Mammary Gland Involution Provides a Unique Model to Study the TGF-β Cancer Paradox

Celecoxib Alters the Intestinal Microbiota and Metabolome in Association with Reducing Polyp Burden

(2016) D. C. Montrose et al.   Cancer Prevention Research

Quantitative extracellular matrix proteomics to study mammary and liver tissue microenvironments

(2016) Erica T. Goddard et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Janus Kinase 1 Is Essential for Inflammatory Cytokine Signaling and Mammary Gland Remodeling

(2016) Kazuhito Sakamoto et al.   MOLECULAR AND CELLULAR BIOLOGY

TGF-β Signaling from Receptors to Smads

(2016) Akiko Hata et al.   Cold Spring Harbor Perspectives in Biology

Cyclooxygenase-Dependent Tumor Growth through Evasion of Immunity

(2015) Santiago Zelenay et al.   CELL

TGF-β Promotes Heterogeneity and Drug Resistance in Squamous Cell Carcinoma

(2015) Naoki Oshimori et al.   CELL

Th17 Cell Induction by Adhesion of Microbes to Intestinal Epithelial Cells

(2015) Koji Atarashi et al.   CELL

Mammary epithelial cell phagocytosis downstream of TGF-β3 is characterized by adherens junction reorganization

(2015) J Fornetti et al.   CELL DEATH AND DIFFERENTIATION

A phase III study of belagenpumatucel-L, an allogeneic tumour cell vaccine, as maintenance therapy for non-small cell lung cancer

(2015) G. Giaccone et al.   EUROPEAN JOURNAL OF CANCER

Prostaglandin E2 transactivates the colony-stimulating factor-1 receptor and synergizes with colony-stimulating factor-1 in the induction of macrophage migration via the mitogen-activated protein kinase ERK1/2

(2015) Graziana Digiacomo et al.   FASEB JOURNAL

Molecular Phenotype of Breast Cancer According to Time Since Last Pregnancy in a Large Cohort of Young Women

(2015) L. C. Collins et al.   ONCOLOGIST

Targeting the TGFβ pathway for cancer therapy

(2015) Cindy Neuzillet et al.   PHARMACOLOGY & THERAPEUTICS

Platelet-derived CXCL12 regulates monocyte function, survival, differentiation into macrophages and foam cells through differential involvement of CXCR4–CXCR7

(2015) M Chatterjee et al.   Cell Death & Disease

CXCL12-CXCR4 Promotes Proliferation and Invasion of Pancreatic Cancer Cells

(2014) Bo Shen et al.   Asian Pacific Journal of Cancer Prevention

Early but not late pregnancy induces lifelong reductions in the proportion of mammary progesterone sensing cells and epithelial Wnt signaling

(2014) Fabienne Meier-Abt et al.   BREAST CANCER RESEARCH

The miR-424(322)/503 cluster orchestrates remodeling of the epithelium in the involuting mammary gland

(2014) D. Llobet-Navas et al.   GENES & DEVELOPMENT

Wound healing-like immune program facilitates postpartum mammary gland involution and tumor progression

(2014) Holly A. Martinson et al.   INTERNATIONAL JOURNAL OF CANCER

A phase I dose-escalation study to a predefined dose of a transforming growth factor-β1 monoclonal antibody (TβM1) in patients with metastatic cancer

(2014) ALLEN COHN et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Efferocytosis produces a prometastatic landscape during postpartum mammary gland involution

(2014) Jamie C. Stanford et al.   JOURNAL OF CLINICAL INVESTIGATION

Cyclooxygenase-2–dependent lymphangiogenesis promotes nodal metastasis of postpartum breast cancer

(2014) Traci R. Lyons et al.   JOURNAL OF CLINICAL INVESTIGATION

An Indispensable Role for the Chemokine Receptor CCR10 in IgA Antibody-Secreting Cell Accumulation

(2014) O. Morteau et al.   JOURNAL OF IMMUNOLOGY

Mammary Gland Involution as an Immunotherapeutic Target for Postpartum Breast Cancer

(2014) Jaime Fornetti et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

The MicroRNA 424/503 Cluster Reduces CDC25A Expression during Cell Cycle Arrest Imposed by Transforming Growth Factor   in Mammary Epithelial Cells

(2014) D. Llobet-Navas et al.   MOLECULAR AND CELLULAR BIOLOGY

Stat3 controls cell death during mammary gland involution by regulating uptake of milk fat globules and lysosomal membrane permeabilization

(2014) Timothy J. Sargeant et al.   NATURE CELL BIOLOGY

Impaired cell death and mammary gland involution in the absence of Dock1 and Rac1 signaling

(2014) H Bagci et al.   Cell Death & Disease

Postpartum diagnosis demonstrates a high risk for metastasis and merits an expanded definition of pregnancy-associated breast cancer

(2013) Eryn B. Callihan et al.   BREAST CANCER RESEARCH AND TREATMENT

Attenuation of TGF-β signaling supports tumor progression of a mesenchymal-like mammary tumor cell line in a syngeneic murine model

(2013) Tanuka Biswas et al.   CANCER LETTERS

Cyclooxygenase-2 Inhibition Blocks M2 Macrophage Differentiation and Suppresses Metastasis in Murine Breast Cancer Model

(2013) Yi-Rang Na et al.   PLoS One

T Helper 17-Associated Cytokines Are Produced during Antigen-Specific Inflammation in the Mammary Gland

(2013) Pascal Rainard et al.   PLoS One

Induction of TGF-β1 Synthesis by Macrophages in Response to Apoptotic Cells Requires Activation of the Scavenger Receptor CD36

