Summary: This study analyzed the DNA methylation and gene expression patterns of the human kinome in 32 cancers, revealing significant differences in methylation levels between tumor and normal samples from the same tissue. The meQTL analysis showed a highly significant and mostly negative correlation between kinase gene expression and methylated probes within 1.5 kb from the transcription start site (TSS). Additionally, several understudied kinases were identified with a significant impact on patient survival, highlighting the potential of kinases as prognostic and diagnostic markers in cancer.
Article
Multidisciplinary Sciences
Sara Garcia-Garcia, Maria Rodrigo-Faus, Noelia Fonseca, Sara Manzano, Balazs Gyorffy, Alberto Ocana, Paloma Bragado, Almudena Porras, Alvaro Gutierrez-Uzquiza
Summary: The study identifies MAP4K4 as a key gene in prostate cancer metastasis, with its deletion or inhibition blocking cell migration and clonogenic properties, suggesting a potential role of MAP4K4 in promoting tumor dissemination and growth. Moreover, the upregulation of HGK correlates with poor prognosis in prostate cancer, indicating its potential use as a prognostic biomarker for predicting aggressive phenotype and metastasis appearance.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Ioanna Antoniades, Maria Kyriakou, Anna Charalambous, Katerina Kalalidou, Andri Christodoulou, Maria Christoforou, Paris A. Skourides
Summary: The study successfully prevented the action of FAK at focal adhesions by generating a specific peptide structure, thereby effectively inhibiting the migration and invasion of tumor cells and providing a new direction for the development of anti-metastatic agents.
CELL COMMUNICATION AND SIGNALING
(2021)
Article
Genetics & Heredity
Chenming Zhang, Sicheng Ma, Xiaohui Hao, Zulong Wang, Zixue Sun
Summary: This study revealed that TK1 is overexpressed in prostate cancer, correlated with tumor stage and prognosis. The expression and methylation status of TK1 are linked to immune infiltrates and immunomodulators in prostate cancer. The research highlights the potential of TK1 as a target for prostate cancer therapy.
FRONTIERS IN GENETICS
(2022)
Article
Biochemistry & Molecular Biology
Chad J. Creighton, Flora Zhang, Yiqun Zhang, Patricia Castro, Rong Hu, Md Islam, Somiranjan Ghosh, Michael Ittmann, Bernard Kwabi-Addo
Summary: African American (AA) men have a higher incidence and mortality rate of prostate cancer compared to other ethnic groups. Genome-wide methylation analysis in AA prostate tissues identified significant differentially methylated probes associated with mRNA expression. Comparison with TCGA dataset showed similarities in methylation patterns and differences in enriched genes. Differential methylation of specific genes was uniquely associated with prostate cancer progression in the AA cohort.
Article
Medicine, Research & Experimental
Junsuke Uwada, Shoichiro Mukai, Naoki Terada, Hitomi Nakazawa, Mohammad Sayful Islam, Takahiro Nagai, Masato Fujii, Koji Yamasaki, Takanobu Taniguchi, Toshiyuki Kamoto, Takashi Yazawa
Summary: In 3D-cultured prostate cancer cells, probenecid demonstrated pleiotropic effects such as chemosensitization, growth suppression, inhibition of spheroid compaction, and suppression of anchorage-independent growth. Elucidating the detailed mechanism underlying these probenecid actions could result in the identification of novel therapeutic targets toward the advanced prostate cancer.
