Article
Multidisciplinary Sciences
Emilie J. Cosway, Kieran D. James, Andrea J. White, Sonia M. Parnell, Andrea Bacon, Andrew N. J. Mckenzie, W. E. Jenkinson, Graham Anderson
Summary: The study demonstrates the importance of interleukin 33 (IL-33) in thymus regeneration, showing that it stimulates the expansion of innate lymphoid cells (ILC2) and triggers the production of IL-4 by eosinophils, leading to the recovery of thymus mesenchyme.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Judith C. J. Holzer-Geissler, Simon Schwingenschuh, Martin Zacharias, Johanna Einsiedler, Sonja Kainz, Peter Reisenegger, Christian Holecek, Elisabeth Hofmann, Barbara Wolff-Winiski, Hermann Fahrngruber, Thomas Birngruber, Lars-Peter Kamolz, Petra Kotzbeck
Summary: The treatment of chronic wounds poses a challenge for modern medicine due to the complex pathophysiology involved. Previous wound models used for studying chronic wounds lack translatability to patients and often overlook the impact of exaggerated inflammation. This study aims to investigate the role of prolonged inflammation in a porcine wound model using the TLR7 and TLR8 agonist resiquimod. The results demonstrate that prolonged inflammation delays wound healing, a common observation in chronic wounds. This model highlights the importance of inflammation in wound healing and provides insights into the progression of chronic wounds.
Article
Biochemistry & Molecular Biology
Yapeng Lu, Xiaopeng Zhu, Chao Hu, Peng Li, Meihui Zhao, Jinfeng Lu, Guanghua Xia
Summary: A tilapia fish skin gelatin-fucose gum-tannic acid hydrogel wound dressing was designed to promote wound healing. The hydrogel showed excellent properties and could effectively accelerate wound healing while reducing inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Cell Biology
Alireza Hassanshahi, Mohammad Moradzad, Saman Ghalamkari, Moosa Fadaei, Allison J. Cowin, Mohammadhossein Hassanshahi
Summary: This review discusses the role and mechanisms of macrophages in skin wound healing, including cellular and molecular aspects such as subtypes, metabolism, plasticity, and epigenetics. The interactions between macrophages and factors important for wound healing are also highlighted.
Review
Biochemistry & Molecular Biology
Ewa A. Burian, Lubna Sabah, Tonny Karlsmark, Klaus Kirketerp-Moller, Christine J. Moffatt, Jacob P. Thyssen, Magnus S. Agren
Summary: This systematic review investigated the association between cytokine levels and the healing of venous leg ulcers (VLUs). The findings suggest that non-healing VLUs may be associated with elevated pro-inflammatory cytokine levels, which decline with healing. TGF-beta 1 levels tended to increase with VLU healing. Further research is needed to explore other cytokines.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Luisa A. DiPietro, Traci A. Wilgus, Timothy J. Koh
Summary: Macrophages play a prominent role in skin wound healing, with functions including host defense and support of new tissue growth. However, the exact role of macrophages in wound healing remains elusive, as some wounds can heal well even with limited or no functional macrophages. Recent advances in understanding macrophage phenotypes and cellular plasticity in wounds may provide new insights and paradigms on macrophage function in wounds.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Kang Geng, Xiumei Ma, Zongzhe Jiang, Wei Huang, Chenlin Gao, Yueli Pu, Lifang Luo, Youhua Xu, Yong Xu
Summary: Recent studies have shown that the interaction between immune and metabolic responses is crucial for maintaining tissue and organ homeostasis, playing a significant role in the development of chronic diseases. In diabetic wound healing, the abnormal activation of innate immune cells is essential in triggering and sustaining inflammation. Targeting these innate immune pathways and reprogramming immune cell phenotypes show great potential in diabetic wound therapy.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biotechnology & Applied Microbiology
Varun Arvind, Alice H. Huang
Summary: Inflammation plays a dual role in tendon healing, serving as the root cause of chronic tendinopathy while also aiding tissue repair. Recent research focuses on the cells and cytokines involved in reparative inflammation.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Immunology
Yuanyuan Jiang, Xiang Xu, Long Xiao, Lihong Wang, Sheng Qiang
Summary: This article discusses the role and significance of microRNA in the inflammatory process of wound healing. It points out that the initiation and resolution of the inflammatory response are crucial for wound healing and may provide a new direction for wound treatment.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Nanoscience & Nanotechnology
Jia-Ying Ji, Dan-Yang Ren, Ying-Zheng Weng
Summary: This review article discusses the recent developments and innovations of antibacterial hydrogels for diabetic chronic wound healing.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Peripheral Vascular Disease
Celso Tarso Rodrigues Viana, Laura Alejandra Ariza Orellano, Clara Tolentino Machado, Camila Pereira Almeida, Marcela Guimaraes Takahashi de Lazari, Paula Peixoto Campos, Silvia Passos Andrade
Summary: The study demonstrated that the IL-33/ST2 axis plays a role in modulating neovascularization and matrix remodeling after implantation of synthetic matrix. In mice lacking the ST2 receptor, there was increased proliferative activity, angiogenesis, and remodeling of fibrovascular tissue induced by implants, suggesting a potential for IL-33/ST2 axis intervention to improve integration of biomaterials and host tissue.