(2013) Weipeng Xiong et al.   PLoS One

Inflammation-Mediated Genetic and Epigenetic Alterations Drive Cancer Development in the Neighboring Epithelium upon Stromal Abrogation of TGF-β Signaling

(2013) B. R. Achyut et al.   PLoS Genetics

Mechanoregulation of the Myofibroblast in Wound Contraction, Scarring, and Fibrosis: Opportunities for New Therapeutic Intervention

(2013) Livingston Van De Water et al.   Advances in Wound Care

Prostaglandin E2 restrains macrophage maturation via E prostanoid receptor 2/protein kinase A signaling

(2012) Z. Zaslona et al.   BLOOD

TGFβ signaling plays a critical role in promoting alternative macrophage activation

(2012) Dapeng Gong et al.   BMC IMMUNOLOGY

SMAD2, SMAD3 and SMAD4 Mutations in Colorectal Cancer

(2012) N. I. Fleming et al.   CANCER RESEARCH

Complexities of TGF-β Targeted Cancer Therapy

(2012) Erin C. Connolly et al.   International Journal of Biological Sciences

Rat Mammary Extracellular Matrix Composition and Response to Ibuprofen Treatment During Postpartum Involution by Differential GeLC–MS/MS Analysis

(2012) Jenean H. O’Brien et al.   JOURNAL OF PROTEOME RESEARCH

T-bet and GATA3 orchestrate Th1 and Th2 differentiation through lineage-specific targeting of distal regulatory elements

(2012) Aditi Kanhere et al.   Nature Communications

Mammary gland development

(2012) Hector Macias et al.   Wiley Interdisciplinary Reviews-Developmental Biology

Altered TGF-β Signaling in a Subpopulation of Human Stromal Cells Promotes Prostatic Carcinogenesis

(2011) Omar E. Franco et al.   CANCER RESEARCH

Loss of one Tgfbr2 allele in fibroblasts promotes metastasis in MMTV: polyoma middle T transgenic and transplant mouse models of mammary tumor progression

(2011) Wei Bin Fang et al.   CLINICAL & EXPERIMENTAL METASTASIS

Macrophages are crucial for epithelial cell death and adipocyte repopulation during mammary gland involution

(2011) J. O'Brien et al.   DEVELOPMENT

Non-steroidal anti-inflammatory drugs target the pro-tumorigenic extracellular matrix of the postpartum mammary gland

(2011) Jenean OBrien et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Mechanisms by Which the Extracellular Matrix and Integrin Signaling Act to Regulate the Switch Between Tumor Suppression and Tumor Promotion

(2011) Patricia J. Keely   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Postpartum mammary gland involution drives progression of ductal carcinoma in situ through collagen and COX-2

(2011) Traci R Lyons et al.   NATURE MEDICINE

Epithelial to Mesenchymal Transition by TGFβ-1 Induction Increases Stemness Characteristics in Primary Non Small Cell Lung Cancer Cell Line

(2011) Giuseppe Pirozzi et al.   PLoS One

Alternatively Activated Macrophages and Collagen Remodeling Characterize the Postpartum Involuting Mammary Gland across Species

(2010) Jenean O'Brien et al.   AMERICAN JOURNAL OF PATHOLOGY

IL-13 and TH2 cytokine exposure triggers matrix metalloproteinase 7–mediated Fas ligand cleavage from bronchial epithelial cells

(2010) Samuel J. Wadsworth et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IgA ASC accumulation to the lactating mammary gland is dependent on VCAM-1 and alpha4 integrins

(2010) Elizabeth N. Low et al.   MOLECULAR IMMUNOLOGY

The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment

(2009) A. Greenhough et al.   CARCINOGENESIS

Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria

(2009) Ivaylo I. Ivanov et al.   CELL

TGF-β-induced epithelial to mesenchymal transition

(2009) Jian Xu et al.   CELL RESEARCH

Th17 cytokines and host-pathogen interactions at the mucosa: Dichotomies of help and harm

(2009) Janet Z. Liu et al.   CYTOKINE

The TGF-β paradox in human cancer: an update

(2009) Maozhen Tian et al.   Future Oncology

Collagen density promotes mammary tumor initiation and progression

(2008) Paolo P Provenzano et al.   BMC Medicine

DAP-kinase is a mediator of endoplasmic reticulum stress-induced caspase activation and autophagic cell death

(2008) D Gozuacik et al.   CELL DEATH AND DIFFERENTIATION

Specific Microbiota Direct the Differentiation of IL-17-Producing T-Helper Cells in the Mucosa of the Small Intestine

(2008) Ivaylo I. Ivanov et al.   Cell Host & Microbe

Non-Smad pathways in TGF-β signaling

(2008) Ying E Zhang   CELL RESEARCH

Immunosuppression induced by immature dendritic cells is mediated by TGF-β/IL-10 double-positive CD4+regulatory T cells

(2008) N. Cools et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

TGF-β promotes cell death and suppresses lactation during the second stage of mammary involution

(2008) Brian Bierie et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The Immune Tolerance of Cancer is Mediated by IDO That is Inhibited by COX-2 Inhibitors Through Regulatory T Cells

(2008) Sung Yong Lee et al.   JOURNAL OF IMMUNOTHERAPY

Cancer as an overhealing wound: an old hypothesis revisited

(2008) Matthias Schäfer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Epithelial Cells Remove Apoptotic Epithelial Cells During Post-Lactation Involution of the Mouse Mammary Gland1

(2007) Jenifer Monks et al.   BIOLOGY OF REPRODUCTION