Fighting microbial drug resistance: a primer on the role of evolutionary biology in public health

A new antibiotic kills pathogens without detectable resistance

(2015) Losee L. Ling et al.   NATURE

Functional Characterization of Bacteria Isolated from Ancient Arctic Soil Exposes Diverse Resistance Mechanisms to Modern Antibiotics

(2015) Gabriel G. Perron et al.   PLoS One

Antagonism between Bacteriostatic and Bactericidal Antibiotics Is Prevalent

(2014) Paolo S. Ocampo et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Large-Scale Metagenomic-Based Study of Antibiotic Resistance in the Environment

(2014) Joseph Nesme et al.   CURRENT BIOLOGY

Underappreciated Role of Regionally Poor Water Quality on Globally Increasing Antibiotic Resistance

(2014) David W. Graham et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Understanding genetic variation inin vivotolerance to artesunate: implications for treatment efficacy and resistance monitoring

(2014) Laura C. Pollitt et al.   Evolutionary Applications

Costs of antibiotic resistance - separating trait effects and selective effects

(2014) Alex R. Hall et al.   Evolutionary Applications

Public health evolutionary biology of antimicrobial resistance: priorities for intervention

(2014) Fernando Baquero et al.   Evolutionary Applications

Antibiotics in agriculture and the risk to human health: how worried should we be?

(2014) Qiuzhi Chang et al.   Evolutionary Applications

Role of pleiotropy during adaptation of TEM-1β-lactamase to two novel antibiotics

(2014) Martijn F. Schenk et al.   Evolutionary Applications

The genetic basis of the fitness costs of antimicrobial resistance: a meta-analysis approach

(2014) Tom Vogwill et al.   Evolutionary Applications

The fitness costs of antibiotic resistance mutations

(2014) Anita H. Melnyk et al.   Evolutionary Applications

Waste water effluent contributes to the dissemination of CTX-M-15 in the natural environment

(2014) G. C. A. Amos et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Empirical fitness landscapes and the predictability of evolution

(2014) J. Arjan G.M. de Visser et al.   NATURE REVIEWS GENETICS

Who will develop new antibacterial agents?

(2014) S. T. Cole   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Alternating antibiotic treatments constrain evolutionary paths to multidrug resistance

(2014) Seungsoo Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Global epistasis makes adaptation predictable despite sequence-level stochasticity

(2014) S. Kryazhimskiy et al.   SCIENCE

Selection of a Multidrug Resistance Plasmid by Sublethal Levels of Antibiotics and Heavy Metals

(2014) E. Gullberg et al.   mBio

Prediction of antibiotic resistance by gene expression profiles

(2014) Shingo Suzuki et al.   Nature Communications

The Comprehensive Antibiotic Resistance Database

(2013) Andrew G. McArthur et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The cost of antibiotic resistance depends on evolutionary history in Escherichia coli

(2013) Daniel C Angst et al.   BMC EVOLUTIONARY BIOLOGY

The Scourge of Antibiotic Resistance: The Important Role of the Environment

(2013) R. L. Finley et al.   CLINICAL INFECTIOUS DISEASES

Exploiting social evolution in biofilms

(2013) Kerry E Boyle et al.   CURRENT OPINION IN MICROBIOLOGY

Annual Report of the Chief Medical Officer: infection and the rise of antimicrobial resistance

(2013) Sally C Davies et al.   LANCET

The role of the natural environment in the emergence of antibiotic resistance in Gram-negative bacteria

(2013) Elizabeth MH Wellington et al.   LANCET INFECTIOUS DISEASES

Patterns of Epistasis between Beneficial Mutations in an Antibiotic Resistance Gene

(2013) Martijn F. Schenk et al.   MOLECULAR BIOLOGY AND EVOLUTION

Bacterial cheating drives the population dynamics of cooperative antibiotic resistance plasmids

(2013) Eugene A Yurtsev et al.   Molecular Systems Biology

Evolutionary rescue from extinction is contingent on a lower rate of environmental change

(2013) Haley A. Lindsey et al.   NATURE

The antibiotic alarm

(2013)   NATURE

Use of Collateral Sensitivity Networks to Design Drug Cycling Protocols That Avoid Resistance Development

