Epigenetic Matters: The Link between Early Nutrition, Microbiome, and Long-term Health Development

Maternal phthalate exposure promotes allergic airway inflammation over 2 generations through epigenetic modifications

(2018) Susanne Jahreis et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Gestational high-fat diet and bisphenol A exposure heightens mammary cancer risk

(2017) Yuet-Kin Leung et al.   ENDOCRINE-RELATED CANCER

Oxidative injuries induced by maternal low-protein diet in female brainstem

(2017) Shirley Maria de Sousa et al.   NUTRITIONAL NEUROSCIENCE

The Gut Microbiota and Autism Spectrum Disorders

(2017) Qinrui Li et al.   Frontiers in Cellular Neuroscience

Maternal Low-Protein Diet Modulates Glucose Metabolism and Hepatic MicroRNAs Expression in the Early Life of Offspring †

(2017) Jia Zheng et al.   Nutrients

A critical assessment of the “sterile womb” and “in utero colonization” hypotheses: implications for research on the pioneer infant microbiome

(2017) Maria Elisa Perez-Muñoz et al.   Microbiome

Childhood BMI in relation to microbiota in infancy and lifetime antibiotic use

(2017) K. Korpela et al.   Microbiome

A preliminary investigation on the relationship between gut microbiota and gene expressions in peripheral mononuclear cells of infants with autism spectrum disorders

(2016) Ryo Inoue et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Antibiotics, obesity and the link to microbes - what are we doing to our children?

(2016) Olli Turta et al.   BMC Medicine

Epigenome-Microbiome crosstalk: A potential new paradigm influencing neonatal susceptibility to disease

(2016) Rene Cortese et al.   Epigenetics

Does vaginal delivery mitigate or strengthen the intergenerational association of overweight and obesity? Findings from the Boston Birth Cohort

(2016) N T Mueller et al.   INTERNATIONAL JOURNAL OF OBESITY

Different immunological responses to early-life antibiotic exposure affecting autoimmune diabetes development in NOD mice

(2016) Youjia Hu et al.   JOURNAL OF AUTOIMMUNITY

Microbiome–Epigenome Interactions and the Environmental Origins of Inflammatory Bowel Diseases

(2016) Tatiana Y. Fofanova et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

The Gut-Brain Axis, BDNF, NMDA and CNS Disorders

(2016) Raeesah Maqsood et al.   NEUROCHEMICAL RESEARCH

The Infant Microbiome

(2016) Irene Yang et al.   NURSING RESEARCH

Modulation of type 1 and type 2 diabetes risk by the intestinal microbiome

(2016) Alexandra Paun et al.   PEDIATRIC DIABETES

Variable Methylation Potential in Preterm Placenta: Implication for Epigenetic Programming of the Offspring

(2016) Vinita V. Khot et al.   Reproductive Sciences

The microbiome during pregnancy and early postnatal life

(2016) Josef Neu   Seminars in Fetal & Neonatal Medicine

Exploring the contribution of maternal antibiotics and breastfeeding to development of the infant microbiome and pediatric obesity

(2016) Dominick J. Lemas et al.   Seminars in Fetal & Neonatal Medicine

How Our Other Genome Controls Our Epi-Genome

(2016) Antonella Celluzzi et al.   TRENDS IN MICROBIOLOGY

Distant Site Effects of Ingested Prebiotics

(2016) Stephanie Collins et al.   Nutrients

Prenatal phthalate exposure: epigenetic changes leading to lifelong impact on steroid formation

(2016) D. B. Martinez-Arguelles et al.   Andrology

The Eukaryotic Microbiome: Origins and Implications for Fetal and Neonatal Life

(2016) William B. Miller   Frontiers in Pediatrics

Human gut colonisation may be initiated in utero by distinct microbial communities in the placenta and amniotic fluid

(2016) Maria Carmen Collado et al.   Scientific Reports

Obesity and Pro12Ala Polymorphism of Peroxisome Proliferator-Activated Receptor-Gamma Gene in Healthy Adults: A Systematic Review and Meta-Analysis

