Nanoparticles that do not adhere to mucus provide uniform and long-lasting drug delivery to airways following inhalation

PEGylation as a strategy for improving nanoparticle-based drug and gene delivery

(2016) Jung Soo Suk et al.   ADVANCED DRUG DELIVERY REVIEWS

Barriers to inhaled gene therapy of obstructive lung diseases: A review

(2016) Namho Kim et al.   JOURNAL OF CONTROLLED RELEASE

Impact of Surface Polyethylene Glycol (PEG) Density on Biodegradable Nanoparticle Transport in Mucus ex Vivo and Distribution in Vivo

(2015) Qingguo Xu et al.   ACS Nano

Effect of surface chemistry on nanoparticle interaction with gastrointestinal mucus and distribution in the gastrointestinal tract following oral and rectal administration in the mouse

(2015) Katharina Maisel et al.   JOURNAL OF CONTROLLED RELEASE

Highly compacted biodegradable DNA nanoparticles capable of overcoming the mucus barrier for inhaled lung gene therapy

(2015) Panagiotis Mastorakos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lung gene therapy with highly compacted DNA nanoparticles that overcome the mucus barrier

(2014) Jung Soo Suk et al.   JOURNAL OF CONTROLLED RELEASE

Antibiotic-free nanotherapeutics: Ultra-small, mucus-penetrating solid lipid nanoparticles enhance the pulmonary delivery and anti-virulence efficacy of novel quorum sensing inhibitors

(2014) Noha Nafee et al.   JOURNAL OF CONTROLLED RELEASE

Overcoming the Cystic Fibrosis Sputum Barrier to Leading Adeno-associated Virus Gene Therapy Vectors

(2014) Benjamin S Schuster et al.   MOLECULAR THERAPY

The Microstructure and Bulk Rheology of Human Cervicovaginal Mucus Are Remarkably Resistant to Changes in pH

(2013) Ying-Ying Wang et al.   BIOMACROMOLECULES

Enhanced vaginal drug delivery through the use of hypotonic formulations that induce fluid uptake

(2013) Laura M. Ensign et al.   BIOMATERIALS

Nanoparticle diffusion in respiratory mucus from humans without lung disease

(2013) Benjamin S. Schuster et al.   BIOMATERIALS

Scalable method to produce biodegradable nanoparticles that rapidly penetrate human mucus

(2013) Qingguo Xu et al.   JOURNAL OF CONTROLLED RELEASE

Chitosan-based drug delivery systems

(2012) Andreas Bernkop-Schnürch et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Optical tweezers reveal relationship between microstructure and nanoparticle penetration of pulmonary mucus

(2012) J. Kirch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Walking on Solid Ground

(2012) B. F. Dickey   SCIENCE

A Periciliary Brush Promotes the Lung Health by Separating the Mucus Layer from Airway Epithelia

(2012) B. Button et al.   SCIENCE

Mucus-Penetrating Nanoparticles for Vaginal Drug Delivery Protect Against Herpes Simplex Virus

(2012) L. M. Ensign et al.   Science Translational Medicine

A Dense Poly(Ethylene Glycol) Coating Improves Penetration of Large Polymeric Nanoparticles Within Brain Tissue

(2012) E. A. Nance et al.   Science Translational Medicine

Mucociliary interactions and mucus dynamics in ciliated human bronchial epithelial cell cultures

(2011) Patrick R. Sears et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Biodegradable Nanoparticles Composed Entirely of Safe Materials that Rapidly Penetrate Human Mucus

(2011) Ming Yang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Drug carrier nanoparticles that penetrate human chronic rhinosinusitis mucus

(2011) Samuel K. Lai et al.   BIOMATERIALS

Induction of potent anti-tumor responses while eliminating systemic side effects via liposome-anchored combinatorial immunotherapy

(2011) Brandon Kwong et al.   BIOMATERIALS

Rapid transport of muco-inert nanoparticles in cystic fibrosis sputum treated withN-acetyl cysteine

(2011) Jung Soo Suk et al.   Nanomedicine

Influence of Particle Size and Material Properties on Mucociliary Clearance from the Airways

(2010) Andreas Henning et al.   Journal of Aerosol Medicine and Pulmonary Drug Delivery

Update on Macrophage Clearance of Inhaled Micro- and Nanoparticles

(2010) Marianne Geiser   Journal of Aerosol Medicine and Pulmonary Drug Delivery

Nanoparticle-mediated local delivery of methylprednisolone after spinal cord injury

(2009) Young-tae Kim et al.   BIOMATERIALS

The penetration of fresh undiluted sputum expectorated by cystic fibrosis patients by non-adhesive polymer nanoparticles

(2009) Jung Soo Suk et al.   BIOMATERIALS

Nanoparticles reveal that human cervicovaginal mucus is riddled with pores larger than viruses

(2009) S. K. Lai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cystic fibrosis gene therapy: successes, failures and hopes for the future

(2009) Uta Griesenbach et al.   Expert Review of Respiratory Medicine

Targeted delivery of nanoparticles for the treatment of lung diseases

(2008) Shirzad Azarmi et al.   ADVANCED DRUG DELIVERY REVIEWS

Gene transfer to the lung: Lessons learned from more than 2 decades of CF gene therapy

(2008) Uta Griesenbach et al.   ADVANCED DRUG DELIVERY REVIEWS

Deposition, Retention, and Translocation of Ultrafine Particles from the Central Airways and Lung Periphery

(2008) Winfried Möller et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Addressing the PEG Mucoadhesivity Paradox to Engineer Nanoparticles that “Slip” through the Human Mucus Barrier

(2008) Ying-Ying Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Pulmonary delivery of scutellarin solution and mucoadhesive particles in rats

(2008) Xiao-Bin Liu et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Inhaled nanoparticles—A current review

(2008) Wei Yang et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Efficient encapsulation of a water-soluble corticosteroid in biodegradable nanoparticles

(2008) T ISHIHARA et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS