Extracellular Vesicles As Modulators of Tumor Microenvironment and Disease Progression in Glioma

In silico gene expression analysis reveals glycolysis and acetate anaplerosis in IDH1 wild-type glioma and lactate and glutamate anaplerosis in IDH1-mutated glioma

(2017) Mohammed Khurshed et al.   Oncotarget

Systemic T Cells Immunosuppression of Glioma Stem Cell-Derived Exosomes Is Mediated by Monocytic Myeloid-Derived Suppressor Cells

(2017) Rossana Domenis et al.   PLoS One

Exosomal miR-221 targets DNM3 to induce tumor progression and temozolomide resistance in glioma

(2016) Jian-Kai Yang et al.   JOURNAL OF NEURO-ONCOLOGY

The limited capacity of malignant glioma-derived exosomes to suppress peripheral immune effectors

(2016) J. Bryan Iorgulescu et al.   JOURNAL OF NEUROIMMUNOLOGY

Tumor exosomes: cellular postmen of cancer diagnosis and personalized therapy

(2016) Aman Sharma et al.   Nanomedicine

The angiogenic switch leads to a metabolic shift in human glioblastoma

(2016) Krishna M. Talasila et al.   NEURO-ONCOLOGY

Fatty acid oxidation is required for the respiration and proliferation of malignant glioma cells

(2016) Hua Lin et al.   NEURO-ONCOLOGY

Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes

(2016) Joanna Kowal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ISGylation controls exosome secretion by promoting lysosomal degradation of MVB proteins

(2016) Carolina Villarroya-Beltri et al.   Nature Communications

TrkB-containing exosomes promote the transfer of glioblastoma aggressiveness to YKL-40-inactivated glioblastoma cells

(2016) Sandra Pinet et al.   Oncotarget

DNA sequences within glioma-derived extracellular vesicles can cross the intact blood-brain barrier and be detected in peripheral blood of patients

(2016) Noemí García-Romero et al.   Oncotarget

Extracellular vesicle sorting of α-Synuclein is regulated by sumoylation

(2015) Marcel Kunadt et al.   ACTA NEUROPATHOLOGICA

STAT3 Blockade Inhibits Radiation-Induced Malignant Progression in Glioma

(2015) J. Lau et al.   CANCER RESEARCH

Cancer stem cells in glioblastoma

(2015) Justin D. Lathia et al.   GENES & DEVELOPMENT

Glioblastoma-derived extracellular vesicles modify the phenotype of monocytic cells

(2015) Jeroen de Vrij et al.   INTERNATIONAL JOURNAL OF CANCER

miRNA contents of cerebrospinal fluid extracellular vesicles in glioblastoma patients

(2015) Johnny C. Akers et al.   JOURNAL OF NEURO-ONCOLOGY

TMIC-09GLIOBLASTOMA STEM CELL-DERIVED EXOSOMES PROMOTE M2 POLARIZATION OF HUMAN MONOCYTES

(2015) Konrad Gabrusiewicz et al.   NEURO-ONCOLOGY

Metabolic reprogramming in glioblastoma: the influence of cancer metabolism on epigenetics and unanswered questions

(2015) Sameer Agnihotri et al.   NEURO-ONCOLOGY

Directly visualized glioblastoma-derived extracellular vesicles transfer RNA to microglia/macrophages in the brain

(2015) Kristan E. van der Vos et al.   NEURO-ONCOLOGY

Extracellular vesicle-transported Semaphorin3A promotes vascular permeability in glioblastoma

(2015) L Treps et al.   ONCOGENE

Extracellular vesicles in the biology of brain tumour stem cells – Implications for inter-cellular communication, therapy and biomarker development

(2015) Ichiro Nakano et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Chip-based analysis of exosomal mRNA mediating drug resistance in glioblastoma

(2015) Huilin Shao et al.   Nature Communications

Inhibition of DNA-repair genes Ercc1 and Mgmt enhances temozolomide efficacy in gliomas treatment: a pre-clinical study

(2015) Sandra G. Boccard et al.   Oncotarget

IDH mutation, 1p19q codeletion and ATRX loss in WHO grade II gliomas

(2015) Heather E. Leeper et al.   Oncotarget

Extracellular vesicle-mediated transfer of CLIC1 protein is a novel mechanism for the regulation of glioblastoma growth

(2015) Matteo Setti et al.   Oncotarget

Role of extracellular RNA-carrying vesicles in cell differentiation and reprogramming

(2015) Peter J. Quesenberry et al.   Stem Cell Research & Therapy

Exosomes isolated from plasma of glioma patients enrolled in a vaccination trial reflect antitumor immune activity and might predict survival

(2015) Laurent Muller et al.   OncoImmunology

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

(2014) Marina Colombo et al.   Annual Review of Cell and Developmental Biology

WNT5A induces release of exosomes containing pro-angiogenic and immunosuppressive factors from malignant melanoma cells

(2014) Elin J Ekström et al.   Molecular Cancer

A small noncoding RNA signature found in exosomes of GBM patient serum as a diagnostic tool

(2014) Lorea Manterola et al.   NEURO-ONCOLOGY

Gliomas and the vascular fragility of the blood brain barrier

(2014) Luiz Gustavo Dubois et al.   Frontiers in Cellular Neuroscience

Syntenin-ALIX exosome biogenesis and budding into multivesicular bodies are controlled by ARF6 and PLD2

(2014) Rania Ghossoub et al.   Nature Communications

Role of extracellular membrane vesicles in intercellular communication of the tumour microenvironment: Figure 1

(2013) Katrin J. Svensson et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Mesenchymal Differentiation Mediated by NF-κB Promotes Radiation Resistance in Glioblastoma

(2013) Krishna P.L. Bhat et al.   CANCER CELL

Extracellular Vesicles Modulate the Glioblastoma Microenvironment via a Tumor Suppression Signaling Network Directed by miR-1

(2013) A. Bronisz et al.   CANCER RESEARCH

IDH1 and IDH2 Mutations in Gliomas

(2013) Adam L. Cohen et al.   Current Neurology and Neuroscience Reports

Qualitative changes in the proteome of extracellular vesicles accompanying cancer cell transition to mesenchymal state

(2013) Delphine Garnier et al.   EXPERIMENTAL CELL RESEARCH

Extracellular vesicles: Exosomes, microvesicles, and friends

(2013) Graça Raposo et al.   JOURNAL OF CELL BIOLOGY

Extracellular vesicles: biology and emerging therapeutic opportunities

(2013) Samir EL Andaloussi et al.   NATURE REVIEWS DRUG DISCOVERY

Synergy between the ectoenzymes CD39 and CD73 contributes to adenosinergic immunosuppression in human malignant gliomas

(2013) Shuo Xu et al.   NEURO-ONCOLOGY

miR-21 in the Extracellular Vesicles (EVs) of Cerebrospinal Fluid (CSF): A Platform for Glioblastoma Biomarker Development

(2013) Johnny C. Akers et al.   PLoS One

Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development

(2013) P. Kucharzewska et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glioma microvesicles carry selectively packaged coding and non-coding RNAs which alter gene expression in recipient cells

(2013) Cheryl CY Li et al.   RNA Biology

Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs

(2013) Carolina Villarroya-Beltri et al.   Nature Communications

Delivery of Functional Anti-miR-9 by Mesenchymal Stem Cell–derived Exosomes to Glioblastoma Multiforme Cells Conferred Chemosensitivity

(2013) Jessian L Munoz et al.   Molecular Therapy-Nucleic Acids

BEAMing and Droplet Digital PCR Analysis of Mutant IDH1 mRNA in Glioma Patient Serum and Cerebrospinal Fluid Extracellular Vesicles

(2013) Walter W Chen et al.   Molecular Therapy-Nucleic Acids

Two Distinct Populations of Exosomes Are Released from LIM1863 Colon Carcinoma Cell-derived Organoids

(2012) Bow J. Tauro et al.   MOLECULAR & CELLULAR PROTEOMICS

STAT3 Inhibition Overcomes Temozolomide Resistance in Glioblastoma by Downregulating MGMT Expression

(2012) Shinji Kohsaka et al.   MOLECULAR CANCER THERAPEUTICS

Syndecan–syntenin–ALIX regulates the biogenesis of exosomes

(2012) Maria Francesca Baietti et al.   NATURE CELL BIOLOGY

Protein typing of circulating microvesicles allows real-time monitoring of glioblastoma therapy

(2012) Huilin Shao et al.   NATURE MEDICINE

The Tumor Suppressor PTEN Is Exported in Exosomes and Has Phosphatase Activity in Recipient Cells

(2012) U. Putz et al.   Science Signaling

Regulation of suppressive function of myeloid-derived suppressor cells by CD4+ T cells

(2012) Srinivas Nagaraj et al.   SEMINARS IN CANCER BIOLOGY

Oncogenic extracellular vesicles in brain tumor progression

(2012) Esterina D’Asti et al.   Frontiers in Physiology

Autocrine Endothelin-3/Endothelin Receptor B Signaling Maintains Cellular and Molecular Properties of Glioblastoma Stem Cells

(2011) Y. Liu et al.   MOLECULAR CANCER RESEARCH

Hypoxia triggers a proangiogenic pathway involving cancer cell microvesicles and PAR-2–mediated heparin-binding EGF signaling in endothelial cells

(2011) Katrin J. Svensson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1

(2010) Roel G.W. Verhaak et al.   CANCER CELL

mir-17-92, a cluster of miRNAs in the midst of the cancer network

(2010) Virginie Olive et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A–C

(2010) Chieh Hsu et al.   JOURNAL OF CELL BIOLOGY

Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells

(2010) Fanny Chalmin et al.   JOURNAL OF CLINICAL INVESTIGATION

Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells

(2010) Lucia Ricci-Vitiani et al.   NATURE

Glioblastoma stem-like cells give rise to tumour endothelium

(2010) Rong Wang et al.   NATURE

ARF6-Regulated Shedding of Tumor Cell-Derived Plasma Membrane Microvesicles

(2009) Vandhana Muralidharan-Chari et al.   CURRENT BIOLOGY

Astrocytes and Glioblastoma cells release exosomes carrying mtDNA

(2009) Michele Guescini et al.   JOURNAL OF NEURAL TRANSMISSION

The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins

(2009) Camilla Raiborg et al.   NATURE

Exosome secretion, including the DNA damage-induced p53-dependent secretory pathway, is severely compromised in TSAP6/Steap3-null mice

(2008) A Lespagnol et al.   CELL DEATH AND DIFFERENTIATION

Proteomic and immunologic analyses of brain tumor exosomes

(2008) Michael W. Graner et al.   FASEB JOURNAL

Stem Cell–Related “Self-Renewal” Signature and High Epidermal Growth Factor Receptor Expression Associated With Resistance to Concomitant Chemoradiotherapy in Glioblastoma

(2008) Anastasia Murat et al.   JOURNAL OF CLINICAL ONCOLOGY

Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells

(2008) Khalid Al-Nedawi et al.   NATURE CELL BIOLOGY

Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers

(2008) Johan Skog et al.   NATURE CELL BIOLOGY

Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

(2008) K. Trajkovic et al.   SCIENCE