(2015) Anahita Mansoori et al.   ANNALS OF NUTRITION AND METABOLISM

The microbiome and childhood diseases: Focus on brain-gut axis

(2015) Siobhain M. O’ Mahony et al.   BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS

New Approaches for Bacteriotherapy: Prebiotics, New-Generation Probiotics, and Synbiotics

(2015) Rachna Patel et al.   CLINICAL INFECTIOUS DISEASES

Maternal Antibiotic Treatment Protects Offspring from Diabetes Development in Nonobese Diabetic Mice by Generation of Tolerogenic APCs

(2015) Youjia Hu et al.   JOURNAL OF IMMUNOLOGY

Maternal high-zinc diet attenuates intestinal inflammation by reducing DNA methylation and elevating H3K9 acetylation in the A20 promoter of offspring chicks

(2015) Changwu Li et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

First trimester vitamin D status and placental epigenomics in preeclampsia among Northern Plains primiparas

(2015) Cindy M. Anderson et al.   LIFE SCIENCES

Proposing interactions between maternal phospholipids and the one carbon cycle: A novel mechanism influencing the risk for cardiovascular diseases in the offspring in later life

(2015) Vinita Khot et al.   LIFE SCIENCES

Developmental exposure to bisphenol A alters expression and DNA methylation of Fkbp5, an important regulator of the stress response

(2015) Efthymia Kitraki et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Zinc deficiency enhanced inflammatory response by increasing immune cell activation and inducing IL6 promoter demethylation

(2015) Carmen P. Wong et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Association between caesarean section and childhood obesity: a systematic review and meta-analysis

(2015) S. Kuhle et al.   Obesity Reviews

Introducing enteral feeding induces intestinal subclinical inflammation and respective chromatin changes in preterm pigs

(2015) Rhea Willems et al.   Epigenomics

Antibiotics in Early Life Alter the Gut Microbiome and Increase Disease Incidence in a Spontaneous Mouse Model of Autoimmune Insulin-Dependent Diabetes

(2015) Sophie Candon et al.   PLoS One

Prenatal and Postnatal Exposure to Phthalate Esters and Asthma: A 9-Year Follow-Up Study of a Taiwanese Birth Cohort

(2015) Hsiu Ying Ku et al.   PLoS One

Comparison of Fecal Microbiota in Children with Autism Spectrum Disorders and Neurotypical Siblings in the Simons Simplex Collection

(2015) Joshua S. Son et al.   PLoS One

Vitamin D status and hypertensive disorders in pregnancy

(2014) Heather H. Burris et al.   ANNALS OF EPIDEMIOLOGY

Establishment of Intestinal Microbiota during Early Life: a Longitudinal, Explorative Study of a Large Cohort of Danish Infants

(2014) A. Bergstrom et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Altering the Intestinal Microbiota during a Critical Developmental Window Has Lasting Metabolic Consequences

(2014) Laura M. Cox et al.   CELL

Overweight and Obesity before, during and after Pregnancy

(2014) J. Stupin et al.   GEBURTSHILFE UND FRAUENHEILKUNDE

Prenatal exposure to antibiotics, cesarean section and risk of childhood obesity

(2014) N T Mueller et al.   INTERNATIONAL JOURNAL OF OBESITY

Effects of maternal protein or energy restriction during late gestation on immune status and responses to lipopolysaccharide challenge in postnatal young goats1

(2014) Z. X. He et al.   JOURNAL OF ANIMAL SCIENCE

Early Empiric Antibiotic Use in Preterm Infants Is Associated with Lower Bacterial Diversity and Higher Relative Abundance of Enterobacter

(2014) Corryn Greenwood et al.   JOURNAL OF PEDIATRICS

Probiotics and primary prevention of atopic dermatitis: a meta-analysis of randomized controlled studies

(2014) M. Panduru et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Bifidobacteriaexert strain-specific effects on stress-related behavior and physiology in BALB/c mice

(2014) H. M. Savignac et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Maternal high-fat diet alters anxiety behavior and glucocorticoid signaling in adolescent offspring