(2013) L. Imamovic et al.   Science Translational Medicine

Livestock Origin for a Human Pandemic Clone of Community-Associated Methicillin-Resistant Staphylococcus aureus

(2013) L. E. Spoor et al.   mBio

β-lactam antibiotics promote bacterial mutagenesis via an RpoS-mediated reduction in replication fidelity

(2013) A. Gutierrez et al.   Nature Communications

Novel resistance functions uncovered using functional metagenomic investigations of resistance reservoirs

(2013) Erica C. Pehrsson et al.   Frontiers in Microbiology

Evolutionary rescue: an emerging focus at the intersection between ecology and evolution

(2012) A. Gonzalez et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Identification of New Delhi Metallo-β-lactamase 1 in Acinetobacter lwoffii of Food Animal Origin

(2012) Yang Wang et al.   PLoS One

The Shared Antibiotic Resistome of Soil Bacteria and Human Pathogens

(2012) K. J. Forsberg et al.   SCIENCE

Microbiota-Targeted Therapies: An Ecological Perspective

(2012) K. P. Lemon et al.   Science Translational Medicine

Natural Antibiotic Resistance and Contamination by Antibiotic Resistance Determinants: The Two Ages in the Evolution of Resistance to Antimicrobials

(2012) José L. Martínez   Frontiers in Microbiology

EPISTASIS BUFFERS THE FITNESS EFFECTS OF RIFAMPICIN- RESISTANCE MUTATIONS IN PSEUDOMONAS AERUGINOSA

(2011) Alex R. Hall et al.   EVOLUTION

Impacts of anthropogenic activity on the ecology of class 1 integrons and integron-associated genes in the environment

(2011) William H Gaze et al.   ISME Journal

Discovery research: the scientific challenge of finding new antibiotics

(2011) D. M. Livermore et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Resolution of Gene Regulatory Conflicts Caused by Combinations of Antibiotics

(2011) Tobias Bollenbach et al.   MOLECULAR CELL

Antibiotic resistance is ancient

(2011) Vanessa M. D’Costa et al.   NATURE

Parallel bacterial evolution within multiple patients identifies candidate pathogenicity genes

(2011) Tami D Lieberman et al.   NATURE GENETICS

Whole-genome sequencing of rifampicin-resistant Mycobacterium tuberculosis strains identifies compensatory mutations in RNA polymerase genes

(2011) Iñaki Comas et al.   NATURE GENETICS

Tackling antibiotic resistance

(2011) Karen Bush et al.   NATURE REVIEWS MICROBIOLOGY

Bacterial recombination promotes the evolution of multi-drug-resistance in functionally diverse populations

(2011) G. G. Perron et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Negative Epistasis Between Beneficial Mutations in an Evolving Bacterial Population

(2011) A. I. Khan et al.   SCIENCE

Diminishing Returns Epistasis Among Beneficial Mutations Decelerates Adaptation

(2011) H.-H. Chou et al.   SCIENCE

Acceleration of Emergence of Bacterial Antibiotic Resistance in Connected Microenvironments

(2011) Q. Zhang et al.   SCIENCE

Molecular mechanisms of epistasis within and between genes

(2011) Ben Lehner   TRENDS IN GENETICS

Pervasive Sign Epistasis between Conjugative Plasmids and Drug-Resistance Chromosomal Mutations

(2011) Rui F. Silva et al.   PLoS Genetics

Selection of Resistant Bacteria at Very Low Antibiotic Concentrations

(2011) Erik Gullberg et al.   PLoS Pathogens

Hypermutability and Compensatory Adaptation in Antibiotic‐Resistant Bacteria

(2010) Gabriel G. Perron et al.   AMERICAN NATURALIST

Diminishing Returns From Beneficial Mutations and Pervasive Epistasis Shape the Fitness Landscape for Rifampicin Resistance in Pseudomonas aeruginosa

(2010) R. C. MacLean et al.   GENETICS

What traits are carried on mobile genetic elements and why?

