In VivoandIn VitroMetabolites from the Main Diester and Monoester Diterpenoid Alkaloids in a Traditional Chinese Herb, theAconitumSpecies

Monoester-DiterpeneAconitumAlkaloid Metabolism in Human Liver Microsomes: Predominant Role of CYP3A4 and CYP3A5

(2013) Ling Ye et al.   Evidence-based Complementary and Alternative Medicine

Genetically humanized mouse models of drug metabolizing enzymes and transporters and their applications

(2013) Nico Scheer et al.   XENOBIOTICA

Characterization of UDP-Glucuronosyltransferases Involved in Glucuronidation of Diethylstilbestrol in Human Liver and Intestine

(2012) Liangliang Zhu et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Study on the Metabolic Characteristics of Aconite Alkaloids in the Extract of Radix aconiti under Intestinal Bacteria of Rat by UPLC/MSn Technique

(2012) Yang Xin et al.   CHINESE JOURNAL OF CHEMISTRY

An update on the ability of St. John's wort to affect the metabolism of other drugs

(2012) Roja Rahimi et al.   Expert Opinion on Drug Metabolism & Toxicology

Simultaneous determination of 11 aconitum alkaloids in human serum and urine using liquid chromatography–tandem mass spectrometry

(2012) Kiyotaka Usui et al.   Legal Medicine

Metabolite profile analysis of aconitine in rabbit stomach after oral administration by liquid chromatography/electrospray ionization/multiple-stage tandem mass spectrometry

(2012) Zhigang Sui et al.   XENOBIOTICA

Screening and analysis of aconitum alkaloids and their metabolites in rat urine after oral administration of aconite roots extract using LC-TOFMS-based metabolomics

(2011) Guangguo Tan et al.   BIOMEDICAL CHROMATOGRAPHY

Effect of pH on the Metabolism of Aconitine under Rat Intestinal Bacteria and Analysis of Metabolites Using HPLC/MS-MSn Technique

(2011) Xiye Wang et al.   CHINESE JOURNAL OF CHEMISTRY

In vitroandin vivosmall intestinal metabolism of CYP3A and UGT substrates in preclinical animals species and humans: species differences

(2011) Hiroshi Komura et al.   DRUG METABOLISM REVIEWS

Microsomal cytochrome P450-mediated metabolism of hypaconitine, an active and highly toxic constituent derived from Aconitum species

(2011) Ling Ye et al.   TOXICOLOGY LETTERS

Involvement of CYP3A4/5 and CYP2D6 in the metabolism of aconitine using human liver microsomes and recombinant CYP450 enzymes

(2011) Lan Tang et al.   TOXICOLOGY LETTERS

Development and validation of a highly sensitive UPLC-MS/MS method for simultaneous determination of aconitine, mesaconitine, hypaconitine, and five of their metabolites in rat blood and its application to a pharmacokinetics study of aconitine, mesaconitine, and hypaconitine

(2011) Ling Ye et al.   XENOBIOTICA

Functions and transcriptional regulation of adult human hepatic UDP-glucuronosyl-transferases (UGTs): Mechanisms responsible for interindividual variation of UGT levels

(2010) Karl Walter Bock   BIOCHEMICAL PHARMACOLOGY

Characterization of metabolites and human P450 isoforms involved in the microsomal metabolism of mesaconitine

(2010) Ling Ye et al.   XENOBIOTICA

Aconite poisoning

(2009) Thomas Y.K. Chan   CLINICAL TOXICOLOGY

Aconite poisoning presenting as hypotension and bradycardia

(2009) Thomas YK Chan   HUMAN & EXPERIMENTAL TOXICOLOGY

Aconitum in Traditional Chinese Medicine—A valuable drug or an unpredictable risk?

(2009) Judith Singhuber et al.   JOURNAL OF ETHNOPHARMACOLOGY

Gut Microbiota and Its Possible Relationship With Obesity

(2009) John K. DiBaise et al.   MAYO CLINIC PROCEEDINGS

Expression of UGT1A and UGT2B mRNA in Human Normal Tissues and Various Cell Lines

(2008) A. Nakamura et al.   DRUG METABOLISM AND DISPOSITION

Potential role of intestinal first-pass metabolism in the prediction of drug–drug interactions

(2008) Aleksandra Galetin et al.   Expert Opinion on Drug Metabolism & Toxicology

The gastrointestinal microbiota as a site for the biotransformation of drugs

(2008) Tiago Sousa et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Studies on the stability of diester-diterpenoid alkaloids from the genusAconitum L. by high performance liquid chromatography combined with electrospray ionisation tandem mass spectrometry (HPLC/ESI/MSn)

(2007) Hao Yue et al.   PHYTOCHEMICAL ANALYSIS