- Home
- Publications
- Publication Search
- Publication Details
Title
Control of the Unfolded Protein Response in Health and Disease
Authors
Keywords
-
Journal
SLAS Discovery
Volume 22, Issue 7, Pages 787-800
Publisher
SAGE Publications
Online
2017-05-26
DOI
10.1177/2472555217701685
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Mipsagargin, a novel thapsigargin-based PSMA-activated prodrug: results of a first-in-man phase I clinical trial in patients with refractory, advanced or metastatic solid tumours
- (2016) D Mahalingam et al. BRITISH JOURNAL OF CANCER
- Compounds Triggering ER Stress Exert Anti-Melanoma Effects and Overcome BRAF Inhibitor Resistance
- (2016) Michaël Cerezo et al. CANCER CELL
- A Covalent Cysteine-Targeting Kinase Inhibitor of Ire1 Permits Allosteric Control of Endoribonuclease Activity
- (2016) Daniel D. Waller et al. CHEMBIOCHEM
- PDIA6 regulates insulin secretion by selectively inhibiting the RIDD activity of IRE1
- (2016) Daniela Eletto et al. FASEB JOURNAL
- Acridine Derivatives as Inhibitors of the IRE1 -XBP1 Pathway Are Cytotoxic to Human Multiple Myeloma
- (2016) D. Jiang et al. MOLECULAR CANCER THERAPEUTICS
- A High-Throughput Screen Identifies 2,9-Diazaspiro[5.5]Undecanes as Inducers of the Endoplasmic Reticulum Stress Response with Cytotoxic Activity in 3D Glioma Cell Models
- (2016) Natalia J. Martinez et al. PLoS One
- ER stress in temozolomide-treated glioblastomas interferes with DNA repair and induces apoptosis
- (2016) Jessica L. Weatherbee et al. Oncotarget
- Genome-wide screen identifies a novel p97/CDC-48-dependent pathway regulating ER-stress-induced gene transcription
- (2015) E. Marza et al. EMBO REPORTS
- Proteostasis control by the unfolded protein response
- (2015) Claudio Hetz et al. NATURE CELL BIOLOGY
- Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit
- (2015) I. Das et al. SCIENCE
- Phenotypic assays identify azoramide as a small-molecule modulator of the unfolded protein response with antidiabetic activity
- (2015) Suneng Fu et al. Science Translational Medicine
- Novel roles of the unfolded protein response in the control of tumor development and aggressiveness
- (2015) Nicolas Dejeans et al. SEMINARS IN CANCER BIOLOGY
- Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis
- (2015) Alpa Sidhu et al. ACS Medicinal Chemistry Letters
- Molecular mechanisms of human IRE1 activation through dimerization and ligand binding
- (2015) Amar Joshi et al. Oncotarget
- Glioblastoma invasion and cooption depend on IRE1α endoribonuclease activity
- (2015) Arnaud Jabouille et al. Oncotarget
- Endoplasmic Reticulum Stress, Genome Damage, and Cancer
- (2015) Naomi Dicks et al. Frontiers in Oncology
- Allosteric Inhibition of the IRE1α RNase Preserves Cell Viability and Function during Endoplasmic Reticulum Stress
- (2014) Rajarshi Ghosh et al. CELL
- Inhibition of ER stress–associated IRE-1/XBP-1 pathway reduces leukemic cell survival
- (2014) Chih-Hang Anthony Tang et al. JOURNAL OF CLINICAL INVESTIGATION
- Endoplasmic Reticulum Stress-Activated Transcription Factor ATF6 Requires the Disulfide Isomerase PDIA5 To Modulate Chemoresistance
- (2014) A. Higa et al. MOLECULAR AND CELLULAR BIOLOGY
- VEGF Signals through ATF6 and PERK to Promote Endothelial Cell Survival and Angiogenesis in the Absence of ER Stress
- (2014) Evdoxia Karali et al. MOLECULAR CELL
- A Synthetic Biology Approach Identifies the Mammalian UPR RNA Ligase RtcB
- (2014) Yanyan Lu et al. MOLECULAR CELL
- Protein Disulfide Isomerase A6 Controls the Decay of IRE1α Signaling via Disulfide-Dependent Association
- (2014) Davide Eletto et al. MOLECULAR CELL
- Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models
- (2014) Sami J Barmada et al. Nature Chemical Biology
- Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases
- (2014) Claudio Hetz et al. NATURE REVIEWS NEUROSCIENCE
- High-throughput Screening Identifies Aclacinomycin as a Radiosensitizer of EGFR-Mutant Non-Small Cell Lung Cancer
- (2014) Daniel C Bennett et al. Translational Oncology
- Getting RIDD of RNA: IRE1 in cell fate regulation
- (2014) M. Maurel et al. TRENDS IN BIOCHEMICAL SCIENCES
- Addicted to secrete – novel concepts and targets in cancer therapy
- (2014) Nicolas Dejeans et al. TRENDS IN MOLECULAR MEDICINE
- Discovery of Sulfonamidebenzamides as Selective Apoptotic CHOP Pathway Activators of the Unfolded Protein Response
- (2014) Daniel P. Flaherty et al. ACS Medicinal Chemistry Letters
- Structure and mechanism of action of the hydroxy–aryl–aldehyde class of IRE1 endoribonuclease inhibitors
- (2014) Mario Sanches et al. Nature Communications
- When ER stress reaches a dead end
- (2013) Hery Urra et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Characterization of a Novel PERK Kinase Inhibitor with Antitumor and Antiangiogenic Activity
- (2013) C. Atkins et al. CANCER RESEARCH
- Posttranscriptional Regulation of PER1 Underlies the Oncogenic Function of IRE
- (2013) O. Pluquet et al. CANCER RESEARCH
- Hydroxynaphthoic Acids Identified in a High Throughput Screening Potently Ameliorate Endoplasmic Reticulum Stress as Novel Chemical Chaperones
- (2013) Kwi-wan Jeong et al. CHEMICAL & PHARMACEUTICAL BULLETIN
- Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2
- (2013) Pallav D Patel et al. Nature Chemical Biology
- Targeting the unfolded protein response in disease
- (2013) Claudio Hetz et al. NATURE REVIEWS DRUG DISCOVERY
- The eIF2α/ATF4 pathway is essential for stress-induced autophagy gene expression
- (2013) Wafa B’chir et al. NUCLEIC ACIDS RESEARCH
- Negative feedback by IRE1 optimizes mucin production in goblet cells
- (2013) A. Tsuru et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Valosin-containing protein regulates the proteasome-mediated degradation of DNA-PKcs in glioma cells
- (2013) N Jiang et al. Cell Death & Disease
- Discovery of GSK2656157: An Optimized PERK Inhibitor Selected for Preclinical Development
- (2013) Jeffrey M. Axten et al. ACS Medicinal Chemistry Letters
- Stress-Independent Activation of XBP1s and/or ATF6 Reveals Three Functionally Diverse ER Proteostasis Environments
- (2013) Matthew D. Shoulders et al. Cell Reports
- Pharmacological brake-release of mRNA translation enhances cognitive memory
- (2013) Carmela Sidrauski et al. eLife
- Blockade of XBP1 splicing by inhibition of IRE1 is a promising therapeutic option in multiple myeloma
- (2012) N. Mimura et al. BLOOD
- Protein disulfide isomerase in ALS mouse glia links protein misfolding with NADPH oxidase-catalyzed superoxide production
- (2012) M. Jaronen et al. HUMAN MOLECULAR GENETICS
- Autocrine control of glioma cells adhesion and migration through IRE1 -mediated cleavage of SPARC mRNA
- (2012) N. Dejeans et al. JOURNAL OF CELL SCIENCE
- Protein disulfide isomerase inhibitors constitute a new class of antithrombotic agents
- (2012) Reema Jasuja et al. JOURNAL OF CLINICAL INVESTIGATION
- Discovery of 7-Methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a Potent and Selective First-in-Class Inhibitor of Protein Kinase R (PKR)-like Endoplasmic Reticulum Kinase (PERK)
- (2012) Jeffrey M. Axten et al. JOURNAL OF MEDICINAL CHEMISTRY
- Reduced Calreticulin Levels Link Endoplasmic Reticulum Stress and Fas-Triggered Cell Death in Motoneurons Vulnerable to ALS
- (2012) N. Bernard-Marissal et al. JOURNAL OF NEUROSCIENCE
- The ER stress transducer IRE1β is required for airway epithelial mucin production
- (2012) M B Martino et al. Mucosal Immunology
- Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors
- (2012) Likun Wang et al. Nature Chemical Biology
- The unfolded protein response: controlling cell fate decisions under ER stress and beyond
- (2012) Claudio Hetz NATURE REVIEWS MOLECULAR CELL BIOLOGY
- The critical roles of endoplasmic reticulum chaperones and unfolded protein response in tumorigenesis and anticancer therapies
- (2012) B Luo et al. ONCOGENE
- RNA surveillance is required for endoplasmic reticulum homeostasis
- (2012) K. Sakaki et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule
- (2012) B. C. S. Cross et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Identification of Toyocamycin, an agent cytotoxic for multiple myeloma cells, as a potent inhibitor of ER stress-induced XBP1 mRNA splicing
- (2012) M Ri et al. Blood Cancer Journal
- The unfolded protein response transducer IRE1α prevents ER stress-induced hepatic steatosis
- (2011) Kezhong Zhang et al. EMBO JOURNAL
- Peptides derived from the bifunctional kinase/RNase enzyme IRE1α modulate IRE1α activity and protect cells from endoplasmic reticulum stress
- (2011) Marion Bouchecareilh et al. FASEB JOURNAL
- Physiological unfolded protein response regulated by OASIS family members, transmembrane bZIP transcription factors
- (2011) Shinichi Kondo et al. IUBMB LIFE
- The signalling from endoplasmic reticulum-resident bZIP transcription factors involved in diverse cellular physiology
- (2011) R. Asada et al. JOURNAL OF BIOCHEMISTRY
- Potent and Selective Inhibitors of the Inositol-requiring Enzyme 1 Endoribonuclease
- (2011) Kori Volkmann et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Dual and opposing roles of the unfolded protein response regulated by IRE1 and XBP1 in proinsulin processing and insulin secretion
- (2011) A.-H. Lee et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Selective Inhibition of a Regulatory Subunit of Protein Phosphatase 1 Restores Proteostasis
- (2011) P. Tsaytler et al. SCIENCE
- Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma
- (2010) I. Papandreou et al. BLOOD
- TDP-43 and FUS in amyotrophic lateral sclerosis and frontotemporal dementia
- (2010) Ian RA Mackenzie et al. LANCET NEUROLOGY
- Flavonol Activation Defines an Unanticipated Ligand-Binding Site in the Kinase-RNase Domain of IRE1
- (2010) R. Luke Wiseman et al. MOLECULAR CELL
- Inositol-requiring enzyme 1 is a key regulator of angiogenesis and invasion in malignant glioma
- (2010) G. Auf et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- BiP Binding to the ER-Stress Sensor Ire1 Tunes the Homeostatic Behavior of the Unfolded Protein Response
- (2010) David Pincus et al. PLOS BIOLOGY
- Role of the Unfolded Protein Response Regulator GRP78/BiP in Development, Cancer, and Neurological Disorders
- (2009) Miao Wang et al. ANTIOXIDANTS & REDOX SIGNALING
- Selective Cytotoxicity of Ponciri Fructus against Glucose-Deprived PANC-1 Human Pancreatic Cancer CellsviaBlocking Activation of GRP78
- (2009) Mi-Ran CHA et al. BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
- IRE1α Kinase Activation Modes Control Alternate Endoribonuclease Outputs to Determine Divergent Cell Fates
- (2009) Dan Han et al. CELL
- Activation of mammalian IRE1α upon ER stress depends on dissociation of BiP rather than on direct interaction with unfolded proteins
- (2009) Daisuke Oikawa et al. EXPERIMENTAL CELL RESEARCH
- SAR Study of a Novel Triene-ansamycin Group Compound, Quinotrierixin and Related Compounds, as Inhibitors of ER Stress-induced XBP1 Activation
- (2009) Tatsuro Kawamura et al. JOURNAL OF ANTIBIOTICS
- Role of ERO1-α–mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress–induced apoptosis
- (2009) Gang Li et al. JOURNAL OF CELL BIOLOGY
- Valosin-containing protein (VCP) is required for autophagy and is disrupted in VCP disease
- (2009) Jeong-Sun Ju et al. JOURNAL OF CELL BIOLOGY
- Regulated Ire1-dependent decay of messenger RNAs in mammalian cells
- (2009) Julie Hollien et al. JOURNAL OF CELL BIOLOGY
- Human Golgi Antiapoptotic Protein Modulates Intracellular Calcium Fluxes
- (2009) Fabrizio de Mattia et al. MOLECULAR BIOLOGY OF THE CELL
- ER Stress and Unfolded Protein Response in Amyotrophic Lateral Sclerosis
- (2009) Kohsuke Kanekura et al. MOLECULAR NEUROBIOLOGY
- Caspase-4 is partially cleaved by calpain via the impairment of Ca2+ homeostasis under the ER stress
- (2009) Shinsuke Matsuzaki et al. NEUROCHEMISTRY INTERNATIONAL
- ER Stress Controls Iron Metabolism Through Induction of Hepcidin
- (2009) C. Vecchi et al. SCIENCE
- ATF6 Is a Transcription Factor Specializing in the Regulation of Quality Control Proteins in the Endoplasmic Reticulum
- (2008) Yusuke Adachi et al. CELL STRUCTURE AND FUNCTION
- GTPase-Mediated Regulation of the Unfolded Protein Response in Caenorhabditis elegans Is Dependent on the AAA+ ATPase CDC-48
- (2008) M.-E. Caruso et al. MOLECULAR AND CELLULAR BIOLOGY
- The unfolded protein response signals through high-order assembly of Ire1
- (2008) Alexei V. Korennykh et al. NATURE
- Transgenics, toxicity and therapeutics in rodent models of mutant SOD1-mediated familial ALS
- (2008) B TURNER et al. PROGRESS IN NEUROBIOLOGY
- Activating transcription factor 4
- (2007) Kurosh Ameri et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started