Mucus-Penetrating Nanoparticles for Vaginal Drug Delivery Protect Against Herpes Simplex Virus

Biodegradable Nanoparticles Composed Entirely of Safe Materials that Rapidly Penetrate Human Mucus

(2011) Ming Yang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

In vivo distribution of surface-modified PLGA nanoparticles following intravaginal delivery

(2011) Yen Cu et al.   JOURNAL OF CONTROLLED RELEASE

The last decade of microbicide clinical trials in Africa: from hypothesis to facts

(2010) Gita Ramjee et al.   AIDS

Microbicide excipients can greatly increase susceptibility to genital herpes transmission in the mouse

(2010) Thomas R Moench et al.   BMC INFECTIOUS DISEASES

Effective vaginal DNA delivery with high transfection efficiency is a good system for induction of higher local vaginal immune responses

(2010) Takanori Kanazawa et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

In Vitro and Ex Vivo Testing of Tenofovir Shows It Is Effective As an HIV-1 Microbicide

(2010) Lisa C. Rohan et al.   PLoS One

Effectiveness and Safety of Tenofovir Gel, an Antiretroviral Microbicide, for the Prevention of HIV Infection in Women

(2010) Q. Abdool Karim et al.   SCIENCE

DNA vaccine delivery by densely-packed and short microprojection arrays to skin protects against vaginal HSV-2 challenge

(2010) Angela Shaulov Kask et al.   VACCINE

Susceptibility to genital herpes as a biomarker predictive of increased HIV risk: expansion of a murine model of microbicide safety

(2009) Sarah S Wilson et al.   ANTIVIRAL THERAPY

In vivo evaluation of the vaginal distribution and retention of a multi-particulate pellet formulation

(2009) Nele Poelvoorde et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Nanoparticle-based vaginal drug delivery systems for HIV prevention

(2009) Rama Mallipeddi et al.   Expert Opinion on Drug Delivery

Human Immunodeficiency Virus Type 1 Is Trapped by Acidic but Not by Neutralized Human Cervicovaginal Mucus

(2009) S. K. Lai et al.   JOURNAL OF VIROLOGY

Intravaginal gene silencing using biodegradable polymer nanoparticles densely loaded with small-interfering RNA

(2009) Kim A. Woodrow et al.   NATURE MATERIALS

Biodegradable polymer nanoparticles that rapidly penetrate the human mucus barrier

(2009) B. C. Tang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nanoparticles reveal that human cervicovaginal mucus is riddled with pores larger than viruses

(2009) S. K. Lai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biomarkers of Cervicovaginal Inflammation for the Assessment of Microbicide Safety

(2009) James E. Cummins et al.   SEXUALLY TRANSMITTED DISEASES

A Review of Current Intravaginal Drug Delivery Approaches Employed for the Prophylaxis of HIV/AIDS and Prevention of Sexually Transmitted Infections

(2008) Valence M. K. Ndesendo et al.   AAPS PHARMSCITECH

Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues

(2008) Samuel K. Lai et al.   ADVANCED DRUG DELIVERY REVIEWS

Addressing the PEG Mucoadhesivity Paradox to Engineer Nanoparticles that “Slip” through the Human Mucus Barrier

(2008) Ying-Ying Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Topical Microbicides to Prevent HIV: Clinical Drug Development Challenges

(2008) Craig W. Hendrix et al.   Annual Review of Pharmacology and Toxicology