(2014) A. Sasaki et al.   NEUROSCIENCE

Impact of nutrition on brain development and its neuroprotective implications following preterm birth

(2014) Kristin Keunen et al.   PEDIATRIC RESEARCH

Cesarean Section and Chronic Immune Disorders

(2014) A. Sevelsted et al.   PEDIATRICS

Gut Microbiota as an Epigenetic Regulator: Pilot Study Based on Whole-Genome Methylation Analysis

(2014) Himanshu Kumar et al.   mBio

Epigenetic Modification of the Leptin Promoter in Diet-Induced Obese Mice and the Effects of N-3 Polyunsaturated Fatty Acids

(2014) Wenwen Shen et al.   Scientific Reports

Microbiota and epigenetic regulation of inflammatory mediators in type 2 diabetes and obesity

(2014) M. Remely et al.   Beneficial Microbes

Assessing the association of early life antibiotic prescription with asthma exacerbations, impaired antiviral immunity, and genetic variants in 17q21: a population-based birth cohort study

(2014) Aida Semic-Jusufagic et al.   Lancet Respiratory Medicine

PPARβ mRNA expression, reduced by n−3 PUFA diet in mammary tumor, controls breast cancer cell growth

(2013) Ramez Wannous et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Omega-3 phospholipids from fish suppress hepatic steatosis by integrated inhibition of biosynthetic pathways in dietary obese mice

(2013) Martin Rossmeisl et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

You are what you eat, and so are your children: the impact of micronutrients on the epigenetic programming of offspring

(2013) Kimberly Vanhees et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Microbial genes, brain & behaviour - epigenetic regulation of the gut-brain axis

(2013) R. M. Stilling et al.   GENES BRAIN AND BEHAVIOR

The regulation of hepatic Pon1 by a maternal high-fat diet is gender specific and may occur through promoter histone modifications in neonatal rats

(2013) Rita S. Strakovsky et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Evidence-based interventions for improvement of maternal and child nutrition: what can be done and at what cost?

(2013) Zulfiqar A Bhutta et al.   LANCET

Microbiota is essential for social development in the mouse

(2013) L Desbonnet et al.   MOLECULAR PSYCHIATRY

Innate Immunity in the CNS: Redefining the Relationship between the CNS and Its Environment

(2013) Antoine Lampron et al.   NEURON

Intestinal Microbial Ecology and Environmental Factors Affecting Necrotizing Enterocolitis

(2013) Roberto Murgas Torrazza et al.   PLoS One

Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice

(2013) V. K. Ridaura et al.   SCIENCE

Gut–brain axis: how the microbiome influences anxiety and depression

(2013) Jane A. Foster et al.   TRENDS IN NEUROSCIENCES

The role of gut microbiota in programming the immune phenotype

(2013) M. Weng et al.   Journal of Developmental Origins of Health and Disease

Mom Knows Best: The Universality of Maternal Microbial Transmission

(2013) Lisa J. Funkhouser et al.   PLOS BIOLOGY

Review article: probiotics for the treatment of irritable bowel syndrome - focus on lactic acid bacteria

(2012) G. Clarke et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Association of Maternal Vitamin D and Placenta Growth Factor with the Diagnosis of Early Onset Severe Preeclampsia

(2012) Carol Wagner et al.   AMERICAN JOURNAL OF PERINATOLOGY

Irritable Bowel Syndrome: Methods, Mechanisms, and Pathophysiology. Methods to assess visceral hypersensitivity in irritable bowel syndrome

(2012) D. Keszthelyi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

The Human Microbiome: Our Second Genome

(2012) Elizabeth A. Grice et al.   Annual Review of Genomics and Human Genetics

Molecular Characterisation of Gastrointestinal Microbiota of Children With Autism (With and Without Gastrointestinal Dysfunction) and Their Neurotypical Siblings