(2010) D J Rankin et al.   HEREDITY

Origins and Evolution of Antibiotic Resistance

(2010) J. Davies et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Sublethal Antibiotic Treatment Leads to Multidrug Resistance via Radical-Induced Mutagenesis

(2010) Michael A. Kohanski et al.   MOLECULAR CELL

The population genetics of antibiotic resistance: integrating molecular mechanisms and treatment contexts

(2010) R. Craig MacLean et al.   NATURE REVIEWS GENETICS

Call of the wild: antibiotic resistance genes in natural environments

(2010) Heather K. Allen et al.   NATURE REVIEWS MICROBIOLOGY

Antibiotic resistant mutants of Escherichia coli K12 show increases in heterologous gene expression

(2010) Adnan Ahmetagic et al.   PLASMID

Genetic Analysis of Colistin Resistance in Salmonella enterica Serovar Typhimurium

(2009) S. Sun et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antibiotics in the aquatic environment – A review – Part I

(2009) Klaus Kümmerer   CHEMOSPHERE

The role of antibiotics and antibiotic resistance in nature

(2009) Rustam I. Aminov   ENVIRONMENTAL MICROBIOLOGY

Evidence of Increasing Antibiotic Resistance Gene Abundances in Archived Soils since 1940

(2009) Charles W. Knapp et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Contribution of Gene Amplification to Evolution of Increased Antibiotic Resistance in Salmonella typhimurium

(2009) Song Sun et al.   GENETICS

The cost of multiple drug resistance inPseudomonas aeruginosa

(2009) H. WARD et al.   JOURNAL OF EVOLUTIONARY BIOLOGY

Drug interactions and the evolution of antibiotic resistance

(2009) Pamela J. Yeh et al.   NATURE REVIEWS MICROBIOLOGY

Bacterial gene amplification: implications for the evolution of antibiotic resistance

(2009) Linus Sandegren et al.   NATURE REVIEWS MICROBIOLOGY

Social evolution in micro-organisms and a Trojan horse approach to medical intervention strategies

(2009) S. P. Brown et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Protection of Salmonella by ampicillin-resistant Escherichia coli in the presence of otherwise lethal drug concentrations

(2009) M. H. Perlin et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Mutational neighbourhood and mutation supply rate constrain adaptation in Pseudomonas aeruginosa

(2009) A. R. Hall et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Functional Characterization of the Antibiotic Resistance Reservoir in the Human Microflora

(2009) M. O. A. Sommer et al.   SCIENCE

Why do bacteria engage in homologous recombination?

(2009) Michiel Vos   TRENDS IN MICROBIOLOGY

Need for Both Antibiotic Cycling and Stringent Environmental Controls to Prevent Pseudomonas Infections

(2009) Luke Curtis   Surgical Infections

The Distribution of Fitness Effects of Beneficial Mutations in Pseudomonas aeruginosa

(2009) R. Craig MacLean et al.   PLoS Genetics

Positive Epistasis Drives the Acquisition of Multidrug Resistance

(2009) Sandra Trindade et al.   PLoS Genetics

Parallel evolution of multidrug-resistance in Salmonella enterica isolated from swine

(2008) Gabriel G. Perron et al.   FEMS MICROBIOLOGY LETTERS

Functional metagenomics reveals diverse β-lactamases in a remote Alaskan soil

(2008) Heather K Allen et al.   ISME Journal

Acinetobacter baylyi as a Pathogen for Opportunistic Infection

(2008) T.-L. Chen et al.   JOURNAL OF CLINICAL MICROBIOLOGY

The rate of environmental change drives adaptation to an antibiotic sink

(2008) G. G. PERRON et al.   JOURNAL OF EVOLUTIONARY BIOLOGY

A Reservoir of Drug-Resistant Pathogenic Bacteria in Asymptomatic Hosts

(2008) Gabriel G. Perron et al.   PLoS One

Drug interactions modulate the potential for evolution of resistance

(2008) J.-B. Michel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ubiquity of Biological Ice Nucleators in Snowfall

(2008) B. C. Christner et al.   SCIENCE

Antibiotics and Antibiotic Resistance Genes in Natural Environments

(2008) J. L. Martinez   SCIENCE