Review
Oncology
Ximin Tan, Yuheng Yan, Bin Song, Shuangli Zhu, Qi Mei, Kongming Wu
Summary: Focal adhesion kinase (FAK) plays a crucial role in cellular functions and tumor microenvironment. Increased FAK expression and activity are strongly associated with unfavorable clinical outcomes and metastatic characteristics in cancer. Modulating FAK activity has potential as an effective approach in cancer therapy.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2023)
Article
Cell Biology
Jiazhou Liu, Xiaoyu Wang, Jiazheng Sun, Yuru Chen, Jie Li, Jing Huang, Huimin Du, Lu Gan, Zhu Qiu, Hongzhong Li, Guosheng Ren, Yuxian Wei
Summary: In this study, the researchers identified NPY5R as a hub gene in breast cancer and found that it was frequently downregulated in breast cancer tissues. Higher expression of NPY5R was associated with better prognosis for breast cancer patients. Mechanistically, NPY5R suppressed breast tumor cell growth, induced apoptosis and cell cycle arrest, and enhanced sensitivity to doxorubicin through inhibiting the STAT3 signaling pathway. These findings suggest that NPY5R functions as a tumor suppressor in breast cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Parasitology
Takahiko Tamura, Kazumi Kimura, Katsuyuki Yui, Shigeto Yoshida
EXPERIMENTAL PARASITOLOGY
(2015)
Article
Biotechnology & Applied Microbiology
Takahiko Tamura, Chiaki Kawabata, Shunsuke Matsushita, Miako Sakaguchi, Shigeto Yoshida
JOURNAL OF GENE MEDICINE
(2016)
Article
Infectious Diseases
Mitsuhiro Iyori, Daisuke S. Yamamoto, Miako Sakaguchi, Masanori Mizutani, Sota Ogata, Hidesato Nishiura, Takahiko Tamura, Hiroyuki Matsuoka, Shigeto Yoshida
Article
Immunology
Takahiko Tamura, Kazumi Kimura, Masao Yuda, Katsuyuki Yui
INFECTION AND IMMUNITY
(2011)
Article
Biotechnology & Applied Microbiology
Takahiko Tamura, Joe Chiba
JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY
(2009)
Article
Immunology
Rika Kamei, Mana Miyakoda, Takahiko Tamura, Daisuke Kimura, Kiri Honma, Kazumi Kimura, Katsuyuki Yui
MICROBIOLOGY AND IMMUNOLOGY
(2013)
Article
Immunology
T. Tamura, M. Akbari, K. Kimura, D. Kimura, K. Yui
PARASITE IMMUNOLOGY
(2014)
Article
Pharmacology & Pharmacy
Yusuke Kawai, Chiaki Kawabata, Miako Sakaguchi, Takahiko Tamura
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2018)
Article
Immunology
Ryosuke Adachi, Takahiko Tamura
MICROBIOLOGY AND IMMUNOLOGY
(2020)
Article
Pharmacology & Pharmacy
Chiaki Kawabata, Yusuke Kawai, Takahiko Tamura
Summary: The study investigated the combination of CSP and CRPs in a BV system to enhance transduction efficacy and resist complement attack. By infecting CSP type BV to insect Sf9 cells stably expressing CRPs, the resulting CSP-CD46-DAF-CD59 BV showed significantly improved transduction efficacy in human hepatoma HepG2 cells under intact serum exposure, indicating the potential for generating BVs with novel functions through stable protein expression in cells.
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2021)
Article
Microbiology
Ryosuke Adachi, Takahiko Tamura
Summary: Malaria is a global infectious disease and immunity against it can be achieved through multiple infection-cure cycles. This study investigated the impact of repeated infection-cure cycles on the functionality of conventional dendritic cells (cDCs) and found that it can significantly affect their phagocytic capacity, potentially influencing immune responses against subsequent malaria infections.
Article
Pharmacology & Pharmacy
Chiaki Kawabata, Ryosuke Adachi, Benoit Gamain, Takahiko Tamura
Summary: A BV displaying malarial var2CSA molecules was developed to improve the transduction efficiency in human cancer cells. The var2CSA BV showed significantly higher gene transduction in hepatic and pancreatic cancer cells, suggesting its potential as an improved vector for cancer gene therapies.
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2023)
Meeting Abstract
Public, Environmental & Occupational Health
Mitsuhiro Iyori, Andrew M. Blagborough, Sota Ogata, Hidesato Nishiura, Miako Sakaguchi, Masanori Mizutani, Takahiko Tamura, Kento Genshi, Satoshi Shimada, Daisuke S. Yamamoto, Hiroyuki Matsuoka, Shigeto Yoshida
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2017)
Article
Multidisciplinary Sciences
Mikael J. Pittet, Jan Grimm, Cedric R. Berger, Takahiko Tamura, Gregory Wojtkiewicz, Matthias Nahrendorf, Pedro Romero, Filip K. Swirski, Ralph Weissleder
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2007)