(2012) Shakuntla V. Gondalia et al.   Autism Research

Host Remodeling of the Gut Microbiome and Metabolic Changes during Pregnancy

(2012) Omry Koren et al.   CELL

A maternal high-fat diet modulates fetal SIRT1 histone and protein deacetylase activity in nonhuman primates

(2012) Melissa A. Suter et al.   FASEB JOURNAL

Can Traumatic Stress Alter the Brain? Understanding the Implications of Early Trauma on Brain Development and Learning

(2012) Victor G. Carrion et al.   JOURNAL OF ADOLESCENT HEALTH

Maternal probiotic supplementation during pregnancy and breast-feeding reduces the risk of eczema in the infant

(2012) Samuli Rautava et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Modulation of Inflammatory Cytokines and Mitogen-activated Protein Kinases by Acetate in Primary Astrocytes

(2012) Mahmoud L. Soliman et al.   Journal of Neuroimmune Pharmacology

Fish oil supplementation for two generations increases insulin sensitivity in rats

(2012) Sandro M. Hirabara et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Folate deficiency enhances the inflammatory response of macrophages

(2012) Andreas F. Kolb et al.   MOLECULAR IMMUNOLOGY

The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner

(2012) G Clarke et al.   MOLECULAR PSYCHIATRY

Contributions of central and systemic inflammation to the pathophysiology of Parkinson's disease

(2012) Louise M. Collins et al.   NEUROPHARMACOLOGY

Genetic and Non-Genetic Influences during Pregnancy on Infant Global and Site Specific DNA Methylation: Role for Folate Gene Variants and Vitamin B12

(2012) Jill A. McKay et al.   PLoS One

Diversity of Bifidobacteria within the Infant Gut Microbiota

(2012) Francesca Turroni et al.   PLoS One

New Insights in Gut Microbiota Establishment in Healthy Breast Fed Neonates

(2012) Ted Jost et al.   PLoS One

Early nutrition programming of long-term health

(2012) Berthold Koletzko et al.   PROCEEDINGS OF THE NUTRITION SOCIETY

Regulation of the stress response by the gut microbiota: Implications for psychoneuroendocrinology

(2012) Timothy G. Dinan et al.   PSYCHONEUROENDOCRINOLOGY

Importance of epigenetic mechanisms in visceral pain induced by chronic water avoidance stress

(2012) L. Tran et al.   PSYCHONEUROENDOCRINOLOGY

The epigenetic effects of butyrate: potential therapeutic implications for clinical practice

(2012) Roberto Berni Canani et al.   Clinical Epigenetics

Structure of the full human RXR/VDR nuclear receptor heterodimer complex with its DR3 target DNA

(2011) Igor Orlov et al.   EMBO JOURNAL

An irritable bowel syndrome subtype defined by species-specific alterations in faecal microbiota

(2011) Ian B Jeffery et al.   GUT

Epigenetic regulation in murine offspring as a novel mechanism for transmaternal asthma protection induced by microbes

(2011) Stephanie Brand et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Influence of gastrointestinal commensal bacteria on the immune responses that mediate allergy and asthma

(2011) Rachel M. McLoughlin et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The ageing systemic milieu negatively regulates neurogenesis and cognitive function

(2011) Saul A. Villeda et al.   NATURE

Gut feelings: the emerging biology of gut–brain communication

(2011) Emeran A. Mayer   NATURE REVIEWS NEUROSCIENCE

Normal gut microbiota modulates brain development and behavior

(2011) R. D. Heijtz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The germfree murine animal: An important animal model for research on the relationship between gut microbiota and the host

(2011) Ping Yi et al.   VETERINARY MICROBIOLOGY

Maternal obesity associated with inflammation in their children

(2011) Karen L. Leibowitz et al.   World Journal of Pediatrics

Folate Production by Probiotic Bacteria

(2011) Maddalena Rossi et al.   Nutrients

Epigenetics of programmed obesity: alteration in IUGR rat hepatic IGF1 mRNA expression and histone structure in rapid vs. delayed postnatal catch-up growth

(2010) Darran N. Tosh et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Maternal obesity programmes offspring development of non-alcoholic fatty pancreas disease