MICROVASCULAR RESEARCH
(2022)
Review
Cell & Tissue Engineering
Mengting Zhu, Lijuan Cao, Sonia Melino, Eleonora Candi, Ying Wang, Changshun Shao, Gerry Melino, Yufang Shi, Xiaodong Chen
Summary: This review outlines the role of mesenchymal stem/stromal cells (MSCs) in wound healing and regeneration, with a focus on the central role of neutrophils, macrophages, and T cells in the interaction between MSCs and the immune system. The specific effects of MSC-based therapy on different pathological wound healing are also discussed, along with the translation of scientific advances in MSCs into clinical strategies.
STEM CELLS TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Livia Interdonato, Ylenia Marino, Gianluca Antonio Franco, Alessia Arangia, Ramona D'Amico, Rosalba Siracusa, Marika Cordaro, Daniela Impellizzeri, Roberta Fusco, Salvatore Cuzzocrea, Rosanna Di Paola
Summary: Recently, wound healing has become a topic of increased interest in both scientific and clinical communities. The study aimed to investigate the molecular mechanism of acai berry in wound healing using a mouse model. The results showed that acai berry could modulate the Wnt/beta-catenin pathway, reducing the expression of Wnt3a and FZ8, and the accumulation of beta-catenin. It also showed anti-inflammatory activities by reducing the expression of TNF-alpha and IL-18, and modulating the NF-kappa B pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Maurizio Sabbatini, Valeria Magnelli, Filippo Reno
Summary: Neutrophils extracellular traps (NETs) have both positive effects, such as aiding wound healing, and negative effects, which can lead to tissue physiological issues in certain pathological conditions. Recent research suggests there are additional positive physiological effects of NETs that warrant further investigation.
Article
Nanoscience & Nanotechnology
Kunbao Zhang, Chao Yang, Chuanxu Cheng, Chengxin Shi, Madi Sun, Hanze Hu, Tongfei Shi, Xuenian Chen, Xuan He, Xiao Zheng, Mingqiang Li, Dan Shao
Summary: A bioactive hydrogel is developed for efficient and safe bacteria-infected diabetic wound healing by targeting inflammation and infection. The hydrogel can capture danger molecules and deliver antibiotics, resulting in improved wound closure rate and anti-inflammatory and antibacterial effects.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Letter
Dermatology
David M. Ansell, Charlotte Marsh, Liam Walker, Matthew I. Hardman, Kirsty Holden
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2018)
Article
Cell Biology
Nur Azida Mohd Nasir, Ralf Paus, David M. Ansell
WOUND REPAIR AND REGENERATION
(2019)
Article
Dermatology
Holly N. Wilkinson, Christopher Clowes, Kayleigh L. Banyard, Paolo Matteuci, Kimberly A. Mace, Matthew J. Hardman
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2019)
Article
Dermatology
Holly N. Wilkinson, Sophie E. Upson, Kayleigh L. Banyard, Robert Knight, Kimberly A. Mace, Matthew J. Hardman
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2019)
Article
Biology
Richard W. Clayton, Ewan A. Langan, David M. Ansell, Ivo J. H. M. de Vos, Klaus Goebel, Marlon R. Schneider, Mauro Picardo, Xinhong Lim, Maurice A. M. van Steensel, Ralf Paus
BIOLOGICAL REVIEWS
(2020)
Article
Dermatology
Holly N. Wilkinson, Matthew J. Hardman
Summary: Diabetes and aging are two significant factors contributing to pathological skin healing. Recent studies suggest a potential mechanistic link between these factors. Cellular senescence appears to play a role in both diabetes, wound repair, and aging, though its exact impact remains controversial.
EXPERIMENTAL DERMATOLOGY
(2021)
Article
Cell Biology
Holly N. Wilkinson, Francesca L. Longhorne, Elizabeth R. Roberts, Varuni R. Brownhill, Matthew J. Hardman
Summary: This study compared the efficacy of single-use negative pressure wound therapy devices to traditional devices on ex vivo human skin, showing that single-use devices caused less damage to wound edge tissue and reduced pro-inflammatory markers activation compared to traditional therapy, possibly explaining their greater efficacy in clinical settings.
