Management of Statin Intolerance in 2018: Still More Questions Than Answers

Evaluating bempedoic acid for the treatment of hyperlipidaemia

(2017) Peter Penson et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Hydrophilic vs lipophilic statins in coronary artery disease: A meta-analysis of randomized controlled trials

(2017) Ibadete Bytyçi et al.   Journal of Clinical Lipidology

Statin Intolerance and Risk of Coronary Heart Events and All-Cause Mortality Following Myocardial Infarction

(2017) Maria-Corina Serban et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Optimizing Cholesterol Treatment in Patients With Muscle Complaints

(2017) Robert S. Rosenson et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Evolocumab and Clinical Outcomes in Patients with Cardiovascular Disease

(2017) Marc S. Sabatine et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inclisiran in Patients at High Cardiovascular Risk with Elevated LDL Cholesterol

(2017) Kausik K. Ray et al.   NEW ENGLAND JOURNAL OF MEDICINE

Joint position statement on “Nutraceuticals for the treatment of hypercholesterolemia” of the Italian Society of Diabetology (SID) and of the Italian Society for the Study of Arteriosclerosis (SISA)

(2017) M. Pirro et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Regulation of PCSK9 by nutraceuticals

(2017) Amir Abbas Momtazi et al.   PHARMACOLOGICAL RESEARCH

Effects of curcumin on HDL functionality

(2017) Shiva Ganjali et al.   PHARMACOLOGICAL RESEARCH

Intensive LDL-cholesterol lowering therapy and neurocognitive function

(2017) Maciej Banach et al.   PHARMACOLOGY & THERAPEUTICS

Lipoprotein(a) and inhibitors of proprotein convertase subtilisin/kexin type 9

(2017) Kazuhiko Kotani et al.   Journal of Thoracic Disease

Effect of ETC-1002 on Serum Low-Density Lipoprotein Cholesterol in Hypercholesterolemic Patients Receiving Statin Therapy

(2016) Christie M. Ballantyne et al.   AMERICAN JOURNAL OF CARDIOLOGY

Molecular mechanisms of statin intolerance

(2016) Anna Gluba-Brzozka et al.   Archives of Medical Science

Is statin-modified reduction in lipids the most important preventive therapy for cardiovascular disease? A pro/con debate

(2016) FD Richard Hobbs et al.   BMC Medicine

Diagnosis, Prevention, and Management of Statin Adverse Effects and Intolerance: Canadian Consensus Working Group Update (2016)

(2016) G.B. John Mancini et al.   CANADIAN JOURNAL OF CARDIOLOGY

A systematic review and meta-analysis of the impact of Spirulina supplementation on plasma lipid concentrations

(2016) Maria-Corina Serban et al.   CLINICAL NUTRITION

Statin intolerance – a question of definition

(2016) Engi Abdel-Hady Algharably et al.   Expert Opinion On Drug Safety

Expert opinion: the therapeutic challenges faced by statin intolerance

(2016) Jaideep Patel et al.   EXPERT OPINION ON PHARMACOTHERAPY

Statin non-adherence and residual cardiovascular risk: There is need for substantial improvement

(2016) Maciej Banach et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Efficacy and Tolerability of Evolocumab vs Ezetimibe in Patients With Muscle-Related Statin Intolerance

(2016) Steven E. Nissen et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Influence of statins on distinct circulating microRNAs during prolonged aerobic exercise

(2016) Pil-Ki Min et al.   JOURNAL OF APPLIED PHYSIOLOGY

Treatment with ETC-1002 alone and in combination with ezetimibe lowers LDL cholesterol in hypercholesterolemic patients with or without statin intolerance

(2016) Paul D. Thompson et al.   Journal of Clinical Lipidology

Lipid-modifying effects of nutraceuticals: An evidence-based approach

(2016) Amirhossein Sahebkar et al.   NUTRITION

Evaluation of microRNAs−208 and 133a/b as differential biomarkers of acute cardiac and skeletal muscle toxicity in rats

(2016) Jacqueline Calvano et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Discussion around statin discontinuation in older adults and patients with wasting diseases

(2016) Maciej Banach et al.   Journal of Cachexia Sarcopenia and Muscle

Curcumin: An effective adjunct in patients with statin-associated muscle symptoms?

(2016) Amirhossein Sahebkar et al.   Journal of Cachexia Sarcopenia and Muscle

Position paper Statin intolerance – an attempt at a unified definition. Position paper from an International Lipid Expert Panel

(2015) Maciej Banach et al.   Archives of Medical Science

PCSK9 inhibition: the way forward in the treatment of dyslipidemia

(2015) Robert M. Stoekenbroek et al.   BMC Medicine

Impact of statin therapy on coronary plaque composition: a systematic review and meta-analysis of virtual histology intravascular ultrasound studies

(2015) Maciej Banach et al.   BMC Medicine

Statin Intolerance: the Clinician’s Perspective

(2015) Tomáš Stulc et al.   Current Atherosclerosis Reports

Negative statin-related news stories decrease statin persistence and increase myocardial infarction and cardiovascular mortality: a nationwide prospective cohort study

(2015) Sune Fallgaard Nielsen et al.   EUROPEAN HEART JOURNAL

Statin-associated muscle symptoms: impact on statin therapy—European Atherosclerosis Society Consensus Panel Statement on Assessment, Aetiology and Management

(2015) Erik S. Stroes et al.   EUROPEAN HEART JOURNAL

Statin intolerance – an attempt at a unified definition. Position paper from an International Lipid Expert Panel

(2015) Maciej Banach et al.   Expert Opinion On Drug Safety

Clinical implications of the IMPROVE-IT trial in the light of current and future lipid-lowering treatment options

(2015) Maria-Corina Serban et al.   EXPERT OPINION ON PHARMACOTHERAPY

Analysis of vitamin D levels in patients with and without statin-associated myalgia — A systematic review and meta-analysis of 7 studies with 2420 patients

(2015) Marta Michalska-Kasiczak et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Use of ETC-1002 to treat hypercholesterolemia in patients with statin intolerance

(2015) Paul D. Thompson et al.   Journal of Clinical Lipidology

Efficacy and safety of alirocumab vs ezetimibe in statin-intolerant patients, with a statin rechallenge arm: The ODYSSEY ALTERNATIVE randomized trial

(2015) Patrick M. Moriarty et al.   Journal of Clinical Lipidology

Effects of Coenzyme Q10 on Statin-Induced Myopathy

(2015) Maciej Banach et al.   MAYO CLINIC PROCEEDINGS

Evaluation of the Relative Performance of Drug-Induced Skeletal Muscle Injury Biomarkers in Rats

(2015) Peter M. Burch et al.   TOXICOLOGICAL SCIENCES

MicroRNA-33b, upregulated by EF24, a curcumin analog, suppresses the epithelial-to-mesenchymal transition (EMT) and migratory potential of melanoma cells by targeting HMGA2

(2015) Pu Zhang et al.   TOXICOLOGY LETTERS

ETC-1002: A future option for lipid disorders?

(2014) Dragana Nikolic et al.   ATHEROSCLEROSIS

Rationale and Design of LAPLACE-2: A Phase 3, Randomized, Double-Blind, Placebo- and Ezetimibe-Controlled Trial Evaluating the Efficacy and Safety of Evolocumab in Subjects With Hypercholesterolemia on Background Statin Therapy

(2014) Jennifer G. Robinson et al.   CLINICAL CARDIOLOGY

Statins and New-Onset Diabetes

(2014) Marcin Barylski et al.   CURRENT PHARMACEUTICAL DESIGN

Efficacy and safety of evolocumab (AMG 145), a fully human monoclonal antibody to PCSK9, in hyperlipidaemic patients on various background lipid therapies: pooled analysis of 1359 patients in four phase 2 trials

(2014) E. A. Stein et al.   EUROPEAN HEART JOURNAL

Effect of Evolocumab or Ezetimibe Added to Moderate- or High-Intensity Statin Therapy on LDL-C Lowering in Patients With Hypercholesterolemia

(2014) Jennifer G. Robinson et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Proprotein Convertase Subtilisin/Kexin 9 Inhibitors

(2014) Simona Dragan et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS

An assessment by the Statin Muscle Safety Task Force: 2014 update

(2014) Robert S. Rosenson et al.   Journal of Clinical Lipidology

National Lipid Association recommendations for patient-centered management of dyslipidemia: Part 1 – executive summary

(2014) Terry A. Jacobson et al.   Journal of Clinical Lipidology

Curcuminoids for the management of hypertriglyceridaemia

(2014) Amirhossein Sahebkar   Nature Reviews Cardiology

Lipid lowering with PCSK9 inhibitors

(2014) Razvan T. Dadu et al.   Nature Reviews Cardiology

Narrative Review: Statin-Related Myopathy

(2013) Tisha R. Joy   ANNALS OF INTERNAL MEDICINE

Diagnosis, Prevention, and Management of Statin Adverse Effects and Intolerance: Canadian Working Group Consensus Update

(2013) G.B. John Mancini et al.   CANADIAN JOURNAL OF CARDIOLOGY

The Role of Fibrate Treatment in Dyslipidemia: An Overview

(2013) Niki Katsiki et al.   CURRENT PHARMACEUTICAL DESIGN

Statin Therapy and New-onset Diabetes: Molecular Mechanisms and Clinical Relevance

(2013) Maciej Banach et al.   CURRENT PHARMACEUTICAL DESIGN

Nutraceutical approach to moderate cardiometabolic risk: Results of a randomized, double-blind and crossover study with Armolipid Plus

(2013) Massimiliano Ruscica et al.   Journal of Clinical Lipidology

2013 ACC/AHA Guideline on the Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in Adults

(2013) Neil J. Stone et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Efficacy and Safety of Eicosapentaenoic Acid Ethyl Ester (AMR101) Therapy in Statin-Treated Patients With Persistent High Triglycerides (from the ANCHOR Study)

(2012) Christie M. Ballantyne et al.   AMERICAN JOURNAL OF CARDIOLOGY

Effect of Statins on Skeletal Muscle Function

(2012) Beth A. Parker et al.   CIRCULATION

LDL-cholesterol-lowering effect of a dietary supplement with plant extracts in subjects with moderate hypercholesterolemia

(2012) Nicolas Ogier et al.   EUROPEAN JOURNAL OF NUTRITION

The Role of Nutraceutical Supplements in the Treatment of Dyslipidemia

(2012) Mark Houston   Journal of Clinical Hypertension

Understanding Statin Use in America and Gaps in Patient Education (USAGE): An internet-based survey of 10,138 current and former statin users

(2012) Jerome D. Cohen et al.   Journal of Clinical Lipidology

Efficacy, safety, and tolerability of a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 in combination with a statin in patients with hypercholesterolaemia (LAPLACE-TIMI 57): a randomised, placebo-controlled, dose-ranging, phase 2 study

(2012) Robert P Giugliano et al.   LANCET

Cardiovascular benefits and diabetes risks of statin therapy in primary prevention: an analysis from the JUPITER trial

(2012) Paul M Ridker et al.   LANCET

Nutraceutical pill containing berberine versus ezetimibe on plasma lipid pattern in hypercholesterolemic subjects and its additive effect in patients with familial hypercholesterolemia on stable cholesterol-lowering treatment

(2012) Livia Pisciotta et al.   Lipids in Health and Disease

Biomarker panel of cardiac and skeletal muscle troponins, fatty acid binding protein 3 and myosin light chain 3 for the accurate diagnosis of cardiotoxicity and musculoskeletal toxicity in rats

(2012) Yutaka Tonomura et al.   TOXICOLOGY

A randomized controlled trial on the anti-inflammatory effects of curcumin in patients with chronic sulphur mustard-induced cutaneous complications

(2012) Y. Panahi et al.   ANNALS OF CLINICAL BIOCHEMISTRY

Diagnosis, Prevention, and Management of Statin Adverse Effects and Intolerance: Proceedings of a Canadian Working Group Consensus Conference

(2011) G.B. John Mancini et al.   CANADIAN JOURNAL OF CARDIOLOGY

Residual Cardiovascular Risk Despite Optimal LDL Cholesterol Reduction with Statins: The Evidence, Etiology, and Therapeutic Challenges

(2011) Uchechukwu K. Sampson et al.   Current Atherosclerosis Reports

Risk of Incident Diabetes With Intensive-Dose Compared With Moderate-Dose Statin Therapy

(2011) David Preiss   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Effects of statin treatment on endothelial function, oxidative stress and inflammation in patients with arterial hypertension and normal cholesterol levels

(2011) Niki Katsiki et al.   JOURNAL OF HYPERTENSION

Predictors of New-Onset Diabetes in Patients Treated With Atorvastatin

(2011) David D. Waters et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Degradation of Chlorpyrifos by an alkaline phosphatase from the cyanobacterium Spirulina platensis

(2010) Rutwik Ravindra Mandakini Thengodkar et al.   BIODEGRADATION

Curcumin as a therapeutic agent: the evidence from in vitro, animal and human studies

(2010) Jenny Epstein et al.   BRITISH JOURNAL OF NUTRITION

Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170 000 participants in 26 randomised trials

(2010)   LANCET

Evaluation of skeletal muscle during calf exercise by 31-phosphorus magnetic resonance spectroscopy in patients on statin medications

(2010) Jim S. Wu et al.   MUSCLE & NERVE

Effects of Statins on Skeletal Muscle: A Perspective for Physical Therapists

(2010) Stephanie L. Di Stasi et al.   PHYSICAL THERAPY

Rebound inflammatory response during the acute phase of myocardial infarction after simvastatin withdrawal

(2009) Andrei C. Sposito et al.   ATHEROSCLEROSIS

Evaluation of the usefulness of biomarkers for cardiac and skeletal myotoxicity in rats

(2009) Yutaka Tonomura et al.   TOXICOLOGY

The creatine kinase response to eccentric exercise with atorvastatin 10mg or 80mg

(2008) Amy K. Kearns et al.   ATHEROSCLEROSIS

Molecular basis of statin-associated myopathy

(2008) Christos Vaklavas et al.   ATHEROSCLEROSIS

Efficacy of alternate day dosing of atorvastatin

(2007) Kamran Aghasadeghi et al.   Open Medicine