Application of Physiologically Based Absorption Modeling to Formulation Development of a Low Solubility, Low Permeability Weak Base: Mechanistic Investigation of Food Effect

Title
Application of Physiologically Based Absorption Modeling to Formulation Development of a Low Solubility, Low Permeability Weak Base: Mechanistic Investigation of Food Effect
Authors
Keywords
GastroPlus, particle size, physiologically based pharmacokinetics, precipitation, solubility
Journal
AAPS PHARMSCITECH
Volume 15, Issue 2, Pages 400-406
Publisher
American Association of Pharmaceutical Scientists (AAPS)
Online
2014-01-17
DOI
10.1208/s12249-014-0075-1

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