WOUND REPAIR AND REGENERATION
(2021)
Article
Dermatology
Rachel A. Crompton, Helen Williams, Laura Campbell, Lim Hui Kheng, Charis Saville, David M. Ansell, Adam Reid, Jason Wong, Leah A. Vardy, Matthew J. Hardman, Sheena M. Cruickshank
Summary: Nonhealing wounds represent a significant clinical challenge with limited treatment options. This study reveals a previously unknown intrinsic role of epidermal ARG1 in cutaneous wound healing, highlighting the potential of targeting epidermal ARG1 and its downstream mediators as therapeutic strategies for wound repair.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Lynsey Steel, David M. Ansell, Enrique Amaya, Sarah H. Cartmell
Summary: This study found that PPIA and YWHAZ are stable reference genes in gene expression studies of mesenchymal stem cells under electrical stimulation, while GAPDH and ACTB showed reduced stability at lower seeding densities.
APPLIED SCIENCES-BASEL
(2022)
Article
Dermatology
Iqra Fatima, Guodong Chen, Natalia Botchkareva, Andrey A. Sharov, Daniel Thornton, Holly N. Wilkinson, Matthew J. Hardman, Andreas Grutzkau, Joao Pedro de Magalhaes, Andrei Seluanov, Ewan St J. Smith, Vera Gorbunova, Andrei N. Mardaryev, Chris G. Faulkes, Vladimir A. Botchkarev
Summary: Naked mole-rats show similar skin aging characteristics to humans, including a decrease in epidermal thickness and keratinocyte proliferation. However, interestingly, the expression levels of several longevity-associated and tumor-suppressor genes are increased in aged naked mole-rat skin. These findings provide a basis for using naked mole-rats as a model organism to study the biology and disease resistance of human skin.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Paul J. Weldrick, Matthew J. Hardman, Vesselin N. Paunov
Summary: An innovative solution has been developed to address antibiotic resistance and biofilm formation through the design of active antibiotic nanocarriers with protease surface functionality. These active nanocarriers have shown the ability to efficiently degrade biofilms of resistant bacteria and enhance the effectiveness of antibiotics in killing bacterial cells.
MATERIALS CHEMISTRY FRONTIERS
(2021)
Article
Chemistry, Multidisciplinary
Paul J. Weldrick, Sammi Iveson, Matthew J. Hardman, Vesselin N. Paunov
Article
Chemistry, Multidisciplinary
Mohammed J. Al-Awady, Paul J. Weldrick, Matthew J. Hardman, Gillian M. Greenway, Vesselin N. Paunov
MATERIALS CHEMISTRY FRONTIERS
(2018)
Article
Engineering, Biomedical
Paul J. Weldrick, Matthew J. Hardman, Vesselin N. Paunov
Summary: The antifungal activity of amphotericin B encapsulated into shellac nanoparticles surface functionalized with protease is significantly enhanced, showing remarkable efficacy against Candida albicans. The surface functionalization allows the nanoparticles to adhere to fungal cell walls and deliver the drug directly to their membranes. Additionally, the presence of a protease coating helps degrade the biofilm matrix, increasing the effectiveness of the encapsulated drug compared to free amphotericin B.
ADVANCED NANOBIOMED RESEARCH
(2021)
Article
Dermatology
Matthew J. Davis, Gokul Srinivasan, Rachael Chacko, Sophie Chen, Anish Suvarna, Louis J. Vaickus, Veronica C. Torres, Sassan Hodge, Eunice Y. Chen, Sarah Preum, Kimberley S. Samkoe, Brock C. Christensen, Matthew R. Leboeuf, Joshua J. Levy
Summary: The development and application of AI algorithms are of great significance for the removal of cSCC, as they can improve operational efficiency and accuracy, especially for moderately and poorly differentiated tumors/ neoplasms. Further improvement is needed to maintain sensitivity to surrounding tissue and determine anatomical positioning.
EXPERIMENTAL DERMATOLOGY
(2024)
Article
Dermatology
Lingjing Chen, Qing Yu, Feiying Guo, Xuewen Wang, Zhenying Cai, Qiang Zhou
Summary: This study investigated the role and mechanisms of NTS in stress-induced hair growth inhibition. The results demonstrated that NTS effectively counteracted hair growth inhibition caused by stress and regulated the expression of multiple genes related to hair growth at the transcriptional level.
EXPERIMENTAL DERMATOLOGY
(2024)