(2010) Jude A. Oben et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Epigenomic disruption: The effects of early developmental exposures

(2010) Autumn J. Bernal et al.   BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY

RNA and transcriptional modulation of gene expression

(2010) Peter G. Hawkins et al.   CELL CYCLE

Antibiotic use and inflammatory bowel diseases in childhood

(2010) A. Hviid et al.   GUT

Maternal obesity induces sustained inflammation in both fetal and offspring large intestine of sheep

(2010) Xu Yan et al.   INFLAMMATORY BOWEL DISEASES

Conserved role of intragenic DNA methylation in regulating alternative promoters

(2010) Alika K. Maunakea et al.   NATURE

The probiotic Bifidobacterium infantis 35624 displays visceral antinociceptive effects in the rat

(2010) D. P Mckernan et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Zinc restriction during different periods of life: Influence in renal and cardiovascular diseases

(2010) Analía Lorena Tomat et al.   NUTRITION

Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota

(2010) J. L. Round et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns

(2010) M. G. Dominguez-Bello et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epigenetic programming by maternal nutrition: shaping future generations

(2010) Cheryl Chui Ying Li et al.   Epigenomics

Maternal obesity accelerates fetal pancreatic β-cell but not α-cell development in sheep: prenatal consequences

(2009) Stephen P. Ford et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Influence of early gut microbiota on the maturation of childhood mucosal and systemic immune responses

(2009) Y. M. Sjögren et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Breast-Feeding Modulates the Influence of the Peroxisome Proliferator-Activated Receptor-  (PPARG2) Pro12Ala Polymorphism on Adiposity in Adolescents: The Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) cross-sectional study

(2009) C. Verier et al.   DIABETES CARE

High-dose folate and dietary purines promote scavenging of peroxynitrite-derived radicals – Clinical potential in inflammatory disorders

(2009) Mark F. McCarty et al.   MEDICAL HYPOTHESES

Cytokines and CNS Development

(2009) Benjamin E. Deverman et al.   NEURON

Importance of methyl donors during reproduction

(2008) Steven H Zeisel   AMERICAN JOURNAL OF CLINICAL NUTRITION

Folic acid supplements in pregnancy and early childhood respiratory health

(2008) S E Haberg et al.   ARCHIVES OF DISEASE IN CHILDHOOD

Transgenerational effects of prenatal exposure to the Dutch famine on neonatal adiposity and health in later life

(2008) RC Painter et al.   BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY

APC dysfunction is correlated with defective suppression of T cell proliferation in human type 1 diabetes

(2008) Yulan Jin et al.   CLINICAL IMMUNOLOGY

Effects of preterm birth and fetal growth retardation on cardiovascular risk factors in young adulthood

(2008) Kari Anne Indredavik Evensen et al.   EARLY HUMAN DEVELOPMENT

Farm exposure in utero may protect against asthma, hay fever and eczema

(2008) J. Douwes et al.   EUROPEAN RESPIRATORY JOURNAL

Gestational Choline Supply Regulates Methylation of Histone H3, Expression of Histone Methyltransferases G9a (Kmt1c) and Suv39h1 (Kmt1a), and DNA Methylation of Their Genes in Rat Fetal Liver and Brain

(2008) Jessica M. Davison et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Histone Code Modifications Repress Glucose Transporter 4 Expression in the Intrauterine Growth-restricted Offspring

(2008) Nupur Raychaudhuri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Development of type 2 diabetes following intrauterine growth retardation in rats is associated with progressive epigenetic silencing of Pdx1

(2008) Jun H. Park et al.   JOURNAL OF CLINICAL INVESTIGATION

In utero supplementation with methyl donors enhances allergic airway disease in mice

(2008) John W. Hollingsworth et al.   JOURNAL OF CLINICAL INVESTIGATION

Developmental origins of disease and determinants of chromatin structure: maternal diet modifies the primate fetal epigenome

(2008) Kjersti M Aagaard-Tillery et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Predictive adaptive responses in perspective

(2008) Peter D. Gluckman et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM