The Potential of Targeting Brain Pathology with Ascl1/Mash1

Reactive Astrocytes: Production, Function, and Therapeutic Potential

(2017) Shane A. Liddelow et al.   IMMUNITY

Adult Glioblastoma

(2017) Brian M. Alexander et al.   JOURNAL OF CLINICAL ONCOLOGY

Induction of functional dopamine neurons from human astrocytes in vitro and mouse astrocytes in a Parkinson's disease model

(2017) Pia Rivetti di Val Cervo et al.   NATURE BIOTECHNOLOGY

Post-translational Control of the Temporal Dynamics of Transcription Factor Activity Regulates Neurogenesis

(2016) Xiao-Jiang Quan et al.   CELL

Hes1: the maestro in neurogenesis

(2016) Sivadasan Bindu Dhanesh et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Direct Conversion of Somatic Cells into Induced Neurons

(2016) Na An et al.   MOLECULAR NEUROBIOLOGY

Astrocyte scar formation aids central nervous system axon regeneration

(2016) Mark A. Anderson et al.   NATURE

Return to quiescence of mouse neural stem cells by degradation of a proactivation protein

(2016) Noelia Urbán et al.   SCIENCE

Functionalizing Ascl1 with Novel Intracellular Protein Delivery Technology for Promoting Neuronal Differentiation of Human Induced Pluripotent Stem Cells

(2016) Meghan Robinson et al.   Stem Cell Reviews and Reports

Functionalizing Ascl1 with Novel Intracellular Protein Delivery Technology for Promoting Neuronal Differentiation of Human Induced Pluripotent Stem Cells

(2016) Meghan Robinson et al.   Stem Cell Reviews and Reports

Adult Neural Stem Cells from the Subventricular Zone Give Rise to Reactive Astrocytes in the Cortex after Stroke

(2015) Maryam Faiz et al.   Cell Stem Cell

Transcriptional Mechanisms of Proneural Factors and REST in Regulating Neuronal Reprogramming of Astrocytes

(2015) Giacomo Masserdotti et al.   Cell Stem Cell

Single-Cell Transcriptomics Reveals a Population of Dormant Neural Stem Cells that Become Activated upon Brain Injury

(2015) Enric Llorens-Bobadilla et al.   Cell Stem Cell

Striatal astrocytes produce neuroblasts in an excitotoxic model of Huntington's disease

(2015) G. Nato et al.   DEVELOPMENT

The role of glioma stem cells in chemotherapy resistance and glioblastoma multiforme recurrence

(2015) Brenda Auffinger et al.   Expert Review of Neurotherapeutics

Ascl1 Converts Dorsal Midbrain Astrocytes into Functional Neurons In Vivo

(2015) Y. Liu et al.   JOURNAL OF NEUROSCIENCE

Astrocyte barriers to neurotoxic inflammation

(2015) Michael V. Sofroniew   NATURE REVIEWS NEUROSCIENCE

Ascl1 Coordinately Regulates Gene Expression and the Chromatin Landscape during Neurogenesis

(2015) Alexandre A.S.F. Raposo et al.   Cell Reports

The role of glioma stem cells in chemotherapy resistance and glioblastoma multiforme recurrence

(2015) Brenda Auffinger et al.   Expert Review of Neurotherapeutics

MASH1/Ascl1a Leads to GAP43 Expression and Axon Regeneration in the Adult CNS

(2015) Ryan R. Williams et al.   PLoS One

The phosphorylation status of Ascl1 is a key determinant of neuronal differentiation and maturation in vivo and in vitro

(2014) F. R. Ali et al.   DEVELOPMENT

ASCL1 is a lineage oncogene providing therapeutic targets for high-grade neuroendocrine lung cancers

(2014) A. Augustyn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A latent neurogenic program in astrocytes regulated by Notch signaling in the mouse

(2014) J. P. Magnusson et al.   SCIENCE

Transcriptional control of vertebrate neurogenesis by the proneural factor Ascl1

(2014) Francisca F. Vasconcelos et al.   Frontiers in Cellular Neuroscience

In vivo conversion of astrocytes to neurons in the injured adult spinal cord

(2014) Zhida Su et al.   Nature Communications

Vertebrate animal models of glioma: Understanding the mechanisms and developing new therapies

(2013) Leon Chen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Hierarchical Mechanisms for Direct Reprogramming of Fibroblasts to Neurons

(2013) Orly L. Wapinski et al.   CELL

Oscillatory Control of Factors Determining Multipotency and Fate in Mouse Neural Progenitors

(2013) I. Imayoshi et al.   SCIENCE

Environmental impact on direct neuronal reprogramming in vivo in the adult brain

(2013) Andrew Grande et al.   Nature Communications

Reprogramming of Pericyte-Derived Cells of the Adult Human Brain into Induced Neuronal Cells

(2012) Marisa Karow et al.   Cell Stem Cell

Neuronal Transcription Factors Induce Conversion of Human Glioma Cells to Neurons and Inhibit Tumorigenesis

(2012) Junli Zhao et al.   PLoS One

Direct Lineage Conversion of Terminally Differentiated Hepatocytes to Functional Neurons

(2011) Samuele Marro et al.   Cell Stem Cell

Induction of human neuronal cells by defined transcription factors

(2011) Zhiping P. Pang et al.   NATURE

Ascl1 Lineage Cells Contribute to Ischemia-Induced Neurogenesis and Oligodendrogenesis

(2010) Rui Lan Zhang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Astrocytes as Gatekeepers of GABAB Receptor Function

(2010) M. P. Beenhakker et al.   JOURNAL OF NEUROSCIENCE

Direct conversion of fibroblasts to functional neurons by defined factors

(2010) Thomas Vierbuchen et al.   NATURE

Reactive Astrocytes Form Scar-Like Perivascular Barriers to Leukocytes during Adaptive Immune Inflammation of the CNS

(2009) R. R. Voskuhl et al.   JOURNAL OF NEUROSCIENCE

Molecular dissection of reactive astrogliosis and glial scar formation

(2009) Michael V. Sofroniew   TRENDS IN NEUROSCIENCES

Oscillations in Notch Signaling Regulate Maintenance of Neural Progenitors

(2008) Hiromi Shimojo et al.   NEURON