Predicting Oral Drug Absorption: Mini Review on Physiologically-Based Pharmacokinetic Models

Mechanistic investigation of the negative food effect of modified release zolpidem

(2017) Cord J. Andreas et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Food, gastrointestinal pH, and models of oral drug absorption

(2017) Ahmad Y. Abuhelwa et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Mechanistic prediction of food effects for Compound A tablet using PBPK model

(2017) Xueqing Li et al.   SAUDI JOURNAL OF BIOLOGICAL SCIENCES

Utilizing Physiologically Based Pharmacokinetic Modeling to Inform Formulation and Clinical Development for a Compound with pH-Dependent Solubility

(2015) John Chung et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Analysis of Intra- and Intersubject Variability in Oral Drug Absorption in Human Bioequivalence Studies of 113 Generic Products

(2015) Masahisa Sugihara et al.   MOLECULAR PHARMACEUTICS

An analysis of the attrition of drug candidates from four major pharmaceutical companies

(2015) Michael J. Waring et al.   NATURE REVIEWS DRUG DISCOVERY

Application of Physiologically Based Absorption Modeling to Formulation Development of a Low Solubility, Low Permeability Weak Base: Mechanistic Investigation of Food Effect

(2014) Hefei Zhang et al.   AAPS PHARMSCITECH

Characterization of preclinicalin vitroandin vivoADME properties and prediction of human PK using a physiologically based pharmacokinetic model for YQA-14, a new dopamine D3receptor antagonist candidate for treatment of drug addiction

(2014) Fei Liu et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Incorporation of Physiologically Based Pharmacokinetic Modeling in the Evaluation of Solubility Requirements for the Salt Selection Process: A Case Study Using Phenytoin

(2013) Po-Chang Chiang et al.   AAPS Journal

Drug dissolution: significance of physicochemical properties and physiological conditions

(2013) Sunil S. Jambhekar et al.   DRUG DISCOVERY TODAY

Species differences in drug transporters and implications for translating preclinical findings to humans

(2012) Xiaoyan Chu et al.   Expert Opinion on Drug Metabolism & Toxicology

Developability assessment of clinical drug products with maximum absorbable doses

(2012) Xuan Ding et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Physiologically Based Pharmacokinetic Modeling of Intestinal First-Pass Metabolism of CYP3A Substrates with High Intestinal Extraction

(2011) M. Gertz et al.   DRUG METABOLISM AND DISPOSITION

PHRMA CPCDC initiative on predictive models of human pharmacokinetics, part 5: Prediction of plasma concentration–time profiles in human by using the physiologically‐based pharmacokinetic modeling approach

(2011) Patrick Poulin et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Physiological Parameters for Oral Delivery andin VitroTesting

(2010) Deanna M. Mudie et al.   MOLECULAR PHARMACEUTICS

In vitro-in vivo Extrapolation of Transporter-mediated Clearance in the Liver and Kidney

(2009) Hiroyuki Kusuhara et al.   Drug Metabolism and Pharmacokinetics

Intestinal efflux transporters and drug absorption

(2008) Teruo Murakami et al.   Expert Opinion on Drug Metabolism & Toxicology

Applications of Physiologically Based Absorption Models in Drug Discovery and Development

(2008) Neil Parrott et al.   MOLECULAR PHARMACEUTICS

Recent progresses in the experimental methods and evaluation strategies of transporter functions for the prediction of the pharmacokinetics in humans

(2008) Satoshi Kitamura et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY